{ "site": { "title_cn": "非临床骨髓涂片与细胞形态图谱", "title_en": "Nonclinical Bone Marrow Smear & Cytomorphology Atlas", "edition": "toxpathmap.cn Public Learning Edition", "generated_at": "2026-08-11", "notice_cn": "本共享版仅保留可公开再利用图片与可追溯教学内容；程序整理内容不替代临床病理学家或毒理病理学家的判断。", "notice_en": "This sharing edition contains only reusable images and traceable educational content. Programmatic summaries do not replace qualified clinical or toxicologic pathology review.", "canonical_url": "https://toxpathmap.cn/bone-marrow/" }, "metrics": { "public_images": 36, "terms": 18, "toxicity_types": 12, "quality_defects": 16, "cytology_images": 36, "peripheral_blood_comparators": 7, "pathology_evidence_records": 77, "all_reusable_image_records": 120 }, "images": [ { "image_id": "BMAT-0002-MORPH-A", "source_id": "LEGACY-RPBM-001", "title_cn": "卡铂处理后大鼠骨髓冲洗物巨核细胞减少", "title_en": "Reduced megakaryocytes in rat marrow washout after carboplatin", "description_cn": "大鼠骨髓冲洗物经固定和刘氏染色后的对照与处理组比较。箭头标示巨核细胞；原作者报告卡铂处理后巨核细胞计数下降。", "description_en": "Control and treated rat marrow washout after fixation and Liu staining. Arrows identify megakaryocytes; the authors reported a lower megakaryocyte count after carboplatin treatment.", "species": "Rat", "strain": "Sprague-Dawley", "specimen_type": "Bone_marrow_washout_cytology", "stain": "Liu's stain", "lineage": "Megakaryocytic", "figure_label": "Figure 2A", "panel_label": "A", "caption_original_en": "Number of megakaryocytes decreased after carboplatin treatment in vivo. Bone marrow washout from control and 35 mg/kg carboplatin-treated rat at the sixth day were used for the analysis. ( A ) After fixation and Liu’s staining, the megakaryocyte number was determined by counting. Scale bar = 120 μm. ( B ) Experiment was carried out in three different rats and result was statistically significant. ( C ) The CD61+ cells in the bone marrow washout were analyzed by flow cytometry. ( D ) A representative image from the flow cytometry was shown. Cells in the green square with the increased green fluorescence by the binding with FITC-conjugated annexin V were characterized as early apoptotic cells. On the other hand, cells in the red square with the increase of green fluorescence by the binding with FITC-conjugated annexin V and also the increase of red fluorescence from the PI inside the cytosol were characterized as late apoptotic cells. ( E ) Percentage of the early and late apoptotic cells in bone marrow washout was analyzed based on the results of flow cytometry. (* p -value < 0.05, ** p -value < 0.01, three independent experiments were performed).", "article_title": "Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes", "doi": "10.3390/ijms23116290", "pmid": "35682967", "pmcid": "PMC9181531", "source_url": "https://www.mdpi.com/1422-0067/23/11/6290", "license": "CC BY 4.0", "reuse_status": "cc_reuse_allowed", "attribution": "Wu Y-H, Chen H-Y, Hong W-C, Wei C-Y, Pang J-HS. Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes. Int J Mol Sci. 2022;23(11):6290. doi:10.3390/ijms23116290. CC BY 4.0. Figure 2A.", "expert_review_status": "Pending", "asset_path": "images/BMAT-0002-MORPH-A.jpg", "sha256": "350318b1e7f202a737ca03573e77a45056bf2752b288c7e9bdb858bd2cebf7bb", "license_url": "https://creativecommons.org/licenses/by/4.0/", "primary_morphology_class": "Cytotoxic_change", "secondary_features": [ "Megakaryocyte_decrease" ], "evidence_role": "Toxicity_image", "causality_level": "Author_attributed", "third_party_credit_line": "None reported in the article figure legend", "processing_note": "Panel A was extracted from the composite source figure; no cellular structures were generated or retouched.", "preview_path": "previews/BMAT-0002-MORPH-A.jpg", "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-GCSF-FS3-D", "map_image_id": "NR", "source_id": "PMC7723243-MOUSE-GCSF-GRANULOPOIESIS", "title_cn": "小鼠G-CSF反应：骨髓粒细胞生成增强的低倍与高倍对照", "title_en": "Mouse G-CSF response: low- and high-power comparison of enhanced marrow granulopoiesis", "description_cn": "C57BL/6雄性小鼠接受G-CSF 50 μg/kg、每日两次、连续9天。Panel D并列显示对照与处理组骨髓Wright–Giemsa涂片的100倍和1000倍代表视野；原作者据此并结合流式结果描述骨髓粒细胞生成增强。本图是同研究、同组别和同时间点的代表性比较，不证明所有视野来自同一只动物。", "description_en": "Male C57BL/6 mice received G-CSF at 50 μg/kg twice daily for 9 days. Panel D juxtaposes representative Wright–Giemsa-stained marrow fields from control and treated groups at ×100 and ×1,000. Together with the study's flow-cytometric data, the authors described enhanced marrow granulopoiesis. This is a same-study, same-group/time-point comparison and does not establish that every field came from the same animal.", "species": "Mouse", "strain": "C57BL/6 male; 8–10 weeks", "specimen_type": "Cytology_smear", "stain": "Wright–Giemsa", "lineage": "Granulocytic", "maturation_stage": "Mixed_granulocytic_maturation", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Granulocytic_increase", "GCSF_response", "Emergency_granulopoiesis_reference" ], "evidence_role": "Mechanistic_reference", "causality_level": "Treatment_associated", "figure_label": "Figure S3", "panel_label": "D — bone marrow, control and G-CSF; ×100 and ×1,000", "source_page": "Supplementary Figure S3, panel D", "caption_original_en": "G-CSF treatment enhances granulopoiesis in the BM of mice. (A, B) Flow cytometric analysis of the BM neutrophils (CD11b+Ly6G+) in control and G-CSF–treated mice. (A) Representative flow cytometric plots of CD11b+Ly6G+ cells in the BMs of control and G-CSF–treated mice. (B) Flow cytometric quantification of CD11b+Ly6G+ neutrophils in the BMs of control and G-CSF–treated mice. (C) Peripheral neutrophil counts in control and G-CSF–treated mice. (D) Wright–Giemsa staining of BM cells from control and G-CSF–treated mice. Original magnification ×100 (upper panels); ×1,000 (lower panels) (E) Wright–Giemsa staining of peripheral blood cells from control and G-CSF–treated mice. (F) Representative fields of CFU-GM–derived colonies in BM cultures from control and G-CSF–treated mice (×100 magnification; scale bar = 200 μm). (G) Quantification of the number of CFU-GM–derived colonies in BM cultures from control and G-CSF treated mice. n = 5/group (A, B, C, D, E), n = 3/group (F, G). ***P < 0.001.", "article_title": "G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation", "authors": "Jing W, Guo X, Qin F, Li Y, Wang G, Bi Y, Jin X, Han L, Dong X, Zhao Y", "journal": "Life Science Alliance", "year": "2020", "doi": "10.26508/lsa.202000737", "pmid": "33234677", "pmcid": "PMC7723243", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7723243/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7723243/figure/figS3/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Jing W, Guo X, Qin F, Li Y, Wang G, Bi Y, Jin X, Han L, Dong X, Zhao Y. G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation. Life Science Alliance. 2020. doi:10.26508/lsa.202000737. Figure S3, D — bone marrow, control and G-CSF; ×100 and ×1,000. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC JATS permissions block: Creative Commons Attribution 4.0 International; no separate third-party credit line was observed in the Figure S3 legend.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-GCSF-FS3-D.png", "preview_path": "previews/BM-CC-GCSF-FS3-D.jpg", "sha256": "0e3f2f4c5ee2553ed5f1c1e3f5c74f2662c6453e7d06c1bb0354311fefa32375", "processing_note": "Complete panel D was cropped from the CC BY 4.0 composite Figure S3 at parent pixel coordinates [0,168,235,352] and saved losslessly as PNG. Panel letter, specimen label, treatment labels, both magnification rows, and scale bars are retained; no cells or annotations were altered.", "source_mode": "derived_crop", "parent_figure_id": "S2E-FF-NEW-MOUSE-S3", "parent_sha256": "517525c21f471aa0b53d2d2b73fde1b0e9b5a4261065d5d2e4dcf3f3d0003898", "parent_asset_path": "images/S2E-FF-NEW-MOUSE-S3.jpg", "crop_coordinates": [ 0, 168, 235, 352 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-DYSERYTHRO-F02-A", "map_image_id": "BMPM-IMG-0080", "source_id": "PMC8478025", "title_cn": "犬红系发育异常鉴别：红系前体异型有丝分裂", "title_en": "Canine dyserythropoiesis differential: atypical mitosis in an erythroid precursor", "description_cn": "拉布拉多犬病例骨髓Wright–Giemsa细胞学，100倍物镜。原作者将panel A描述为红系前体异型有丝分裂；用于疾病性红系发育异常鉴别，不代表给药相关骨髓毒性。", "description_en": "Wright–Giemsa-stained marrow cytology from a Labrador Retriever case at a ×100 objective. The authors describe panel A as an atypical mitotic figure in an erythroid precursor. It is a disease differential for dyserythropoiesis, not evidence of treatment-related marrow toxicity.", "species": "Dog", "strain": "Labrador Retriever; case 1", "specimen_type": "Bone_marrow_aspirate_cytology", "stain": "Wright–Giemsa", "lineage": "Erythroid", "maturation_stage": "Erythroid_mitosis", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Atypical_mitotic_figure" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 2", "panel_label": "A", "source_page": "Figure 2, panel A", "caption_original_en": "Representative cytologic bone marrow images of case 1 illustrating dysplastic changes and erythrophagocytosis. Wright‐Giemsa, ×100 objective. A, Atypical mitotic figure; B, cytoplasmic vacuolation of metarubricytes. Note the contrast of vacuolation (left metarubricyte) compared to water artifact (adjacent right metarubricyte), C, binucleated erythroid precursor; D, nuclear blebbing within a metarubricyte; E, cytoplasmic bridging of rubricytes; F, macrophage displaying metarubricyte phagocytosis.", "article_title": "Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates", "authors": "Thomas-Hollands A, Shelton GD, Guo LT, Loughran K, Kaiman G, Hutton TA, Walsh KA", "journal": "Journal of Veterinary Internal Medicine", "year": "2021", "doi": "10.1111/jvim.16214", "pmid": "34227150", "pmcid": "PMC8478025", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8478025/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e0/8478025/bc06bef904e4/JVIM-35-2409-g001.jpg", "license": "CC BY-NC 4.0", "license_url": "https://creativecommons.org/licenses/by-nc/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Thomas-Hollands A, Shelton GD, Guo LT, Loughran K, Kaiman G, Hutton TA, Walsh KA. Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates. Journal of Veterinary Internal Medicine. 2021. doi:10.1111/jvim.16214. Figure 2, A. CC BY-NC 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 2 legend", "rights_basis": "The article permits noncommercial use, distribution, reproduction, and adaptation with attribution. Exact-pixel panel crops preserve the panel letters, arrows, cells, and scale bar where present. PMC full-text copyright and license block: Creative Commons Attribution-NonCommercial 4.0; Figure 2 has no separate third-party credit line, and each panel is an exact-pixel crop linked to the complete source figure.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-DYSERYTHRO-F02-A.png", "preview_path": "previews/BM-CC-DOG-DYSERYTHRO-F02-A.jpg", "sha256": "538911408a5a943239d818edac54212d9fa99ac61ec5d2afb072a6b031efb760", "processing_note": "Exact-pixel panel crop from the CC BY-NC 4.0 composite Figure 2 at parent coordinates [0,0,237,240]. The panel letter is retained; no cells, color, or annotations were altered. The global 10 μm scale bar remains visible in the linked complete parent Figure and panel F.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC8478025-FIGURE-2", "parent_sha256": "553d7305357e7ef15eebd5c8d10bfd7770ad1521e71e9ae280e7bbc5ab20c23d", "parent_asset_path": "images/PMC8478025-FIGURE-2.jpg", "crop_coordinates": [ 0, 0, 237, 240 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-DYSERYTHRO-F02-B", "map_image_id": "BMPM-IMG-0082", "source_id": "PMC8478025", "title_cn": "犬红系发育异常鉴别：晚幼红细胞胞质空泡与水伪影", "title_en": "Canine dyserythropoiesis differential: metarubricyte vacuolation versus water artifact", "description_cn": "Panel B将左侧晚幼红细胞胞质空泡与相邻右侧细胞的水伪影并列。该图重点是鉴别真正细胞内空泡与制片/染色伪影，不能由单个视野推断群体性毒性改变。", "description_en": "Panel B contrasts cytoplasmic vacuolation in the left metarubricyte with water artifact in the adjacent right metarubricyte. It is useful for separating a true intracellular finding from preparation or staining artifact; one field does not establish a population-level toxic effect.", "species": "Dog", "strain": "Labrador Retriever; case 1", "specimen_type": "Bone_marrow_aspirate_cytology", "stain": "Wright–Giemsa", "lineage": "Erythroid", "maturation_stage": "Metarubricyte", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Cytoplasmic_vacuolation", "Water_artifact_differential" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 2", "panel_label": "B", "source_page": "Figure 2, panel B", "caption_original_en": "Representative cytologic bone marrow images of case 1 illustrating dysplastic changes and erythrophagocytosis. Wright‐Giemsa, ×100 objective. A, Atypical mitotic figure; B, cytoplasmic vacuolation of metarubricytes. Note the contrast of vacuolation (left metarubricyte) compared to water artifact (adjacent right metarubricyte), C, binucleated erythroid precursor; D, nuclear blebbing within a metarubricyte; E, cytoplasmic bridging of rubricytes; F, macrophage displaying metarubricyte phagocytosis.", "article_title": "Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates", "authors": "Thomas-Hollands A, Shelton GD, Guo LT, Loughran K, Kaiman G, Hutton TA, Walsh KA", "journal": "Journal of Veterinary Internal Medicine", "year": "2021", "doi": "10.1111/jvim.16214", "pmid": "34227150", "pmcid": "PMC8478025", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8478025/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e0/8478025/bc06bef904e4/JVIM-35-2409-g001.jpg", "license": "CC BY-NC 4.0", "license_url": "https://creativecommons.org/licenses/by-nc/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Thomas-Hollands A, Shelton GD, Guo LT, Loughran K, Kaiman G, Hutton TA, Walsh KA. Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates. Journal of Veterinary Internal Medicine. 2021. doi:10.1111/jvim.16214. Figure 2, B. CC BY-NC 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 2 legend", "rights_basis": "The article permits noncommercial use, distribution, reproduction, and adaptation with attribution. Exact-pixel panel crops preserve the panel letters, arrows, cells, and scale bar where present. PMC full-text copyright and license block: Creative Commons Attribution-NonCommercial 4.0; Figure 2 has no separate third-party credit line, and each panel is an exact-pixel crop linked to the complete source figure.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-DYSERYTHRO-F02-B.png", "preview_path": "previews/BM-CC-DOG-DYSERYTHRO-F02-B.jpg", "sha256": "cc0cb1592b5a653845cebb27cb84932d64115fb5a343002a83b3cbbf15163646", "processing_note": "Exact-pixel panel crop from the CC BY-NC 4.0 composite Figure 2 at parent coordinates [237,0,480,240]. The panel letter is retained; no cells, color, or annotations were altered. The global 10 μm scale bar remains visible in the linked complete parent Figure and panel F.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC8478025-FIGURE-2", "parent_sha256": "553d7305357e7ef15eebd5c8d10bfd7770ad1521e71e9ae280e7bbc5ab20c23d", "parent_asset_path": "images/PMC8478025-FIGURE-2.jpg", "crop_coordinates": [ 237, 0, 480, 240 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-DYSERYTHRO-F02-C", "map_image_id": "BMPM-IMG-0081", "source_id": "PMC8478025", "title_cn": "犬红系发育异常鉴别：双核红系前体", "title_en": "Canine dyserythropoiesis differential: binucleated erythroid precursor", "description_cn": "Panel C显示双核红系前体。该观察可纳入红系发育异常的形态证据，但必须结合出现频率、其他异常和研究背景，不应由单个细胞自动诊断发育不良。", "description_en": "Panel C shows a binucleated erythroid precursor. It can contribute to the morphologic evidence for dyserythropoiesis, but frequency, accompanying abnormalities, and study context are required; one cell must not automatically establish a diagnosis of dysplasia.", "species": "Dog", "strain": "Labrador Retriever; case 1", "specimen_type": "Bone_marrow_aspirate_cytology", "stain": "Wright–Giemsa", "lineage": "Erythroid", "maturation_stage": "Erythroid_precursor_or_mixed", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Binucleation" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 2", "panel_label": "C", "source_page": "Figure 2, panel C", "caption_original_en": "Representative cytologic bone marrow images of case 1 illustrating dysplastic changes and erythrophagocytosis. Wright‐Giemsa, ×100 objective. A, Atypical mitotic figure; B, cytoplasmic vacuolation of metarubricytes. Note the contrast of vacuolation (left metarubricyte) compared to water artifact (adjacent right metarubricyte), C, binucleated erythroid precursor; D, nuclear blebbing within a metarubricyte; E, cytoplasmic bridging of rubricytes; F, macrophage displaying metarubricyte phagocytosis.", "article_title": "Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates", "authors": "Thomas-Hollands A, Shelton GD, Guo LT, Loughran K, Kaiman G, Hutton TA, Walsh KA", "journal": "Journal of Veterinary Internal Medicine", "year": "2021", "doi": "10.1111/jvim.16214", "pmid": "34227150", "pmcid": "PMC8478025", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8478025/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e0/8478025/bc06bef904e4/JVIM-35-2409-g001.jpg", "license": "CC BY-NC 4.0", "license_url": "https://creativecommons.org/licenses/by-nc/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Thomas-Hollands A, Shelton GD, Guo LT, Loughran K, Kaiman G, Hutton TA, Walsh KA. Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates. Journal of Veterinary Internal Medicine. 2021. doi:10.1111/jvim.16214. Figure 2, C. CC BY-NC 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 2 legend", "rights_basis": "The article permits noncommercial use, distribution, reproduction, and adaptation with attribution. Exact-pixel panel crops preserve the panel letters, arrows, cells, and scale bar where present. PMC full-text copyright and license block: Creative Commons Attribution-NonCommercial 4.0; Figure 2 has no separate third-party credit line, and each panel is an exact-pixel crop linked to the complete source figure.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-DYSERYTHRO-F02-C.png", "preview_path": "previews/BM-CC-DOG-DYSERYTHRO-F02-C.jpg", "sha256": "7184b55ba4cff93243f5c5c9145aa77c5d84738b8d599f3d712b4cd99d3dc1d9", "processing_note": "Exact-pixel panel crop from the CC BY-NC 4.0 composite Figure 2 at parent coordinates [480,0,709,240]. The panel letter is retained; no cells, color, or annotations were altered. The global 10 μm scale bar remains visible in the linked complete parent Figure and panel F.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC8478025-FIGURE-2", "parent_sha256": "553d7305357e7ef15eebd5c8d10bfd7770ad1521e71e9ae280e7bbc5ab20c23d", "parent_asset_path": "images/PMC8478025-FIGURE-2.jpg", "crop_coordinates": [ 480, 0, 709, 240 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-DYSERYTHRO-F02-D", "map_image_id": "BMPM-IMG-0083", "source_id": "PMC8478025", "title_cn": "犬红系发育异常鉴别：晚幼红细胞核出芽", "title_en": "Canine dyserythropoiesis differential: nuclear blebbing in a metarubricyte", "description_cn": "Panel D显示晚幼红细胞核出芽。它是形态观察词，在毒理评价中需与细胞破坏、涂片伪影、其他核异常及背景频率一并评估。", "description_en": "Panel D shows nuclear blebbing in a metarubricyte. This is an observational morphologic term; toxicologic interpretation requires assessment of cell damage, smear artifact, other nuclear abnormalities, and background frequency.", "species": "Dog", "strain": "Labrador Retriever; case 1", "specimen_type": "Bone_marrow_aspirate_cytology", "stain": "Wright–Giemsa", "lineage": "Erythroid", "maturation_stage": "Metarubricyte", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Nuclear_blebbing" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 2", "panel_label": "D", "source_page": "Figure 2, panel D", "caption_original_en": "Representative cytologic bone marrow images of case 1 illustrating dysplastic changes and erythrophagocytosis. Wright‐Giemsa, ×100 objective. A, Atypical mitotic figure; B, cytoplasmic vacuolation of metarubricytes. Note the contrast of vacuolation (left metarubricyte) compared to water artifact (adjacent right metarubricyte), C, binucleated erythroid precursor; D, nuclear blebbing within a metarubricyte; E, cytoplasmic bridging of rubricytes; F, macrophage displaying metarubricyte phagocytosis.", "article_title": "Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates", "authors": "Thomas-Hollands A, Shelton GD, Guo LT, Loughran K, Kaiman G, Hutton TA, Walsh KA", "journal": "Journal of Veterinary Internal Medicine", "year": "2021", "doi": "10.1111/jvim.16214", "pmid": "34227150", "pmcid": "PMC8478025", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8478025/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e0/8478025/bc06bef904e4/JVIM-35-2409-g001.jpg", "license": "CC BY-NC 4.0", "license_url": "https://creativecommons.org/licenses/by-nc/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Thomas-Hollands A, Shelton GD, Guo LT, Loughran K, Kaiman G, Hutton TA, Walsh KA. Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates. Journal of Veterinary Internal Medicine. 2021. doi:10.1111/jvim.16214. Figure 2, D. CC BY-NC 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 2 legend", "rights_basis": "The article permits noncommercial use, distribution, reproduction, and adaptation with attribution. Exact-pixel panel crops preserve the panel letters, arrows, cells, and scale bar where present. PMC full-text copyright and license block: Creative Commons Attribution-NonCommercial 4.0; Figure 2 has no separate third-party credit line, and each panel is an exact-pixel crop linked to the complete source figure.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-DYSERYTHRO-F02-D.png", "preview_path": "previews/BM-CC-DOG-DYSERYTHRO-F02-D.jpg", "sha256": "df65b5d92c7f7678dc172296691f6e45afee0d2ec8ef5bf15b65a7fc9d24933f", "processing_note": "Exact-pixel panel crop from the CC BY-NC 4.0 composite Figure 2 at parent coordinates [0,240,237,478]. The panel letter is retained; no cells, color, or annotations were altered. The global 10 μm scale bar remains visible in the linked complete parent Figure and panel F.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC8478025-FIGURE-2", "parent_sha256": "553d7305357e7ef15eebd5c8d10bfd7770ad1521e71e9ae280e7bbc5ab20c23d", "parent_asset_path": "images/PMC8478025-FIGURE-2.jpg", "crop_coordinates": [ 0, 240, 237, 478 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-DYSERYTHRO-F02-E", "map_image_id": "BMPM-IMG-0079", "source_id": "PMC8478025", "title_cn": "犬红系发育异常鉴别：幼红细胞间胞质桥", "title_en": "Canine dyserythropoiesis differential: cytoplasmic bridging between rubricytes", "description_cn": "Panel E显示两个幼红细胞之间的胞质桥。它可作为红系发育异常的鉴别特征，但需要多个细胞、频率资料和相关血液学证据支持。", "description_en": "Panel E shows cytoplasmic bridging between rubricytes. It can support a dyserythropoiesis differential, but interpretation requires multiple cells, frequency data, and correlated hematology findings.", "species": "Dog", "strain": "Labrador Retriever; case 1", "specimen_type": "Bone_marrow_aspirate_cytology", "stain": "Wright–Giemsa", "lineage": "Erythroid", "maturation_stage": "Rubricyte", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Cytoplasmic_bridging" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 2", "panel_label": "E", "source_page": "Figure 2, panel E", "caption_original_en": "Representative cytologic bone marrow images of case 1 illustrating dysplastic changes and erythrophagocytosis. Wright‐Giemsa, ×100 objective. A, Atypical mitotic figure; B, cytoplasmic vacuolation of metarubricytes. Note the contrast of vacuolation (left metarubricyte) compared to water artifact (adjacent right metarubricyte), C, binucleated erythroid precursor; D, nuclear blebbing within a metarubricyte; E, cytoplasmic bridging of rubricytes; F, macrophage displaying metarubricyte phagocytosis.", "article_title": "Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates", "authors": "Thomas-Hollands A, Shelton GD, Guo LT, Loughran K, Kaiman G, Hutton TA, Walsh KA", "journal": "Journal of Veterinary Internal Medicine", "year": "2021", "doi": "10.1111/jvim.16214", "pmid": "34227150", "pmcid": "PMC8478025", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8478025/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e0/8478025/bc06bef904e4/JVIM-35-2409-g001.jpg", "license": "CC BY-NC 4.0", "license_url": "https://creativecommons.org/licenses/by-nc/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Thomas-Hollands A, Shelton GD, Guo LT, Loughran K, Kaiman G, Hutton TA, Walsh KA. Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates. Journal of Veterinary Internal Medicine. 2021. doi:10.1111/jvim.16214. Figure 2, E. CC BY-NC 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 2 legend", "rights_basis": "The article permits noncommercial use, distribution, reproduction, and adaptation with attribution. Exact-pixel panel crops preserve the panel letters, arrows, cells, and scale bar where present. PMC full-text copyright and license block: Creative Commons Attribution-NonCommercial 4.0; Figure 2 has no separate third-party credit line, and each panel is an exact-pixel crop linked to the complete source figure.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-DYSERYTHRO-F02-E.png", "preview_path": "previews/BM-CC-DOG-DYSERYTHRO-F02-E.jpg", "sha256": "0745105a70f79f8cbffd1352f45ee359bee5a52041646874a617b4d2f47b19a6", "processing_note": "Exact-pixel panel crop from the CC BY-NC 4.0 composite Figure 2 at parent coordinates [237,240,480,478]. The panel letter is retained; no cells, color, or annotations were altered. The global 10 μm scale bar remains visible in the linked complete parent Figure and panel F.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC8478025-FIGURE-2", "parent_sha256": "553d7305357e7ef15eebd5c8d10bfd7770ad1521e71e9ae280e7bbc5ab20c23d", "parent_asset_path": "images/PMC8478025-FIGURE-2.jpg", "crop_coordinates": [ 237, 240, 480, 478 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-DYSERYTHRO-F02-F", "map_image_id": "BMPM-IMG-0084", "source_id": "PMC8478025", "title_cn": "犬骨髓吞噬性改变鉴别：巨噬细胞吞噬晚幼红细胞", "title_en": "Canine marrow phagocytic differential: macrophage phagocytosis of a metarubricyte", "description_cn": "Panel F显示巨噬细胞内吞噬的晚幼红细胞，可描述为红细胞吞噬或rubriphagocytosis。这一观察不应自动扩展为广义嗜血细胞现象，也不能单独确立毒性机制。", "description_en": "Panel F shows a macrophage containing a phagocytosed metarubricyte, which may be described as erythrophagocytosis or rubriphagocytosis. The observation must not automatically be broadened to generalized hemophagocytosis and does not alone establish a toxic mechanism.", "species": "Dog", "strain": "Labrador Retriever; case 1", "specimen_type": "Bone_marrow_aspirate_cytology", "stain": "Wright–Giemsa", "lineage": "Monocytic_macrophagic", "maturation_stage": "Macrophage", "primary_morphology_class": "Phagocytic_or_hemophagocytic_change", "secondary_features": [ "Erythrophagocytosis", "Rubriphagocytosis" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 2", "panel_label": "F", "source_page": "Figure 2, panel F", "caption_original_en": "Representative cytologic bone marrow images of case 1 illustrating dysplastic changes and erythrophagocytosis. Wright‐Giemsa, ×100 objective. A, Atypical mitotic figure; B, cytoplasmic vacuolation of metarubricytes. Note the contrast of vacuolation (left metarubricyte) compared to water artifact (adjacent right metarubricyte), C, binucleated erythroid precursor; D, nuclear blebbing within a metarubricyte; E, cytoplasmic bridging of rubricytes; F, macrophage displaying metarubricyte phagocytosis.", "article_title": "Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates", "authors": "Thomas-Hollands A, Shelton GD, Guo LT, Loughran K, Kaiman G, Hutton TA, Walsh KA", "journal": "Journal of Veterinary Internal Medicine", "year": "2021", "doi": "10.1111/jvim.16214", "pmid": "34227150", "pmcid": "PMC8478025", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8478025/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b4e0/8478025/bc06bef904e4/JVIM-35-2409-g001.jpg", "license": "CC BY-NC 4.0", "license_url": "https://creativecommons.org/licenses/by-nc/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Thomas-Hollands A, Shelton GD, Guo LT, Loughran K, Kaiman G, Hutton TA, Walsh KA. Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates. Journal of Veterinary Internal Medicine. 2021. doi:10.1111/jvim.16214. Figure 2, F. CC BY-NC 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 2 legend", "rights_basis": "The article permits noncommercial use, distribution, reproduction, and adaptation with attribution. Exact-pixel panel crops preserve the panel letters, arrows, cells, and scale bar where present. PMC full-text copyright and license block: Creative Commons Attribution-NonCommercial 4.0; Figure 2 has no separate third-party credit line, and each panel is an exact-pixel crop linked to the complete source figure.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-DYSERYTHRO-F02-F.png", "preview_path": "previews/BM-CC-DOG-DYSERYTHRO-F02-F.jpg", "sha256": "f774cb7a8bb94bfb8b1efc242356e4163e9dea43927f4a1a5214f172844144cf", "processing_note": "Exact-pixel panel crop from the CC BY-NC 4.0 composite Figure 2 at parent coordinates [480,240,709,478]. The panel letter and the 10 μm scale bar are retained; no cells, color, or annotations were altered.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC8478025-FIGURE-2", "parent_sha256": "553d7305357e7ef15eebd5c8d10bfd7770ad1521e71e9ae280e7bbc5ab20c23d", "parent_asset_path": "images/PMC8478025-FIGURE-2.jpg", "crop_coordinates": [ 480, 240, 709, 478 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-MDSMPN-F03", "map_image_id": "NR", "source_id": "PMC12710095-CANINE-MDS-MPN", "title_cn": "犬MDS/MPN骨髓吸取物：粒系增生、原始细胞增加与红系/巨核系低增生", "title_en": "Canine MDS/MPN marrow aspirate: myeloid hyperplasia, increased blasts, and erythroid/megakaryocytic hypoplasia", "description_cn": "犬MDS/MPN病例的Diff-Quik骨髓吸取物完整Figure 3。原作者报告高细胞性、粒系增生、M:E约10:1、原始细胞约16%，并伴巨核系和红系明显低增生。这是疾病性鉴别案例，不能作为给药相关性或不良性的证据。", "description_en": "Complete Figure 3 from the canine MDS/MPN case. The authors report a hypercellular Diff-Quik-stained marrow aspirate with myeloid hyperplasia, an M:E ratio of approximately 10:1, about 16% myeloblasts, and marked megakaryocytic and erythroid hypoplasia. This is a disease differential and does not establish treatment relationship or adversity.", "species": "Dog", "strain": "NR", "specimen_type": "Aspirate", "stain": "Diff-Quik", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_or_uncertain", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Hypercellularity", "Myeloid_hyperplasia", "Increased_M_E_ratio", "Myeloblast_increase", "Megakaryocytic_hypoplasia", "Erythroid_hypoplasia" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 3", "panel_label": "A–C (complete figure)", "source_page": "Figure 3, complete three-panel figure", "caption_original_en": "Bone marrow aspiration cytology (Diff‐Quik stain). Bone marrow sample showing hypercellularity, myeloid hyperplasia with a markedly increased myeloid‐to‐erythroid (M:E) ratio of 10:1, and dysplastic changes consistent with peripheral blood findings. Additionally, the sample exhibits an increased myeloblast count (16%), with marked megakaryocytic and erythroid hypoplasia. (A) 200× magnification; (B) 400× magnification; and (C) 1000× magnification.", "article_title": "Myelodysplastic/Myeloproliferative Neoplasm in a Dog: A Case Report", "authors": "Cha S, Yu D, Bae H", "journal": "Veterinary Medicine and Science", "year": "2025", "doi": "10.1002/vms3.70722", "pmid": "41405191", "pmcid": "PMC12710095", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12710095/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcd/12710095/59516b91d132/VMS3-12-e70722-g001.jpg", "license": "CC BY-NC-ND 4.0", "license_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Cha S, Yu D, Bae H. Myelodysplastic/Myeloproliferative Neoplasm in a Dog: A Case Report. Veterinary Medicine and Science. 2025. doi:10.1002/vms3.70722. Figure 3, A–C (complete figure). CC BY-NC-ND 4.0; complete figure reproduced without adaptation for noncommercial learning.", "third_party_credit_line": "None reported in the relevant figure legends", "rights_basis": "The article permits noncommercial sharing with attribution and without distribution of adapted material. Only byte-identical complete source figures are used. PMC full-text copyright and license block: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0; the complete figures are reproduced without cropping, annotation, retouching, or other adaptation.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-MDSMPN-F03.jpg", "preview_path": "images/BM-CC-DOG-MDSMPN-F03.jpg", "sha256": "63510f1c5ba6041b30846d51f73ff5c2f27ce9d697f2477211eca4bc0545ef1d", "processing_note": "Byte-identical complete Figure 3 copied from the PMC source media. Panel labels, magnification labels, and scale bars are retained; no crop, annotation, color change, retouching, or other adaptation was applied.", "source_mode": "verbatim_full_figure", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-CVBD-F02", "map_image_id": "BMPM-IMG-0100", "source_id": "S2M-PMC4261574", "title_cn": "犬骨髓疾病鉴别：多核巨幼样红系前体", "title_en": "Canine marrow disease differential: multinucleated megaloblastic erythroid precursor", "description_cn": "图中箭头所示为具有多个细胞核的巨幼样红系前体，旁见另外两个红系前体。该图来自自然感染犬的疾病性骨髓形态研究，是红系发育异常的鉴别案例，不属于药物性骨髓毒性证据；单个细胞不能代替频率和群体背景评价。", "description_en": "The arrow identifies a megaloblastic erythroid precursor with multiple nuclei, with two additional erythroid precursors nearby. This disease-associated example from naturally infected dogs supports a dyserythropoiesis differential, not drug-toxicity attribution; one cell does not replace frequency and population-context assessment.", "species": "Dog", "strain": "Crossbred dogs; naturally infected canine vector-borne disease cohort", "specimen_type": "Cytology_smear", "stain": "Quick Stain", "lineage": "Erythroid", "maturation_stage": "Megaloblastic_erythroid_precursor", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Multinucleation", "Megaloblastic_change", "Dyserythropoiesis" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 2", "panel_label": "Whole", "source_page": "Figure 2", "caption_original_en": "A megaloblastic erythroid precursor with multiple nuclei (arrow); two other eryhtroid precursors are also present. Bone marrow. Quick Stain, 100×.", "article_title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "authors": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D", "journal": "Parasites & Vectors", "year": "2014", "doi": "10.1186/s13071-014-0534-2", "pmid": "25441458", "pmcid": "PMC4261574", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D. Evaluation of blood and bone marrow in selected canine vector-borne diseases. Parasites & Vectors. 2014. doi:10.1186/s13071-014-0534-2. Figure 2, Whole. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC JATS permissions block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 2-6 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-CVBD-F02.png", "preview_path": "previews/BM-CC-DOG-CVBD-F02.jpg", "sha256": "24dbdf397e942447bfe5a42f08e88197e37506808660a1b442ab92276fa51971", "processing_note": "Exact-pixel whole-figure panel retained from the CC BY 4.0 Figure 2 at parent coordinates [0,0,357,248]. The arrow and complete microscopic field are retained; no cells, color, or annotations were altered.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC4261574-FIGURE-2", "parent_sha256": "461ba0ef02c33027ec15a27ee97fbdda4fcbb1feb2d1e17983cf42f910fa17ef", "parent_asset_path": "images/PMC4261574-FIGURE-2.jpg", "crop_coordinates": [ 0, 0, 357, 248 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-CVBD-F03-A", "map_image_id": "BMPM-IMG-0102", "source_id": "S2M-PMC4261574", "title_cn": "犬粒系发育异常鉴别：成熟中性粒细胞过分叶", "title_en": "Canine dysgranulopoiesis differential: hypersegmented mature neutrophil", "description_cn": "Panel A箭头指示过分叶的成熟中性粒细胞，周围可见不同成熟阶段的粒系前体。过分叶属于观察性核形态，应结合出现频率、其他粒系异常及临床病理背景，不能由单个细胞直接归因于试验物质。", "description_en": "Panel A shows a hypersegmented mature neutrophil with myeloid precursors at different maturation stages nearby. Hypersegmentation is an observational nuclear feature that requires frequency, accompanying abnormalities, and clinical-pathology context; one cell cannot establish test-article attribution.", "species": "Dog", "strain": "Crossbred dogs; naturally infected canine vector-borne disease cohort", "specimen_type": "Cytology_smear", "stain": "Quick Stain", "lineage": "Granulocytic", "maturation_stage": "Segmented_neutrophil", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Hypersegmentation", "Dysgranulopoiesis" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 3", "panel_label": "A", "source_page": "Figure 3, panel A", "caption_original_en": "Myeloid dysplasia. A. A hypersegmented mature neutrophil (arrow); myeloid precursors in different maturation stages are also present. B. A giant metamyelocyte (arrow) with two erythroid precursors. Bone marrow. Quick Stain, 100×.", "article_title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "authors": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D", "journal": "Parasites & Vectors", "year": "2014", "doi": "10.1186/s13071-014-0534-2", "pmid": "25441458", "pmcid": "PMC4261574", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D. Evaluation of blood and bone marrow in selected canine vector-borne diseases. Parasites & Vectors. 2014. doi:10.1186/s13071-014-0534-2. Figure 3, A. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC JATS permissions block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 2-6 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-CVBD-F03-A.png", "preview_path": "previews/BM-CC-DOG-CVBD-F03-A.jpg", "sha256": "f921c57924e277465389e33a113a10d6f38085b0e7d289ccef8c89425880289a", "processing_note": "Exact-pixel panel A crop from the CC BY 4.0 composite Figure 3 at parent coordinates [0,0,236,319]. The arrow and panel field are retained; no cells, color, or annotations were altered.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC4261574-FIGURE-3", "parent_sha256": "cbc7a8355debecf4e57a1ad244aee3efeb6e62f3e6752ffe4b06bc6ef32dbb48", "parent_asset_path": "images/PMC4261574-FIGURE-3.jpg", "crop_coordinates": [ 0, 0, 236, 319 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-CVBD-F03-B", "map_image_id": "BMPM-IMG-0101", "source_id": "S2M-PMC4261574", "title_cn": "犬粒系发育异常鉴别：巨型晚幼粒细胞", "title_en": "Canine dysgranulopoiesis differential: giant metamyelocyte", "description_cn": "Panel B箭头指示巨型晚幼粒细胞，旁见两个红系前体。巨型粒系细胞可提示粒系发育异常，但需要频率、成熟序列和其他证据支持，不能凭单个视野确定机制或毒性相关性。", "description_en": "Panel B shows a giant metamyelocyte beside two erythroid precursors. A giant myeloid form may support a dysgranulopoiesis differential, but frequency, the maturation sequence, and additional evidence are required; one field does not establish mechanism or toxicity relationship.", "species": "Dog", "strain": "Crossbred dogs; naturally infected canine vector-borne disease cohort", "specimen_type": "Cytology_smear", "stain": "Quick Stain", "lineage": "Granulocytic", "maturation_stage": "Metamyelocyte", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Giant_form", "Dysgranulopoiesis" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 3", "panel_label": "B", "source_page": "Figure 3, panel B", "caption_original_en": "Myeloid dysplasia. A. A hypersegmented mature neutrophil (arrow); myeloid precursors in different maturation stages are also present. B. A giant metamyelocyte (arrow) with two erythroid precursors. Bone marrow. Quick Stain, 100×.", "article_title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "authors": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D", "journal": "Parasites & Vectors", "year": "2014", "doi": "10.1186/s13071-014-0534-2", "pmid": "25441458", "pmcid": "PMC4261574", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D. Evaluation of blood and bone marrow in selected canine vector-borne diseases. Parasites & Vectors. 2014. doi:10.1186/s13071-014-0534-2. Figure 3, B. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC JATS permissions block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 2-6 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-CVBD-F03-B.png", "preview_path": "previews/BM-CC-DOG-CVBD-F03-B.jpg", "sha256": "8bb5dff52dfb7f3ae1bf7c2423d2ca425cd227bfbf53e7bf71d6b1ab523e389f", "processing_note": "Exact-pixel panel B crop from the CC BY 4.0 composite Figure 3 at parent coordinates [236,0,472,319]. The arrow and panel field are retained; no cells, color, or annotations were altered.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC4261574-FIGURE-3", "parent_sha256": "cbc7a8355debecf4e57a1ad244aee3efeb6e62f3e6752ffe4b06bc6ef32dbb48", "parent_asset_path": "images/PMC4261574-FIGURE-3.jpg", "crop_coordinates": [ 236, 0, 472, 319 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-CVBD-F04-A", "map_image_id": "BMPM-IMG-0122", "source_id": "S2M-PMC4261574", "title_cn": "犬骨髓吞噬性改变：红系前体、血小板与细胞碎片被吞噬", "title_en": "Canine marrow phagocytic change: erythroid precursors, platelets, and cellular debris", "description_cn": "Panel A显示巨噬细胞吞噬红系前体、血小板和细胞碎片。推荐逐项记录被吞噬成分；这一图像不应自动扩展为广义嗜血细胞综合征，也不能单独建立毒性机制。", "description_en": "Panel A shows a macrophage containing erythroid precursors, platelets, and cellular debris. The ingested components should be recorded specifically; the image must not automatically be broadened to generalized hemophagocytic syndrome and does not alone establish a toxic mechanism.", "species": "Dog", "strain": "Crossbred dogs; naturally infected canine vector-borne disease cohort", "specimen_type": "Cytology_smear", "stain": "Quick Stain", "lineage": "Monocytic_macrophagic", "maturation_stage": "Macrophage", "primary_morphology_class": "Phagocytic_or_hemophagocytic_change", "secondary_features": [ "Erythrophagocytosis", "Platelet_phagocytosis", "Cellular_debris_phagocytosis" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 4", "panel_label": "A", "source_page": "Figure 4, panel A", "caption_original_en": "Platelets and erythrophagocytosis. A. A macrophage phagocyting erythroid precursors (red arrow), platelets (black arrow) and cellular debris. B. Two macrophages with the same features described in A. Bone marrow. Quick Stain, 100×.", "article_title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "authors": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D", "journal": "Parasites & Vectors", "year": "2014", "doi": "10.1186/s13071-014-0534-2", "pmid": "25441458", "pmcid": "PMC4261574", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D. Evaluation of blood and bone marrow in selected canine vector-borne diseases. Parasites & Vectors. 2014. doi:10.1186/s13071-014-0534-2. Figure 4, A. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC JATS permissions block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 2-6 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-CVBD-F04-A.png", "preview_path": "previews/BM-CC-DOG-CVBD-F04-A.jpg", "sha256": "003c03213d26e7e8062f10b002ac9329dc08deeb5fde0f09ee35f787f436043e", "processing_note": "Exact-pixel panel A crop from the CC BY 4.0 composite Figure 4 at parent coordinates [0,0,284,249]. The red and black arrows are retained; no cells, color, or annotations were altered.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC4261574-FIGURE-4", "parent_sha256": "73d68039fcd21f6fc6ad376cbe091d8fd8cfc8a76f56f2cf0a8620d2df6c0ccd", "parent_asset_path": "images/PMC4261574-FIGURE-4.jpg", "crop_coordinates": [ 0, 0, 284, 249 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-CVBD-F04-B", "map_image_id": "BMPM-IMG-0123", "source_id": "S2M-PMC4261574", "title_cn": "犬骨髓吞噬性改变：两个具有复合吞噬表现的巨噬细胞", "title_en": "Canine marrow phagocytic change: two macrophages with composite phagocytic features", "description_cn": "Panel B显示两个具有与Panel A相同吞噬表现的巨噬细胞。该视野可用于确认现象并非单个巨噬细胞的孤立观察，但仍需结合全片频率、CBC和疾病背景。", "description_en": "Panel B shows two macrophages with the same phagocytic features as panel A. The field helps demonstrate that the finding is not confined to one macrophage, but whole-smear frequency, CBC data, and disease context remain necessary.", "species": "Dog", "strain": "Crossbred dogs; naturally infected canine vector-borne disease cohort", "specimen_type": "Cytology_smear", "stain": "Quick Stain", "lineage": "Monocytic_macrophagic", "maturation_stage": "Macrophage", "primary_morphology_class": "Phagocytic_or_hemophagocytic_change", "secondary_features": [ "Erythrophagocytosis", "Platelet_phagocytosis", "Cellular_debris_phagocytosis" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 4", "panel_label": "B", "source_page": "Figure 4, panel B", "caption_original_en": "Platelets and erythrophagocytosis. A. A macrophage phagocyting erythroid precursors (red arrow), platelets (black arrow) and cellular debris. B. Two macrophages with the same features described in A. Bone marrow. Quick Stain, 100×.", "article_title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "authors": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D", "journal": "Parasites & Vectors", "year": "2014", "doi": "10.1186/s13071-014-0534-2", "pmid": "25441458", "pmcid": "PMC4261574", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D. Evaluation of blood and bone marrow in selected canine vector-borne diseases. Parasites & Vectors. 2014. doi:10.1186/s13071-014-0534-2. Figure 4, B. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC JATS permissions block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 2-6 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-CVBD-F04-B.png", "preview_path": "previews/BM-CC-DOG-CVBD-F04-B.jpg", "sha256": "c7f908008d54e28fd78e863c347e08f3d4416a6f776903fc570397629a479128", "processing_note": "Exact-pixel panel B crop from the CC BY 4.0 composite Figure 4 at parent coordinates [284,0,567,249]. The complete panel field is retained; no cells, color, or annotations were altered.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC4261574-FIGURE-4", "parent_sha256": "73d68039fcd21f6fc6ad376cbe091d8fd8cfc8a76f56f2cf0a8620d2df6c0ccd", "parent_asset_path": "images/PMC4261574-FIGURE-4.jpg", "crop_coordinates": [ 284, 0, 567, 249 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-CVBD-F05-A", "map_image_id": "BMPM-IMG-0117", "source_id": "S2M-PMC4261574", "title_cn": "犬巨核细胞核异常鉴别：四个表观分离核的巨核系前体", "title_en": "Canine megakaryocytic nuclear abnormality: precursor with four apparently separate nuclei", "description_cn": "Panel A显示具有四个表观分离核的巨核系前体。网页保留原作者的“megakaryocytic dysplasia”解释，同时把可见观察单独记录为多个表观独立核；不能由单张图自动迁移为毒理学发育异常结论。", "description_en": "Panel A shows a megakaryocytic precursor with four apparently separate nuclei. The atlas preserves the authors' megakaryocytic-dysplasia interpretation while separately recording the visible observation; the image must not be transferred automatically into a toxicologic dysplasia conclusion.", "species": "Dog", "strain": "Crossbred dogs; naturally infected canine vector-borne disease cohort", "specimen_type": "Cytology_smear", "stain": "Quick Stain", "lineage": "Megakaryocytic", "maturation_stage": "Megakaryocytic_precursor", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Multiple_apparently_separate_nuclei", "Nuclear_division_abnormality" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 5", "panel_label": "A", "source_page": "Figure 5, panel A", "caption_original_en": "Megakaryocytic dysplasia. A. Megakaryocytic precursor with four divided nuclei. B. A megakaryocyte presenting morphologic abnormalities in nucleus shape and emperipolesis (arrow). Bone marrow. Quick Stain, 100×.", "article_title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "authors": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D", "journal": "Parasites & Vectors", "year": "2014", "doi": "10.1186/s13071-014-0534-2", "pmid": "25441458", "pmcid": "PMC4261574", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D. Evaluation of blood and bone marrow in selected canine vector-borne diseases. Parasites & Vectors. 2014. doi:10.1186/s13071-014-0534-2. Figure 5, A. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC JATS permissions block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 2-6 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-CVBD-F05-A.png", "preview_path": "previews/BM-CC-DOG-CVBD-F05-A.jpg", "sha256": "336583376158e34a211ef19fcdacb522855ec336775c322a24cb97f605683ea2", "processing_note": "Exact-pixel panel A crop from the CC BY 4.0 composite Figure 5 at parent coordinates [0,0,236,173]. The complete cell and panel field are retained; no cells, color, or annotations were altered.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC4261574-FIGURE-5", "parent_sha256": "63851038bcddd7255fb759f9560e76b85d3c13e37e1532b705a29afa1f12dc8e", "parent_asset_path": "images/PMC4261574-FIGURE-5.jpg", "crop_coordinates": [ 0, 0, 236, 173 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-CVBD-F05-B", "map_image_id": "BMPM-IMG-0118", "source_id": "S2M-PMC4261574", "title_cn": "犬巨核细胞异常鉴别：核形异常伴胞穿入", "title_en": "Canine megakaryocytic abnormality: abnormal nuclear shape with emperipolesis", "description_cn": "Panel B显示巨核细胞核形异常并伴胞穿入。胞穿入需与真正吞噬区分；该图来自疾病性队列，不能自动解释为药物性巨核细胞毒性。", "description_en": "Panel B shows abnormal megakaryocytic nuclear shape with emperipolesis. Emperipolesis must be distinguished from true phagocytosis; this disease-cohort image must not be interpreted automatically as drug-related megakaryocytic toxicity.", "species": "Dog", "strain": "Crossbred dogs; naturally infected canine vector-borne disease cohort", "specimen_type": "Cytology_smear", "stain": "Quick Stain", "lineage": "Megakaryocytic", "maturation_stage": "Mature_megakaryocyte", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Nuclear_shape_abnormality", "Emperipolesis" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 5", "panel_label": "B", "source_page": "Figure 5, panel B", "caption_original_en": "Megakaryocytic dysplasia. A. Megakaryocytic precursor with four divided nuclei. B. A megakaryocyte presenting morphologic abnormalities in nucleus shape and emperipolesis (arrow). Bone marrow. Quick Stain, 100×.", "article_title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "authors": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D", "journal": "Parasites & Vectors", "year": "2014", "doi": "10.1186/s13071-014-0534-2", "pmid": "25441458", "pmcid": "PMC4261574", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D. Evaluation of blood and bone marrow in selected canine vector-borne diseases. Parasites & Vectors. 2014. doi:10.1186/s13071-014-0534-2. Figure 5, B. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC JATS permissions block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 2-6 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-CVBD-F05-B.png", "preview_path": "previews/BM-CC-DOG-CVBD-F05-B.jpg", "sha256": "d16f5a1365a0b15ecb87f5006b6f24a624a46e5f6eacfc326943849aa3081bc6", "processing_note": "Exact-pixel panel B crop from the CC BY 4.0 composite Figure 5 at parent coordinates [236,0,472,173]. The arrow and complete cell are retained; no cells, color, or annotations were altered.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC4261574-FIGURE-5", "parent_sha256": "63851038bcddd7255fb759f9560e76b85d3c13e37e1532b705a29afa1f12dc8e", "parent_asset_path": "images/PMC4261574-FIGURE-5.jpg", "crop_coordinates": [ 236, 0, 472, 173 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-CVBD-F06", "map_image_id": "BMPM-IMG-0099", "source_id": "S2M-PMC4261574", "title_cn": "犬骨髓疾病鉴别：异常有丝分裂", "title_en": "Canine marrow disease differential: atypical mitosis", "description_cn": "原作者将该视野标注为异常有丝分裂。图注未明确所属细胞谱系，因此本图保持Mixed_or_uncertain，不依据视觉猜测红系或粒系来源；应结合全片和病例背景复核。", "description_en": "The authors label the field as an atypical mitosis. Because the legend does not identify the lineage, the atlas retains Mixed_or_uncertain and does not infer erythroid or myeloid origin from appearance alone; whole-smear and case-context review are required.", "species": "Dog", "strain": "Crossbred dogs; naturally infected canine vector-borne disease cohort", "specimen_type": "Cytology_smear", "stain": "Quick Stain", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Atypical_mitosis" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 6", "panel_label": "Whole", "source_page": "Figure 6", "caption_original_en": "Atypical mitosis. Bone marrow. Quick Stain, 100×.", "article_title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "authors": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D", "journal": "Parasites & Vectors", "year": "2014", "doi": "10.1186/s13071-014-0534-2", "pmid": "25441458", "pmcid": "PMC4261574", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D. Evaluation of blood and bone marrow in selected canine vector-borne diseases. Parasites & Vectors. 2014. doi:10.1186/s13071-014-0534-2. Figure 6, Whole. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC JATS permissions block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 2-6 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-CVBD-F06.png", "preview_path": "previews/BM-CC-DOG-CVBD-F06.jpg", "sha256": "1aa647b8c29f5f8ead69983d4722eaf1d50f9928314abdc39b91245881b16f94", "processing_note": "Exact-pixel whole-figure panel retained from the CC BY 4.0 Figure 6 at parent coordinates [0,0,358,286]. The complete microscopic field is retained; no cells, color, or annotations were altered.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC4261574-FIGURE-6", "parent_sha256": "6b87ba2b08d8ab7a37b99f9e9d1064514d93708af6d11a9290c46f4a79ea3339", "parent_asset_path": "images/PMC4261574-FIGURE-6.jpg", "crop_coordinates": [ 0, 0, 358, 286 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-MDS-F01-B", "map_image_id": "BMPM-IMG-0106", "source_id": "SUP-PMC11697499", "title_cn": "犬MDS骨髓吸取物：粒系占优、原始细胞增加与中性粒细胞发育异常", "title_en": "Canine MDS marrow aspirate: granulocytic predominance, increased blasts, and neutrophil dysplasia", "description_cn": "骨髓吸取物细胞丰富且粒系占优，原作者报告约10%原始细胞、约15%分叶中性粒细胞有发育异常，并见异常杆状核中性粒细胞。比例及发育异常解释来自原文，不应转化为药物相关性。", "description_en": "The cellular marrow aspirate is granulocyte-predominant; the authors report approximately 10% blasts, dysplastic change in about 15% of segmented neutrophils, and dysplastic band neutrophils. These source-reported proportions and interpretations do not establish drug causality.", "species": "Dog", "strain": "Clinical canine MDS cohort; case-specific breed NR in legend", "specimen_type": "Aspirate", "stain": "Wright stain", "lineage": "Granulocytic", "maturation_stage": "Mixed_myeloid_series_with_blasts", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Granulocytic_predominance", "Blasts_approximately_10_percent", "Dysplastic_segmented_neutrophils", "Dysplastic_band_neutrophils" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "b", "source_page": "Figure 1, panel b", "caption_original_en": "Myelodysplastic syndrome, dog. (a) Blood film with dysplastic neutrophils (*) that have unevenly sized nuclear lobes and giant red blood cells (^) reflecting increased red cell distribution width. Case 1. Wright stain (WS). (b) The marrow aspirate is highly cellular and has a predominance of granulocytes. There are approximately 10% blasts (arrowheads). Of total, 15% of segmented neutrophils have dysplastic changes (*), and there are dysplastic band neutrophils (arrows). Case 2. WS. (c) An immature megakaryocyte with abnormal nuclear lobulation (left) and an abnormally small megakaryocyte with mature cytoplasm and a hypolobulated nucleus (right). Case 2. WS. (d) A micromegakaryocyte, ~24 µm in diameter with multiple, widely separated nuclei (arrow). Case 2. WS. (e) The marrow core is hypercellular despite chronic marked anemia, and megakaryocytes are clustered (arrows). Case 3. Hematoxylin and eosin (HE). (f) Higher magnification of (e) illustrating an increased proportion of blasts (arrowheads) in the center of the intertrabecular space; a megakaryocyte with abnormal nuclear lobulation, open chromatin, and nucleoli (arrow); and dysplastic giant band neutrophils (*). Case 3. HE.", "article_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "authors": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D", "journal": "Veterinary Pathology", "year": "2024", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D. Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia. Veterinary Pathology. 2024. doi:10.1177/03009858241277982. Figure 1, b. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 1-4 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-MDS-F01-B.jpg", "preview_path": "previews/BM-CC-DOG-MDS-F01-B.jpg", "sha256": "907f0eff40e822063bebc8dc0e755392def435f787a490cd55941edab918e3df", "processing_note": "Exact-pixel panel b crop from the CC BY 4.0 composite Figure 1 at parent coordinates [180,0,535,240]. Arrows, arrowheads, asterisks, and the full panel field are retained.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC11697499-FIGURE-1", "parent_sha256": "5a483add2bbc9fd987d7603436aa2e972a9b71b8d8889bb981fb4c5fc5834d50", "parent_asset_path": "images/PMC11697499-FIGURE-1.jpg", "crop_coordinates": [ 180, 0, 535, 240 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-MDS-F01-C", "map_image_id": "BMPM-IMG-0121", "source_id": "SUP-PMC11697499", "title_cn": "犬MDS巨核细胞鉴别：核分叶异常与低分叶微小巨核细胞", "title_en": "Canine MDS megakaryocyte differential: abnormal lobulation and a hypolobulated small megakaryocyte", "description_cn": "左侧为核分叶异常的未成熟巨核细胞，右侧为胞质较成熟但体积异常小、核低分叶的巨核细胞。应分别记录体积、成熟度和核形，不宜把所有表现压缩为一个“多核”标签。", "description_en": "The left cell is an immature megakaryocyte with abnormal nuclear lobulation; the right cell is abnormally small with mature cytoplasm and a hypolobulated nucleus. Cell size, maturation, and nuclear form should be recorded separately rather than collapsed into a generic multinuclear label.", "species": "Dog", "strain": "Clinical canine MDS cohort; case-specific breed NR in legend", "specimen_type": "Aspirate", "stain": "Wright stain", "lineage": "Megakaryocytic", "maturation_stage": "Immature_and_mature_megakaryocyte", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Abnormal_nuclear_lobulation", "Hypolobulation", "Small_megakaryocyte" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "c", "source_page": "Figure 1, panel c", "caption_original_en": "Myelodysplastic syndrome, dog. (a) Blood film with dysplastic neutrophils (*) that have unevenly sized nuclear lobes and giant red blood cells (^) reflecting increased red cell distribution width. Case 1. Wright stain (WS). (b) The marrow aspirate is highly cellular and has a predominance of granulocytes. There are approximately 10% blasts (arrowheads). Of total, 15% of segmented neutrophils have dysplastic changes (*), and there are dysplastic band neutrophils (arrows). Case 2. WS. (c) An immature megakaryocyte with abnormal nuclear lobulation (left) and an abnormally small megakaryocyte with mature cytoplasm and a hypolobulated nucleus (right). Case 2. WS. (d) A micromegakaryocyte, ~24 µm in diameter with multiple, widely separated nuclei (arrow). Case 2. WS. (e) The marrow core is hypercellular despite chronic marked anemia, and megakaryocytes are clustered (arrows). Case 3. Hematoxylin and eosin (HE). (f) Higher magnification of (e) illustrating an increased proportion of blasts (arrowheads) in the center of the intertrabecular space; a megakaryocyte with abnormal nuclear lobulation, open chromatin, and nucleoli (arrow); and dysplastic giant band neutrophils (*). Case 3. HE.", "article_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "authors": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D", "journal": "Veterinary Pathology", "year": "2024", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D. Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia. Veterinary Pathology. 2024. doi:10.1177/03009858241277982. Figure 1, c. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 1-4 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-MDS-F01-C.jpg", "preview_path": "previews/BM-CC-DOG-MDS-F01-C.jpg", "sha256": "e78b502dee53ef0c56675e38982659410ba05e558544abedec2473e30b341e47", "processing_note": "Exact-pixel panel c crop from the CC BY 4.0 composite Figure 1 at parent coordinates [535,0,712,238]. Both megakaryocytes and the complete panel field are retained.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC11697499-FIGURE-1", "parent_sha256": "5a483add2bbc9fd987d7603436aa2e972a9b71b8d8889bb981fb4c5fc5834d50", "parent_asset_path": "images/PMC11697499-FIGURE-1.jpg", "crop_coordinates": [ 535, 0, 712, 238 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-MDS-F01-D", "map_image_id": "BMPM-IMG-0120", "source_id": "SUP-PMC11697499", "title_cn": "犬MDS鉴别：伴多枚广泛分离核的微巨核细胞", "title_en": "Canine MDS differential: micromegakaryocyte with multiple widely separated nuclei", "description_cn": "图中微巨核细胞直径约24 µm，含多枚广泛分离的核。该形态同时涉及异常小体积和核分离，较单纯核叶增多更具疾病鉴别价值；仍需结合频率和其他谱系异常。", "description_en": "The micromegakaryocyte is approximately 24 µm in diameter and contains multiple widely separated nuclei. The combination of abnormal small size and nuclear separation is more informative than lobulation alone, but frequency and abnormalities in other lineages remain essential.", "species": "Dog", "strain": "Clinical canine MDS cohort; case-specific breed NR in legend", "specimen_type": "Aspirate", "stain": "Wright stain", "lineage": "Megakaryocytic", "maturation_stage": "Micromegakaryocyte", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Micromegakaryocyte", "Multiple_widely_separated_nuclei" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "d", "source_page": "Figure 1, panel d", "caption_original_en": "Myelodysplastic syndrome, dog. (a) Blood film with dysplastic neutrophils (*) that have unevenly sized nuclear lobes and giant red blood cells (^) reflecting increased red cell distribution width. Case 1. Wright stain (WS). (b) The marrow aspirate is highly cellular and has a predominance of granulocytes. There are approximately 10% blasts (arrowheads). Of total, 15% of segmented neutrophils have dysplastic changes (*), and there are dysplastic band neutrophils (arrows). Case 2. WS. (c) An immature megakaryocyte with abnormal nuclear lobulation (left) and an abnormally small megakaryocyte with mature cytoplasm and a hypolobulated nucleus (right). Case 2. WS. (d) A micromegakaryocyte, ~24 µm in diameter with multiple, widely separated nuclei (arrow). Case 2. WS. (e) The marrow core is hypercellular despite chronic marked anemia, and megakaryocytes are clustered (arrows). Case 3. Hematoxylin and eosin (HE). (f) Higher magnification of (e) illustrating an increased proportion of blasts (arrowheads) in the center of the intertrabecular space; a megakaryocyte with abnormal nuclear lobulation, open chromatin, and nucleoli (arrow); and dysplastic giant band neutrophils (*). Case 3. HE.", "article_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "authors": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D", "journal": "Veterinary Pathology", "year": "2024", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D. Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia. Veterinary Pathology. 2024. doi:10.1177/03009858241277982. Figure 1, d. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 1-4 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-MDS-F01-D.jpg", "preview_path": "previews/BM-CC-DOG-MDS-F01-D.jpg", "sha256": "a5d20a24ba460215447dc91998fbc273c4f089f3b805a6b531f39b60ff429ba5", "processing_note": "Exact-pixel panel d crop from the CC BY 4.0 composite Figure 1 at parent coordinates [0,240,180,480]. The arrow and complete cell are retained.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC11697499-FIGURE-1", "parent_sha256": "5a483add2bbc9fd987d7603436aa2e972a9b71b8d8889bb981fb4c5fc5834d50", "parent_asset_path": "images/PMC11697499-FIGURE-1.jpg", "crop_coordinates": [ 0, 240, 180, 480 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-AML-F04-B", "map_image_id": "BMPM-IMG-0133", "source_id": "SUP-PMC11697499", "title_cn": "犬AML骨髓吸取物：高细胞性并含约45%原始细胞", "title_en": "Canine AML marrow aspirate: high cellularity with approximately 45% blasts", "description_cn": "同一病例骨髓吸取物细胞丰富，原作者报告约45%原始细胞。该panel可与外周血约40%大型原始细胞并列，形成同病例支持性血液—骨髓对照。", "description_en": "The marrow aspirate from the same case is highly cellular and contains approximately 45% blasts according to the authors. It can be viewed beside the blood film showing approximately 40% large blasts as a same-case supportive blood-marrow comparison.", "species": "Dog", "strain": "Clinical canine AML cohort; case-specific breed NR in legend", "specimen_type": "Aspirate", "stain": "Wright stain", "lineage": "Granulocytic", "maturation_stage": "Blast", "primary_morphology_class": "Proliferative_change", "secondary_features": [ "Hypercellular_aspirate", "Blasts_approximately_45_percent" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 4", "panel_label": "b", "source_page": "Figure 4, panel b", "caption_original_en": "Acute myeloid leukemia, dog. Case 7. Wright stain. (a) The dog had neutropenia, anemia, and thrombocytopenia. Approximately 40% of leukocytes are large blasts. (b) The marrow aspirate is highly cellular and contains approximately 45% blasts (*).", "article_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "authors": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D", "journal": "Veterinary Pathology", "year": "2024", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D. Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia. Veterinary Pathology. 2024. doi:10.1177/03009858241277982. Figure 4, b. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 1-4 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-AML-F04-B.jpg", "preview_path": "previews/BM-CC-DOG-AML-F04-B.jpg", "sha256": "18ef295f458300868310ed650a641eab7ba0b22b2a4e51f9c7c38c2fa9a7c9b9", "processing_note": "Exact-pixel panel b crop from the CC BY 4.0 composite Figure 4 at parent coordinates [368,0,738,241]. The asterisk and complete marrow field are retained.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC11697499-FIGURE-4", "parent_sha256": "217b86c19ccae052c0ec8f626e5f0fed0722e88859f1cb84fcf519444dca49b9", "parent_asset_path": "images/PMC11697499-FIGURE-4.jpg", "crop_coordinates": [ 368, 0, 738, 241 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-EHBP1L1-F01-B", "map_image_id": "BMPM-IMG-0086", "source_id": "PMC9407898", "title_cn": "犬先天性红系发育异常：红系前体间胞质桥", "title_en": "Canine congenital dyserythropoiesis: cytoplasmic bridging between erythroid precursors", "description_cn": "Wright-Giemsa骨髓细胞学显示红系前体之间的胞质桥。该形态适合作为红系发育异常的疾病鉴别图，不应由单个细胞直接外推为处理相关群体性异常。", "description_en": "Wright-Giemsa marrow cytology shows cytoplasmic bridging between erythroid precursors. This is a disease-differential example of dyserythropoiesis and should not be extrapolated from one cell to a treatment-related population change.", "species": "Dog", "strain": "Labrador Retriever", "specimen_type": "Cytology_smear", "stain": "Wright-Giemsa", "lineage": "Erythroid", "maturation_stage": "Erythroid_precursor_or_mixed", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Cytoplasmic_bridging" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "B", "source_page": "Figure 1, panel B", "caption_original_en": "Review of histopathological changes in red blood cells, bone marrow and muscle in Labrador Retrievers with an EHBP1L1 variant. (A) Review of Wrights Giemsa stained peripheral blood from an affected Labrador Retriever demonstrating poikilocytosis and a metarubricyte (arrow). (B) Review of Wrights Giemsa stained bone marrow cytology demonstrating cytoplasmic bridging (arrow). (C) Review of Wrights Giemsa stained bone marrow cytology demonstrating an atypical mitotic figure (arrow). (D) Review of Wrights Giemsa stained bone marrow cytology demonstrating rubriphagocytosis (arrow) and increased proportion of metarubricytes. (E) Review of the biceps femoris muscle biopsy from one dog showing myofiber size variation, pale, floccular sarcoplasmic inclusions (arrows) and endomysial fibrosis. (F) In severely affected biceps femoris muscle biopsies, endomysial fibrosis (asterisk) and numerous pale, floccular sarcoplasmic inclusions are present. H&E. Bar=10 µm for A-D and 50 µm for E-F.", "article_title": "An EHPB1L1 Nonsense Mutation Associated with Congenital Dyserythropoietic Anemia and Polymyopathy in Labrador Retriever Littermates", "authors": "Shelton GD, Minor KM, Guo LT, Thomas-Hollands A, Walsh KA, Friedenberg SG, Cullen JN, Mickelson JR", "journal": "Genes", "year": "2022", "doi": "10.3390/genes13081427", "pmid": "36011338", "pmcid": "PMC9407898", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9407898/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9407898/figure/genes-13-01427-f001/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Shelton GD, Minor KM, Guo LT, Thomas-Hollands A, Walsh KA, Friedenberg SG, Cullen JN, Mickelson JR. An EHPB1L1 Nonsense Mutation Associated with Congenital Dyserythropoietic Anemia and Polymyopathy in Labrador Retriever Littermates. Genes. 2022. doi:10.3390/genes13081427. Figure 1, B. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the Figure 1 legend.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-EHBP1L1-F01-B.png", "preview_path": "previews/BM-CC-DOG-EHBP1L1-F01-B.jpg", "sha256": "5bb82c6eab3e26d44feb0f89be8158889411e0c9a180241069906c541ef76ab0", "processing_note": "Exact-pixel panel B crop from the CC BY 4.0 composite Figure 1 at parent coordinates [384,0,768,286]. The arrow and complete marrow field are retained.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC9407898-FIGURE-1", "parent_sha256": "7e52e6752410f4e4c5be30c9891fb5b7e70587d2e303a41ba98a269c6b119ca3", "parent_asset_path": "images/PMC9407898-FIGURE-1.jpg", "crop_coordinates": [ 384, 0, 768, 286 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-EHBP1L1-F01-C", "map_image_id": "BMPM-IMG-0088", "source_id": "PMC9407898", "title_cn": "犬先天性红系发育异常：红系前体异型有丝分裂", "title_en": "Canine congenital dyserythropoiesis: atypical erythroid mitosis", "description_cn": "骨髓涂片中红系前体可见异型有丝分裂象。该图用于识别异常分裂形态；发生频率、群体意义和毒理相关性仍需固定分母计数及专家判断。", "description_en": "An atypical mitotic figure is present in an erythroid precursor on the marrow smear. The panel supports recognition of abnormal mitosis; frequency, population significance, and toxicologic relevance require denominator-based assessment and expert review.", "species": "Dog", "strain": "Labrador Retriever", "specimen_type": "Cytology_smear", "stain": "Wright-Giemsa", "lineage": "Erythroid", "maturation_stage": "Erythroid_precursor", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Atypical_mitosis" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "C", "source_page": "Figure 1, panel C", "caption_original_en": "Review of histopathological changes in red blood cells, bone marrow and muscle in Labrador Retrievers with an EHBP1L1 variant. (A) Review of Wrights Giemsa stained peripheral blood from an affected Labrador Retriever demonstrating poikilocytosis and a metarubricyte (arrow). (B) Review of Wrights Giemsa stained bone marrow cytology demonstrating cytoplasmic bridging (arrow). (C) Review of Wrights Giemsa stained bone marrow cytology demonstrating an atypical mitotic figure (arrow). (D) Review of Wrights Giemsa stained bone marrow cytology demonstrating rubriphagocytosis (arrow) and increased proportion of metarubricytes. (E) Review of the biceps femoris muscle biopsy from one dog showing myofiber size variation, pale, floccular sarcoplasmic inclusions (arrows) and endomysial fibrosis. (F) In severely affected biceps femoris muscle biopsies, endomysial fibrosis (asterisk) and numerous pale, floccular sarcoplasmic inclusions are present. H&E. Bar=10 µm for A-D and 50 µm for E-F.", "article_title": "An EHPB1L1 Nonsense Mutation Associated with Congenital Dyserythropoietic Anemia and Polymyopathy in Labrador Retriever Littermates", "authors": "Shelton GD, Minor KM, Guo LT, Thomas-Hollands A, Walsh KA, Friedenberg SG, Cullen JN, Mickelson JR", "journal": "Genes", "year": "2022", "doi": "10.3390/genes13081427", "pmid": "36011338", "pmcid": "PMC9407898", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9407898/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9407898/figure/genes-13-01427-f001/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Shelton GD, Minor KM, Guo LT, Thomas-Hollands A, Walsh KA, Friedenberg SG, Cullen JN, Mickelson JR. An EHPB1L1 Nonsense Mutation Associated with Congenital Dyserythropoietic Anemia and Polymyopathy in Labrador Retriever Littermates. Genes. 2022. doi:10.3390/genes13081427. Figure 1, C. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the Figure 1 legend.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-EHBP1L1-F01-C.png", "preview_path": "previews/BM-CC-DOG-EHBP1L1-F01-C.jpg", "sha256": "f32fd1360f3c3a4c3246dc0ed4731953f1a0f8016d4aa33217a868c6b5c61545", "processing_note": "Exact-pixel panel C crop from the CC BY 4.0 composite Figure 1 at parent coordinates [0,286,384,590]. The arrow and complete marrow field are retained.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC9407898-FIGURE-1", "parent_sha256": "7e52e6752410f4e4c5be30c9891fb5b7e70587d2e303a41ba98a269c6b119ca3", "parent_asset_path": "images/PMC9407898-FIGURE-1.jpg", "crop_coordinates": [ 0, 286, 384, 590 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-EHBP1L1-F01-D", "map_image_id": "BMPM-IMG-0085", "source_id": "PMC9407898", "title_cn": "犬先天性红系发育异常：红系前体吞噬与晚幼红细胞增加", "title_en": "Canine congenital dyserythropoiesis: rubriphagocytosis and increased metarubricytes", "description_cn": "骨髓细胞学显示红系前体吞噬现象，并见晚幼红细胞比例增加。应将可见吞噬、巨噬细胞数量和更广义的嗜血细胞现象分别记录。", "description_en": "Marrow cytology shows rubriphagocytosis together with an increased proportion of metarubricytes. The visible phagocytic event, macrophage quantity, and broader hemophagocytic syndrome should be recorded separately.", "species": "Dog", "strain": "Labrador Retriever", "specimen_type": "Cytology_smear", "stain": "Wright-Giemsa", "lineage": "Erythroid_and_macrophagic", "maturation_stage": "Metarubricyte_and_erythroid_precursor", "primary_morphology_class": "Phagocytic_or_hemophagocytic_change", "secondary_features": [ "Rubriphagocytosis", "Metarubricyte_increase" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "D", "source_page": "Figure 1, panel D", "caption_original_en": "Review of histopathological changes in red blood cells, bone marrow and muscle in Labrador Retrievers with an EHBP1L1 variant. (A) Review of Wrights Giemsa stained peripheral blood from an affected Labrador Retriever demonstrating poikilocytosis and a metarubricyte (arrow). (B) Review of Wrights Giemsa stained bone marrow cytology demonstrating cytoplasmic bridging (arrow). (C) Review of Wrights Giemsa stained bone marrow cytology demonstrating an atypical mitotic figure (arrow). (D) Review of Wrights Giemsa stained bone marrow cytology demonstrating rubriphagocytosis (arrow) and increased proportion of metarubricytes. (E) Review of the biceps femoris muscle biopsy from one dog showing myofiber size variation, pale, floccular sarcoplasmic inclusions (arrows) and endomysial fibrosis. (F) In severely affected biceps femoris muscle biopsies, endomysial fibrosis (asterisk) and numerous pale, floccular sarcoplasmic inclusions are present. H&E. Bar=10 µm for A-D and 50 µm for E-F.", "article_title": "An EHPB1L1 Nonsense Mutation Associated with Congenital Dyserythropoietic Anemia and Polymyopathy in Labrador Retriever Littermates", "authors": "Shelton GD, Minor KM, Guo LT, Thomas-Hollands A, Walsh KA, Friedenberg SG, Cullen JN, Mickelson JR", "journal": "Genes", "year": "2022", "doi": "10.3390/genes13081427", "pmid": "36011338", "pmcid": "PMC9407898", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9407898/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9407898/figure/genes-13-01427-f001/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Shelton GD, Minor KM, Guo LT, Thomas-Hollands A, Walsh KA, Friedenberg SG, Cullen JN, Mickelson JR. An EHPB1L1 Nonsense Mutation Associated with Congenital Dyserythropoietic Anemia and Polymyopathy in Labrador Retriever Littermates. Genes. 2022. doi:10.3390/genes13081427. Figure 1, D. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the Figure 1 legend.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-EHBP1L1-F01-D.png", "preview_path": "previews/BM-CC-DOG-EHBP1L1-F01-D.jpg", "sha256": "44cf650453540c501614e518415bfc2ceda49a9ce63b6bbd877c0b6cea4862b7", "processing_note": "Exact-pixel panel D crop from the CC BY 4.0 composite Figure 1 at parent coordinates [384,286,768,590]. The arrow and complete marrow field are retained.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC9407898-FIGURE-1", "parent_sha256": "7e52e6752410f4e4c5be30c9891fb5b7e70587d2e303a41ba98a269c6b119ca3", "parent_asset_path": "images/PMC9407898-FIGURE-1.jpg", "crop_coordinates": [ 384, 286, 768, 590 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-DOG-MARROW-DISORDERS-F02", "map_image_id": "NR", "source_id": "PMC7324823", "title_cn": "犬多系骨髓异常：红系核碎裂、环形中性粒细胞与多核巨核细胞", "title_en": "Canine multilineage marrow abnormalities: erythroid nuclear fragmentation, ringed neutrophil, and multinucleated megakaryocyte", "description_cn": "Miniature Dachshund骨髓涂片完整Figure 2并列展示红系核碎裂、粒系环形中性粒细胞及具有多个核的形态异常巨核细胞。它是疾病性多系异常鉴别，不应自动归因为药物毒性。", "description_en": "Complete Figure 2 from Miniature Dachshunds juxtaposes erythroid nuclear fragmentation, a ringed neutrophil, and a dysmorphic megakaryocyte with multiple nuclei. It is a disease differential for multilineage abnormalities, not automatic evidence of drug toxicity.", "species": "Dog", "strain": "Miniature Dachshund", "specimen_type": "Bone_marrow_smear", "stain": "Wright-Giemsa", "lineage": "Erythroid_granulocytic_and_megakaryocytic", "maturation_stage": "Mixed", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Erythroid_nuclear_fragmentation", "Ringed_neutrophil", "Megakaryocyte_multiple_nuclei" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Fig. 2", "panel_label": "a-c (complete figure)", "source_page": "Figure 2, complete three-panel figure", "caption_original_en": "Fragmented nucleus in the erythroid lineage (a), ringed neutrophil in the myeloid linage (b), and dysmorphic megakaryocyte with multiple nuclei (c) observed in bone marrow smears stained with Wright-Giemsa stain. Bar=10 µm.", "article_title": "Clinical and clinicopathological features and outcomes of Miniature Dachshunds with bone marrow disorders", "authors": "Tani A, Tomiyasu H, Ohmi A, Ohno K, Tsujimoto H", "journal": "The Journal of Veterinary Medical Science", "year": "2020", "doi": "10.1292/jvms.19-0439", "pmid": "32307340", "pmcid": "PMC7324823", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7324823/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c5/7324823/71d6f402218b/jvms-82-771-g002.jpg", "license": "CC BY-NC-ND 4.0", "license_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Tani A, Tomiyasu H, Ohmi A, Ohno K, Tsujimoto H. Clinical and clinicopathological features and outcomes of Miniature Dachshunds with bone marrow disorders. The Journal of Veterinary Medical Science. 2020. doi:10.1292/jvms.19-0439. Fig. 2, a-c (complete figure). CC BY-NC-ND 4.0; complete figure reproduced without adaptation for noncommercial learning.", "third_party_credit_line": "None reported in the relevant figure legends", "rights_basis": "The article permits noncommercial sharing with attribution and without distribution of adapted material. Only byte-identical complete source figures are used. PMC full-text copyright and license block: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0; complete Figures 2 and 3 are reproduced without cropping, annotation, retouching, or other adaptation.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-MARROW-DISORDERS-F02.jpg", "preview_path": "images/BM-CC-DOG-MARROW-DISORDERS-F02.jpg", "sha256": "ca67f5d198c7d6beb8c17a5ab5c8ea7cf6b32759f38fd359efe8a1dc0f014ab1", "processing_note": "Byte-identical complete Figure 2 copied from the PMC source media. All three panels, panel letters, cellular fields, and scale bars are retained; no crop, annotation, color change, retouching, or other adaptation was applied.", "source_mode": "verbatim_full_figure", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC0-MOUSE-ENU-MDS-F03-K", "map_image_id": "NR", "source_id": "PMC4948781", "title_cn": "ENU诱导小鼠MDS模型：骨髓涂片中巨核细胞核形态异常", "title_en": "ENU-induced mouse MDS model: abnormal megakaryocyte nuclear morphology in a marrow smear", "description_cn": "1000×骨髓涂片中，箭头标示一枚具有多枚表观分离核的巨核细胞。原作者在ENU诱导MDS背景下将巨核细胞多枚分离核归入巨核系发育异常；网站先记录可见核形，再保留该原文解释。单张代表图不能给出发生频率。", "description_en": "In this 1000× marrow smear, the arrow identifies a megakaryocyte with multiple apparently separated nuclei. In the ENU-induced MDS context, the authors include multiple separated nuclei among megakaryocytic dysplastic changes. The atlas records the visible nuclear form before the source interpretation; one field does not establish frequency.", "species": "Mouse", "strain": "DBA/2J or SWR/J ENU cohort; case-specific strain and dose NR in the Figure 3 legend", "specimen_type": "Bone_marrow_smear", "stain": "Wright-Giemsa", "lineage": "Megakaryocytic", "maturation_stage": "Megakaryocyte", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Abnormal_megakaryocyte_nuclear_morphology", "Multiple_apparently_separate_nuclei", "ENU_associated_MDS_model" ], "evidence_role": "Treatment_associated_model", "causality_level": "Author_attributed", "figure_label": "Figure 3", "panel_label": "k — ENU-associated MDS marrow megakaryocyte", "source_page": "Figure 3, panel k", "caption_original_en": "Smears from peripheral blood, bone marrow, spleen, and liver were prepared from mice at sacrifice and stained with Wright-Giemsa stain. Samples of tibia, spleen, liver, kidney, and brain were fixed in formalin, paraffin-embedded, sectioned, and stained with hematoxylin and eosin. Representative smears (1000x) from an AML case show circulating peripheral blood blasts (a) and blasts infiltrating the bone marrow (b), spleen (c), and liver (d). Representative images (400x) show infiltrates of blasts in bone marrow (e), spleen (f), liver (g), kidney (h), and brain (i) sections from a mouse with AML. Representative smears (1000x) from the peripheral blood (j), bone marrow (k), and spleen (l) from a mouse with MDS show dysplastic hematopoiesis including abnormal neutrophil nuclear maturation, target cells, basophilic stippling, and large platelets in the peripheral blood, abnormal megakaryocyte nuclear morphology in the bone marrow, and bi-nucleated red cell precursors in the spleen. Examples are highlighted with arrows.", "article_title": "Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity", "authors": "Jonas BA, Johnson C, Gratzinger D, Majeti R", "journal": "PLoS ONE", "year": "2016", "doi": "10.1371/journal.pone.0159189", "pmid": "27428079", "pmcid": "PMC4948781", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4948781/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/030c/4948781/e3582796cbdc/pone.0159189.g003.jpg", "license": "CC0 1.0 Universal", "license_url": "https://creativecommons.org/publicdomain/zero/1.0/", "reuse_status": "public_domain", "attribution": "Jonas BA, Johnson C, Gratzinger D, Majeti R. Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity. PLoS ONE. 2016. doi:10.1371/journal.pone.0159189. Figure 3, k — ENU-associated MDS marrow megakaryocyte. CC0 1.0 Universal; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 3 legend", "rights_basis": "The article is dedicated to the public domain under CC0. Figure 3 has no separate third-party credit line; the exact-pixel panel k crop remains linked to the complete figure and original legend. The locally retained PMC full text states that the article is free of copyright and made available under the Creative Commons CC0 public domain dedication.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC0-MOUSE-ENU-MDS-F03-K.png", "preview_path": "previews/BM-CC0-MOUSE-ENU-MDS-F03-K.jpg", "sha256": "a0c6cfd0b06c963a7a1ada1f64556efda4007ae9960e9501112a6397b0355203", "processing_note": "Exact-pixel panel k crop from the CC0 composite Figure 3 at parent coordinates [354,401,550,622]. The panel letter, arrow, complete megakaryocyte, surrounding marrow cells, and 20 μm scale bar are preserved; no resampling or visual enhancement was applied.", "source_mode": "declared_local_asset", "parent_figure_id": "PMC4948781-FIGURE-3", "parent_sha256": "5d56db046d64bd8d13f722b4344f0a209db24c446f71b637f4192974bb6295ed", "parent_asset_path": "images/PMC4948781-FIGURE-3.jpg", "crop_coordinates": [ 354, 401, 550, 622 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-RAT-CYPERMETHRIN-P11-CONTROL", "map_image_id": "NR", "source_id": "PMC4427713-RAT-CYPERMETHRIN", "title_cn": "同期对照大鼠骨髓涂片：早幼粒细胞与多染性幼红细胞", "title_en": "Concurrent-control rat marrow smear: promyelocyte and polychromatic erythroblast", "description_cn": "对照雄性白化大鼠Leishman染色骨髓涂片，原图标示早幼粒细胞和多染性幼红细胞，作为处理时序的正常成熟对照。该复合图分辨率有限，细胞亚阶段仍待专家复核。", "description_en": "Leishman-stained marrow from a control male albino rat. The source labels a promyelocyte and a polychromatic erythroblast, providing a normal-maturation comparator for the treatment time course. Composite-image resolution limits stage confirmation, which remains pending expert review.", "species": "Rat", "strain": "Male albino rat, inbred colony; exact strain NR", "specimen_type": "Bone_marrow_smear", "stain": "Leishman", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Normal_maturation", "secondary_features": [ "Promyelocyte", "Polychromatic_erythroblast", "Control_comparator" ], "evidence_role": "Normal_comparator", "causality_level": "Differential_only", "figure_label": "Plates XI-XVII", "panel_label": "Plate XI — control marrow", "source_page": "Plate XI", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus of control group depicting promyelocyte (PMC) and polychromatic erythroblast (PE).", "article_title": "Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats", "authors": "Pande S, Saxena PN, Bhushan B, Saxena N", "journal": "Interdisciplinary Toxicology", "year": "2014", "doi": "10.2478/intox-2014-0006", "pmid": "26038674", "pmcid": "PMC4427713", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/bin/ITX-7-033-g002.jpg", "license": "CC BY 2.0", "license_url": "https://creativecommons.org/licenses/by/2.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Pande S, Saxena PN, Bhushan B, Saxena N. Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats. Interdisciplinary Toxicology. 2014. doi:10.2478/intox-2014-0006. Plates XI-XVII, Plate XI — control marrow. CC BY 2.0; cropped teaching panel.", "third_party_credit_line": "None reported for Plates XI-XVII", "rights_basis": "The article permits reuse and adaptation with attribution under CC BY 2.0. Exact-pixel panel crops retain the Roman-numeral plate labels, source arrows, and cellular fields and remain linked to the complete composite and individual legends. The locally retained PMC JATS permissions block identifies the article as open access under the Creative Commons Attribution 2.0 license; no separate third-party credit line is present for Plates XI-XVII.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-RAT-CYPERMETHRIN-P11-CONTROL.png", "preview_path": "previews/BM-CC-RAT-CYPERMETHRIN-P11-CONTROL.jpg", "sha256": "7b6a58c79a0cc18a805c8fa17af8ddb37ec45a8ce0eba15e32587d1babc601fd", "processing_note": "Exact-pixel crop of Plate XI from the CC BY 2.0 Plates XI-XVII composite at parent coordinates [0,0,318,216]. The Roman-numeral label, source arrows, cell labels, and complete field are retained; no resampling or visual enhancement was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC4427713-PLATES-XI-XVII", "parent_sha256": "1352e3bd7b768fc870b9f570e8df96c9973c0087351fc537d1181a8660c35398", "parent_asset_path": "images/PMC4427713-PLATES-XI-XVII.jpg", "crop_coordinates": [ 0, 0, 318, 216 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-RAT-CYPERMETHRIN-P12-DAY1", "map_image_id": "NR", "source_id": "PMC4427713-RAT-CYPERMETHRIN", "title_cn": "氯氰菊酯急性处理后大鼠骨髓：正染性幼红细胞", "title_en": "Rat marrow after acute cypermethrin exposure: orthochromatic erythroblast", "description_cn": "急性氯氰菊酯处理1天后的骨髓涂片，原图箭头标示正染性幼红细胞。该细胞阶段本身不等同于毒性异常；本panel仅作处理背景形态参考。", "description_en": "Marrow smear after one day of acute cypermethrin exposure, with the source arrow identifying an orthochromatic erythroblast. The presence of this maturation stage alone is not a toxic abnormality; the panel is retained as a treatment-context reference.", "species": "Rat", "strain": "Male albino rat, inbred colony; exact strain NR", "specimen_type": "Bone_marrow_smear", "stain": "Leishman", "lineage": "Erythroid", "maturation_stage": "Orthochromatic_erythroblast", "primary_morphology_class": "Normal_maturation", "secondary_features": [ "Orthochromatic_erythroblast", "Acute_exposure_context" ], "evidence_role": "Treatment_context_reference", "causality_level": "Treatment_associated", "figure_label": "Plates XI-XVII", "panel_label": "Plate XII — acute day 1", "source_page": "Plate XII", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus after acute cypermethrin treatment showing orthochromatic erythroblast (OE).", "article_title": "Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats", "authors": "Pande S, Saxena PN, Bhushan B, Saxena N", "journal": "Interdisciplinary Toxicology", "year": "2014", "doi": "10.2478/intox-2014-0006", "pmid": "26038674", "pmcid": "PMC4427713", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/bin/ITX-7-033-g002.jpg", "license": "CC BY 2.0", "license_url": "https://creativecommons.org/licenses/by/2.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Pande S, Saxena PN, Bhushan B, Saxena N. Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats. Interdisciplinary Toxicology. 2014. doi:10.2478/intox-2014-0006. Plates XI-XVII, Plate XII — acute day 1. CC BY 2.0; cropped teaching panel.", "third_party_credit_line": "None reported for Plates XI-XVII", "rights_basis": "The article permits reuse and adaptation with attribution under CC BY 2.0. Exact-pixel panel crops retain the Roman-numeral plate labels, source arrows, and cellular fields and remain linked to the complete composite and individual legends. The locally retained PMC JATS permissions block identifies the article as open access under the Creative Commons Attribution 2.0 license; no separate third-party credit line is present for Plates XI-XVII.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-RAT-CYPERMETHRIN-P12-DAY1.png", "preview_path": "previews/BM-CC-RAT-CYPERMETHRIN-P12-DAY1.jpg", "sha256": "ead737b818896c7b11037201c3f4a368c4de2076a69ac03a0c99a066abc670b4", "processing_note": "Exact-pixel crop of Plate XII from the CC BY 2.0 Plates XI-XVII composite at parent coordinates [328,0,646,216]. The Roman-numeral label, source arrow, cell label, and complete field are retained; no resampling or visual enhancement was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC4427713-PLATES-XI-XVII", "parent_sha256": "1352e3bd7b768fc870b9f570e8df96c9973c0087351fc537d1181a8660c35398", "parent_asset_path": "images/PMC4427713-PLATES-XI-XVII.jpg", "crop_coordinates": [ 328, 0, 646, 216 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-RAT-CYPERMETHRIN-P13-DAY7", "map_image_id": "NR", "source_id": "PMC4427713-RAT-CYPERMETHRIN", "title_cn": "氯氰菊酯处理7天：原作者标注巨幼样细胞及轻度红系增加", "title_en": "Cypermethrin day 7: source-labeled megaloblast and slight erythroid increase", "description_cn": "原作者在7天骨髓涂片中标注“megaloblast”，并报告红系细胞轻度增加。该旧式或非标准化细胞名称保留为原文术语，不由网站自动等同于巨幼细胞性发育异常。", "description_en": "The authors label a 'megaloblast' and report a slight erythroid increase in the day-7 marrow smear. This source term is retained verbatim as terminology requiring review and is not automatically equated with megaloblastic dysplasia by the atlas.", "species": "Rat", "strain": "Male albino rat, inbred colony; exact strain NR", "specimen_type": "Bone_marrow_smear", "stain": "Leishman", "lineage": "Erythroid", "maturation_stage": "Erythroid_precursor", "primary_morphology_class": "Proliferative_change", "secondary_features": [ "Erythroid_increase_slight", "Megaloblast_author_term_requires_review" ], "evidence_role": "Treatment_associated_response", "causality_level": "Author_attributed", "figure_label": "Plates XI-XVII", "panel_label": "Plate XIII — day 7", "source_page": "Plate XIII", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus after 7 days of cypermethrin treatment showing megaloblast (MB) and slight increase in cells of erythroid series.", "article_title": "Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats", "authors": "Pande S, Saxena PN, Bhushan B, Saxena N", "journal": "Interdisciplinary Toxicology", "year": "2014", "doi": "10.2478/intox-2014-0006", "pmid": "26038674", "pmcid": "PMC4427713", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/bin/ITX-7-033-g002.jpg", "license": "CC BY 2.0", "license_url": "https://creativecommons.org/licenses/by/2.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Pande S, Saxena PN, Bhushan B, Saxena N. Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats. Interdisciplinary Toxicology. 2014. doi:10.2478/intox-2014-0006. Plates XI-XVII, Plate XIII — day 7. CC BY 2.0; cropped teaching panel.", "third_party_credit_line": "None reported for Plates XI-XVII", "rights_basis": "The article permits reuse and adaptation with attribution under CC BY 2.0. Exact-pixel panel crops retain the Roman-numeral plate labels, source arrows, and cellular fields and remain linked to the complete composite and individual legends. The locally retained PMC JATS permissions block identifies the article as open access under the Creative Commons Attribution 2.0 license; no separate third-party credit line is present for Plates XI-XVII.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-RAT-CYPERMETHRIN-P13-DAY7.png", "preview_path": "previews/BM-CC-RAT-CYPERMETHRIN-P13-DAY7.jpg", "sha256": "456c2760a45b34e95344bdf42a3c48e8c04be110e71300ca1cbe5cefaa4b4e8a", "processing_note": "Exact-pixel crop of Plate XIII from the CC BY 2.0 Plates XI-XVII composite at parent coordinates [0,210,318,431]. The Roman-numeral label, source arrow, MB label, and complete field are retained; no resampling or visual enhancement was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC4427713-PLATES-XI-XVII", "parent_sha256": "1352e3bd7b768fc870b9f570e8df96c9973c0087351fc537d1181a8660c35398", "parent_asset_path": "images/PMC4427713-PLATES-XI-XVII.jpg", "crop_coordinates": [ 0, 210, 318, 431 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-RAT-CYPERMETHRIN-P14-DAY14", "map_image_id": "NR", "source_id": "PMC4427713-RAT-CYPERMETHRIN", "title_cn": "氯氰菊酯处理14天：红系前体增加", "title_en": "Cypermethrin day 14: increased erythroid precursors", "description_cn": "14天骨髓涂片中可见原图标示的多染性幼红细胞，原作者报告红系前体增加。这是代表性视野和原作者组水平解释，不代替固定分母分类计数。", "description_en": "The day-14 smear contains the source-labeled polychromatic erythroblast, and the authors report increased erythroid precursors. This representative field and group-level interpretation do not replace a fixed-denominator differential count.", "species": "Rat", "strain": "Male albino rat, inbred colony; exact strain NR", "specimen_type": "Bone_marrow_smear", "stain": "Leishman", "lineage": "Erythroid", "maturation_stage": "Polychromatic_erythroblast", "primary_morphology_class": "Proliferative_change", "secondary_features": [ "Erythroid_precursor_increase", "Polychromatic_erythroblast" ], "evidence_role": "Treatment_associated_response", "causality_level": "Author_attributed", "figure_label": "Plates XI-XVII", "panel_label": "Plate XIV — day 14", "source_page": "Plate XIV", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus after subchronic (14 days) cypermethrin treatment showing polychromatic erythroblast (PE) and increase in erythroid precursors.", "article_title": "Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats", "authors": "Pande S, Saxena PN, Bhushan B, Saxena N", "journal": "Interdisciplinary Toxicology", "year": "2014", "doi": "10.2478/intox-2014-0006", "pmid": "26038674", "pmcid": "PMC4427713", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/bin/ITX-7-033-g002.jpg", "license": "CC BY 2.0", "license_url": "https://creativecommons.org/licenses/by/2.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Pande S, Saxena PN, Bhushan B, Saxena N. Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats. Interdisciplinary Toxicology. 2014. doi:10.2478/intox-2014-0006. Plates XI-XVII, Plate XIV — day 14. CC BY 2.0; cropped teaching panel.", "third_party_credit_line": "None reported for Plates XI-XVII", "rights_basis": "The article permits reuse and adaptation with attribution under CC BY 2.0. Exact-pixel panel crops retain the Roman-numeral plate labels, source arrows, and cellular fields and remain linked to the complete composite and individual legends. The locally retained PMC JATS permissions block identifies the article as open access under the Creative Commons Attribution 2.0 license; no separate third-party credit line is present for Plates XI-XVII.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-RAT-CYPERMETHRIN-P14-DAY14.png", "preview_path": "previews/BM-CC-RAT-CYPERMETHRIN-P14-DAY14.jpg", "sha256": "e4a12ef486399aa57843a97b66c4bd412f48ae439f4d4d981a77bfe02f25259b", "processing_note": "Exact-pixel crop of Plate XIV from the CC BY 2.0 Plates XI-XVII composite at parent coordinates [328,210,646,431]. The Roman-numeral label, source arrow, PE label, and complete field are retained; no resampling or visual enhancement was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC4427713-PLATES-XI-XVII", "parent_sha256": "1352e3bd7b768fc870b9f570e8df96c9973c0087351fc537d1181a8660c35398", "parent_asset_path": "images/PMC4427713-PLATES-XI-XVII.jpg", "crop_coordinates": [ 328, 210, 646, 431 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-RAT-CYPERMETHRIN-P15-DAY21", "map_image_id": "NR", "source_id": "PMC4427713-RAT-CYPERMETHRIN", "title_cn": "氯氰菊酯处理21天：中幼粒细胞与中度红系前体增加", "title_en": "Cypermethrin day 21: myelocyte and moderate erythroid-precursor increase", "description_cn": "21天骨髓涂片中原图标示中幼粒细胞，原作者同时报告红系前体中度增加。单一图中的中幼粒细胞不证明粒系增生或成熟阻滞。", "description_en": "The source labels a myelocyte in the day-21 marrow smear and reports a moderate increase in erythroid precursors. One visible myelocyte does not establish myeloid hyperplasia or maturation arrest.", "species": "Rat", "strain": "Male albino rat, inbred colony; exact strain NR", "specimen_type": "Bone_marrow_smear", "stain": "Leishman", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Proliferative_change", "secondary_features": [ "Myelocyte", "Erythroid_precursor_increase_moderate" ], "evidence_role": "Treatment_associated_response", "causality_level": "Author_attributed", "figure_label": "Plates XI-XVII", "panel_label": "Plate XV — day 21", "source_page": "Plate XV", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus after subchronic (21 days) cypermethrin treatment depicting myelocyte (MC) and moderate increase in erythroid precursors.", "article_title": "Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats", "authors": "Pande S, Saxena PN, Bhushan B, Saxena N", "journal": "Interdisciplinary Toxicology", "year": "2014", "doi": "10.2478/intox-2014-0006", "pmid": "26038674", "pmcid": "PMC4427713", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/bin/ITX-7-033-g002.jpg", "license": "CC BY 2.0", "license_url": "https://creativecommons.org/licenses/by/2.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Pande S, Saxena PN, Bhushan B, Saxena N. Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats. Interdisciplinary Toxicology. 2014. doi:10.2478/intox-2014-0006. Plates XI-XVII, Plate XV — day 21. CC BY 2.0; cropped teaching panel.", "third_party_credit_line": "None reported for Plates XI-XVII", "rights_basis": "The article permits reuse and adaptation with attribution under CC BY 2.0. Exact-pixel panel crops retain the Roman-numeral plate labels, source arrows, and cellular fields and remain linked to the complete composite and individual legends. The locally retained PMC JATS permissions block identifies the article as open access under the Creative Commons Attribution 2.0 license; no separate third-party credit line is present for Plates XI-XVII.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-RAT-CYPERMETHRIN-P15-DAY21.png", "preview_path": "previews/BM-CC-RAT-CYPERMETHRIN-P15-DAY21.jpg", "sha256": "8ebf66d604a912090573c0425e9b91f0ec2f957d70452a61a6e4e30e8dd2c62d", "processing_note": "Exact-pixel crop of Plate XV from the CC BY 2.0 Plates XI-XVII composite at parent coordinates [0,426,318,648]. The Roman-numeral label, source arrow, MC label, and complete field are retained; no resampling or visual enhancement was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC4427713-PLATES-XI-XVII", "parent_sha256": "1352e3bd7b768fc870b9f570e8df96c9973c0087351fc537d1181a8660c35398", "parent_asset_path": "images/PMC4427713-PLATES-XI-XVII.jpg", "crop_coordinates": [ 0, 426, 318, 648 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-RAT-CYPERMETHRIN-P16-DAY28", "map_image_id": "NR", "source_id": "PMC4427713-RAT-CYPERMETHRIN", "title_cn": "氯氰菊酯处理28天：粒系成熟阶段与高度红系比例增加", "title_en": "Cypermethrin day 28: granulocytic maturation stages and markedly increased erythroid proportion", "description_cn": "28天骨髓涂片中原图标示晚幼粒细胞、杆状核及分叶中性粒细胞，并报告红系细胞比例高度增加。“比例增加”不自动等同于红系绝对增生，需结合同期分类计数和骨髓细胞量。", "description_en": "The day-28 smear labels a metamyelocyte, band form, and segmented neutrophils, while the authors report a highly increased erythroid proportion. A relative increase is not automatically an absolute erythroid hyperplasia and requires concurrent differential counts and cellularity.", "species": "Rat", "strain": "Male albino rat, inbred colony; exact strain NR", "specimen_type": "Bone_marrow_smear", "stain": "Leishman", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Proliferative_change", "secondary_features": [ "Metamyelocyte", "Band_neutrophil", "Segmented_neutrophil", "Erythroid_relative_increase_marked" ], "evidence_role": "Treatment_associated_response", "causality_level": "Author_attributed", "figure_label": "Plates XI-XVII", "panel_label": "Plate XVI — day 28", "source_page": "Plate XVI", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus after subchronic (28 days) treatment showing metamyelocyte (MMC) band stage (B), polymorphonuclear neutrophils (PMN) and highly increased proportion of erythroid cells.", "article_title": "Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats", "authors": "Pande S, Saxena PN, Bhushan B, Saxena N", "journal": "Interdisciplinary Toxicology", "year": "2014", "doi": "10.2478/intox-2014-0006", "pmid": "26038674", "pmcid": "PMC4427713", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/bin/ITX-7-033-g002.jpg", "license": "CC BY 2.0", "license_url": "https://creativecommons.org/licenses/by/2.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Pande S, Saxena PN, Bhushan B, Saxena N. Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats. Interdisciplinary Toxicology. 2014. doi:10.2478/intox-2014-0006. Plates XI-XVII, Plate XVI — day 28. CC BY 2.0; cropped teaching panel.", "third_party_credit_line": "None reported for Plates XI-XVII", "rights_basis": "The article permits reuse and adaptation with attribution under CC BY 2.0. Exact-pixel panel crops retain the Roman-numeral plate labels, source arrows, and cellular fields and remain linked to the complete composite and individual legends. The locally retained PMC JATS permissions block identifies the article as open access under the Creative Commons Attribution 2.0 license; no separate third-party credit line is present for Plates XI-XVII.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-RAT-CYPERMETHRIN-P16-DAY28.png", "preview_path": "previews/BM-CC-RAT-CYPERMETHRIN-P16-DAY28.jpg", "sha256": "9b8448220d81f33c14d19e1f325f158bfd6ed08637a2f2a651c641986b3fe69b", "processing_note": "Exact-pixel crop of Plate XVI from the CC BY 2.0 Plates XI-XVII composite at parent coordinates [328,426,646,648]. The Roman-numeral label, source arrows, cell labels, and complete field are retained; no resampling or visual enhancement was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC4427713-PLATES-XI-XVII", "parent_sha256": "1352e3bd7b768fc870b9f570e8df96c9973c0087351fc537d1181a8660c35398", "parent_asset_path": "images/PMC4427713-PLATES-XI-XVII.jpg", "crop_coordinates": [ 328, 426, 646, 648 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-RAT-CYPERMETHRIN-P17-RECOVERY", "map_image_id": "NR", "source_id": "PMC4427713-RAT-CYPERMETHRIN", "title_cn": "氯氰菊酯恢复期大鼠骨髓：粒系成熟序列", "title_en": "Rat marrow during cypermethrin recovery: granulocytic maturation sequence", "description_cn": "恢复组第60天骨髓涂片显示发育中的中性粒细胞、嗜酸性和嗜碱性粒细胞。原作者报告22天恢复期后相关血液学参数趋于正常；但单一代表视野不证明每只动物完全恢复。", "description_en": "The day-60 recovery smear shows developing neutrophils, an eosinophil, and a basophil. The authors report normalization of related hematology after the 22-day recovery period, but one representative field does not establish complete recovery in every animal.", "species": "Rat", "strain": "Male albino rat, inbred colony; exact strain NR", "specimen_type": "Bone_marrow_smear", "stain": "Leishman", "lineage": "Granulocytic", "maturation_stage": "Mixed_granulocytic_maturation", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Developing_neutrophils", "Eosinophil", "Basophil", "Recovery_phase" ], "evidence_role": "Recovery_response", "causality_level": "Author_attributed", "figure_label": "Plates XI-XVII", "panel_label": "Plate XVII — recovery day 60", "source_page": "Plate XVII", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus of recovery group (60 days) showing developing neutrophils (NP), polymorphonuclear eosinophil (PNE) and polymorphonuclear basophil (PNB).", "article_title": "Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats", "authors": "Pande S, Saxena PN, Bhushan B, Saxena N", "journal": "Interdisciplinary Toxicology", "year": "2014", "doi": "10.2478/intox-2014-0006", "pmid": "26038674", "pmcid": "PMC4427713", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/bin/ITX-7-033-g002.jpg", "license": "CC BY 2.0", "license_url": "https://creativecommons.org/licenses/by/2.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Pande S, Saxena PN, Bhushan B, Saxena N. Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats. Interdisciplinary Toxicology. 2014. doi:10.2478/intox-2014-0006. Plates XI-XVII, Plate XVII — recovery day 60. CC BY 2.0; cropped teaching panel.", "third_party_credit_line": "None reported for Plates XI-XVII", "rights_basis": "The article permits reuse and adaptation with attribution under CC BY 2.0. Exact-pixel panel crops retain the Roman-numeral plate labels, source arrows, and cellular fields and remain linked to the complete composite and individual legends. The locally retained PMC JATS permissions block identifies the article as open access under the Creative Commons Attribution 2.0 license; no separate third-party credit line is present for Plates XI-XVII.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-RAT-CYPERMETHRIN-P17-RECOVERY.png", "preview_path": "previews/BM-CC-RAT-CYPERMETHRIN-P17-RECOVERY.jpg", "sha256": "ea9a1ef30d7116e0546b69a2d593a5991cf796e1fb09556267e51abb7b7fd217", "processing_note": "Exact-pixel crop of Plate XVII from the CC BY 2.0 Plates XI-XVII composite at parent coordinates [0,642,318,861]. The Roman-numeral label, source arrows, cell labels, and complete field are retained; no resampling or visual enhancement was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC4427713-PLATES-XI-XVII", "parent_sha256": "1352e3bd7b768fc870b9f570e8df96c9973c0087351fc537d1181a8660c35398", "parent_asset_path": "images/PMC4427713-PLATES-XI-XVII.jpg", "crop_coordinates": [ 0, 642, 318, 861 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-NC-MOUSE-BMT-DEPLETION-F01-A", "map_image_id": "BMPM-IMG-0156", "source_id": "S2M-PMC2807276", "title_cn": "小鼠骨髓移植后严重造血细胞丢失：残存混合细胞群", "title_en": "Severe hematopoietic-cell loss after mouse BMT: residual mixed marrow cells", "description_cn": "同一只C57BL/6雄鼠在7.5 Gy照射和mock-transduced骨髓移植后第19天濒死。Panel A按原图标注显示少量嗜碱性幼红细胞、嗜碱性粒细胞、巨噬细胞、浆细胞和淋巴细胞；正文另报告粒系细胞近乎完全耗竭。该单动物病例适合作为严重造血细胞丢失的鉴别图，不足以单独区分照射、植入失败、移植相关免疫反应或其他机制。", "description_en": "The same male C57BL/6 mouse was found moribund 19 days after 7.5 Gy irradiation and transplantation of mock-transduced marrow. Source labels in panel A identify sparse basophilic erythroblasts, a basophil, macrophage, plasma cell, and lymphocyte; the text additionally reports near-complete depletion of myeloid cells. This single-animal case is a differential image of severe hematopoietic-cell loss and cannot by itself distinguish irradiation, engraftment failure, transplant-associated immune effects, or other mechanisms.", "species": "Mouse", "strain": "C57BL/6 male mouse", "specimen_type": "Cytology_smear", "stain": "Wright-Giemsa (source legend: Wright-Geimsa)", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Cytotoxic_change", "secondary_features": [ "Severe_hematopoietic_cell_loss", "Myeloid_near_complete_depletion_author_reported", "Residual_basophilic_erythroblasts", "Macrophage", "Plasma_cell", "Lymphocyte" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Fig. 1", "panel_label": "A — residual mixed marrow cells", "source_page": "Figure 1, panel A", "caption_original_en": "Bone marrow (BM) cytology from the mouse found moribund 19 days after BM transplantation (BMT). BM cytology showed a severe loss of hematopoietic cells. (A) Few basophilic erythroblasts, basophils, macrophages, plasma cells, and lymphoblasts. (B) Proerythroblasts, polychromatic erythroblasts, and lymphocytes are present. Wright-Geimsa stain.", "article_title": "Pathological features of bone marrow transplantation-related toxicity in a mouse", "authors": "Kim Y-H, Ha C-S, Lee H-S, Lim S-H, Moon K-S, Chung M-K, Son H-Y", "journal": "Journal of Veterinary Science", "year": "2009", "doi": "10.4142/jvs.2009.10.4.361", "pmid": "19934605", "pmcid": "PMC2807276", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2807276/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2807276/figure/F1/", "license": "CC BY-NC 4.0", "license_url": "https://creativecommons.org/licenses/by-nc/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Kim Y-H, Ha C-S, Lee H-S, Lim S-H, Moon K-S, Chung M-K, Son H-Y. Pathological features of bone marrow transplantation-related toxicity in a mouse. Journal of Veterinary Science. 2009. doi:10.4142/jvs.2009.10.4.361. Fig. 1, A — residual mixed marrow cells. CC BY-NC 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 1 legend", "rights_basis": "The article permits noncommercial reuse and adaptation with attribution under CC BY-NC 4.0. The panel crops preserve source labels, arrows, complete fields, and 20 µm scale bars and are distributed only in the noncommercial learning atlas. The locally retained PMC JATS permissions block identifies the article as CC BY-NC 4.0. Figure 1 contains no separate third-party credit line, and the two exact-pixel panel crops remain linked to the complete figure and original legend.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-NC-MOUSE-BMT-DEPLETION-F01-A.png", "preview_path": "previews/BM-CC-NC-MOUSE-BMT-DEPLETION-F01-A.jpg", "sha256": "d423f15d4068bee6d426fac5d2658d7ab0999cc4db8d84e53b9bc51ae01bd9a6", "processing_note": "Exact-pixel panel A crop from the CC BY-NC 4.0 complete Figure 1 at parent coordinates [0,0,490,368]. The panel letter, source labels, arrows, complete field, and 20 µm scale bar are retained; no resampling or visual enhancement was applied.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC2807276-FIGURE-1", "parent_sha256": "f1a2c124aece14a4105b45450620a41000c80f32d10a2df3630a59bd166e5560", "parent_asset_path": "images/PMC2807276-FIGURE-1.jpg", "crop_coordinates": [ 0, 0, 490, 368 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-NC-MOUSE-BMT-DEPLETION-F01-B", "map_image_id": "BMPM-IMG-0157", "source_id": "S2M-PMC2807276", "title_cn": "小鼠骨髓移植后严重造血细胞丢失：残存红系前体与淋巴细胞", "title_en": "Severe hematopoietic-cell loss after mouse BMT: residual erythroid precursors and lymphocytes", "description_cn": "同一濒死小鼠的Panel B按原图标注显示原幼红细胞、多染性幼红细胞和淋巴细胞。该视野支持严重耗竭背景中仍可见局灶残存细胞，但不能据此认定红系恢复、红系绝对增生或各细胞群发生率；应与Panel A、固定分母分类计数、CBC和组织学一并解释。", "description_en": "Panel B from the same moribund mouse contains source-labeled proerythroblasts, polychromatic erythroblasts, and lymphocytes. The field demonstrates focal residual cells in a severely depleted marrow context, but it does not establish erythroid recovery, absolute erythroid hyperplasia, or cell-population frequency; interpretation requires panel A, denominator-based cytology, CBC, and histology.", "species": "Mouse", "strain": "C57BL/6 male mouse", "specimen_type": "Cytology_smear", "stain": "Wright-Giemsa (source legend: Wright-Geimsa)", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Cytotoxic_change", "secondary_features": [ "Severe_hematopoietic_cell_loss", "Myeloid_near_complete_depletion_author_reported", "Residual_proerythroblasts", "Polychromatic_erythroblasts", "Lymphocytes" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Fig. 1", "panel_label": "B — residual erythroid precursors and lymphocytes", "source_page": "Figure 1, panel B", "caption_original_en": "Bone marrow (BM) cytology from the mouse found moribund 19 days after BM transplantation (BMT). BM cytology showed a severe loss of hematopoietic cells. (A) Few basophilic erythroblasts, basophils, macrophages, plasma cells, and lymphoblasts. (B) Proerythroblasts, polychromatic erythroblasts, and lymphocytes are present. Wright-Geimsa stain.", "article_title": "Pathological features of bone marrow transplantation-related toxicity in a mouse", "authors": "Kim Y-H, Ha C-S, Lee H-S, Lim S-H, Moon K-S, Chung M-K, Son H-Y", "journal": "Journal of Veterinary Science", "year": "2009", "doi": "10.4142/jvs.2009.10.4.361", "pmid": "19934605", "pmcid": "PMC2807276", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2807276/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2807276/figure/F1/", "license": "CC BY-NC 4.0", "license_url": "https://creativecommons.org/licenses/by-nc/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Kim Y-H, Ha C-S, Lee H-S, Lim S-H, Moon K-S, Chung M-K, Son H-Y. Pathological features of bone marrow transplantation-related toxicity in a mouse. Journal of Veterinary Science. 2009. doi:10.4142/jvs.2009.10.4.361. Fig. 1, B — residual erythroid precursors and lymphocytes. CC BY-NC 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 1 legend", "rights_basis": "The article permits noncommercial reuse and adaptation with attribution under CC BY-NC 4.0. The panel crops preserve source labels, arrows, complete fields, and 20 µm scale bars and are distributed only in the noncommercial learning atlas. The locally retained PMC JATS permissions block identifies the article as CC BY-NC 4.0. Figure 1 contains no separate third-party credit line, and the two exact-pixel panel crops remain linked to the complete figure and original legend.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-NC-MOUSE-BMT-DEPLETION-F01-B.png", "preview_path": "previews/BM-CC-NC-MOUSE-BMT-DEPLETION-F01-B.jpg", "sha256": "e2d3f35befb9c22411c2e45db212dcf8f70a208de8a5d7c204127af0093f6134", "processing_note": "Exact-pixel panel B crop from the CC BY-NC 4.0 complete Figure 1 at parent coordinates [0,372,490,740]. The panel letter, source labels, arrows, complete field, and 20 µm scale bar are retained; no resampling or visual enhancement was applied.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC2807276-FIGURE-1", "parent_sha256": "f1a2c124aece14a4105b45450620a41000c80f32d10a2df3630a59bd166e5560", "parent_asset_path": "images/PMC2807276-FIGURE-1.jpg", "crop_coordinates": [ 0, 372, 490, 740 ], "display_surface": "Bone_marrow_cytology_grid" }, { "image_id": "BM-CC-NC-DOG-PIMA-F02", "map_image_id": "BMPM-IMG-0098", "source_id": "S2M-PMC12910396", "title_cn": "犬PIMA鉴别：红系低生成与成熟阻滞背景中的髓系占优势", "title_en": "Canine PIMA differential: myeloid predominance in erythroid hypoplasia with maturation arrest", "description_cn": "8岁绝育混种母犬持续70日非再生性贫血。Figure 2为骨髓细针吸取涂片，作者描述髓系相对红系占优势；正文将M:E升高归因于红系低生成伴成熟阻滞，并报告红系核质不同步、未见红系前体吞噬。该400×整体视野支持构成不平衡的教学识别，但不能从单一视野量化M:E或独立确认PIMA。", "description_en": "An 8-year-old spayed mixed-breed dog had a 70-day history of non-regenerative anemia. Figure 2 is a marrow fine-needle aspirate smear showing author-described myeloid predominance; the text attributes the increased M:E ratio to erythroid hypoplasia with maturation arrest, reports erythroid nuclear-cytoplasmic asynchrony, and notes absent rubriphagocytosis. This 400x overview supports teaching recognition of lineage imbalance but cannot quantify M:E or independently establish PIMA from one field.", "species": "Dog", "strain": "8-year-old spayed mixed-breed female dog", "specimen_type": "Cytology_smear", "stain": "May–Grunwald–Giemsa Wright", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Increased_M_E_ratio_author_reported", "Erythroid_hypoplasia_author_reported", "Erythroid_maturation_arrest_author_reported", "Nuclear_cytoplasmic_asynchrony_author_reported", "Rubriphagocytosis_not_observed" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "FIGURE 2", "panel_label": "Whole Figure 2 — myeloid predominance in a PIMA differential", "source_page": "Figure 2", "caption_original_en": "Fine‐needle aspiration smear of bone marrow. May–Grunwald–Giemsa Wright. 400×. Predominance of myeloid over erythroid elements (increased myeloid‐to‐erythroid ratio).", "article_title": "First Case Report of Precursor‐Targeted Immune‐Mediated Anaemia in a Dog From Italy Lacking Rubriphagocytosis and With Severe Hyperferraemia: Diagnosis, Treatment, and Clinical Outcome", "authors": "Nasar S, Uva A, Girardi G, Tanas G, Ciccarelli S, Zatelli A, Cavalera MA, Gernone F", "journal": "Veterinary Medicine and Science", "year": "2026", "doi": "10.1002/vms3.70852", "pmid": "41700447", "pmcid": "PMC12910396", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12910396/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12910396/figure/vms370852-fig-0002/", "license": "CC BY-NC 4.0", "license_url": "https://creativecommons.org/licenses/by-nc/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Nasar S, Uva A, Girardi G, Tanas G, Ciccarelli S, Zatelli A, Cavalera MA, Gernone F. First Case Report of Precursor‐Targeted Immune‐Mediated Anaemia in a Dog From Italy Lacking Rubriphagocytosis and With Severe Hyperferraemia: Diagnosis, Treatment, and Clinical Outcome. Veterinary Medicine and Science. 2026. doi:10.1002/vms3.70852. FIGURE 2, Whole Figure 2 — myeloid predominance in a PIMA differential. CC BY-NC 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 2 legend", "rights_basis": "The article permits noncommercial reuse and adaptation with attribution under CC BY-NC 4.0. The complete 400 × 300 field is retained without cropping, resampling, retouching, or generative enhancement, and the original JPEG is preserved as the parent figure. The locally retained PMC JATS permissions block identifies the article as CC BY-NC 4.0. Figure 2 has no separate third-party credit line; the PNG teaching asset is pixel-equivalent to the complete source JPEG and remains linked to that parent figure and the unmodified legend.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-NC-DOG-PIMA-F02.png", "preview_path": "previews/BM-CC-NC-DOG-PIMA-F02.jpg", "sha256": "5f535b83f857fa164af52f77586c2dc2825c9f4b776facc91a7b0513f0e725e0", "processing_note": "Pixel-equivalent whole-image PNG derived from the CC BY-NC 4.0 complete Figure 2 JPEG at parent coordinates [0,0,400,300]. The full field is retained without cropping, resampling, retouching, or generative enhancement; the source figure contains no panel letter, arrow, or scale bar.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC12910396-FIGURE-2", "parent_sha256": "ea1daac3525be00bd7ffbe6c13d2fb4c2503b4a18abda0c3b463e833f4c87fbd", "parent_asset_path": "images/PMC12910396-FIGURE-2.jpg", "crop_coordinates": [ 0, 0, 400, 300 ], "display_surface": "Bone_marrow_cytology_grid" } ], "terms": [ { "id": "INHAND-BM-001", "term_en": "Angiectasis", "term_cn": "血管扩张", "synonyms": [], "species": "Rat; Mouse", "category": "Nonproliferative", "definition_en": "Marrow vascular spaces are variably dilated and blood-filled; distinguish from hemorrhage and postmortem congestion.", "definition_cn": "骨髓血管腔不同程度扩张并充血；需与出血和死后淤血鉴别。", "criteria": "Marrow vascular spaces are variably dilated and blood-filled; distinguish from hemorrhage and postmortem congestion.", "differentials": [], "report_phrase": "Requires expert review before direct report use.", "common_misuse": "No curated misuse note available; interpret in source context.", "evidence_source": "PMC6752743", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-002", "term_en": "Dyshematopoiesis", "term_cn": "造血发育异常", "synonyms": [ "Dysplastic hematopoiesis", "Abnormal hematopoietic maturation" ], "species": "Rat; Mouse", "category": "Nonproliferative", "definition_en": "Maturation failure with altered cell or nuclear size, morphology, N:C ratio, asynchronous maturation, missing stages or arrest; cytology is preferred for detailed lineage assessment.", "definition_cn": "成熟失败，可见细胞或细胞核大小/形态、核胞比异常，核质发育不同步、阶段缺失或成熟阻滞；详细谱系判断宜结合细胞学。", "criteria": "Maturation failure with altered cell or nuclear size, morphology, N:C ratio, asynchronous maturation, missing stages or arrest; cytology is preferred for detailed lineage assessment.", "differentials": [ "Degeneration", "Smear artefact", "Regenerative shift", "Neoplastic population" ], "report_phrase": "Dyshematopoietic changes were observed in the [lineage] series.", "common_misuse": "Do not use for isolated atypia without evidence of maturation disturbance.", "evidence_source": "PMC6752743", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-003", "term_en": "Dyshematopoiesis, erythroid", "term_cn": "红系造血发育异常", "synonyms": [ "Marrow hypocellularity", "Reduced marrow cellularity" ], "species": "Rat; Mouse", "category": "Nonproliferative", "definition_en": "Multiple or satellite nuclei, nuclear fragmentation or abnormal shapes, megaloblastic change, abnormal sideroblasts, or nuclear-cytoplasmic asynchrony.", "definition_cn": "可见多核/卫星核、核碎裂或异常核形、巨幼样改变、异常铁粒幼细胞或核质发育不同步。", "criteria": "Multiple or satellite nuclei, nuclear fragmentation or abnormal shapes, megaloblastic change, abnormal sideroblasts, or nuclear-cytoplasmic asynchrony.", "differentials": [ "Hemodilution", "Poor particle yield", "Postmortem change" ], "report_phrase": "Decreased marrow particle cellular density was observed.", "common_misuse": "Do not infer hypoplasia of a specific lineage from smear dilution or a relative differential alone.", "evidence_source": "PMC6752743", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-004", "term_en": "Dyshematopoiesis, megakaryocytic", "term_cn": "巨核系造血发育异常", "synonyms": [ "Marrow hypercellularity", "Increased marrow cellular density" ], "species": "Rat; Mouse", "category": "Nonproliferative", "definition_en": "Abnormal megakaryocyte size or nuclear morphology and/or nuclear-cytoplasmic maturation asynchrony.", "definition_cn": "巨核细胞大小或核形态异常，和/或核质成熟不同步。", "criteria": "Abnormal megakaryocyte size or nuclear morphology and/or nuclear-cytoplasmic maturation asynchrony.", "differentials": [ "Lineage-selective hyperplasia", "Reduced marrow fat", "Sampling variation" ], "report_phrase": "Increased marrow cellularity was observed in the evaluated particles.", "common_misuse": "Do not equate overall cellularity with selective erythroid or myeloid hyperplasia.", "evidence_source": "PMC6752743", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-005", "term_en": "Cellularity, decreased", "term_cn": "骨髓细胞密度降低", "synonyms": [], "species": "Rat; Mouse; Rabbit", "category": "Nonproliferative", "definition_en": "Reduced hematopoietic cellularity with increased adipose space; use concurrent same-site controls and distinguish lineage-selective decrease when possible.", "definition_cn": "造血细胞密度降低、脂肪间隙增多；应与同部位同期对照比较，并尽可能说明受累谱系。", "criteria": "Reduced hematopoietic cellularity with increased adipose space; use concurrent same-site controls and distinguish lineage-selective decrease when possible.", "differentials": [], "report_phrase": "Requires expert review before direct report use.", "common_misuse": "No curated misuse note available; interpret in source context.", "evidence_source": "PMC6752743; PMC8544166", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-006", "term_en": "Cellularity, increased", "term_cn": "骨髓细胞密度增加", "synonyms": [], "species": "Rat; Mouse; Rabbit", "category": "Non-neoplastic proliferative", "definition_en": "Increased hematopoietic cellularity relative to concurrent same-site controls; cytology may be required to identify the expanded lineage and precise M:E ratio.", "definition_cn": "相对同部位同期对照造血细胞密度增加；确定增生谱系和精确M:E常需细胞学。", "criteria": "Increased hematopoietic cellularity relative to concurrent same-site controls; cytology may be required to identify the expanded lineage and precise M:E ratio.", "differentials": [], "report_phrase": "Requires expert review before direct report use.", "common_misuse": "No curated misuse note available; interpret in source context.", "evidence_source": "PMC6752743; PMC8544166", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-007", "term_en": "Fibrosis", "term_cn": "纤维化", "synonyms": [ "Erythrocyte phagocytosis" ], "species": "Rat; Mouse; Rabbit", "category": "Nonproliferative", "definition_en": "Increased stromal collagen or reticulin replacing or separating hematopoietic tissue; special stains may support confirmation.", "definition_cn": "基质胶原或网状纤维增多，分隔或替代造血组织；必要时用特殊染色确认。", "criteria": "Increased stromal collagen or reticulin replacing or separating hematopoietic tissue; special stains may support confirmation.", "differentials": [ "Hemophagocytosis", "Erythroid island macrophage", "Processing artefact" ], "report_phrase": "Erythrophagocytosis by marrow macrophages was observed.", "common_misuse": "Do not use hemophagocytosis when only erythroid cells are involved.", "evidence_source": "PMC6752743; PMC8544166", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-008", "term_en": "Necrosis", "term_cn": "坏死", "synonyms": [ "Hemophagocytic activity" ], "species": "Rat; Mouse; Rabbit", "category": "Nonproliferative", "definition_en": "Loss of viable marrow cells with karyorrhectic debris, eosinophilic material and possible inflammation or hemorrhage; distinguish from autolysis.", "definition_cn": "活细胞丧失，伴核碎屑、嗜酸性物质，可伴炎症或出血；需与自溶鉴别。", "criteria": "Loss of viable marrow cells with karyorrhectic debris, eosinophilic material and possible inflammation or hemorrhage; distinguish from autolysis.", "differentials": [ "Erythrophagocytosis", "Cellular debris clearance", "Emperipolesis" ], "report_phrase": "Hemophagocytosis was observed and requires clinicopathologic correlation.", "common_misuse": "A single phagocytic event does not establish a syndrome or group-level diagnosis.", "evidence_source": "PMC6752743; PMC8544166", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-009", "term_en": "Serous atrophy of fat", "term_cn": "脂肪浆液性萎缩", "synonyms": [], "species": "Rabbit", "category": "Nonproliferative", "definition_en": "Loss or atrophy of marrow adipocytes with pale myxoid extracellular material, usually in severe negative energy balance.", "definition_cn": "骨髓脂肪细胞减少/萎缩并出现淡染黏液样细胞外物质，常见于严重负能量平衡。", "criteria": "Loss or atrophy of marrow adipocytes with pale myxoid extracellular material, usually in severe negative energy balance.", "differentials": [], "report_phrase": "Requires expert review before direct report use.", "common_misuse": "No curated misuse note available; interpret in source context.", "evidence_source": "PMC8544166", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-010", "term_en": "Granulocyte hypersegmentation", "term_cn": "粒细胞核过分叶", "synonyms": [], "species": "Rabbit", "category": "Nonproliferative", "definition_en": "Granulocytes show excessive nuclear segmentation; interpret with smear quality, age and systemic context.", "definition_cn": "粒细胞核分叶过多；解释时需结合涂片质量、年龄和全身背景。", "criteria": "Granulocytes show excessive nuclear segmentation; interpret with smear quality, age and systemic context.", "differentials": [], "report_phrase": "Requires expert review before direct report use.", "common_misuse": "No curated misuse note available; interpret in source context.", "evidence_source": "PMC8544166", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-011", "term_en": "Inflammation / inflammatory infiltrate", "term_cn": "炎症/炎性细胞浸润", "synonyms": [], "species": "Rat; Mouse; Rabbit", "category": "Nonproliferative", "definition_en": "Inflammatory cells exceed expected marrow background or form a lesion; specify predominant cell type and distribution.", "definition_cn": "炎性细胞超过骨髓预期背景或形成病灶；应说明主要细胞类型和分布。", "criteria": "Inflammatory cells exceed expected marrow background or form a lesion; specify predominant cell type and distribution.", "differentials": [], "report_phrase": "Requires expert review before direct report use.", "common_misuse": "No curated misuse note available; interpret in source context.", "evidence_source": "PMC6752743; PMC8544166", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-012", "term_en": "Pigment, macrophage", "term_cn": "巨噬细胞色素沉积", "synonyms": [], "species": "Rat; Mouse; Rabbit", "category": "Nonproliferative", "definition_en": "Pigmented material accumulates in marrow macrophages; identify pigment where possible and correlate with hemolysis or treatment.", "definition_cn": "骨髓巨噬细胞内色素蓄积；应尽可能确定色素种类，并与溶血或处理因素关联。", "criteria": "Pigmented material accumulates in marrow macrophages; identify pigment where possible and correlate with hemolysis or treatment.", "differentials": [], "report_phrase": "Requires expert review before direct report use.", "common_misuse": "No curated misuse note available; interpret in source context.", "evidence_source": "PMC6752743; PMC8544166", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-013", "term_en": "Apoptosis, increased", "term_cn": "凋亡增加", "synonyms": [], "species": "Rabbit", "category": "Nonproliferative", "definition_en": "Increased individual apoptotic hematopoietic cells; identify lineage when supported and distinguish from necrosis.", "definition_cn": "单个造血细胞凋亡增多；证据充分时标注谱系，并与坏死鉴别。", "criteria": "Increased individual apoptotic hematopoietic cells; identify lineage when supported and distinguish from necrosis.", "differentials": [], "report_phrase": "Requires expert review before direct report use.", "common_misuse": "No curated misuse note available; interpret in source context.", "evidence_source": "PMC8544166", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-014", "term_en": "Osseous metaplasia", "term_cn": "骨化生", "synonyms": [], "species": "Rabbit", "category": "Nonproliferative", "definition_en": "Formation of mature or immature bone within marrow where not normally expected.", "definition_cn": "在非预期部位形成成熟或未成熟骨组织。", "criteria": "Formation of mature or immature bone within marrow where not normally expected.", "differentials": [], "report_phrase": "Requires expert review before direct report use.", "common_misuse": "No curated misuse note available; interpret in source context.", "evidence_source": "PMC8544166", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-015", "term_en": "Leukemia, myeloid/erythroid/megakaryocytic/NOS", "term_cn": "白血病（髓系/红系/巨核系/未特指）", "synonyms": [], "species": "Rat; Mouse; Rabbit", "category": "Neoplastic", "definition_en": "Neoplastic blasts or atypical cells expand in marrow, often with tissue infiltration; distinguish dyshematopoiesis, which generally lacks nonhematopoietic tissue involvement and has a lower blast burden.", "definition_cn": "肿瘤性原始细胞或异型细胞在骨髓扩增，常伴组织浸润；应与通常无非造血组织浸润、原始细胞负荷较低的发育异常鉴别。", "criteria": "Neoplastic blasts or atypical cells expand in marrow, often with tissue infiltration; distinguish dyshematopoiesis, which generally lacks nonhematopoietic tissue involvement and has a lower blast burden.", "differentials": [], "report_phrase": "Requires expert review before direct report use.", "common_misuse": "No curated misuse note available; interpret in source context.", "evidence_source": "PMC6752743; PMC8544166", "evidence_status": "Published terminology", "expert_review_status": "Pending" }, { "id": "INHAND-BM-016", "term_en": "Hyperplasia, erythroid/myeloid", "term_cn": "红系/髓系增生", "synonyms": [], "species": "Rat; Mouse", "category": "Interpretation guidance", "definition_en": "Use descriptive cellularity increased in the morphologic diagnosis; lineage-specific hyperplasia can be used in narrative interpretation when supported by cytology and context.", "definition_cn": "形态诊断优先使用“细胞密度增加”；当细胞学和研究背景支持时，可在叙述性解释中使用“红系/髓系增生”。", "criteria": "Use descriptive cellularity increased in the morphologic diagnosis; lineage-specific hyperplasia can be used in narrative interpretation when supported by cytology and context.", "differentials": [], "report_phrase": "Requires expert review before direct report use.", "common_misuse": "No curated misuse note available; interpret in source context.", "evidence_source": "NTP-BONE-MARROW-HYPERCELLULARITY", "evidence_status": "Internal working term", "expert_review_status": "Pending" }, { "id": "INHAND-BM-017", "term_en": "M:E ratio change", "term_cn": "M:E比值改变", "synonyms": [], "species": "Rat; Mouse", "category": "Interpretation guidance", "definition_en": "Histology provides only an approximate M:E impression; marrow cytology is required for a precise ratio and maturation-stage assessment.", "definition_cn": "组织切片只能粗略判断M:E趋势；精确比值和成熟阶段评价需骨髓细胞学。", "criteria": "Histology provides only an approximate M:E impression; marrow cytology is required for a precise ratio and maturation-stage assessment.", "differentials": [], "report_phrase": "Requires expert review before direct report use.", "common_misuse": "No curated misuse note available; interpret in source context.", "evidence_source": "NTP-BONE-MARROW-HYPERCELLULARITY", "evidence_status": "Internal working term", "expert_review_status": "Pending" }, { "id": "INHAND-BM-018", "term_en": "Nonhuman-primate hematolymphoid terminology context", "term_cn": "非人灵长类血液淋巴系统术语适用背景", "synonyms": [], "species": "Cynomolgus_monkey", "category": "Species application guidance", "definition_en": "Use the NHP INHAND publication for species-specific histopathology context and background findings; do not assume rodent marrow criteria are fully equivalent without primate evidence.", "definition_cn": "使用非人灵长类INHAND资料核对物种特异的组织病理背景；缺乏猴证据时，不应把啮齿类骨髓判据直接视为完全等同。", "criteria": "Use the NHP INHAND publication for species-specific histopathology context and background findings; do not assume rodent marrow criteria are fully equivalent without primate evidence.", "differentials": [], "report_phrase": "Requires expert review before direct report use.", "common_misuse": "No curated misuse note available; interpret in source context.", "evidence_source": "PMC8544165", "evidence_status": "Internal working term", "expert_review_status": "Pending" } ], "toxicity_types": [ { "id": "T01", "title_cn": "骨髓低细胞性、全系减少和再生障碍", "title_en": "Hypocellularity, pancytopenia and aplasia", "definition_cn": "造血细胞总体减少，可局灶或弥漫，并可伴脂肪组织相对增加；严重时表现为全系耗竭或再生障碍。", "definition_en": "A global reduction in hematopoietic cells, focal or diffuse, sometimes with relative adipose replacement; severe forms may include multilineage depletion or aplasia.", "smear_assessment_cn": "NR", "smear_assessment_en": "NR", "histology_assessment_cn": "NR", "histology_assessment_en": "NR", "cbc_correlation_cn": [ "可伴贫血、网织红细胞减少、中性粒细胞减少或血小板减少", "外周血改变可能滞后于骨髓损伤" ], "cbc_correlation_en": [ "May accompany anemia, reticulocytopenia, neutropenia, or thrombocytopenia", "Peripheral blood changes may lag behind marrow injury" ], "differential_cn": "NR", "differential_en": "NR", "report_phrase_en": "NR", "evidence_status": "Internal_working_taxonomy_supported_by_traceable_sources", "expert_review_status": "Pending" }, { "id": "T02", "title_cn": "红系、粒系或巨核系选择性减少", "title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "definition_cn": "一个主要造血谱系选择性减少，而其他谱系相对保留。比例变化本身不能证明绝对减少。", "definition_en": "Preferential reduction of one hematopoietic lineage with relative preservation of others. A proportional change alone does not establish an absolute decrease.", "smear_assessment_cn": "NR", "smear_assessment_en": "NR", "histology_assessment_cn": "NR", "histology_assessment_en": "NR", "cbc_correlation_cn": [ "红系减少与RBC/HGB/HCT/RET关联", "粒系减少与NEU关联", "巨核系减少与PLT关联" ], "cbc_correlation_en": [ "Correlate erythroid reduction with RBC/HGB/HCT/RET", "Correlate myeloid reduction with NEU", "Correlate megakaryocytic reduction with PLT" ], "differential_cn": "NR", "differential_en": "NR", "report_phrase_en": "NR", "evidence_status": "Internal_working_taxonomy_supported_by_traceable_sources", "expert_review_status": "Pending" }, { "id": "T03", "title_cn": "成熟阻滞和发育异常", "title_en": "Maturation arrest and dysmaturation", "definition_cn": "成熟序列在特定阶段前聚集、后续阶段减少，或出现核/胞质成熟不同步及群体性发育异常。", "definition_en": "Accumulation before a maturation stage with reduction beyond it, or population-level asynchronous nuclear/cytoplasmic maturation and abnormal development.", "smear_assessment_cn": "NR", "smear_assessment_en": "NR", "histology_assessment_cn": "NR", "histology_assessment_en": "NR", "cbc_correlation_cn": [ "结合外周细胞减少、左移、异常细胞和恢复时序", "无效造血可与骨髓增生并存" ], "cbc_correlation_en": [ "Correlate with cytopenia, left shift, abnormal circulating cells, and recovery kinetics", "Ineffective hematopoiesis may coexist with marrow hyperplasia" ], "differential_cn": "NR", "differential_en": "NR", "report_phrase_en": "NR", "evidence_status": "Internal_working_taxonomy_supported_by_traceable_sources", "expert_review_status": "Pending" }, { "id": "T04", "title_cn": "细胞凋亡、变性和骨髓坏死", "title_en": "Apoptosis, degeneration and marrow necrosis", "definition_cn": "造血细胞出现凋亡、变性、碎裂或较大片骨髓坏死，可为直接损伤或继发改变。", "definition_en": "Apoptosis, degeneration, fragmentation, or confluent marrow necrosis involving hematopoietic cells; the change may be direct or secondary.", "smear_assessment_cn": "NR", "smear_assessment_en": "NR", "histology_assessment_cn": "NR", "histology_assessment_en": "NR", "cbc_correlation_cn": [ "可出现一系或多系细胞减少", "外周血时相与损伤程度可能不同步" ], "cbc_correlation_en": [ "One or multiple cytopenias may occur", "Peripheral blood timing may not parallel lesion severity" ], "differential_cn": "NR", "differential_en": "NR", "report_phrase_en": "NR", "evidence_status": "Internal_working_taxonomy_supported_by_traceable_sources", "expert_review_status": "Pending" }, { "id": "T05", "title_cn": "骨髓纤维化和基质改变", "title_en": "Fibrosis and stromal or microenvironment change", "definition_cn": "网状纤维/胶原增加、基质成分改变或造血微环境受损。", "definition_en": "Increased reticulin/collagen, altered stromal components, or injury to the hematopoietic microenvironment.", "smear_assessment_cn": "NR", "smear_assessment_en": "NR", "histology_assessment_cn": "NR", "histology_assessment_en": "NR", "cbc_correlation_cn": [ "可伴进行性细胞减少、泪滴样红细胞或髓外造血，但均非特异", "结合脾、肝和恢复数据" ], "cbc_correlation_en": [ "May accompany progressive cytopenias, tear-drop erythrocytes, or extramedullary hematopoiesis, none of which is specific", "Correlate with spleen, liver, and recovery data" ], "differential_cn": "NR", "differential_en": "NR", "report_phrase_en": "NR", "evidence_status": "Internal_working_taxonomy_supported_by_traceable_sources", "expert_review_status": "Pending" }, { "id": "T06", "title_cn": "反应性增生、恢复期反跳和高细胞性", "title_en": "Reactive hyperplasia, rebound and hypercellularity", "definition_cn": "某一或多个造血谱系增加，包括治疗期反应性增生、骨髓抑制后反跳或总体高细胞性。", "definition_en": "Expansion of one or more hematopoietic lineages, including treatment-period reactive hyperplasia, post-suppression rebound, or global hypercellularity.", "smear_assessment_cn": "NR", "smear_assessment_en": "NR", "histology_assessment_cn": "NR", "histology_assessment_en": "NR", "cbc_correlation_cn": [ "与网织红细胞、中性粒细胞或血小板反应关联", "外周血增多不要求骨髓比例同步增加" ], "cbc_correlation_en": [ "Correlate with reticulocyte, neutrophil, or platelet responses", "Peripheral increases do not require a synchronous proportional marrow increase" ], "differential_cn": "NR", "differential_en": "NR", "report_phrase_en": "NR", "evidence_status": "Internal_working_taxonomy_supported_by_traceable_sources", "expert_review_status": "Pending" }, { "id": "T07", "title_cn": "巨核细胞损伤、减少及血小板毒性", "title_en": "Megakaryocyte injury, decrease and platelet toxicity", "definition_cn": "巨核细胞数量、成熟、核形、胞质成熟或产板表现改变，并与血小板毒性证据关联。", "definition_en": "Changes in megakaryocyte quantity, maturation, nuclear morphology, cytoplasmic maturation, or platelet shedding, correlated with platelet toxicity evidence.", "smear_assessment_cn": "NR", "smear_assessment_en": "NR", "histology_assessment_cn": "NR", "histology_assessment_en": "NR", "cbc_correlation_cn": [ "血小板减少伴巨核细胞增加可提示代偿，但不能自动定因", "血小板减少伴巨核细胞减少/成熟异常需重点复核" ], "cbc_correlation_en": [ "Thrombocytopenia with increased megakaryocytes may suggest compensation but does not establish cause", "Thrombocytopenia with decreased or abnormally maturing megakaryocytes requires focused review" ], "differential_cn": "NR", "differential_en": "NR", "report_phrase_en": "NR", "evidence_status": "Internal_working_taxonomy_supported_by_traceable_sources", "expert_review_status": "Pending" }, { "id": "T08", "title_cn": "嗜血、红细胞吞噬和巨噬细胞改变", "title_en": "Hemophagocytosis, erythrophagocytosis and macrophage change", "definition_cn": "巨噬细胞吞噬红细胞、红系前体或其他血细胞，或伴巨噬细胞数量/活化形态改变。", "definition_en": "Macrophage ingestion of erythrocytes, erythroid precursors, or other blood cells, with or without altered macrophage quantity or activation morphology.", "smear_assessment_cn": "NR", "smear_assessment_en": "NR", "histology_assessment_cn": "NR", "histology_assessment_en": "NR", "cbc_correlation_cn": [ "与贫血、血小板减少、白细胞减少及炎症指标关联", "单个吞噬细胞不足以解释外周血改变" ], "cbc_correlation_en": [ "Correlate with anemia, thrombocytopenia, leukopenia, and inflammatory indicators", "One phagocytic cell is insufficient to explain peripheral blood changes" ], "differential_cn": "NR", "differential_en": "NR", "report_phrase_en": "NR", "evidence_status": "Internal_working_taxonomy_supported_by_traceable_sources", "expert_review_status": "Pending" }, { "id": "T09", "title_cn": "色素、含铁血黄素及异物蓄积", "title_en": "Pigment, hemosiderin and foreign material accumulation", "definition_cn": "巨噬细胞或基质中出现含铁血黄素、其他内源性色素或外源性物质蓄积。", "definition_en": "Accumulation of hemosiderin, other endogenous pigment, or exogenous material in macrophages or marrow stroma.", "smear_assessment_cn": "NR", "smear_assessment_en": "NR", "histology_assessment_cn": "NR", "histology_assessment_en": "NR", "cbc_correlation_cn": [ "含铁血黄素可与慢性出血、溶血或铁代谢改变相关", "CBC关联不具特异性" ], "cbc_correlation_en": [ "Hemosiderin may accompany chronic hemorrhage, hemolysis, or altered iron handling", "CBC associations are nonspecific" ], "differential_cn": "NR", "differential_en": "NR", "report_phrase_en": "NR", "evidence_status": "Internal_working_taxonomy_supported_by_traceable_sources", "expert_review_status": "Pending" }, { "id": "T10", "title_cn": "血管扩张、缺血和骨髓微环境损伤", "title_en": "Angiectasis, ischemia and marrow vascular injury", "definition_cn": "骨髓血窦/血管扩张、充血、出血、缺血性损伤或血管相关微环境改变。", "definition_en": "Sinusoidal or vascular dilation, congestion, hemorrhage, ischemic injury, or vascular-associated microenvironment change.", "smear_assessment_cn": "NR", "smear_assessment_en": "NR", "histology_assessment_cn": "NR", "histology_assessment_en": "NR", "cbc_correlation_cn": [ "可伴贫血、血小板变化或炎症，但通常缺乏特异性", "结合其他器官血管病变" ], "cbc_correlation_en": [ "May accompany anemia, platelet changes, or inflammation but is usually nonspecific", "Correlate with vascular lesions in other organs" ], "differential_cn": "NR", "differential_en": "NR", "report_phrase_en": "NR", "evidence_status": "Internal_working_taxonomy_supported_by_traceable_sources", "expert_review_status": "Pending" }, { "id": "T11", "title_cn": "炎症、感染性改变和异常细胞浸润", "title_en": "Inflammation, infection and abnormal cellular infiltration", "definition_cn": "骨髓炎症、感染性病原体、反应性炎细胞或异常细胞群浸润。", "definition_en": "Marrow inflammation, infectious organisms, reactive inflammatory cells, or infiltration by an abnormal cell population.", "smear_assessment_cn": "NR", "smear_assessment_en": "NR", "histology_assessment_cn": "NR", "histology_assessment_en": "NR", "cbc_correlation_cn": [ "可见白细胞增多/减少、左移、贫血或血小板变化", "外周血方向取决于时相和病理生理过程" ], "cbc_correlation_en": [ "Leukocytosis/leukopenia, left shift, anemia, or platelet changes may occur", "Peripheral direction depends on timing and pathophysiology" ], "differential_cn": "NR", "differential_en": "NR", "report_phrase_en": "NR", "evidence_status": "Internal_working_taxonomy_supported_by_traceable_sources", "expert_review_status": "Pending" }, { "id": "T12", "title_cn": "MDS、AML及增殖性病变鉴别对照", "title_en": "MDS, AML and proliferative disease differentials", "definition_cn": "MDS、AML及其他增殖性病变的疾病鉴别层，用于避免把克隆性/自发病变误称为药物毒性。", "definition_en": "Disease-differential layer for MDS, AML, and other proliferative disorders, preventing clonal or spontaneous disease from being mislabeled as drug toxicity.", "smear_assessment_cn": "NR", "smear_assessment_en": "NR", "histology_assessment_cn": "NR", "histology_assessment_en": "NR", "cbc_correlation_cn": [ "可见持续性细胞减少、白细胞增多、异常细胞或非再生性贫血", "一次时间点不足以建立克隆性疾病" ], "cbc_correlation_en": [ "Persistent cytopenias, leukocytosis, abnormal circulating cells, or nonregenerative anemia may occur", "A single time point is insufficient to establish clonal disease" ], "differential_cn": "NR", "differential_en": "NR", "report_phrase_en": "NR", "evidence_status": "Internal_working_taxonomy_supported_by_traceable_sources", "expert_review_status": "Pending" } ], "quality": { "grades": [ { "Detailed_Quality_Grade": "Fully_evaluable", "Main_Status": "Fully evaluable", "Label_CN": "完全可评价", "Permitted_Use_CN": "可进行颗粒内细胞密度、完整分类计数、M:E、成熟序列、巨核细胞和特殊形态评价。", "Report_Phrase_EN": "The bone marrow smear was adequate for the intended cytologic evaluation." }, { "Detailed_Quality_Grade": "Minor_defect_no_major_impact", "Main_Status": "Fully evaluable", "Label_CN": "轻微缺陷但不影响主要评价", "Permitted_Use_CN": "主要评价可完成；记录局灶色偏、厚薄不均或背景伪影及其范围。", "Report_Phrase_EN": "Minor technical limitations were present but did not preclude the intended marrow evaluation." }, { "Detailed_Quality_Grade": "Partially_evaluable", "Main_Status": "Partially evaluable", "Label_CN": "部分可评价", "Permitted_Use_CN": "只报告明确可评价的项目，不将局部可用区域外推为整张涂片。", "Report_Phrase_EN": "The smear was partially evaluable; interpretation was limited to the specified assessable components." }, { "Detailed_Quality_Grade": "Qualitative_only", "Main_Status": "Partially evaluable", "Label_CN": "仅可定性评价", "Permitted_Use_CN": "可描述保存尚可的形态或明显特殊发现，不生成完整分类计数或正式M:E。", "Report_Phrase_EN": "The smear supported qualitative assessment only and was not suitable for a reliable differential count or M:E ratio." }, { "Detailed_Quality_Grade": "Limited_differential_only", "Main_Status": "Partially evaluable", "Label_CN": "仅有限分类计数", "Permitted_Use_CN": "记录实际计数分母和限制；结果仅供方向性参考，不单独支持毒理结论。", "Report_Phrase_EN": "Only a limited differential count was completed; the result should be interpreted with the stated sampling limitations." }, { "Detailed_Quality_Grade": "Not_evaluable", "Main_Status": "Not evaluable", "Label_CN": "不可评价", "Permitted_Use_CN": "不得生成细胞密度、完整分类计数、M:E或确定性形态结论。", "Report_Phrase_EN": "The smear was not evaluable because critical technical quality requirements were not met." }, { "Detailed_Quality_Grade": "Excluded_traceability_failure", "Main_Status": "Not evaluable", "Label_CN": "身份或追溯异常，不得纳入正式评价", "Permitted_Use_CN": "停止正式报告并启动偏差调查；即使镜下质量良好也不得归属到动物或研究。", "Report_Phrase_EN": "The smear was excluded from formal evaluation because sample identity or traceability could not be confirmed." } ], "dimensions": [ { "Dimension_ID": "QD01", "Dimension_CN": "身份与可追溯性", "Dimension_EN": "Identity and traceability", "Adequate": "动物、研究、取材部位、制备方法和染色可追溯。", "Limited": "个别非关键字段缺失，但样本身份和来源明确。", "Inadequate": "样本身份、动物或来源无法可靠对应。", "Why": "身份不确定时，任何形态结论都不能安全归属到动物或研究。", "Evidence_Level": "Data-governance requirement" }, { "Dimension_ID": "QD02", "Dimension_CN": "骨髓颗粒/骨髓小粒", "Dimension_EN": "Marrow particles or spicules", "Adequate": "存在多个代表性颗粒或足量明确的骨髓细胞区。", "Limited": "颗粒少，但仍有可确认的骨髓细胞和局部代表区。", "Inadequate": "无颗粒且缺少可确认的骨髓前体/代表区。", "Why": "颗粒不足会限制颗粒内细胞密度、巨核细胞和完整分类计数评价。", "Evidence_Level": "Published quality criterion" }, { "Dimension_ID": "QD03", "Dimension_CN": "血液稀释", "Dimension_EN": "Hemodilution", "Adequate": "背景清洁，成熟外周血细胞不主导样本。", "Limited": "轻度稀释，但不妨碍主要形态和代表区判读。", "Inadequate": "中到重度稀释，成熟外周血细胞占主导并影响解释。", "Why": "稀释造成的低细胞量不能当作真正的骨髓低细胞性。", "Evidence_Level": "Published quality criterion" }, { "Dimension_ID": "QD04", "Dimension_CN": "细胞保存", "Dimension_EN": "Cell preservation", "Adequate": "核、胞质和颗粒边界清晰，大多数细胞完整。", "Limited": "局灶破碎，但存在足够保存良好的可评价区。", "Inadequate": "多数细胞破裂、裸核、拖尾或不可识别。", "Why": "保存不良会模拟变性、凋亡、异常成熟或发育异常。", "Evidence_Level": "Published quality criterion" }, { "Dimension_ID": "QD05", "Dimension_CN": "铺片厚度与细胞分布", "Dimension_EN": "Smear thickness and distribution", "Adequate": "有足够面积的单层区，细胞均匀分布且重叠少。", "Limited": "仅局部单层可用，厚区或空白区较多。", "Inadequate": "广泛过厚、细胞重叠或分布极不均，无可靠计数区。", "Why": "分类计数应在代表性单层区进行，不能从厚区或尾端偏倚区域推断全片。", "Evidence_Level": "Nonclinical best-practice criterion" }, { "Dimension_ID": "QD06", "Dimension_CN": "染色质量", "Dimension_EN": "Staining quality", "Adequate": "核染色、胞质颜色和颗粒清晰，背景干净。", "Limited": "局部染色偏差或沉淀，但仍有清晰可评价区。", "Inadequate": "广泛过蓝/过红、褪色、沉淀或细节模糊。", "Why": "染色不佳首先影响成熟亚阶段、颗粒、包涵体和发育异常判定。", "Evidence_Level": "Published quality criterion" }, { "Dimension_ID": "QD07", "Dimension_CN": "干燥、抗凝与背景", "Dimension_EN": "Drying, anticoagulant and background", "Adequate": "及时制片干燥，无广泛水样伪影、凝块或污染。", "Limited": "局灶水样伪影、凝块或背景沉淀。", "Inadequate": "广泛凝固、延迟制片/干燥伪影或污染阻断判读。", "Why": "延迟和凝固可选择性损失细胞，并改变核与胞质形态。", "Evidence_Level": "Published preparation principle" }, { "Dimension_ID": "QD08", "Dimension_CN": "代表性区域", "Dimension_EN": "Representative evaluable areas", "Adequate": "多个区域可在低倍和高倍复核，包含不同细胞系和巨核细胞搜索区。", "Limited": "代表区数量少，结论需限定于可评价部分。", "Inadequate": "无可重复确认的代表区。", "Why": "局部好视野不能自动代表整张涂片或整份骨髓样本。", "Evidence_Level": "Nonclinical best-practice criterion" }, { "Dimension_ID": "QD09", "Dimension_CN": "用途适配性", "Dimension_EN": "Fitness for intended assessment", "Adequate": "样本质量足以支持所计划的密度、分类计数、M:E和形态评价。", "Limited": "仅支持部分任务，限制范围被明确记录。", "Inadequate": "计划任务所需的关键证据缺失。", "Why": "合格是用途相关的：可识别异常细胞不等于可完成300细胞分类计数。", "Evidence_Level": "Internal evidence-gating rule" }, { "Dimension_ID": "QD10", "Dimension_CN": "与切片及CBC的互补性", "Dimension_EN": "Complementarity with histology and CBC", "Adequate": "清楚区分涂片粒子细胞密度、组织学细胞量和外周血结果。", "Limited": "相关资料缺失，但涂片观察仍可作限定性描述。", "Inadequate": "把稀释/低产量直接当作组织学低细胞性或作机制结论。", "Why": "涂片、切片和CBC回答不同问题，不能互相替代。", "Evidence_Level": "Nonclinical integrated-evaluation principle" } ], "defects": [ { "Defect_ID": "QDEF-01", "Defect_CN": "取材前生物学因素", "Cause_CN": "年龄、营养、濒死状态或基础疾病", "Gross_Clue_CN": "涂片可无技术异常", "Microscopic_Clue_CN": "真实细胞量或谱系构成改变", "Bias_CN": "把真实生物学改变误作技术失败，或反之", "Evaluability_CN": "技术可评价；解释需结合对照、CBC和组织学", "Control_CN": "统一动物背景并记录摄食、体重和病程", "Evidence_Status": "Peer_reviewed_source_supported" }, { "Defect_ID": "QDEF-02", "Defect_CN": "取材部位或进针偏差", "Cause_CN": "未进入活跃骨髓区或局部脂肪髓占优", "Gross_Clue_CN": "血多、颗粒少或脂性外观", "Microscopic_Clue_CN": "代表性颗粒不足、巨核细胞少见", "Bias_CN": "假性低细胞密度和谱系偏移", "Evaluability_CN": "部分可评价；无代表区时不作定量", "Control_CN": "固定物种取材部位并记录骨与侧别", "Evidence_Status": "Peer_reviewed_source_supported" }, { "Defect_ID": "QDEF-03", "Defect_CN": "抽吸量过大或重复抽吸", "Cause_CN": "后续大体积抽吸引入外周血", "Gross_Clue_CN": "血样外观、颗粒减少", "Microscopic_Clue_CN": "成熟血细胞占优、前体相对减少", "Bias_CN": "M:E和成熟阶段分布失真", "Evaluability_CN": "轻度可限评；blood tap不可定量", "Control_CN": "优先首抽和最小必要量", "Evidence_Status": "Peer_reviewed_source_supported" }, { "Defect_ID": "QDEF-04", "Defect_CN": "FBS稀释不当", "Cause_CN": "机械固定体积、过量、状态异常", "Gross_Clue_CN": "颗粒感消失、过稀或过黏", "Microscopic_Clue_CN": "颗粒、密度和巨核细胞可见性下降", "Bias_CN": "假性低密度并掩盖真实药物改变", "Evaluability_CN": "需按代表性和可计数区判定", "Control_CN": "逐滴最小量并完成本实验室验证", "Evidence_Status": "Internal_working_rule" }, { "Defect_ID": "QDEF-05", "Defect_CN": "凝集、凝块或微凝块", "Cause_CN": "采后延迟、混匀不足或纤维蛋白形成", "Gross_Clue_CN": "丝状物、凝块、推片拖拽不均", "Microscopic_Clue_CN": "细胞被截留、裂解或分布偏倚", "Bias_CN": "任何谱系均可假性减少", "Evaluability_CN": "局灶限评；明显凝块不作可靠定量", "Control_CN": "采后立即制片；先制片再处理余样", "Evidence_Status": "Peer_reviewed_source_supported" }, { "Defect_ID": "QDEF-06", "Defect_CN": "制片延迟", "Cause_CN": "人员或器材衔接不足", "Gross_Clue_CN": "可无明显肉眼警示", "Microscopic_Clue_CN": "细胞肿胀、退变和裂解增加", "Bias_CN": "模拟变性并掩盖轻微形态改变", "Evaluability_CN": "按退变范围限评或弃评", "Control_CN": "器材和标签预先就位", "Evidence_Status": "Peer_reviewed_source_supported" }, { "Defect_ID": "QDEF-07", "Defect_CN": "推片或压片损伤", "Cause_CN": "下压过重、角度不当或拉片不稳", "Gross_Clue_CN": "边缘不规则、断裂纹或团块", "Microscopic_Clue_CN": "裸核、拖尾、核膜和胞质破裂", "Bias_CN": "机械伪影误作坏死或发育异常", "Evaluability_CN": "仅在保存良好区评价", "Control_CN": "轻接触、无额外下压并培训", "Evidence_Status": "Peer_reviewed_source_supported" }, { "Defect_ID": "QDEF-08", "Defect_CN": "厚度、长度或分布异常", "Cause_CN": "滴量、稀释度、速度或角度不当", "Gross_Clue_CN": "过厚、过薄、过短或单侧聚集", "Microscopic_Clue_CN": "重叠或细胞过疏，无稳定单层区", "Bias_CN": "假性高/低细胞量和视野选择偏倚", "Evaluability_CN": "局部有单层区时限评，否则重做", "Control_CN": "先肉眼检查颗粒、拖尾和单层区", "Evidence_Status": "Peer_reviewed_source_supported" }, { "Defect_ID": "QDEF-09", "Defect_CN": "干燥或水样伪影", "Cause_CN": "上染前未充分风干或环境潮湿", "Gross_Clue_CN": "水痕或反光不均", "Microscopic_Clue_CN": "空泡样结构、背景沉着和边界模糊", "Bias_CN": "假性包涵体、颗粒或胞质改变", "Evaluability_CN": "轻度定性；重度不作正式评价", "Control_CN": "快速充分风干，避免带水入染", "Evidence_Status": "Peer_reviewed_source_supported" }, { "Defect_ID": "QDEF-10", "Defect_CN": "固定不适配", "Cause_CN": "固定体系、甲醇质量或时机不当", "Gross_Clue_CN": "常无明显肉眼表现", "Microscopic_Clue_CN": "核染和轮廓不佳、色调失衡", "Bias_CN": "细胞亚阶段和异常细节丢失", "Evaluability_CN": "根据形态保存程度限评", "Control_CN": "按染色体系规定固定路径", "Evidence_Status": "Peer_reviewed_source_supported" }, { "Defect_ID": "QDEF-11", "Defect_CN": "染色失败或沉淀", "Cause_CN": "pH、染液老化、污染、过滤或洗涤异常", "Gross_Clue_CN": "偏蓝、偏红、背景脏或沉淀", "Microscopic_Clue_CN": "核/胞质细节和颗粒失真", "Bias_CN": "误判毒性颗粒、感染体或铁颗粒", "Evaluability_CN": "明显色偏或沉淀时不作精细分类", "Control_CN": "监测pH、换液、过滤和对照片", "Evidence_Status": "Peer_reviewed_source_supported" }, { "Defect_ID": "QDEF-12", "Defect_CN": "清洗、封片或储存问题", "Cause_CN": "洗涤、干燥、封片或长期保存不当", "Gross_Clue_CN": "雾状、气泡、灰尘或背景脏", "Microscopic_Clue_CN": "焦平面杂质遮挡细胞", "Bias_CN": "降低重复阅片一致性", "Evaluability_CN": "优先备用片或重染", "Control_CN": "避湿、防尘并记录保存条件", "Evidence_Status": "Peer_reviewed_source_supported" }, { "Defect_ID": "QDEF-13", "Defect_CN": "标签或样本追溯异常", "Cause_CN": "漏标、错标或记录与实物不一致", "Gross_Clue_CN": "标签缺失或信息冲突", "Microscopic_Clue_CN": "镜下质量可正常但归属不可信", "Bias_CN": "结果无法合法归属动物和研究", "Evaluability_CN": "一律排除正式评价并调查", "Control_CN": "即时双重标识和GLP可追溯记录", "Evidence_Status": "Peer_reviewed_source_supported" }, { "Defect_ID": "QDEF-14", "Defect_CN": "运输或福尔马林暴露", "Cause_CN": "同包运输、破损、温湿度或延迟", "Gross_Clue_CN": "破片、潮湿、气味或标签模糊", "Microscopic_Clue_CN": "蓝雾、染色失败和退变", "Bias_CN": "广泛阻断形态识别", "Evaluability_CN": "疑似限评；确认污染通常不可评价", "Control_CN": "与福尔马林组织分开防震防潮运输", "Evidence_Status": "Peer_reviewed_source_supported" }, { "Defect_ID": "QDEF-15", "Defect_CN": "镜下代表区不足", "Cause_CN": "颗粒、拖尾、巨核搜索区或可数细胞不足", "Gross_Clue_CN": "低倍难找到重复可确认区域", "Microscopic_Clue_CN": "只能见零散细胞或成熟血细胞", "Bias_CN": "不能支持完整计数、M:E和巨核数量", "Evaluability_CN": "按项目输出全评、限评或弃评", "Control_CN": "先低倍质量分层再进入高倍", "Evidence_Status": "Peer_reviewed_source_supported" }, { "Defect_ID": "QDEF-16", "Defect_CN": "技术缺陷与真实毒性混淆", "Cause_CN": "稀释、厚薄、取材差与真实病变并存", "Gross_Clue_CN": "无单一特异肉眼表现", "Microscopic_Clue_CN": "技术和病理形态叠加", "Bias_CN": "把伪影当药物效应或漏掉真实改变", "Evaluability_CN": "需CBC、组织学、同期对照和同行复核", "Control_CN": "训练并保留限制性报告与复核记录", "Evidence_Status": "Internal_working_rule" } ], "notice": "内部工作规则与机器整理，尚未完成专家复核。技术合格不等于生物学正常；本模块支持人工判断，不替代临床病理学家结论。" }, "reporting_principles": [ { "title_cn": "先观察，后解释", "title_en": "Observation before interpretation", "body_cn": "分别记录镜下观察、形态学诊断和机制解释；缺乏证据时不自动认定给药相关性、不良性或NOAEL。", "body_en": "Record microscopic observations, morphologic diagnoses, and mechanistic interpretations separately. Do not infer treatment relationship, adversity, or NOAEL without supporting evidence." }, { "title_cn": "比例不等于绝对数量", "title_en": "Relative proportion is not absolute quantity", "body_cn": "M:E变化必须结合红系、粒系的绝对或定性变化以及CBC、网织红细胞和组织学结果解释。", "body_en": "Interpret M:E changes with lineage-specific findings, CBC, reticulocytes, and histology rather than treating a ratio as an absolute cell-number change." }, { "title_cn": "不可评价不是阴性", "title_en": "Not evaluable is not negative", "body_cn": "应区分not observed、no apparent change与not evaluable；受限样本不得生成过度确定的正常结论。", "body_en": "Distinguish not observed, no apparent change, and not evaluable. Limited specimens should not generate overconfident normal conclusions." }, { "title_cn": "整合外周血与组织学", "title_en": "Integrate blood and histology", "body_cn": "骨髓涂片、CBC、网织红细胞、血小板和组织切片应在时间点与组别一致的前提下综合评价。", "body_en": "Integrate marrow smears, CBC, reticulocytes, platelets, and histology only after checking group and time-point alignment." } ], "references": [ { "Reference_ID": "REF-REAGAN-2011", "Title": "Best Practices for Evaluation of Bone Marrow in Nonclinical Toxicity Studies", "Year": 2011, "DOI": "10.1177/0192623310396907", "Status": "Published peer-reviewed guidance", "URL": "https://doi.org/10.1177/0192623310396907" }, { "Reference_ID": "REF-INHAND-RM-2019", "Title": "Nonproliferative and Proliferative Lesions of the Rat and Mouse Hematolymphoid System", "Year": 2019, "PMCID": "PMC6752743", "Status": "INHAND publication", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6752743/" }, { "Reference_ID": "REF-INHAND-NHP-2021", "Title": "Hematolymphoid system of nonhuman primates", "Year": 2021, "PMCID": "PMC8544165", "Status": "INHAND publication", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/" }, { "Reference_ID": "REF-INHAND-RABBIT-2021", "Title": "Hematolymphoid system of the rabbit", "Year": 2021, "PMCID": "PMC8544166", "Status": "INHAND publication", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544166/" }, { "Reference_ID": "REF-TRAVLOS-2006", "Title": "Normal Structure, Function, and Histology of the Bone Marrow", "Authors_or_Organization": "Travlos GS", "Year": 2006, "DOI": "10.1080/01926230600939856", "Status": "Peer_reviewed_source_supported", "Use_in_site": "Bilingual structured summary and method cards only; full text is not republished", "URL": "https://doi.org/10.1080/01926230600939856" }, { "Reference_ID": "REF-OECD-TG474-2016", "Title": "Test No. 474: Mammalian Erythrocyte Micronucleus Test", "Authors_or_Organization": "OECD", "Year": 2016, "URL": "https://doi.org/10.1787/9789264264762-en", "Status": "Official_guideline_verified", "Use_in_site": "Genetic toxicology teaching area only" }, { "Reference_ID": "REF-OECD-TG475-2016", "Title": "Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test", "Authors_or_Organization": "OECD", "Year": 2016, "URL": "https://doi.org/10.1787/9789264264786-en", "Status": "Official_guideline_verified", "Use_in_site": "Genetic toxicology teaching area only" }, { "Reference_ID": "REF-STAGE2I-QUALITY-NOTE", "Title": "毒理试验中骨髓涂片常见样本不合格情况及其质量评价研究报告", "Year": 2026, "Status": "Requires_expert_review", "Use_in_site": "Internal decision matrix and checklist; individual rules retain source-level status" }, { "Reference_ID": "REF-STAGE2I-MEGAK-NOTE", "Title": "毒理试验中巨核细胞评价的监管框架与实操方法", "Year": 2026, "Status": "Requires_expert_review", "Use_in_site": "Only source-note lines 1-169 were adopted; later search-result contamination was excluded" }, { "Reference_ID": "REF-CARBOPLATIN-2022", "Title": "Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes", "Year": 2022, "DOI": "10.3390/ijms23116290", "PMCID": "PMC9181531", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9181531/", "Status": "Peer-reviewed; Creative Commons Attribution", "Use_in_site": "Source for the three license-screened morphology panels" }, { "Reference_ID": "REF-NTP-BM-HYPERCELLULARITY", "Title": "Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas", "Authors_or_Organization": "National Toxicology Program", "Year": "NR", "URL": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "Status": "Official NTP atlas; public-domain screening completed", "Use_in_site": "Figures 1-5, with normal comparators and treatment-associated response separated" }, { "Reference_ID": "REF-NTP-BM-INFLAMMATION", "Title": "Bone marrow - Inflammation - Nonneoplastic Lesion Atlas", "Authors_or_Organization": "National Toxicology Program", "Year": "NR", "URL": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "Status": "Official NTP atlas; public-domain screening completed", "Use_in_site": "Figures 1-6 as granulomatous and suppurative inflammation differentials" }, { "Reference_ID": "REF-NTP-BM-HYPOCELLULARITY", "Title": "Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas", "Authors_or_Organization": "National Toxicology Program", "Year": "NR", "URL": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "Status": "Official NTP atlas; public-domain screening completed", "Use_in_site": "Figures 1-6, with normal comparators and treatment-associated hypocellularity separated" }, { "Reference_ID": "REF-NTP-BM-NECROSIS", "Title": "Bone marrow - Necrosis - Nonneoplastic Lesion Atlas", "Authors_or_Organization": "National Toxicology Program", "Year": "NR", "URL": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "Status": "Official NTP atlas; public-domain screening completed", "Use_in_site": "Figures 1-5 as necrosis teaching patterns and differentials" }, { "Reference_ID": "REF-NTP-BM-FIBROSIS", "Title": "Bone marrow - Fibrosis - Nonneoplastic Lesion Atlas", "Authors_or_Organization": "National Toxicology Program", "Year": "NR", "URL": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Fibrosis", "Status": "Official NTP atlas; public-domain screening completed", "Use_in_site": "Figures 1-3 as marrow fibrosis teaching patterns" }, { "Reference_ID": "REF-NTP-BM-ANGIECTASIS", "Title": "Bone marrow - Angiectasis - Nonneoplastic Lesion Atlas", "Authors_or_Organization": "National Toxicology Program", "Year": "NR", "URL": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "Status": "Official NTP atlas; public-domain screening completed", "Use_in_site": "Figures 1-4 as two low/high-power angiectasis teaching groups" }, { "Reference_ID": "REF-NTP-BM-HISTIOCYTIC-INFILTRATION", "Title": "Bone marrow - Histiocytic Infiltration - Nonneoplastic Lesion Atlas", "Authors_or_Organization": "National Toxicology Program", "Year": "NR", "URL": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "Status": "Official NTP atlas; public-domain screening completed", "Use_in_site": "Figures 1-4 as histiocytic infiltration teaching patterns and an inflammation differential" }, { "Reference_ID": "REF-NTP-BM-MAST-CELL-INFILTRATION", "Title": "Bone marrow - Mast Cell Infiltration - Nonneoplastic Lesion Atlas", "Authors_or_Organization": "National Toxicology Program", "Year": "NR", "URL": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "Status": "Official NTP atlas; public-domain screening completed", "Use_in_site": "Figures 1-4 as H&E and Giemsa mast-cell teaching comparisons" }, { "Reference_ID": "REF-NTP-BM-GELATINOUS-TRANSFORMATION", "Title": "Bone marrow - Gelatinous Transformation - Nonneoplastic Lesion Atlas", "Authors_or_Organization": "National Toxicology Program", "Year": "NR", "URL": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/GelatinousTransformation", "Status": "Official NTP atlas; public-domain screening completed", "Use_in_site": "Figures 1-3 as gelatinous transformation and advanced-illness differential patterns" }, { "Reference_ID": "REF-NTP-BM-PIGMENT", "Title": "Bone marrow - Pigment - Nonneoplastic Lesion Atlas", "Authors_or_Organization": "National Toxicology Program", "Year": "NR", "URL": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Pigment", "Status": "Official NTP atlas; public-domain screening completed", "Use_in_site": "Figures 1-2 as low and moderate pigment teaching examples without unconfirmed hemosiderin labeling" }, { "Reference_ID": "REF-NTP-WEB-POLICIES", "Title": "NTP Web Policies - Copyright Information", "Authors_or_Organization": "National Toxicology Program", "Year": "NR", "URL": "https://ntp.niehs.nih.gov/support/policies", "Status": "Official public-domain policy", "Use_in_site": "Rights basis for NTP figures without an indicated copyright or third-party credit line" }, { "Reference_ID": "REF-PMC4837595-MOUSE-5FU", "Title": "Delineating the effects of 5-fluorouracil and follicle-stimulating hormone on mouse bone marrow stem/progenitor cells", "Authors_or_Organization": "Shaikh A, Bhartiya D, Kapoor S, Nimkar H", "Year": "2016", "DOI": "10.1186/s13287-016-0311-6", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4837595/", "Status": "Peer-reviewed article; CC BY 4.0 figure screening completed", "Use_in_site": "Figure 2 panels a-d as a mouse 5-FU injury, nadir, and recovery sequence" }, { "Reference_ID": "REF-PMC13135069-RHESUS-TBI", "Title": "Comparative study of pathology of various organs of rhesus macaques exposed to two different doses of acute total-body radiation", "Authors_or_Organization": "Brink MW, Petrus SA, Carpenter AD, Fatanmi OO, Wise SY, Seed TM, Lee S-H, Singh VK", "Year": "2026", "DOI": "10.1038/s41598-026-49844-x", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13135069/", "Status": "Peer-reviewed article; CC BY 4.0 figure screening completed", "Use_in_site": "Figure 3a sternal marrow fields as 5.8 Gy, 6.5 Gy, and healthy cross-animal comparisons" }, { "Reference_ID": "REF-PMC7723243-MOUSE-GCSF", "Title": "G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation", "Authors_or_Organization": "Jing W, Guo X, Qin F, Li Y, Wang G, Bi Y, Jin X, Han L, Dong X, Zhao Y", "Year": "2020", "DOI": "10.26508/lsa.202000737", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7723243/", "Status": "Peer-reviewed article; CC BY 4.0 figure screening completed", "Use_in_site": "Supplementary Figure S3 panels D-E as a same-study marrow and peripheral-blood G-CSF response comparison" }, { "Reference_ID": "REF-PMC12710095-CANINE-MDS-MPN", "Title": "Myelodysplastic/Myeloproliferative Neoplasm in a Dog: A Case Report", "Authors_or_Organization": "Cha S, Yu D, Bae H", "Year": "2025", "DOI": "10.1002/vms3.70722", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12710095/", "Status": "Peer-reviewed article; CC BY-NC-ND 4.0 complete-figure screening completed", "Use_in_site": "Unmodified complete Figures 1 and 3 as a canine peripheral-blood and marrow disease differential" }, { "Reference_ID": "REF-PMC10699128-RHESUS-EBOV", "Title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "Authors_or_Organization": "Liu DX et al.", "Year": "2023", "DOI": "10.1016/j.ajpath.2023.08.010", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "Status": "Peer-reviewed article; CC BY-NC-ND 4.0 complete-figure screening completed", "Use_in_site": "Unmodified complete Figures 1 and 2 as rhesus macaque infectious-disease, monocyte/macrophage, and megakaryocyte mechanism differentials" }, { "Reference_ID": "REF-PMC9407898-CANINE-DYSERYTHROPOIESIS", "Title": "An EHPB1L1 Nonsense Mutation Associated with Congenital Dyserythropoietic Anemia and Polymyopathy in Labrador Retriever Littermates", "Authors_or_Organization": "Shelton GD, Minor KM, Guo LT, Thomas-Hollands A, Walsh KA, Friedenberg SG, Cullen JN, Mickelson JR", "Year": "2022", "DOI": "10.3390/genes13081427", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9407898/", "Status": "Peer-reviewed article; CC BY 4.0 Figure 1 panel screening completed", "Use_in_site": "Figure 1 panels A-D as canine peripheral-blood and marrow differentials for poikilocytosis, cytoplasmic bridging, atypical erythroid mitosis, and rubriphagocytosis" }, { "Reference_ID": "REF-PMC7324823-CANINE-BONE-MARROW-DISORDERS", "Title": "Clinical and clinicopathological features and outcomes of Miniature Dachshunds with bone marrow disorders", "Authors_or_Organization": "Tani A, Tomiyasu H, Ohmi A, Ohno K, Tsujimoto H", "Year": "2020", "DOI": "10.1292/jvms.19-0439", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7324823/", "Status": "Peer-reviewed article; CC BY-NC-ND 4.0 complete-figure screening completed", "Use_in_site": "Unmodified complete Figures 2 and 3 as canine multilineage dysplasia and myelofibrosis disease differentials" }, { "Reference_ID": "REF-PMC4219468-MOUSE-TELSYK-APMF", "Title": "Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice", "Authors_or_Organization": "Sprissler C et al.", "Year": "2014", "DOI": "10.1038/bcj.2014.53", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4219468/", "Status": "Peer-reviewed article; CC BY-NC-ND 4.0 complete-figure screening completed", "Use_in_site": "Unmodified complete Figure 3 as a mouse APMF-like AML, multilineage dysplasia, megakaryoblast infiltration, and myelofibrosis disease-model differential" }, { "Reference_ID": "REF-PMC8478025-CANINE-DYSERYTHROPOIESIS", "Title": "Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates", "Authors_or_Organization": "Thomas-Hollands A, Shelton GD, Guo LT, Loughran K, Kaiman G, Hutton TA, Walsh KA", "Year": "2021", "DOI": "10.1111/jvim.16214", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8478025/", "Status": "Peer-reviewed article; CC BY-NC 4.0 Figure 2 panel screening completed", "Use_in_site": "Figure 2 panels A-F as canine dyserythropoiesis, artifact, and erythrophagocytosis disease differentials" }, { "Reference_ID": "REF-PMC4261574-CANINE-CVBD-DYSHEMATOPOIESIS", "Title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "Authors_or_Organization": "De Tommasi AS, Otranto D, Furlanello T, Tasca S, Cantacessi C, Breitschwerdt EB, Stanneck D, Dantas-Torres F, Baneth G, Capelli G, de Caprariis D", "Year": "2014", "DOI": "10.1186/s13071-014-0534-2", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "Status": "Peer-reviewed article; CC BY 4.0 Figures 2-6 panel screening completed", "Use_in_site": "Figures 2-6 as canine disease differentials for erythroid and myeloid dysplasia, composite phagocytosis, megakaryocytic nuclear abnormalities, emperipolesis, and atypical mitosis" }, { "Reference_ID": "REF-PMC3972870-CANINE-LEISHMANIASIS", "Title": "Morphological Changes in the Bone Marrow of the Dogs with Visceral Leishmaniasis", "Authors_or_Organization": "Momo C, Jacintho APP, Moreira PRR, Munari DP, Machado GF, Vasconcelos RO", "Year": "2014", "DOI": "10.1155/2014/150582", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3972870/", "Status": "Peer-reviewed article; Creative Commons Attribution Figure 1 panel screening completed (license version not stated in the article)", "Use_in_site": "Figure 1 panel a with insets a1-a2 as a canine infectious-disease differential for granuloma, megakaryocytic emperipolesis, and author-described nuclear fragmentation or abnormal lobulation" }, { "Reference_ID": "REF-PMC11697499-CANINE-MDS-AML", "Title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "Authors_or_Organization": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D", "Year": "2024", "DOI": "10.1177/03009858241277982", "URL": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "Status": "Peer-reviewed article; CC BY 4.0 Figures 1-4 panel screening completed", "Use_in_site": "Figures 1-4 panels as canine MDS/AML disease differentials spanning blood, marrow aspirate, megakaryocytic morphology, marrow histology, fibrosis, and blast burden" } ], "sharing_policy": { "included_statuses": [ "cc_noncommercial_only", "cc_reuse_allowed", "permission_granted", "public_domain", "user_owned" ], "public_image_count": 36, "cytology_image_count": 36, "peripheral_blood_comparator_count": 7, "pathology_evidence_count": 77, "all_reusable_image_records": 120, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "restricted_binary_files_included": 0, "expert_verified_count": 0, "scope_note_cn": "骨髓主网格只展示涂片、抽吸物和骨髓冲洗物细胞学。外周血仅作配对对照；组织切片、芯活检、IHC和其他组织方法转入病理图谱或案例关联证据。", "scope_note_en": "The marrow grid is limited to smear, aspirate, and marrow-washout cytology. Peripheral blood is comparator evidence; histology, core biopsy, IHC, and other tissue methods are routed to the pathology atlas or linked case evidence." }, "peripheral_blood_comparators": [ { "image_id": "BM-CC-GCSF-FS3-E", "map_image_id": "NR", "source_id": "PMC7723243-MOUSE-GCSF-GRANULOPOIESIS", "title_cn": "小鼠G-CSF反应：外周血中性粒细胞增多的涂片对照", "title_en": "Mouse G-CSF response: peripheral-blood smear comparison accompanying neutrophilia", "description_cn": "Panel E并列显示同研究对照与G-CSF处理组的Wright–Giemsa外周血代表视野；Figure S3C同时报告处理组外周中性粒细胞计数升高。该涂片用于形态对应，不能由单个视野反推绝对中性粒细胞计数。", "description_en": "Panel E juxtaposes representative Wright–Giemsa-stained peripheral-blood fields from the control and G-CSF groups. Figure S3C separately reports higher peripheral neutrophil counts in treated mice. The smear supports morphologic correspondence but a single field must not be used to infer an absolute neutrophil count.", "species": "Mouse", "strain": "C57BL/6 male; 8–10 weeks", "specimen_type": "Peripheral_blood_comparator", "stain": "Wright–Giemsa", "lineage": "Granulocytic", "maturation_stage": "Segmented_neutrophil_predominant", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Peripheral_neutrophilia", "GCSF_response" ], "evidence_role": "Mechanistic_reference", "causality_level": "Treatment_associated", "figure_label": "Figure S3", "panel_label": "E — peripheral blood, control and G-CSF", "source_page": "Supplementary Figure S3, panel E", "caption_original_en": "G-CSF treatment enhances granulopoiesis in the BM of mice. (A, B) Flow cytometric analysis of the BM neutrophils (CD11b+Ly6G+) in control and G-CSF–treated mice. (A) Representative flow cytometric plots of CD11b+Ly6G+ cells in the BMs of control and G-CSF–treated mice. (B) Flow cytometric quantification of CD11b+Ly6G+ neutrophils in the BMs of control and G-CSF–treated mice. (C) Peripheral neutrophil counts in control and G-CSF–treated mice. (D) Wright–Giemsa staining of BM cells from control and G-CSF–treated mice. Original magnification ×100 (upper panels); ×1,000 (lower panels) (E) Wright–Giemsa staining of peripheral blood cells from control and G-CSF–treated mice. (F) Representative fields of CFU-GM–derived colonies in BM cultures from control and G-CSF–treated mice (×100 magnification; scale bar = 200 μm). (G) Quantification of the number of CFU-GM–derived colonies in BM cultures from control and G-CSF treated mice. n = 5/group (A, B, C, D, E), n = 3/group (F, G). ***P < 0.001.", "article_title": "G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation", "authors": "Jing W, Guo X, Qin F, Li Y, Wang G, Bi Y, Jin X, Han L, Dong X, Zhao Y", "journal": "Life Science Alliance", "year": "2020", "doi": "10.26508/lsa.202000737", "pmid": "33234677", "pmcid": "PMC7723243", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7723243/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7723243/figure/figS3/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Jing W, Guo X, Qin F, Li Y, Wang G, Bi Y, Jin X, Han L, Dong X, Zhao Y. G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation. Life Science Alliance. 2020. doi:10.26508/lsa.202000737. Figure S3, E — peripheral blood, control and G-CSF. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC JATS permissions block: Creative Commons Attribution 4.0 International; no separate third-party credit line was observed in the Figure S3 legend.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-GCSF-FS3-E.png", "preview_path": "previews/BM-CC-GCSF-FS3-E.jpg", "sha256": "9a8dd81b54368c23632057bac8ff4791efd4f8642909ec8f6e1340f116118978", "processing_note": "Complete panel E was cropped from the CC BY 4.0 composite Figure S3 at parent pixel coordinates [235,168,470,352] and saved losslessly as PNG. Panel letter, specimen label, treatment labels, field layout, and scale bars are retained; no cells or annotations were altered.", "source_mode": "derived_crop", "parent_figure_id": "S2E-FF-NEW-MOUSE-S3", "parent_sha256": "517525c21f471aa0b53d2d2b73fde1b0e9b5a4261065d5d2e4dcf3f3d0003898", "parent_asset_path": "images/S2E-FF-NEW-MOUSE-S3.jpg", "crop_coordinates": [ 235, 168, 470, 352 ], "display_surface": "Peripheral_blood_comparator" }, { "image_id": "BM-CC-DOG-MDSMPN-F01", "map_image_id": "NR", "source_id": "PMC12710095-CANINE-MDS-MPN", "title_cn": "犬MDS/MPN外周血鉴别：过分叶中性粒细胞与核分节单核细胞", "title_en": "Canine MDS/MPN blood differential: hypersegmented neutrophils and monocytes with segmented nuclei", "description_cn": "犬MDS/MPN病例的Diff-Quik外周血涂片完整Figure 1。原作者描述了多种发育异常细胞，包括过分叶中性粒细胞和核分节的单核细胞。该图是骨髓Figure 3的外周血鉴别对照，不是药物性骨髓毒性图。", "description_en": "Complete Figure 1 from a canine MDS/MPN case, showing Diff-Quik-stained peripheral blood. The authors describe multiple dysplastic cells, including hypersegmented neutrophils and monocytes with segmented nuclei. It is the peripheral-blood disease differential for marrow Figure 3, not a drug-toxicity image.", "species": "Dog", "strain": "NR", "specimen_type": "Peripheral_blood_comparator", "stain": "Diff-Quik", "lineage": "Granulocytic_and_monocytic", "maturation_stage": "Mature_neutrophils_and_monocytes", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Hypersegmentation", "Monocyte_nuclear_segmentation", "Disease_differential" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "A–B (complete figure)", "source_page": "Figure 1, complete two-panel figure", "caption_original_en": "Peripheral blood smear examination (Diff‐Quik stain). Peripheral blood smear demonstrating numerous dysplastic cells, including hypersegmented neutrophils and monocytes with segmented nuclei. (A) 400× magnification and (B) 1000× magnification.", "article_title": "Myelodysplastic/Myeloproliferative Neoplasm in a Dog: A Case Report", "authors": "Cha S, Yu D, Bae H", "journal": "Veterinary Medicine and Science", "year": "2025", "doi": "10.1002/vms3.70722", "pmid": "41405191", "pmcid": "PMC12710095", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12710095/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0bcd/12710095/411d0e87c896/VMS3-12-e70722-g002.jpg", "license": "CC BY-NC-ND 4.0", "license_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Cha S, Yu D, Bae H. Myelodysplastic/Myeloproliferative Neoplasm in a Dog: A Case Report. Veterinary Medicine and Science. 2025. doi:10.1002/vms3.70722. Figure 1, A–B (complete figure). CC BY-NC-ND 4.0; complete figure reproduced without adaptation for noncommercial learning.", "third_party_credit_line": "None reported in the relevant figure legends", "rights_basis": "The article permits noncommercial sharing with attribution and without distribution of adapted material. Only byte-identical complete source figures are used. PMC full-text copyright and license block: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0; the complete figures are reproduced without cropping, annotation, retouching, or other adaptation.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-MDSMPN-F01.jpg", "preview_path": "images/BM-CC-DOG-MDSMPN-F01.jpg", "sha256": "2a224524a31ed3014017206e49aa0db246d49839b5293be126eb7d077ba384fa", "processing_note": "Byte-identical complete Figure 1 copied from the PMC source media. No crop, annotation, color change, retouching, or other adaptation was applied.", "source_mode": "verbatim_full_figure", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Peripheral_blood_comparator" }, { "image_id": "BM-CC-DOG-MDS-F01-A", "map_image_id": "BMPM-IMG-0105", "source_id": "SUP-PMC11697499", "title_cn": "犬MDS鉴别：外周血中性粒细胞核叶大小不均", "title_en": "Canine MDS differential: neutrophils with unevenly sized nuclear lobes", "description_cn": "外周血涂片可见核叶大小不均的异常中性粒细胞，并伴巨大红细胞。该图记录疾病性粒系形态异常及血液学背景，不是骨髓涂片，也不能自动作为药物性粒系毒性证据。", "description_en": "The blood film shows dysplastic neutrophils with unevenly sized nuclear lobes and giant erythrocytes. It documents a disease-associated granulocytic abnormality and hematologic context; it is not a marrow smear and does not establish drug-related myeloid toxicity.", "species": "Dog", "strain": "Clinical canine MDS cohort; case-specific breed NR in legend", "specimen_type": "Peripheral_blood_comparator", "stain": "Wright stain", "lineage": "Granulocytic", "maturation_stage": "Segmented_neutrophil", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Uneven_nuclear_lobes", "Giant_erythrocytes" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "a", "source_page": "Figure 1, panel a", "caption_original_en": "Myelodysplastic syndrome, dog. (a) Blood film with dysplastic neutrophils (*) that have unevenly sized nuclear lobes and giant red blood cells (^) reflecting increased red cell distribution width. Case 1. Wright stain (WS). (b) The marrow aspirate is highly cellular and has a predominance of granulocytes. There are approximately 10% blasts (arrowheads). Of total, 15% of segmented neutrophils have dysplastic changes (*), and there are dysplastic band neutrophils (arrows). Case 2. WS. (c) An immature megakaryocyte with abnormal nuclear lobulation (left) and an abnormally small megakaryocyte with mature cytoplasm and a hypolobulated nucleus (right). Case 2. WS. (d) A micromegakaryocyte, ~24 µm in diameter with multiple, widely separated nuclei (arrow). Case 2. WS. (e) The marrow core is hypercellular despite chronic marked anemia, and megakaryocytes are clustered (arrows). Case 3. Hematoxylin and eosin (HE). (f) Higher magnification of (e) illustrating an increased proportion of blasts (arrowheads) in the center of the intertrabecular space; a megakaryocyte with abnormal nuclear lobulation, open chromatin, and nucleoli (arrow); and dysplastic giant band neutrophils (*). Case 3. HE.", "article_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "authors": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D", "journal": "Veterinary Pathology", "year": "2024", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D. Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia. Veterinary Pathology. 2024. doi:10.1177/03009858241277982. Figure 1, a. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 1-4 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-MDS-F01-A.jpg", "preview_path": "previews/BM-CC-DOG-MDS-F01-A.jpg", "sha256": "86e1774eddeae99a5b8dc5aeaab1248f9d4e660052053586c05ef5b10a63161e", "processing_note": "Exact-pixel panel a crop from the CC BY 4.0 composite Figure 1 at parent coordinates [0,0,180,240]. Panel marks and morphologic annotations are retained; no cells or colors were altered.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC11697499-FIGURE-1", "parent_sha256": "5a483add2bbc9fd987d7603436aa2e972a9b71b8d8889bb981fb4c5fc5834d50", "parent_asset_path": "images/PMC11697499-FIGURE-1.jpg", "crop_coordinates": [ 0, 0, 180, 240 ], "display_surface": "Peripheral_blood_comparator" }, { "image_id": "BM-CC-DOG-MDS-F02-A", "map_image_id": "BMPM-IMG-0103", "source_id": "SUP-PMC11697499", "title_cn": "犬MDS鉴别：外周血中性粒细胞核分节不全且不均", "title_en": "Canine MDS differential: incomplete and uneven neutrophil nuclear segmentation", "description_cn": "外周血中性粒细胞显示核分节不全和不均；病例同时有慢性非再生性贫血、正常白细胞计数及血小板增多。骨髓吸取物无颗粒，提示标本质量本身会限制细胞学解释。", "description_en": "Blood neutrophils show incomplete and uneven nuclear segmentation. The dog also had chronic nonregenerative anemia, a normal leukocyte count, and thrombocytosis; the marrow aspirate lacked particles, illustrating how sample quality can constrain cytologic interpretation.", "species": "Dog", "strain": "Clinical canine MDS cohort; case-specific breed NR in legend", "specimen_type": "Peripheral_blood_comparator", "stain": "Wright stain", "lineage": "Granulocytic", "maturation_stage": "Segmented_neutrophil", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Incomplete_nuclear_segmentation", "Uneven_nuclear_segmentation", "Marrow_aspirate_without_particles" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 2", "panel_label": "a", "source_page": "Figure 2, panel a", "caption_original_en": "Myelodysplastic syndrome, dog. (a) The blood film has dysplastic neutrophils (*) characterized by incomplete and uneven nuclear segmentation. Note also frequent platelets. The dog had chronic nonregenerative anemia, a normal leukocyte count, and thrombocytosis (554 × 10^9/L; reference interval 117-418 × 10^9/L). The marrow aspirate had no particles. Case 4. Wright stain. (b) The marrow core is nearly devoid of adipocytes is densely cellular with paratrabecular fibrosis (arrow). Case 5. Hematoxylin and eosin (HE). (c) At higher magnification, there are slender bundles of collagen interspersed among hematopoietic cells (arrow). Blasts comprise approximately 5% of cells (arrowheads). Case 5. HE.", "article_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "authors": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D", "journal": "Veterinary Pathology", "year": "2024", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D. Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia. Veterinary Pathology. 2024. doi:10.1177/03009858241277982. Figure 2, a. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 1-4 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-MDS-F02-A.jpg", "preview_path": "previews/BM-CC-DOG-MDS-F02-A.jpg", "sha256": "356ac98640fd172376fb96b53f2071278520850f10b3fdb1ad7fd6745d36687d", "processing_note": "Exact-pixel panel a crop from the CC BY 4.0 composite Figure 2 at parent coordinates [0,0,245,122]. Asterisks and the complete blood-film field are retained.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC11697499-FIGURE-2", "parent_sha256": "4975bf669afe4e403ff36cdf8c82bfd67d975ef016207a0f41c60def1f74ae0c", "parent_asset_path": "images/PMC11697499-FIGURE-2.jpg", "crop_coordinates": [ 0, 0, 245, 122 ], "display_surface": "Peripheral_blood_comparator" }, { "image_id": "BM-CC-DOG-AML-F03-A", "map_image_id": "BMPM-IMG-0107", "source_id": "SUP-PMC11697499", "title_cn": "犬AML外周血：原始细胞、大型髓单核样细胞与发育异常中性粒细胞", "title_en": "Canine AML blood film: blasts, large myelomonocytic cells, and dysplastic neutrophils", "description_cn": "外周血可见偶见原始细胞、多量大型髓单核样细胞及核形不规则或分节不全的中性粒细胞；病例伴显著白细胞增多、贫血和血小板减少。该图用于AML疾病鉴别，不用于给药相关性判断。", "description_en": "The blood film contains occasional blasts, numerous large myelomonocytic cells, and neutrophils with irregular lobes or incomplete segmentation; the dog also had marked leukocytosis, anemia, and thrombocytopenia. This is an AML disease differential, not evidence of treatment relationship.", "species": "Dog", "strain": "Clinical canine AML cohort; case-specific breed NR in legend", "specimen_type": "Peripheral_blood_comparator", "stain": "Wright stain", "lineage": "Granulocytic", "maturation_stage": "Blast_and_myelomonocytic_cells", "primary_morphology_class": "Proliferative_change", "secondary_features": [ "Circulating_blasts", "Large_myelomonocytic_cells", "Dysplastic_neutrophils", "Leukocytosis" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 3", "panel_label": "a", "source_page": "Figure 3, panel a", "caption_original_en": "Acute myeloid leukemia, dog. Case 6. (a) The blood film contains occasional blasts (arrowhead), numerous large myelomonocytes with irregular nuclear shapes, and occasional cytoplasmic vacuoles. Neutrophils are dysplastic with irregular nuclear lobes and incomplete segmentation (*). The dog had a leukocytosis of 157 × 10^9/L (reference interval = 4.9-15.4 × 10^9/L), thrombocytopenia, and anemia. Wright stain. (b) The postmortem marrow section is nearly 100% cellular and includes many cells with irregular nuclear shapes and large, sometimes amphophilic, nucleoli (arrowheads). Hematoxylin and eosin.", "article_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "authors": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D", "journal": "Veterinary Pathology", "year": "2024", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D. Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia. Veterinary Pathology. 2024. doi:10.1177/03009858241277982. Figure 3, a. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 1-4 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-AML-F03-A.jpg", "preview_path": "previews/BM-CC-DOG-AML-F03-A.jpg", "sha256": "a2bf223a87f96a007bdcca3ce3bd23f28c50191b71f6de5a187381fb882a8681", "processing_note": "Exact-pixel panel a crop from the CC BY 4.0 composite Figure 3 at parent coordinates [0,0,370,241]. Arrowhead, asterisks, and the full blood-film field are retained.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC11697499-FIGURE-3", "parent_sha256": "e5f2ecb1a5292c5932df9fb937819c6841bd385c271c8009f1f5ee561d50b1cd", "parent_asset_path": "images/PMC11697499-FIGURE-3.jpg", "crop_coordinates": [ 0, 0, 370, 241 ], "display_surface": "Peripheral_blood_comparator" }, { "image_id": "BM-CC-DOG-AML-F04-A", "map_image_id": "BMPM-IMG-0132", "source_id": "SUP-PMC11697499", "title_cn": "犬AML外周血：约40%白细胞为大型原始细胞", "title_en": "Canine AML blood film: approximately 40% of leukocytes are large blasts", "description_cn": "病例外周血中约40%的白细胞为大型原始细胞，并伴中性粒细胞减少、贫血和血小板减少。百分比来自原作者，不应仅凭单个视野重新估算。", "description_en": "Approximately 40% of leukocytes were large blasts in this case, accompanied by neutropenia, anemia, and thrombocytopenia. The percentage is source-reported and should not be re-estimated from this single field.", "species": "Dog", "strain": "Clinical canine AML cohort; case-specific breed NR in legend", "specimen_type": "Peripheral_blood_comparator", "stain": "Wright stain", "lineage": "Granulocytic", "maturation_stage": "Blast", "primary_morphology_class": "Proliferative_change", "secondary_features": [ "Circulating_blasts_approximately_40_percent", "Neutropenia", "Anemia", "Thrombocytopenia" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 4", "panel_label": "a", "source_page": "Figure 4, panel a", "caption_original_en": "Acute myeloid leukemia, dog. Case 7. Wright stain. (a) The dog had neutropenia, anemia, and thrombocytopenia. Approximately 40% of leukocytes are large blasts. (b) The marrow aspirate is highly cellular and contains approximately 45% blasts (*).", "article_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "authors": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D", "journal": "Veterinary Pathology", "year": "2024", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D. Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia. Veterinary Pathology. 2024. doi:10.1177/03009858241277982. Figure 4, a. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 1-4 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-AML-F04-A.jpg", "preview_path": "previews/BM-CC-DOG-AML-F04-A.jpg", "sha256": "0e05201b2a8ed4149257bf0e2555d695da4f0524fc8ef8e03339e7e94fea4595", "processing_note": "Exact-pixel panel a crop from the CC BY 4.0 composite Figure 4 at parent coordinates [0,0,368,241]. The complete blood-film field is retained.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC11697499-FIGURE-4", "parent_sha256": "217b86c19ccae052c0ec8f626e5f0fed0722e88859f1cb84fcf519444dca49b9", "parent_asset_path": "images/PMC11697499-FIGURE-4.jpg", "crop_coordinates": [ 0, 0, 368, 241 ], "display_surface": "Peripheral_blood_comparator" }, { "image_id": "BM-CC-DOG-EHBP1L1-F01-A", "map_image_id": "BMPM-IMG-0087", "source_id": "PMC9407898", "title_cn": "犬先天性红系发育异常：外周血异形红细胞与晚幼红细胞", "title_en": "Canine congenital dyserythropoiesis: peripheral poikilocytosis and a metarubricyte", "description_cn": "Labrador Retriever病例外周血可见显著异形红细胞，并见一枚晚幼红细胞。该panel是同一复合图中骨髓红系异常的外周血对应，不代表药物相关毒性。", "description_en": "Peripheral blood from an affected Labrador Retriever shows poikilocytosis and a metarubricyte. This panel is the peripheral-blood counterpart to the marrow erythroid abnormalities in the same composite figure and is not evidence of drug-related toxicity.", "species": "Dog", "strain": "Labrador Retriever", "specimen_type": "Peripheral_blood_comparator", "stain": "Wright-Giemsa", "lineage": "Erythroid", "maturation_stage": "Metarubricyte", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Poikilocytosis", "Metarubricyte" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "A", "source_page": "Figure 1, panel A", "caption_original_en": "Review of histopathological changes in red blood cells, bone marrow and muscle in Labrador Retrievers with an EHBP1L1 variant. (A) Review of Wrights Giemsa stained peripheral blood from an affected Labrador Retriever demonstrating poikilocytosis and a metarubricyte (arrow). (B) Review of Wrights Giemsa stained bone marrow cytology demonstrating cytoplasmic bridging (arrow). (C) Review of Wrights Giemsa stained bone marrow cytology demonstrating an atypical mitotic figure (arrow). (D) Review of Wrights Giemsa stained bone marrow cytology demonstrating rubriphagocytosis (arrow) and increased proportion of metarubricytes. (E) Review of the biceps femoris muscle biopsy from one dog showing myofiber size variation, pale, floccular sarcoplasmic inclusions (arrows) and endomysial fibrosis. (F) In severely affected biceps femoris muscle biopsies, endomysial fibrosis (asterisk) and numerous pale, floccular sarcoplasmic inclusions are present. H&E. Bar=10 µm for A-D and 50 µm for E-F.", "article_title": "An EHPB1L1 Nonsense Mutation Associated with Congenital Dyserythropoietic Anemia and Polymyopathy in Labrador Retriever Littermates", "authors": "Shelton GD, Minor KM, Guo LT, Thomas-Hollands A, Walsh KA, Friedenberg SG, Cullen JN, Mickelson JR", "journal": "Genes", "year": "2022", "doi": "10.3390/genes13081427", "pmid": "36011338", "pmcid": "PMC9407898", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9407898/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9407898/figure/genes-13-01427-f001/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Shelton GD, Minor KM, Guo LT, Thomas-Hollands A, Walsh KA, Friedenberg SG, Cullen JN, Mickelson JR. An EHPB1L1 Nonsense Mutation Associated with Congenital Dyserythropoietic Anemia and Polymyopathy in Labrador Retriever Littermates. Genes. 2022. doi:10.3390/genes13081427. Figure 1, A. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the Figure 1 legend.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-EHBP1L1-F01-A.png", "preview_path": "previews/BM-CC-DOG-EHBP1L1-F01-A.jpg", "sha256": "e9f6f5ea7de0300f3aa1ebfe05a78801cf867ab182659e96e9641549fa3e3226", "processing_note": "Exact-pixel panel A crop from the CC BY 4.0 composite Figure 1 at parent coordinates [0,0,384,286]. The arrow and complete blood-film field are retained; muscle panels E-F are excluded from the marrow atlas.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC9407898-FIGURE-1", "parent_sha256": "7e52e6752410f4e4c5be30c9891fb5b7e70587d2e303a41ba98a269c6b119ca3", "parent_asset_path": "images/PMC9407898-FIGURE-1.jpg", "crop_coordinates": [ 0, 0, 384, 286 ], "display_surface": "Peripheral_blood_comparator" } ], "pathology_evidence": [ { "image_id": "BMAT-0001-MORPH-B", "source_id": "LEGACY-RPBM-001", "title_cn": "卡铂处理后大鼠骨髓巨核细胞减少", "title_en": "Reduced rat marrow megakaryocytes after carboplatin", "description_cn": "大鼠骨髓H&E切片对照与卡铂给药后第6天比较。黄色箭头标示巨核细胞；原作者报告给药组巨核细胞数下降。该图用于教学性形态比较，因果性与毒理意义仍需结合研究设计和定量结果判断。", "description_en": "Control and day-6 post-carboplatin rat marrow H&E sections. Yellow arrows identify megakaryocytes; the authors reported fewer megakaryocytes in the treated group. Causality and toxicologic significance require the study context and quantitative data.", "species": "Rat", "strain": "Sprague-Dawley", "specimen_type": "Bone_marrow_histology_section", "stain": "H&E", "lineage": "Megakaryocytic", "figure_label": "Figure 1B", "panel_label": "B", "caption_original_en": "The time-dependent change of platelet counts in blood and megakaryocyte counts in bone marrow after carboplatin treatment. Rats were randomly divided into five groups (at least five rats in each group) and sacrificed at 0, 3, 6, 9, and 12 days after intraperitoneal injection of 35 mg/kg carboplatin. ( A ) The numbers of platelets in the blood were determined by blood analyzer at 0, 3, 6, 9 and 12 days after carboplatin treatment. ( B ) Photos shown were bone marrow sections prepared from control and carboplatin-treated rat at the sixth day. Megakaryocytes were identified based on their characteristic morphology such as large size, pink cytoplasm and lobated nucleus and indicated by the yellow arrows. Scale bar = 60 μm. ( C ) Megakaryocyte were counted in the HE-stained sections of bone marrow at 0, 3, 6, 9, and 12 days after carboplatin treatment under microscopic examination by Nikon ECLIPSE Ni-U. ( D ) TPO concentrations in the blood prepared from control and carboplatin-treated rat at the sixth day were measured by ELISA. (*** p -value < 0.001, **** p -value < 0.0001, three independent experiments were performed).", "article_title": "Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes", "doi": "10.3390/ijms23116290", "pmid": "35682967", "pmcid": "PMC9181531", "source_url": "https://www.mdpi.com/1422-0067/23/11/6290", "license": "CC BY 4.0", "reuse_status": "cc_reuse_allowed", "attribution": "Wu Y-H, Chen H-Y, Hong W-C, Wei C-Y, Pang J-HS. Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes. Int J Mol Sci. 2022;23(11):6290. doi:10.3390/ijms23116290. CC BY 4.0. Figure 1B.", "expert_review_status": "Pending", "asset_path": "images/BMAT-0001-MORPH-B.jpg", "sha256": "c6d21223ffd5e2d35eb706d13e7c759743eab76191cc3287eda1354256b602d2", "license_url": "https://creativecommons.org/licenses/by/4.0/", "primary_morphology_class": "Cytotoxic_change", "secondary_features": [ "Megakaryocyte_decrease" ], "evidence_role": "Toxicity_image", "causality_level": "Author_attributed", "third_party_credit_line": "None reported in the article figure legend", "processing_note": "Panel B was extracted from the composite source figure; no tissue structures were generated or retouched.", "preview_path": "previews/BMAT-0001-MORPH-B.jpg", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BMAT-0003-MORPH-D", "source_id": "LEGACY-RPBM-001", "title_cn": "卡铂处理后大鼠骨髓巨核细胞JAK2信号降低", "title_en": "Reduced JAK2 signal in rat marrow megakaryocytes after carboplatin", "description_cn": "大鼠骨髓切片JAK2免疫荧光比较。黄色箭头标示巨核细胞；原作者报告处理组JAK2信号降低。该图是机制支持证据，不应单独作为形态学诊断。", "description_en": "JAK2 immunofluorescence in control and treated rat marrow sections. Yellow arrows identify megakaryocytes; the authors reported reduced JAK2 signal in the treated group. This is mechanistic support, not a stand-alone morphologic diagnosis.", "species": "Rat", "strain": "Sprague-Dawley", "specimen_type": "Bone_marrow_section_immunofluorescence", "stain": "JAK2 immunofluorescence (PE) with DAPI counterstain", "lineage": "Megakaryocytic", "figure_label": "Figure 5D", "panel_label": "D", "caption_original_en": "Carboplatin suppressed JAK2 and STAT3 activation in megakaryocytes. ( A , B ) MEG-01 cells were treated by carboplatin dose-dependently and the expressions of JAK2, p-JAK2, STAT3, p-STAT3 and c-Mpl were analyzed by western blot method and ( C ) the JAK2 mRNA expression was analyzed by RT/real-time PCR. ( D ) The JAK2 expression was analyzed in bone marrow sections prepared from control and carboplatin-treated rats at the sixth day by immunohistochemistry. Megakaryocytes were indicated by yellow arrow and the JAK2 expression was revealed by red fluorescent signal. Scale bar = 120 μm. (* p -value < 0.05, ** p -value < 0.01, **** p -value < 0.0001, three independent experiments were performed).", "article_title": "Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes", "doi": "10.3390/ijms23116290", "pmid": "35682967", "pmcid": "PMC9181531", "source_url": "https://www.mdpi.com/1422-0067/23/11/6290", "license": "CC BY 4.0", "reuse_status": "cc_reuse_allowed", "attribution": "Wu Y-H, Chen H-Y, Hong W-C, Wei C-Y, Pang J-HS. Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes. Int J Mol Sci. 2022;23(11):6290. doi:10.3390/ijms23116290. CC BY 4.0. Figure 5D.", "expert_review_status": "Pending", "asset_path": "images/BMAT-0003-MORPH-D.jpg", "sha256": "558ea373914d282934ac15061f5fa8af9a82ac3000d91c039c658513a409c4b4", "license_url": "https://creativecommons.org/licenses/by/4.0/", "primary_morphology_class": "Uncertain", "secondary_features": [ "Reduced_JAK2_signal" ], "evidence_role": "Mechanistic_reference", "causality_level": "Author_attributed", "third_party_credit_line": "None reported in the article figure legend", "processing_note": "Panel D was extracted from the composite source figure; fluorescent signal and tissue structures were not generated or retouched.", "preview_path": "previews/BMAT-0003-MORPH-D.jpg", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HYPER-F01", "map_image_id": "BMPM-IMG-0301", "source_id": "NTP-BONE-MARROW-HYPERCELLULARITY", "title_cn": "对照大鼠骨髓细胞量（低倍）", "title_en": "Control rat bone marrow cellularity, low power", "description_cn": "亚慢性研究对照雌性F344大鼠骨髓低倍切片，用于与处理动物的骨髓高细胞性比较。本图作为正常对照，不代表处理相关改变。", "description_en": "Low-power marrow section from a control female F344 rat in a subchronic study. It serves as the concurrent normal comparator and is not a treatment-related lesion.", "species": "Rat", "strain": "F344", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Normal_maturation", "secondary_features": [ "Normal_cellularity_comparator" ], "evidence_role": "Normal_comparator", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "caption_original_en": "Bone marrow in a control female F344 rat from a subchronic study.", "article_title": "Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/hypercel/images/figure-001-a19162_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas, Figure 1. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HYPER-F01.jpg", "preview_path": "previews/BM-NTP-HYPER-F01.jpg", "sha256": "0b93f2d990a864307037f1e21af1f56c78fabb83cae369b39e3c6e852b803f26", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HYPER-F02", "map_image_id": "BMPM-IMG-0304", "source_id": "NTP-BONE-MARROW-HYPERCELLULARITY", "title_cn": "处理相关贫血后的红系高细胞性（大鼠，低倍）", "title_en": "Erythroid hypercellularity after treatment-related anemia in rat, low power", "description_cn": "处理雌性F344/N大鼠骨髓与同期对照相比出现红系高细胞性。原作者将其解释为处理相关贫血后的反应性改变，而不是单凭本图认定直接骨髓毒性。", "description_en": "Marrow from a treated female F344/N rat shows erythroid hypercellularity relative to the concurrent control. The source interprets this as a response to treatment-related anemia; the image alone does not establish direct marrow toxicity.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Erythroid", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Erythroid_hyperplasia", "Hypercellularity" ], "evidence_role": "Treatment_associated_response", "causality_level": "Author_attributed", "figure_label": "Figure 2", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "caption_original_en": "Bone marrow in a treated female F344/N rat from a subchronic study. Compared with the concurrent control (Figure 1), there is erythroid hypercellularity in response to a treatment-related anemia.", "article_title": "Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/hypercel/images/figure-002-a19166_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas, Figure 2. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HYPER-F02.jpg", "preview_path": "previews/BM-NTP-HYPER-F02.jpg", "sha256": "e301659bc913ef91e334d7823896beb9350206e1dfcd628e5d56b518dc053c77", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HYPER-F03", "map_image_id": "BMPM-IMG-0302", "source_id": "NTP-BONE-MARROW-HYPERCELLULARITY", "title_cn": "对照大鼠骨髓细胞量（高倍）", "title_en": "Control rat bone marrow cellularity, higher magnification", "description_cn": "Figure 1对照大鼠骨髓的高倍视图，用于识别同期对照中的造血细胞与脂肪细胞比例。", "description_en": "Higher-magnification view of the control rat marrow shown in Figure 1, supporting comparison of hematopoietic cells and adipocytes with the treated animal.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Normal_maturation", "secondary_features": [ "Normal_cellularity_comparator" ], "evidence_role": "Normal_comparator", "causality_level": "Differential_only", "figure_label": "Figure 3", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "caption_original_en": "Bone marrow in a control female F344/N rat from a subchronic study (higher magnification of Figure 1).", "article_title": "Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/hypercel/images/figure-003-a19165_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas, Figure 3. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HYPER-F03.jpg", "preview_path": "previews/BM-NTP-HYPER-F03.jpg", "sha256": "7c0d31c5b4f6a34e2dd29d595224b9e805c242fd52986dd6844896147d380843", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HYPER-F04", "map_image_id": "BMPM-IMG-0303", "source_id": "NTP-BONE-MARROW-HYPERCELLULARITY", "title_cn": "处理相关贫血后的红系高细胞性（大鼠，高倍）", "title_en": "Erythroid hypercellularity after treatment-related anemia in rat, higher magnification", "description_cn": "Figure 2处理动物骨髓的高倍视图。与Figure 3同期对照相比，红系造血细胞增加；该变化在原来源中被解释为处理相关贫血的反应。", "description_en": "Higher-magnification view of the treated rat marrow in Figure 2. Erythroid hematopoietic cells are increased relative to the concurrent control in Figure 3, interpreted by the source as a response to treatment-related anemia.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Erythroid", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Erythroid_hyperplasia", "Hypercellularity" ], "evidence_role": "Treatment_associated_response", "causality_level": "Author_attributed", "figure_label": "Figure 4", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "caption_original_en": "Bone marrow in a treated female F344/N rat from a subchronic study (higher magnification of Figure 2). Compared with the concurrent control (Figure 3), there is erythroid hypercellularity in response to a treatment-related anemia.", "article_title": "Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/hypercel/images/figure-004-a19169_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas, Figure 4. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HYPER-F04.jpg", "preview_path": "previews/BM-NTP-HYPER-F04.jpg", "sha256": "9a8fcb7dcd560fbc4930559691548592f48b6d511a32546f47869d3ec67e3f0f", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HYPER-F05", "map_image_id": "BMPM-IMG-0168", "source_id": "NTP-BONE-MARROW-HYPERCELLULARITY", "title_cn": "小鼠骨髓高细胞性组织学模式", "title_en": "Histologic pattern of bone marrow hypercellularity in mouse", "description_cn": "慢性研究雄性B6C3F1小鼠骨髓高细胞性。原图注未报告具体细胞系或处理背景，因此仅作为高细胞性教学模式，不推断机制。", "description_en": "Hypercellular marrow from a male B6C3F1 mouse in a chronic study. The caption does not specify the expanded lineage or treatment context, so this is retained as a teaching pattern without mechanistic inference.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Proliferative_change", "secondary_features": [ "Hypercellularity" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 5", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "caption_original_en": "Hypercellular bone marrow in a male B6C3F1 mouse from a chronic study.", "article_title": "Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/hypercel/images/figure-005-a49167_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas, Figure 5. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HYPER-F05.jpg", "preview_path": "previews/BM-NTP-HYPER-F05.jpg", "sha256": "c560e5e8542cd936750bf5661e77627aecbb60cd58ef3d56c16df64866e7c347", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-INFLAM-F01", "map_image_id": "BMPM-IMG-0322", "source_id": "NTP-BONE-MARROW-INFLAMMATION", "title_cn": "大鼠骨髓肉芽肿性炎症（低倍）", "title_en": "Granulomatous inflammation in rat bone marrow, low power", "description_cn": "慢性研究雄性F344/N大鼠骨髓内可见较淡嗜酸性肉芽肿性炎症区，由巨噬细胞聚集形成，箭头标示病灶。该图作为炎症鉴别，不自动归因于试验物质。", "description_en": "Low-power rat marrow showing pale eosinophilic areas of granulomatous inflammation formed by macrophage aggregates (arrows). It is used as an inflammatory differential and is not automatically attributed to a test article.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Monocytic_macrophagic", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Granulomatous_inflammation", "Macrophage_aggregates" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "caption_original_en": "Bone marrow in a male F344/N rat from a chronic study. This low-power view shows relatively pale eosinophilic areas of granulomatous inflammation consisting of aggregates of macrophages (arrows).", "article_title": "Bone marrow - Inflammation - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/inflamm/images/figure-001-a64166_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Inflammation - Nonneoplastic Lesion Atlas, Figure 1. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-INFLAM-F01.jpg", "preview_path": "previews/BM-NTP-INFLAM-F01.jpg", "sha256": "eb725ff3b9e4025cb928d1927d66056be4a0acb199e16e605adf7a2e42511648", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-INFLAM-F02", "map_image_id": "BMPM-IMG-0321", "source_id": "NTP-BONE-MARROW-INFLAMMATION", "title_cn": "大鼠骨髓肉芽肿性炎症（高倍）", "title_en": "Granulomatous inflammation in rat bone marrow, higher magnification", "description_cn": "Figure 1病灶的高倍视图，可见巨噬细胞聚集，部分呈上皮样或多核形态。仅作为组织病理炎症模式和鉴别依据。", "description_en": "Higher-magnification view of Figure 1 showing macrophage aggregates, including epithelioid and/or multinucleated forms. It is retained as an inflammatory histopathology pattern and differential.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Monocytic_macrophagic", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Granulomatous_inflammation", "Epithelioid_macrophages", "Multinucleated_macrophages" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 2", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "caption_original_en": "Bone marrow in a male F344/N male rat from a chronic study (higher magnification of Figure 1), showing several aggregates of macrophages (arrows), some epithelioid and/or multinucleated.", "article_title": "Bone marrow - Inflammation - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/inflamm/images/figure-002-a64168_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Inflammation - Nonneoplastic Lesion Atlas, Figure 2. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-INFLAM-F02.jpg", "preview_path": "previews/BM-NTP-INFLAM-F02.jpg", "sha256": "a18ec07165778c173f2dc1186835108f753eccf823638c644006c3b014b418dd", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-INFLAM-F03", "map_image_id": "BMPM-IMG-0181", "source_id": "NTP-BONE-MARROW-INFLAMMATION", "title_cn": "小鼠骨髓肉芽肿", "title_en": "Bone marrow granuloma in mouse", "description_cn": "慢性研究雄性B6C3F1小鼠骨髓内见边界较清楚的肉芽肿（箭头）。该病灶可与感染、异物反应或非特异性炎症相关，不能仅凭图像确定病因。", "description_en": "A distinct marrow granuloma (arrows) in a male B6C3F1 mouse from a chronic study. Infection, foreign-material reaction, and nonspecific inflammation remain possible; the image alone does not establish cause.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Monocytic_macrophagic", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Granuloma" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 3", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "caption_original_en": "Bone marrow in a male B6C3F1 mouse from a chronic study showing a distinct granuloma (arrows).", "article_title": "Bone marrow - Inflammation - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/inflamm/images/figure-003-a64163_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Inflammation - Nonneoplastic Lesion Atlas, Figure 3. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-INFLAM-F03.jpg", "preview_path": "previews/BM-NTP-INFLAM-F03.jpg", "sha256": "25be469f9ba984b80f76c76e229d3e77ea4586451336804c40ba5a762e952ca2", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-INFLAM-F04", "map_image_id": "BMPM-IMG-0182", "source_id": "NTP-BONE-MARROW-INFLAMMATION", "title_cn": "小鼠骨髓肉芽肿（高倍）", "title_en": "Bone marrow granuloma in mouse, higher magnification", "description_cn": "Figure 3小鼠骨髓肉芽肿的高倍视图，用于观察病灶组织构成；病因仍需结合研究背景和其他器官结果。", "description_en": "Higher-magnification view of the mouse marrow granuloma in Figure 3. Etiology requires the study context and findings in other organs.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Monocytic_macrophagic", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Granuloma" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 4", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "caption_original_en": "Bone marrow in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 3), showing a distinct granuloma.", "article_title": "Bone marrow - Inflammation - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/inflamm/images/figure-004-a64165_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Inflammation - Nonneoplastic Lesion Atlas, Figure 4. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-INFLAM-F04.jpg", "preview_path": "previews/BM-NTP-INFLAM-F04.jpg", "sha256": "8474ff6e1f4cd52f51366b9be5f09506603f1cbf39da4503d7448545dcc7517c", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-INFLAM-F05", "map_image_id": "BMPM-IMG-0183", "source_id": "NTP-BONE-MARROW-INFLAMMATION", "title_cn": "小鼠骨髓重度化脓性炎症", "title_en": "Severe suppurative inflammation in mouse bone marrow", "description_cn": "慢性研究雄性B6C3F1小鼠骨髓内见大量退变中性粒细胞与坏死碎屑，符合重度化脓性炎症模式。该图用于感染性或炎症性鉴别，不自动归为药物毒性。", "description_en": "Mouse marrow showing severe suppurative inflammation with numerous degenerative neutrophils and necrotic debris. It is used as an infectious or inflammatory differential and is not automatically classified as drug toxicity.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Granulocytic", "maturation_stage": "NR", "primary_morphology_class": "Degenerative_change", "secondary_features": [ "Suppurative_inflammation", "Degenerative_neutrophils", "Necrotic_debris" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 5", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "caption_original_en": "Bone marrow in a male B6C3F1 mouse from a chronic study, showing severe suppurative inflammation with high numbers of degenerative neutrophils mixed with necrotic debris.", "article_title": "Bone marrow - Inflammation - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/inflamm/images/figure-005-a64191_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Inflammation - Nonneoplastic Lesion Atlas, Figure 5. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-INFLAM-F05.jpg", "preview_path": "previews/BM-NTP-INFLAM-F05.jpg", "sha256": "c79736f6468cf8cbfa60ae30dfa6ba718a61fa02ea8ddf455ce909b3bfa3abc3", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-INFLAM-F06", "map_image_id": "BMPM-IMG-0184", "source_id": "NTP-BONE-MARROW-INFLAMMATION", "title_cn": "小鼠骨髓重度化脓性炎症（高倍）", "title_en": "Severe suppurative inflammation in mouse bone marrow, higher magnification", "description_cn": "Figure 5病灶的高倍视图，更清楚显示退变中性粒细胞与坏死碎屑。用于与正常粒系细胞和非化脓性炎症鉴别。", "description_en": "Higher-magnification view of Figure 5, emphasizing degenerative neutrophils and necrotic debris for comparison with normal granulopoiesis and nonsuppurative inflammation.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Granulocytic", "maturation_stage": "NR", "primary_morphology_class": "Degenerative_change", "secondary_features": [ "Suppurative_inflammation", "Degenerative_neutrophils", "Necrotic_debris" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 6", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "caption_original_en": "Bone marrow in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 5), showing severe suppurative inflammation with high numbers of degenerative neutrophils mixed with necrotic debris.", "article_title": "Bone marrow - Inflammation - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/inflamm/images/figure-006-a64192_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Inflammation - Nonneoplastic Lesion Atlas, Figure 6. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-INFLAM-F06.jpg", "preview_path": "previews/BM-NTP-INFLAM-F06.jpg", "sha256": "de6ee5c16640b9dc6a907a8bf6081ac5a1d5932cb6b509be3f73cd7101a9c950", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HYPO-F01", "map_image_id": "BMPM-IMG-0262", "source_id": "NTP-BONE-MARROW-HYPOCELLULARITY", "title_cn": "对照大鼠骨髓细胞量（低倍）", "title_en": "Control rat bone marrow cellularity, low power", "description_cn": "亚慢性研究对照雌性F344/N大鼠骨髓低倍切片，用于与Figure 2处理动物进行同部位、同期对照比较。", "description_en": "Low-power marrow section from a control female F344/N rat in a subchronic study, used as the same-site concurrent comparator for Figure 2.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Normal_maturation", "secondary_features": [ "Normal_cellularity_comparator" ], "evidence_role": "Normal_comparator", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "caption_original_en": "Bone marrow in a control female F344/N rat from a subchronic study.", "article_title": "Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/hypocell/images/figure-001-a13852_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas, Figure 1. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HYPO-F01.jpg", "preview_path": "previews/BM-NTP-HYPO-F01.jpg", "sha256": "f4bd8479d032c95735f22283f878bb1ffef162a366b8fc54e9daaf1270d67da2", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HYPO-F02", "map_image_id": "BMPM-IMG-0259", "source_id": "NTP-BONE-MARROW-HYPOCELLULARITY", "title_cn": "大鼠骨髓轻度低细胞性（低倍）", "title_en": "Mild bone marrow hypocellularity in rat, low power", "description_cn": "处理雌性F344/N大鼠骨髓相对Figure 1同期对照呈轻度低细胞性。低倍重点比较造血细胞与脂肪细胞所占空间。", "description_en": "Marrow from a treated female F344/N rat shows mild hypocellularity relative to the concurrent control in Figure 1. Low power supports comparison of hematopoietic and adipose compartments.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Cytotoxic_change", "secondary_features": [ "Hypocellularity", "Mild" ], "evidence_role": "Treatment_associated_response", "causality_level": "Author_attributed", "figure_label": "Figure 2", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "caption_original_en": "Bone marrow in a treated female F344/N rat from a subchronic study. Compared with concurrent control (Figure 1), there is mild hypocellularity.", "article_title": "Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/hypocell/images/figure-002-a13854_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas, Figure 2. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HYPO-F02.jpg", "preview_path": "previews/BM-NTP-HYPO-F02.jpg", "sha256": "43654043f14ca12b6224574bca5a10d57998323d90eeeea0c2357ddf07f7c9d2", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HYPO-F03", "map_image_id": "BMPM-IMG-0261", "source_id": "NTP-BONE-MARROW-HYPOCELLULARITY", "title_cn": "对照大鼠骨髓细胞量（高倍）", "title_en": "Control rat bone marrow cellularity, higher magnification", "description_cn": "Figure 1对照大鼠骨髓的高倍视图，用于与Figure 4处理动物在相近倍率下比较造血细胞密度。", "description_en": "Higher-magnification view of the control marrow in Figure 1, paired with Figure 4 for comparison of hematopoietic cell density.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Normal_maturation", "secondary_features": [ "Normal_cellularity_comparator" ], "evidence_role": "Normal_comparator", "causality_level": "Differential_only", "figure_label": "Figure 3", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "caption_original_en": "Bone marrow in a control female F344/N rat from a subchronic study (higher magnification of Figure 1).", "article_title": "Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/hypocell/images/figure-003-a13853_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas, Figure 3. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HYPO-F03.jpg", "preview_path": "previews/BM-NTP-HYPO-F03.jpg", "sha256": "db0fa38a085ed950d5ecd2e373112e8efcc9fbc05540fd7b28b942f4966c5164", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HYPO-F04", "map_image_id": "BMPM-IMG-0260", "source_id": "NTP-BONE-MARROW-HYPOCELLULARITY", "title_cn": "大鼠骨髓轻度低细胞性（高倍）", "title_en": "Mild bone marrow hypocellularity in rat, higher magnification", "description_cn": "Figure 2处理动物骨髓的高倍视图；与Figure 3同期对照相比造血细胞密度轻度降低。仅凭组织学不应推定具体细胞系。", "description_en": "Higher-magnification view of Figure 2 showing mildly decreased hematopoietic cellularity relative to Figure 3. Histology alone does not establish a specific affected lineage.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Cytotoxic_change", "secondary_features": [ "Hypocellularity", "Mild" ], "evidence_role": "Treatment_associated_response", "causality_level": "Author_attributed", "figure_label": "Figure 4", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "caption_original_en": "Bone marrow in a treated female F344/N rat from a subchronic study (higher magnification of Figure 2). Compared with concurrent control (Figure 3), there is mild bone marrow hypocellularity.", "article_title": "Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/hypocell/images/figure-004-a13855_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas, Figure 4. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HYPO-F04.jpg", "preview_path": "previews/BM-NTP-HYPO-F04.jpg", "sha256": "7f97989d7ac43e032d8898efdf41a5ba6494c453961605c7be03bda2f609411e", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HYPO-F05", "map_image_id": "BMPM-IMG-0148", "source_id": "NTP-BONE-MARROW-HYPOCELLULARITY", "title_cn": "小鼠骨髓重度低细胞性（低倍）", "title_en": "Severe bone marrow hypocellularity in mouse, low power", "description_cn": "亚慢性研究雄性B6C3F1小鼠骨髓大部分造血细胞消失，髓腔主要由脂肪组织和血管窦构成；原来源将其置于处理诱导再生障碍性贫血背景。", "description_en": "Severely hypocellular marrow from a male B6C3F1 mouse in a subchronic study, with marrow spaces largely occupied by adipose tissue and vascular sinuses. The source places the finding in treatment-induced aplastic anemia.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Cytotoxic_change", "secondary_features": [ "Hypocellularity", "Severe", "Aplastic_anemia_context" ], "evidence_role": "Treatment_associated_response", "causality_level": "Author_attributed", "figure_label": "Figure 5", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "caption_original_en": "Severely hypocellular bone marrow in a male B6C3F1 mouse from a subchronic study. The marrow space is largely devoid of hematopoietic cells and consists primarily of adipose tissue and vascular sinuses due to treatment-induced aplastic anemia.", "article_title": "Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/hypocell/images/figure-005-a14085_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas, Figure 5. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HYPO-F05.jpg", "preview_path": "previews/BM-NTP-HYPO-F05.jpg", "sha256": "88e0daf04806dfb7b38c1e8d5531dc1d2f5fd90f8e3840d7459949ad498dbf31", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HYPO-F06", "map_image_id": "BMPM-IMG-0147", "source_id": "NTP-BONE-MARROW-HYPOCELLULARITY", "title_cn": "小鼠骨髓重度低细胞性（高倍）", "title_en": "Severe bone marrow hypocellularity in mouse, higher magnification", "description_cn": "Figure 5的高倍视图，显示造血细胞显著减少，脂肪细胞和血管窦相对突出。用于与轻度低细胞性及正常骨髓比较。", "description_en": "Higher-magnification view of Figure 5 showing marked loss of hematopoietic cells with relative prominence of adipocytes and vascular sinuses, useful for comparison with mild hypocellularity and normal marrow.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Cytotoxic_change", "secondary_features": [ "Hypocellularity", "Severe", "Aplastic_anemia_context" ], "evidence_role": "Treatment_associated_response", "causality_level": "Author_attributed", "figure_label": "Figure 6", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "caption_original_en": "Severely hypocellular bone marrow in a male B6C3F1 mouse from a subchronic study (higher magnification of Figure 5). The marrow space is largely devoid of hematopoietic cells and consists primarily of adipose tissue and vascular sinuses due to treatment-induced aplastic anemia.", "article_title": "Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/hypocell/images/figure-006-a14868_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas, Figure 6. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HYPO-F06.jpg", "preview_path": "previews/BM-NTP-HYPO-F06.jpg", "sha256": "4e6bfa0717d568f30c0fd4e4e039c876c8baae5fcee70f82e335790c57eceb91", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-NECROSIS-F01", "map_image_id": "BMPM-IMG-0163", "source_id": "NTP-BONE-MARROW-NECROSIS", "title_cn": "小鼠骨髓坏死（低倍）", "title_en": "Bone marrow necrosis in mouse, low power", "description_cn": "慢性研究雌性B6C3F1小鼠骨髓坏死低倍图，提供病灶范围和整体髓腔背景。病因和给药相关性不能由图像单独确定。", "description_en": "Low-power marrow necrosis in a female B6C3F1 mouse from a chronic study, showing lesion extent within the marrow space. Cause and treatment relationship cannot be determined from the image alone.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Degenerative_change", "secondary_features": [ "Necrosis", "Low_power" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 1", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "caption_original_en": "Bone marrow necrosis in a female B6C3F1 mouse from a chronic study (low magnification).", "article_title": "Bone marrow - Necrosis - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/necrosis/images/figure-001-a64188_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Necrosis - Nonneoplastic Lesion Atlas, Figure 1. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-NECROSIS-F01.jpg", "preview_path": "previews/BM-NTP-NECROSIS-F01.jpg", "sha256": "26163c30b62765f7749baf1c7ba0db59eccc461122f34d68c73c436dab74ab50", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-NECROSIS-F02", "map_image_id": "BMPM-IMG-0165", "source_id": "NTP-BONE-MARROW-NECROSIS", "title_cn": "小鼠骨髓坏死的细胞学特征（高倍）", "title_en": "Cellular features of bone marrow necrosis in mouse, higher magnification", "description_cn": "Figure 1病灶高倍图，可见造血细胞残影、细胞边界不清、核固缩、核溶解和核碎裂。需要与死后自溶鉴别。", "description_en": "Higher-magnification view of Figure 1 showing remnants of hematopoietic cells, indistinct borders, pyknosis, karyolysis, and karyorrhexis. Postmortem autolysis remains a key differential.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Degenerative_change", "secondary_features": [ "Necrosis", "Pyknosis", "Karyolysis", "Karyorrhexis" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 2", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "caption_original_en": "Bone marrow in a female B6C3F1 mouse from a chronic study (higher magnification of Figure 1) showing bone marrow necrosis characterized by remnants of hematopoietic cells with indistinct borders, nuclear pyknosis, karyolysis, and karyorrhexis.", "article_title": "Bone marrow - Necrosis - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/necrosis/images/figure-002-a64189_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Necrosis - Nonneoplastic Lesion Atlas, Figure 2. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-NECROSIS-F02.jpg", "preview_path": "previews/BM-NTP-NECROSIS-F02.jpg", "sha256": "7640568b1f6a47274dba730b1d776d124866c44231ac27f41f0dc8cd67d20d4d", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-NECROSIS-F03", "map_image_id": "BMPM-IMG-0164", "source_id": "NTP-BONE-MARROW-NECROSIS", "title_cn": "界限清楚的骨髓坏死区（低倍）", "title_en": "Well-demarcated bone marrow necrosis, low power", "description_cn": "慢性研究雄性B6C3F1小鼠骨髓内见大而界限清楚的嗜酸性坏死区；箭头标示存活组织与坏死区的分界。", "description_en": "Low-power marrow from a male B6C3F1 mouse showing a large, well-demarcated eosinophilic necrotic area. Arrows identify the border between viable and necrotic tissue.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Degenerative_change", "secondary_features": [ "Necrosis", "Well_demarcated", "Low_power" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 3", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "caption_original_en": "Bone marrow in male B6C3F1 mouse from a chronic study (low magnification), showing a large well-demarcated eosinophilic area representing necrosis (asterisk). Arrows represent the line of demarcation between viable cells and the area of necrosis.", "article_title": "Bone marrow - Necrosis - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/necrosis/images/figure-003-a64176_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Necrosis - Nonneoplastic Lesion Atlas, Figure 3. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-NECROSIS-F03.jpg", "preview_path": "previews/BM-NTP-NECROSIS-F03.jpg", "sha256": "69007c18b541cdb8a089b9f677414e364d549b7207d2401a5d24b668e3bc3f91", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-NECROSIS-F04", "map_image_id": "BMPM-IMG-0167", "source_id": "NTP-BONE-MARROW-NECROSIS", "title_cn": "骨髓坏死与存活组织分界（高倍）", "title_en": "Interface between viable marrow and necrosis, higher magnification", "description_cn": "Figure 3的高倍视图，显示坏死区与存活造血组织之间的清楚分界。界限形态可提示鉴别方向，但不能单独证明缺血病因。", "description_en": "Higher-magnification view of Figure 3 showing the interface between viable marrow and necrosis. A sharp border may guide the differential but does not alone prove an ischemic cause.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Degenerative_change", "secondary_features": [ "Necrosis", "Viable_necrotic_interface" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 4", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "caption_original_en": "Bone marrow in a male B6C3F1 mouse from a chronic study (higher magnification of Figure 3), showing the area of necrosis (asterisk) and the line of demarcation (arrows) between the viable cells and the area of necrosis.", "article_title": "Bone marrow - Necrosis - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/necrosis/images/figure-004-a64177_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Necrosis - Nonneoplastic Lesion Atlas, Figure 4. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-NECROSIS-F04.jpg", "preview_path": "previews/BM-NTP-NECROSIS-F04.jpg", "sha256": "83265c25195f5d0202c06ec27684759dfc5d3b8b251651684a5e27d1b73b1449", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-NECROSIS-F05", "map_image_id": "BMPM-IMG-0166", "source_id": "NTP-BONE-MARROW-NECROSIS", "title_cn": "正常骨髓向坏死区的过渡", "title_en": "Transition from viable marrow to necrosis", "description_cn": "慢性研究雄性B6C3F1小鼠骨髓从正常造血区过渡到细节丧失、含无定形嗜酸性碎屑的大片坏死区。", "description_en": "Marrow from a male B6C3F1 mouse showing transition from viable hematopoietic tissue to a large necrotic area with loss of cellular detail and amorphous eosinophilic debris.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Degenerative_change", "secondary_features": [ "Necrosis", "Amorphous_eosinophilic_debris", "Transition_zone" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 5", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "caption_original_en": "Bone marrow in a male B6C3F1 mouse from a chronic study (low magnification), showing normal hematopoietic cells (white asterisk) transitioning to a large area of necrosis characterized by loss of cellular detail and areas of amorphous eosinophilic debris (black asterisk).", "article_title": "Bone marrow - Necrosis - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/necrosis/images/figure-005-a64194_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Necrosis - Nonneoplastic Lesion Atlas, Figure 5. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-NECROSIS-F05.jpg", "preview_path": "previews/BM-NTP-NECROSIS-F05.jpg", "sha256": "812618b4c2aa46c687f6ac5c747c4c272b227892cdd7bca127a2c092a72883e2", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-FIBROSIS-F01", "map_image_id": "BMPM-IMG-0287", "source_id": "NTP-BONE-MARROW-FIBROSIS", "title_cn": "大鼠骨髓致密纤维化伴血管扩张（低倍）", "title_en": "Dense marrow fibrosis with angiectasis in rat, low power", "description_cn": "慢性研究雄性F344/N大鼠骨髓内见致密纤维组织，周围伴血管扩张。低倍用于识别病灶范围与邻近髓腔关系。", "description_en": "Low-power marrow from a male F344/N rat showing dense fibrous tissue surrounded by angiectasis, useful for assessing lesion extent and relationship to adjacent marrow.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Stromal_nonhematopoietic", "maturation_stage": "NR", "primary_morphology_class": "Stromal_or_microenvironment_change", "secondary_features": [ "Fibrosis", "Angiectasis", "Low_power" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 1", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Fibrosis", "caption_original_en": "Dense fibrous tissue surrounded by areas of angiectasis is present in bone marrow in a male F344/N rat from a chronic study.", "article_title": "Bone marrow - Fibrosis - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Fibrosis", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/fibrosis/images/figure-001-a56176_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Fibrosis - Nonneoplastic Lesion Atlas, Figure 1. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-FIBROSIS-F01.jpg", "preview_path": "previews/BM-NTP-FIBROSIS-F01.jpg", "sha256": "630fb693457096dffbc68d245589594aaa8ba452a74b8bdda9800c00422e4f80", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-FIBROSIS-F02", "map_image_id": "BMPM-IMG-0288", "source_id": "NTP-BONE-MARROW-FIBROSIS", "title_cn": "大鼠骨髓致密纤维化（高倍）", "title_en": "Dense marrow fibrosis in rat, higher magnification", "description_cn": "Figure 1的高倍视图，显示致密嗜酸性纤维组织及梭形细胞，并保留周围血管扩张背景。必要时应结合网状纤维或三色染色。", "description_en": "Higher-magnification view of Figure 1 showing dense eosinophilic fibrous tissue and spindle cells with surrounding angiectasis. Reticulin or trichrome stains may be needed for confirmation.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Stromal_nonhematopoietic", "maturation_stage": "NR", "primary_morphology_class": "Stromal_or_microenvironment_change", "secondary_features": [ "Fibrosis", "Angiectasis", "Higher_magnification" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 2", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Fibrosis", "caption_original_en": "Higher magnification of Figure 1 showing dense fibrous tissue surrounded by areas of angiectasis in bone marrow in a male F344/N rat from a chronic study.", "article_title": "Bone marrow - Fibrosis - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Fibrosis", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/fibrosis/images/figure-002-a71907_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Fibrosis - Nonneoplastic Lesion Atlas, Figure 2. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-FIBROSIS-F02.jpg", "preview_path": "previews/BM-NTP-FIBROSIS-F02.jpg", "sha256": "9ffa078eddf31be5284197137b94374e3849bb044dc879ed67a8ee512e9b3ed1", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-FIBROSIS-F03", "map_image_id": "BMPM-IMG-0289", "source_id": "NTP-BONE-MARROW-FIBROSIS", "title_cn": "大鼠骨髓致密纤维化（另一高倍视野）", "title_en": "Dense marrow fibrosis in rat, alternate higher-power field", "description_cn": "同一病灶的另一高倍视野，显示纤维束、梭形细胞和邻近骨小梁。不能仅凭HE判断原发性髓纤维化或具体病因。", "description_en": "Alternate higher-power view of the same lesion showing fibrous bundles, spindle cells, and adjacent trabecular bone. H&E alone does not establish primary myelofibrosis or a specific cause.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Stromal_nonhematopoietic", "maturation_stage": "NR", "primary_morphology_class": "Stromal_or_microenvironment_change", "secondary_features": [ "Fibrosis", "Angiectasis", "Higher_magnification" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 3", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Fibrosis", "caption_original_en": "Higher magnification of Figure 1 showing dense fibrous tissue surrounded by areas of angiectasis in bone marrow in a male F344/N rat from a chronic study.", "article_title": "Bone marrow - Fibrosis - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Fibrosis", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/fibrosis/images/figure-003-a71909_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Fibrosis - Nonneoplastic Lesion Atlas, Figure 3. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-FIBROSIS-F03.jpg", "preview_path": "previews/BM-NTP-FIBROSIS-F03.jpg", "sha256": "f74a32399b51aa1902845d58874a2881b4b6e98a445464e39e96e685101c71ed", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-ANGIECTASIS-F01", "map_image_id": "BMPM-IMG-0179", "source_id": "NTP-BONE-MARROW-ANGIECTASIS", "title_cn": "小鼠骨髓血管扩张（第一组，低倍）", "title_en": "Bone marrow angiectasis in mouse, first low-power example", "description_cn": "慢性研究雌性B6C3F1小鼠骨髓窦扩张并充满血液。识别时应确认完整内皮衬里，并与出血及形成肿块的血管瘤鉴别。", "description_en": "Low-power marrow from a female B6C3F1 mouse showing blood-filled dilated sinusoids. An intact endothelial lining supports angiectasis and helps distinguish it from hemorrhage; a circumscribed mass would raise hemangioma as a differential.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Stromal_nonhematopoietic", "maturation_stage": "NR", "primary_morphology_class": "Stromal_or_microenvironment_change", "secondary_features": [ "Angiectasis", "Dilated_marrow_sinusoids", "Blood_filled_spaces", "Low_power" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 1", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "caption_original_en": "Angiectasis in the bone marrow sinuses in a female B6C3F1 mouse from a chronic study.", "article_title": "Bone marrow - Angiectasis - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/angiect/images/figure-001-a64147_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Angiectasis - Nonneoplastic Lesion Atlas, Figure 1. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-ANGIECTASIS-F01.jpg", "preview_path": "previews/BM-NTP-ANGIECTASIS-F01.jpg", "sha256": "d7657ca8efc4ecde95f404de93ef1bf308015d23e903004ed58649a4a77abd59", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-ANGIECTASIS-F02", "map_image_id": "BMPM-IMG-0177", "source_id": "NTP-BONE-MARROW-ANGIECTASIS", "title_cn": "小鼠骨髓血管扩张（第一组，高倍）", "title_en": "Bone marrow angiectasis in mouse, first higher-power example", "description_cn": "Figure 1的高倍视图，突出显示扩张骨髓窦的边界和内皮衬里。该形态不应仅凭血液充盈区误报为出血。", "description_en": "Higher-magnification view of Figure 1 emphasizing the margins and endothelial lining of the dilated marrow sinusoids. Blood-filled spaces alone should not be reported as hemorrhage without examining the lining.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Stromal_nonhematopoietic", "maturation_stage": "NR", "primary_morphology_class": "Stromal_or_microenvironment_change", "secondary_features": [ "Angiectasis", "Dilated_marrow_sinusoids", "Endothelial_lining", "Higher_magnification" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 2", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "caption_original_en": "Angiectasis in the bone marrow sinuses in a female B6C3F1 mouse from a chronic study (higher magnification of Figure 1).", "article_title": "Bone marrow - Angiectasis - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/angiect/images/figure-002-a64148_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Angiectasis - Nonneoplastic Lesion Atlas, Figure 2. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-ANGIECTASIS-F02.jpg", "preview_path": "previews/BM-NTP-ANGIECTASIS-F02.jpg", "sha256": "ad445d9d83c33104b4c5458de9fc0300dca34edc83b1c5d41e2e6e5820218dec", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-ANGIECTASIS-F03", "map_image_id": "BMPM-IMG-0180", "source_id": "NTP-BONE-MARROW-ANGIECTASIS", "title_cn": "小鼠骨髓血管扩张（第二组，低倍）", "title_en": "Bone marrow angiectasis in mouse, second low-power example", "description_cn": "另一只慢性研究雌性B6C3F1小鼠的骨髓血管扩张低倍示例。与Figures 1-2为不同图组，不应视为同一动物的时序变化。", "description_en": "A second low-power example of marrow angiectasis in a female B6C3F1 mouse from a chronic study. It is a separate teaching set from Figures 1-2 and not a longitudinal image from the same animal.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Stromal_nonhematopoietic", "maturation_stage": "NR", "primary_morphology_class": "Stromal_or_microenvironment_change", "secondary_features": [ "Angiectasis", "Dilated_marrow_sinusoids", "Blood_filled_spaces", "Low_power" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 3", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "caption_original_en": "Angiectasis in the bone marrow sinuses in a female B6C3F1 mouse from a chronic study.", "article_title": "Bone marrow - Angiectasis - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/angiect/images/figure-003-a64156_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Angiectasis - Nonneoplastic Lesion Atlas, Figure 3. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-ANGIECTASIS-F03.jpg", "preview_path": "previews/BM-NTP-ANGIECTASIS-F03.jpg", "sha256": "f762924ff3101921e4935435fbf8627bd151711e1f729f216e5f2f636cfc2acb", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-ANGIECTASIS-F04", "map_image_id": "BMPM-IMG-0178", "source_id": "NTP-BONE-MARROW-ANGIECTASIS", "title_cn": "小鼠骨髓血管扩张（第二组，高倍）", "title_en": "Bone marrow angiectasis in mouse, second higher-power example", "description_cn": "Figure 3的高倍视图，用于复核扩张窦状隙的内皮结构及周围造血组织。病因和处理相关性需结合研究背景。", "description_en": "Higher-magnification view of Figure 3 for assessing the endothelial structure of the dilated sinusoids and adjacent hematopoietic tissue. Cause and treatment relationship require study context.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Stromal_nonhematopoietic", "maturation_stage": "NR", "primary_morphology_class": "Stromal_or_microenvironment_change", "secondary_features": [ "Angiectasis", "Dilated_marrow_sinusoids", "Endothelial_lining", "Higher_magnification" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 4", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "caption_original_en": "Angiectasis in the bone marrow sinuses in a female B6C3F1 mouse from a chronic study (higher magnification of Figure 3).", "article_title": "Bone marrow - Angiectasis - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/angiect/images/figure-004-a64157_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Angiectasis - Nonneoplastic Lesion Atlas, Figure 4. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-ANGIECTASIS-F04.jpg", "preview_path": "previews/BM-NTP-ANGIECTASIS-F04.jpg", "sha256": "ae5b2ddb2c296e4dd17ef20c2c0ca416f176d3bb4a9fcb8faecfb99fe1a4f93a", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HISTIOCYTE-F01", "map_image_id": "BMPM-IMG-0315", "source_id": "NTP-BONE-MARROW-INFILTRATIONCELLULARHISTIOCYTE", "title_cn": "大鼠骨髓组织细胞浸润（箭头示例）", "title_en": "Histiocytic infiltration in rat bone marrow, arrowed example", "description_cn": "2年研究雌性F344/N大鼠骨髓内，箭头标示散在的淡染、空泡化组织细胞。该诊断适用于缺乏其他明显炎症证据的组织细胞增加。", "description_en": "Marrow from a female F344/N rat in a 2-year study showing scattered pale, vacuolated histiocytes indicated by arrows. The term is used when histiocytes are increased without other clear evidence of inflammation.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Monocytic_macrophagic", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Histiocyte_increase", "Pale_vacuolated_histiocytes", "Arrowed_cells" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 1", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "caption_original_en": "Bone marrow in a female F344/N rat from a 2-year study. Increased numbers of pale-staining vacuolated histiocytes (arrows) can be seen among the hematopoietic cells.", "article_title": "Bone marrow - Histiocytic Infiltration - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/infilhi/images/figure-001-a69254_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Histiocytic Infiltration - Nonneoplastic Lesion Atlas, Figure 1. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HISTIOCYTE-F01.jpg", "preview_path": "previews/BM-NTP-HISTIOCYTE-F01.jpg", "sha256": "cdfcfe0c68de5e91b9889e43208326d2fd1d3adfd735fa3c747a2df4039d303d", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HISTIOCYTE-F02", "map_image_id": "BMPM-IMG-0313", "source_id": "NTP-BONE-MARROW-INFILTRATIONCELLULARHISTIOCYTE", "title_cn": "大鼠骨髓淡染空泡化组织细胞增加", "title_en": "Increased pale vacuolated histiocytes in rat bone marrow", "description_cn": "造血细胞之间可见增多的淡染空泡化组织细胞。若伴上皮样或多核巨噬细胞、其他炎细胞或水肿，应优先考虑肉芽肿性炎症。", "description_en": "Increased pale, vacuolated histiocytes are present among hematopoietic cells. Epithelioid or multinucleated macrophages, other inflammatory cells, or edema would favor granulomatous inflammation instead.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Monocytic_macrophagic", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Histiocyte_increase", "Pale_vacuolated_histiocytes" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 2", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "caption_original_en": "Bone marrow in a female F344/N rat from a 2-year study. Increased numbers of pale-staining vacuolated histiocytes can be seen among the hematopoietic cells.", "article_title": "Bone marrow - Histiocytic Infiltration - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/infilhi/images/figure-002-a69255_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Histiocytic Infiltration - Nonneoplastic Lesion Atlas, Figure 2. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HISTIOCYTE-F02.jpg", "preview_path": "previews/BM-NTP-HISTIOCYTE-F02.jpg", "sha256": "43c56b8158025e2eeab980458e6bdb75859851adba65a036f071eb501a931092", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HISTIOCYTE-F03", "map_image_id": "BMPM-IMG-0316", "source_id": "NTP-BONE-MARROW-INFILTRATIONCELLULARHISTIOCYTE", "title_cn": "大鼠骨髓含胆固醇结晶的组织细胞浸润", "title_en": "Histiocytic infiltration with cholesterol crystals in rat bone marrow", "description_cn": "淡染空泡化组织细胞内可见胆固醇结晶。该图支持识别组织细胞内容物，但不应据此推断具体病因或处理相关性。", "description_en": "Pale, vacuolated histiocytes contain cholesterol crystals. The image supports recognition of histiocytic contents but does not establish a specific cause or treatment relationship.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Monocytic_macrophagic", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Histiocyte_increase", "Pale_vacuolated_histiocytes", "Cholesterol_crystals" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 3", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "caption_original_en": "Bone marrow in a female F344/N rat from a 2-year study. Increased numbers of pale-staining vacuolated histiocytes containing cholesterol crystals can be seen among the hematopoietic cells.", "article_title": "Bone marrow - Histiocytic Infiltration - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/infilhi/images/figure-003-a69256_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Histiocytic Infiltration - Nonneoplastic Lesion Atlas, Figure 3. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HISTIOCYTE-F03.jpg", "preview_path": "previews/BM-NTP-HISTIOCYTE-F03.jpg", "sha256": "f2721d9c9e426139d81122846426fb025659bbda0a949c3af2e1eab622b13786", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-HISTIOCYTE-F04", "map_image_id": "BMPM-IMG-0314", "source_id": "NTP-BONE-MARROW-INFILTRATIONCELLULARHISTIOCYTE", "title_cn": "大鼠骨髓组织细胞浸润（另一视野）", "title_en": "Histiocytic infiltration in rat bone marrow, alternate field", "description_cn": "另一骨髓视野显示散在淡染空泡化组织细胞。组织细胞浸润通常为反应性改变，但病因可能不明确。", "description_en": "An alternate marrow field showing scattered pale, vacuolated histiocytes. Histiocytic infiltration is generally reactive, although its cause may remain unclear.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Monocytic_macrophagic", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Histiocyte_increase", "Pale_vacuolated_histiocytes" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 4", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "caption_original_en": "Bone marrow in a female F344/N rat from a 2-year study. Increased numbers of pale-staining vacuolated histiocytes can be seen among the hematopoietic cells.", "article_title": "Bone marrow - Histiocytic Infiltration - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/infilhi/images/figure-004-a69257_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Histiocytic Infiltration - Nonneoplastic Lesion Atlas, Figure 4. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-HISTIOCYTE-F04.jpg", "preview_path": "previews/BM-NTP-HISTIOCYTE-F04.jpg", "sha256": "608c64efa7bf1371a8c1e3916aa44769e496b67c9f9ef324f38944904088f1cc", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-MASTCELL-F01", "map_image_id": "BMPM-IMG-0318", "source_id": "NTP-BONE-MARROW-INFILTRATIONCELLULARMASTCELL", "title_cn": "大鼠骨髓肥大细胞增加（H&E，箭头）", "title_en": "Increased marrow mast cells in rat, H&E arrowed example", "description_cn": "慢性研究雌性F344/N大鼠骨髓内散在肥大细胞增加，箭头标示代表性细胞。该术语用于形态正常的反应性肥大细胞增加，不应自动写为mastocytosis。", "description_en": "H&E section from a female F344/N rat showing a loose increase in morphologically normal mast cells indicated by arrows. This reactive pattern should not automatically be called mastocytosis.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Mast_cell", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Mast_cell_increase", "Loose_scattered_distribution", "Arrowed_cells" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 1", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "caption_original_en": "Bone marrowin a female F344/N rat from a chronic study showing increased mast cells (arrows).", "article_title": "Bone marrow - Mast Cell Infiltration - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/infilmc/images/figure-001-a71464_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Mast Cell Infiltration - Nonneoplastic Lesion Atlas, Figure 1. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-MASTCELL-F01.jpg", "preview_path": "previews/BM-NTP-MASTCELL-F01.jpg", "sha256": "81c2d3afeb477fe615e4aee7f3039056867c1d73b8964f454a0ebbe66280ea2c", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-MASTCELL-F02", "map_image_id": "BMPM-IMG-0317", "source_id": "NTP-BONE-MARROW-INFILTRATIONCELLULARMASTCELL", "title_cn": "大鼠骨髓肥大细胞增加（H&E，另一视野）", "title_en": "Increased marrow mast cells in rat, alternate H&E field", "description_cn": "H&E切片中的另一视野，箭头标示增多的肥大细胞。大鼠骨髓本可含较多肥大细胞，诊断时应与同期对照比较。", "description_en": "An alternate H&E field with arrows indicating increased mast cells. Rat marrow may normally contain appreciable mast-cell numbers, so comparison with concurrent controls is important.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Mast_cell", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Mast_cell_increase", "Loose_scattered_distribution", "Concurrent_control_comparison" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 2", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "caption_original_en": "Bone marrow in a female F344/N rat from a chronic study showing increased mast cells (arrows).", "article_title": "Bone marrow - Mast Cell Infiltration - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/infilmc/images/figure-002-a71466_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Mast Cell Infiltration - Nonneoplastic Lesion Atlas, Figure 2. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-MASTCELL-F02.jpg", "preview_path": "previews/BM-NTP-MASTCELL-F02.jpg", "sha256": "118d4dc4bcce1bc1faf28ee1eccf184bb26446987627163114ccdb751f083413", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-MASTCELL-F03", "map_image_id": "BMPM-IMG-0319", "source_id": "NTP-BONE-MARROW-INFILTRATIONCELLULARMASTCELL", "title_cn": "大鼠骨髓肥大细胞增加（Giemsa）", "title_en": "Increased marrow mast cells in rat, Giemsa stain", "description_cn": "Giemsa染色使肥大细胞紫色胞质颗粒更易识别。该图用于辅助确认细胞身份，不代表所有病例均必须使用特殊染色。", "description_en": "Giemsa staining makes mast cells easier to identify by their purple cytoplasmic granules. This is an identification aid and does not imply that special staining is required in every case.", "species": "Rat", "strain": "F344/N", "specimen_type": "Special_stain", "stain": "Giemsa", "lineage": "Mast_cell", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Mast_cell_increase", "Purple_cytoplasmic_granules", "Special_stain" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 3", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "caption_original_en": "Bone marrow in a male F344/N rat from a chronic study. Stained with Giemsa, increased numbers of mast cells (arrows) are easily identified by their purple cytoplasmic granules.", "article_title": "Bone marrow - Mast Cell Infiltration - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/infilmc/images/figure-003-a71467_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Mast Cell Infiltration - Nonneoplastic Lesion Atlas, Figure 3. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-MASTCELL-F03.jpg", "preview_path": "previews/BM-NTP-MASTCELL-F03.jpg", "sha256": "b559ae88473833f443ebbf59c713610319ec624141b83ecd5373e883d50c573e", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-MASTCELL-F04", "map_image_id": "BMPM-IMG-0320", "source_id": "NTP-BONE-MARROW-INFILTRATIONCELLULARMASTCELL", "title_cn": "大鼠骨髓肥大细胞增加（Giemsa，高倍）", "title_en": "Increased marrow mast cells in rat, higher-power Giemsa view", "description_cn": "Figure 3的高倍视图，突出肥大细胞紫色胞质颗粒。评价数量增加仍需结合低倍分布及同期对照。", "description_en": "Higher-magnification view of Figure 3 highlighting the purple cytoplasmic granules of mast cells. Assessment of an increase still requires low-power distribution and concurrent controls.", "species": "Rat", "strain": "F344/N", "specimen_type": "Special_stain", "stain": "Giemsa", "lineage": "Mast_cell", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Mast_cell_increase", "Purple_cytoplasmic_granules", "Higher_magnification" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 4", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "caption_original_en": "Bone marrow in a male F344/N rat from a chronic study (higher magnification of Figure 3). Mast cells are easily identified by their purple cytoplasmic granules.", "article_title": "Bone marrow - Mast Cell Infiltration - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/infilmc/images/figure-004-a71911_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Mast Cell Infiltration - Nonneoplastic Lesion Atlas, Figure 4. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-MASTCELL-F04.jpg", "preview_path": "previews/BM-NTP-MASTCELL-F04.jpg", "sha256": "eb51b65662a58dddbc4f0a6b5c4d341079a99c542af5dbed1c962608e1c86240", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-GELATINOUS-F01", "map_image_id": "BMPM-IMG-0292", "source_id": "NTP-BONE-MARROW-GELATINOUSTRANSFORMATION", "title_cn": "大鼠骨髓胶样变（低倍）", "title_en": "Gelatinous transformation of rat bone marrow, low power", "description_cn": "亚慢性研究雌性F344/N大鼠骨髓胶样变，表现为重度低细胞性、脂肪细胞萎缩和嗜酸性颗粒状基质。该模式常与恶病质、严重营养不足或晚期疾病相关。", "description_en": "Low-power gelatinous transformation in a female F344/N rat, characterized by severe hypocellularity, atrophied adipocytes, and eosinophilic granular ground substance. The pattern is associated with cachexia, severe undernutrition, or advanced illness.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Stromal_nonhematopoietic", "maturation_stage": "NR", "primary_morphology_class": "Stromal_or_microenvironment_change", "secondary_features": [ "Gelatinous_transformation", "Hypocellularity", "Atrophied_adipocytes", "Ground_substance" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/GelatinousTransformation", "caption_original_en": "Gelatinous transformation of bone marrow in a female F344/N rat from a subchronic study. The marrow is characterized by severe hypocellularity, atrophied fat cells, and the presence of eosinophilic granular ground substance.", "article_title": "Bone marrow - Gelatinous Transformation - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/GelatinousTransformation", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/geltrans/images/figure-001-a71651_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Gelatinous Transformation - Nonneoplastic Lesion Atlas, Figure 1. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-GELATINOUS-F01.jpg", "preview_path": "previews/BM-NTP-GELATINOUS-F01.jpg", "sha256": "ba2a6e1b8c93613f869a5419798cdbc2af3cf77871592c77493f48cf9848787b", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-GELATINOUS-F02", "map_image_id": "BMPM-IMG-0291", "source_id": "NTP-BONE-MARROW-GELATINOUSTRANSFORMATION", "title_cn": "大鼠骨髓胶样变（中倍）", "title_en": "Gelatinous transformation of rat bone marrow, intermediate view", "description_cn": "中倍视图显示造血细胞与脂肪细胞丢失，以及替代性嗜酸性颗粒状基质。推荐使用gelatinous transformation，避免沿用含混的旧式命名。", "description_en": "Intermediate view showing loss of hematopoietic cells and adipocytes with replacement by eosinophilic granular ground substance. Gelatinous transformation is the preferred term; ambiguous historical labels should be avoided.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Stromal_nonhematopoietic", "maturation_stage": "NR", "primary_morphology_class": "Stromal_or_microenvironment_change", "secondary_features": [ "Gelatinous_transformation", "Hypocellularity", "Adipocyte_loss", "Ground_substance" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 2", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/GelatinousTransformation", "caption_original_en": "Gelatinous transformation of bone marrow in a female F344/N rat from a subchronic study. The marrow is characterized by severe hypocellularity, atrophied fat cells, and the presence of eosinophilic granular ground substance.", "article_title": "Bone marrow - Gelatinous Transformation - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/GelatinousTransformation", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/geltrans/images/figure-002-a71654_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Gelatinous Transformation - Nonneoplastic Lesion Atlas, Figure 2. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-GELATINOUS-F02.jpg", "preview_path": "previews/BM-NTP-GELATINOUS-F02.jpg", "sha256": "b9a44db68ac313f0a1cd4552170739393c0f74ce18421041c17888efc3cd521f", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-GELATINOUS-F03", "map_image_id": "BMPM-IMG-0290", "source_id": "NTP-BONE-MARROW-GELATINOUSTRANSFORMATION", "title_cn": "大鼠骨髓胶样变（高倍）", "title_en": "Gelatinous transformation of rat bone marrow, higher magnification", "description_cn": "高倍视图突出显示萎缩脂肪细胞、残余造血细胞和嗜酸性颗粒状基质。应与单纯低细胞性或脂肪性替代区分。", "description_en": "Higher-magnification view highlighting atrophied adipocytes, residual hematopoietic cells, and eosinophilic granular ground substance. It should be distinguished from simple hypocellularity or fatty replacement.", "species": "Rat", "strain": "F344/N", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Stromal_nonhematopoietic", "maturation_stage": "NR", "primary_morphology_class": "Stromal_or_microenvironment_change", "secondary_features": [ "Gelatinous_transformation", "Hypocellularity", "Atrophied_adipocytes", "Ground_substance", "Higher_magnification" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 3", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/GelatinousTransformation", "caption_original_en": "Higher magnification of gelatinous transformation of bone marrow in a female F344/N rat from a subchronic study. The marrow is characterized by severe hypocellularity, atrophied fat cells, and the presence of eosinophilic granular ground substance.", "article_title": "Bone marrow - Gelatinous Transformation - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/GelatinousTransformation", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/geltrans/images/figure-003-a71653_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Gelatinous Transformation - Nonneoplastic Lesion Atlas, Figure 3. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-GELATINOUS-F03.jpg", "preview_path": "previews/BM-NTP-GELATINOUS-F03.jpg", "sha256": "81a0ad3f91319954406f7c2042eeffa94241ff19308d399c4ef469aeb03e1fe8", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-PIGMENT-F01", "map_image_id": "BMPM-IMG-0174", "source_id": "NTP-BONE-MARROW-PIGMENT", "title_cn": "小鼠骨髓少量金棕色色素", "title_en": "Low amount of golden-brown pigment in mouse bone marrow", "description_cn": "亚慢性研究雄性B6C3F1小鼠骨髓内见少量金棕色色素。未用铁染色确认前，推荐诊断为pigment，而不直接命名为hemosiderin。", "description_en": "A low amount of golden-brown pigment is present in marrow from a male B6C3F1 mouse in a subchronic study. Without confirmatory iron staining, the preferred diagnosis is pigment rather than hemosiderin.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Monocytic_macrophagic", "maturation_stage": "NR", "primary_morphology_class": "Expected_background_variation", "secondary_features": [ "Pigment", "Golden_brown_pigment", "Low_amount", "Hemosiderin_unconfirmed" ], "evidence_role": "Background_comparator", "causality_level": "Uncertain", "figure_label": "Figure 1", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Pigment", "caption_original_en": "Low amounts of golden brown pigment in bone marrow in a male B6C3F1 mouse from a subchronic study.", "article_title": "Bone marrow - Pigment - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Pigment", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/pigment/images/figure-001-a24022_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Pigment - Nonneoplastic Lesion Atlas, Figure 1. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-PIGMENT-F01.jpg", "preview_path": "previews/BM-NTP-PIGMENT-F01.jpg", "sha256": "becbb43c4d6b928e9ff5a779513e58bd929d47429b771d086d1fa7985d9a3de3", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-NTP-PIGMENT-F02", "map_image_id": "BMPM-IMG-0175", "source_id": "NTP-BONE-MARROW-PIGMENT", "title_cn": "小鼠骨髓中等量金棕色色素", "title_en": "Moderate amount of golden-brown pigment in mouse bone marrow", "description_cn": "慢性研究雄性B6C3F1小鼠骨髓内见中等量金棕色色素。该图与Figure 1来自不同研究，仅用于程度教学比较；铁染色前不确认含铁血黄素。", "description_en": "A moderate amount of golden-brown pigment is present in marrow from a male B6C3F1 mouse in a chronic study. This is from a different study than Figure 1 and is only a severity teaching comparison; hemosiderin remains unconfirmed without iron staining.", "species": "Mouse", "strain": "B6C3F1", "specimen_type": "Histology_HE", "stain": "NR", "lineage": "Monocytic_macrophagic", "maturation_stage": "NR", "primary_morphology_class": "Uncertain", "secondary_features": [ "Pigment", "Golden_brown_pigment", "Moderate_amount", "Hemosiderin_unconfirmed" ], "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "figure_label": "Figure 2", "panel_label": "NR", "source_page": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Pigment", "caption_original_en": "Moderate amounts of golden brown pigment in bone marrow in a male B6C3F1 mouse from a chronic study.", "article_title": "Bone marrow - Pigment - Nonneoplastic Lesion Atlas", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Pigment", "source_media_url": "https://ntp.niehs.nih.gov/sites/default/files/nnl/hematopoietic/bone_marrow/pigment/images/figure-002-a26454_large.jpg", "license": "Public domain", "license_url": "https://ntp.niehs.nih.gov/support/policies", "reuse_status": "public_domain", "attribution": "National Toxicology Program (NTP), Nonneoplastic Lesion Atlas. Bone marrow - Pigment - Nonneoplastic Lesion Atlas, Figure 2. Accessed 2026-08-11.", "third_party_credit_line": "None observed on the source page as of 2026-08-11", "rights_basis": "NTP Web Policies state that NTP website information is in the public domain unless copyright is indicated. No image-specific copyright, credit, courtesy, or permission marker was observed on the ten audited lesion pages on 2026-08-11.", "rights_reviewed_at": "2026-08-11", "expert_review_status": "Pending", "asset_path": "images/BM-NTP-PIGMENT-F02.jpg", "preview_path": "previews/BM-NTP-PIGMENT-F02.jpg", "sha256": "ccdebd099d4eec49a77261607cd258757d7883442ca6af9f68f2435d78049a82", "processing_note": "Exact NTP source image copied without pixel modification; source figure number and embedded annotations are retained.", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-NC-RAT-CP-RJ-F04-A", "map_image_id": "NR", "source_id": "LEGACY-RPBM-002", "title_cn": "Wistar大鼠股骨骨髓对照：保留的造血组织结构", "title_en": "Wistar rat femoral marrow control: preserved hematopoietic architecture", "description_cn": "Figure 4A为未处理对照组股骨骨髓H&E切片，原作者报告无病理改变。该代表视野用于与同一Figure中的环磷酰胺组比较；单一视野不能替代全切片细胞量评分、细胞系定量或同期CBC。", "description_en": "Figure 4A is an H&E-stained femoral marrow section from the untreated control group, described by the authors as showing no pathological change. It is a same-study comparator for the cyclophosphamide group; one field does not replace whole-section cellularity scoring, lineage quantitation, or concurrent CBC.", "species": "Rat", "strain": "Male Wistar rat, 200 ± 20 g", "specimen_type": "Histology_HE", "stain": "H&E; objective 40×; scale bar 100 µm", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Expected_background_variation", "secondary_features": [ "Untreated_control", "Preserved_hematopoietic_architecture" ], "evidence_role": "Normal_comparator", "causality_level": "Differential_only", "figure_label": "Figure 4", "panel_label": "A — untreated control marrow", "source_page": "Figure 4, panel A", "caption_original_en": "Hisopathological changes of femoral bone marrow in different groups. A. The Control, B. R100, C. R200 groups, showing no pathological changes, megakaryocytes (ð). D. The CP group with decreased cellularity in hematopoietic cells (&), severe hemorrhage (∑) and adipose-like cells (α), E. CP+100 group, and F. CP+200 group (H&E, ×40) (scale bar: 100 µm). CP; Cyclophosphamide and R; Royal Jelly.", "article_title": "Protective Effect of Royal Jelly against Cyclophosphamide-Induced Thrombocytopenia and Spleen and Bone Marrow Damages in Rats", "authors": "Khazaei F, Ghanbari E, Khazaei M", "journal": "Cell Journal (Yakhteh)", "year": "2020", "doi": "10.22074/cellj.2020.6703", "pmid": "31863655", "pmcid": "PMC6947013", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6947013/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c6/6947013/bde8fefefac4/Cell-J-22-302-g04.jpg", "license": "CC BY-NC 3.0", "license_url": "https://creativecommons.org/licenses/by-nc/3.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Khazaei F, Ghanbari E, Khazaei M. Protective Effect of Royal Jelly against Cyclophosphamide-Induced Thrombocytopenia and Spleen and Bone Marrow Damages in Rats. Cell Journal (Yakhteh). 2020. doi:10.22074/cellj.2020.6703. Figure 4, A — untreated control marrow. CC BY-NC 3.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 4 legend", "rights_basis": "The article copyright statement permits noncommercial reuse and adaptation with attribution under CC BY-NC 3.0. Exact-pixel panel crops preserve panel letters, arrows, source symbols, scale bars, and full microscopic fields and remain linked to complete Figure 4. The locally retained JATS contains conflicting CC BY and CC BY-NC labels. The copyright statement and article citation explicitly identify CC BY-NC 3.0, so the more restrictive CC BY-NC 3.0 interpretation is used. Figure 4 has no separate third-party credit line.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-NC-RAT-CP-RJ-F04-A.png", "preview_path": "previews/BM-CC-NC-RAT-CP-RJ-F04-A.jpg", "sha256": "996f65e7ba2b50065758bc66bc1f5f9bb55ef09cbe50d4b7888cf291b6585cf4", "processing_note": "Exact-pixel crop of Figure 4A at parent coordinates [0,0,352,327]. The panel letter, complete microscopic field, and 100 µm scale bar are retained; no resampling, retouching, visual enhancement, or generative modification was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC6947013-FIGURE-4", "parent_sha256": "f43a66a1021e4ff0447075c673cd71dc745afaee4e5f2d380ffde6182154eedc", "parent_asset_path": "images/PMC6947013-FIGURE-4.jpg", "crop_coordinates": [ 0, 0, 352, 327 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-NC-RAT-CP-RJ-F04-D", "map_image_id": "NR", "source_id": "LEGACY-RPBM-002", "title_cn": "环磷酰胺处理大鼠骨髓：造血细胞减少、出血和脂肪样空隙增加", "title_en": "Cyclophosphamide-treated rat marrow: reduced hematopoietic cells, hemorrhage, and increased adipose-like spaces", "description_cn": "Figure图注及图内符号将Panel D标为CP组，并指出造血细胞减少、重度出血和脂肪样细胞增加。正文一处误写为Fig.4B，网站不隐藏这一来源内冲突，当前按图注和图内标记映射为D。该图支持处理相关骨髓损伤的代表性形态，但不能单独量化严重度、谱系选择性或不良性。", "description_en": "The figure legend and in-image symbols identify panel D as the cyclophosphamide group with reduced hematopoietic cellularity, severe hemorrhage, and increased adipose-like cells. The prose inconsistently cites Fig. 4B; the atlas preserves this source conflict and follows the legend and annotations. The field supports representative treatment-associated marrow injury but does not independently quantify severity, lineage selectivity, or adversity.", "species": "Rat", "strain": "Male Wistar rat, 200 ± 20 g", "specimen_type": "Histology_HE", "stain": "H&E; objective 40×; scale bar 100 µm", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Cytotoxic_change", "secondary_features": [ "Hematopoietic_cell_decrease", "Hemorrhage_severe_author_reported", "Adipose_like_cell_increase_author_reported" ], "evidence_role": "Toxicity_image", "causality_level": "Author_attributed", "figure_label": "Figure 4", "panel_label": "D — cyclophosphamide marrow injury", "source_page": "Figure 4, panel D; article text inconsistently cites panel B", "caption_original_en": "Hisopathological changes of femoral bone marrow in different groups. A. The Control, B. R100, C. R200 groups, showing no pathological changes, megakaryocytes (ð). D. The CP group with decreased cellularity in hematopoietic cells (&), severe hemorrhage (∑) and adipose-like cells (α), E. CP+100 group, and F. CP+200 group (H&E, ×40) (scale bar: 100 µm). CP; Cyclophosphamide and R; Royal Jelly.", "article_title": "Protective Effect of Royal Jelly against Cyclophosphamide-Induced Thrombocytopenia and Spleen and Bone Marrow Damages in Rats", "authors": "Khazaei F, Ghanbari E, Khazaei M", "journal": "Cell Journal (Yakhteh)", "year": "2020", "doi": "10.22074/cellj.2020.6703", "pmid": "31863655", "pmcid": "PMC6947013", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6947013/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c6/6947013/bde8fefefac4/Cell-J-22-302-g04.jpg", "license": "CC BY-NC 3.0", "license_url": "https://creativecommons.org/licenses/by-nc/3.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Khazaei F, Ghanbari E, Khazaei M. Protective Effect of Royal Jelly against Cyclophosphamide-Induced Thrombocytopenia and Spleen and Bone Marrow Damages in Rats. Cell Journal (Yakhteh). 2020. doi:10.22074/cellj.2020.6703. Figure 4, D — cyclophosphamide marrow injury. CC BY-NC 3.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 4 legend", "rights_basis": "The article copyright statement permits noncommercial reuse and adaptation with attribution under CC BY-NC 3.0. Exact-pixel panel crops preserve panel letters, arrows, source symbols, scale bars, and full microscopic fields and remain linked to complete Figure 4. The locally retained JATS contains conflicting CC BY and CC BY-NC labels. The copyright statement and article citation explicitly identify CC BY-NC 3.0, so the more restrictive CC BY-NC 3.0 interpretation is used. Figure 4 has no separate third-party credit line.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-NC-RAT-CP-RJ-F04-D.png", "preview_path": "previews/BM-CC-NC-RAT-CP-RJ-F04-D.jpg", "sha256": "45f94e92ee1e46a77096fd4d0216398c951c91912f53d32ba6298e479638f0e3", "processing_note": "Exact-pixel crop of Figure 4D at parent coordinates [352,327,722,596]. The panel letter, all three source arrows/symbols, complete microscopic field, and 100 µm scale bar are retained; no resampling, retouching, visual enhancement, or generative modification was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC6947013-FIGURE-4", "parent_sha256": "f43a66a1021e4ff0447075c673cd71dc745afaee4e5f2d380ffde6182154eedc", "parent_asset_path": "images/PMC6947013-FIGURE-4.jpg", "crop_coordinates": [ 352, 327, 722, 596 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-NC-RAT-CP-RJ-F04-E", "map_image_id": "NR", "source_id": "LEGACY-RPBM-002", "title_cn": "Royal Jelly 100 mg/kg预处理加环磷酰胺：骨髓保护性对照", "title_en": "Royal jelly 100 mg/kg pretreatment plus cyclophosphamide: marrow-protection comparator", "description_cn": "Panel E为Royal Jelly 100 mg/kg预处理后再给予环磷酰胺的代表性股骨骨髓视野。原作者认为预处理对CP组织损伤具有保护作用；这是同研究组水平支持性比较，不是同一动物治疗前后图，也不应仅凭图片认定完全恢复或保护机制。", "description_en": "Panel E is a representative femoral marrow field after royal jelly 100 mg/kg pretreatment followed by cyclophosphamide. The authors interpret pretreatment as protective against CP-associated tissue injury. This is a same-study group-level comparison, not a within-animal before-after image, and the field alone cannot establish complete recovery or mechanism.", "species": "Rat", "strain": "Male Wistar rat, 200 ± 20 g", "specimen_type": "Histology_HE", "stain": "H&E; objective 40×; scale bar 100 µm", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Protective_cotreatment_author_interpretation", "Hematopoietic_architecture_partly_preserved" ], "evidence_role": "Treatment_associated_response", "causality_level": "Author_attributed", "figure_label": "Figure 4", "panel_label": "E — royal jelly 100 mg/kg pretreatment plus cyclophosphamide", "source_page": "Figure 4, panel E", "caption_original_en": "Hisopathological changes of femoral bone marrow in different groups. A. The Control, B. R100, C. R200 groups, showing no pathological changes, megakaryocytes (ð). D. The CP group with decreased cellularity in hematopoietic cells (&), severe hemorrhage (∑) and adipose-like cells (α), E. CP+100 group, and F. CP+200 group (H&E, ×40) (scale bar: 100 µm). CP; Cyclophosphamide and R; Royal Jelly.", "article_title": "Protective Effect of Royal Jelly against Cyclophosphamide-Induced Thrombocytopenia and Spleen and Bone Marrow Damages in Rats", "authors": "Khazaei F, Ghanbari E, Khazaei M", "journal": "Cell Journal (Yakhteh)", "year": "2020", "doi": "10.22074/cellj.2020.6703", "pmid": "31863655", "pmcid": "PMC6947013", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6947013/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c6/6947013/bde8fefefac4/Cell-J-22-302-g04.jpg", "license": "CC BY-NC 3.0", "license_url": "https://creativecommons.org/licenses/by-nc/3.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Khazaei F, Ghanbari E, Khazaei M. Protective Effect of Royal Jelly against Cyclophosphamide-Induced Thrombocytopenia and Spleen and Bone Marrow Damages in Rats. Cell Journal (Yakhteh). 2020. doi:10.22074/cellj.2020.6703. Figure 4, E — royal jelly 100 mg/kg pretreatment plus cyclophosphamide. CC BY-NC 3.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 4 legend", "rights_basis": "The article copyright statement permits noncommercial reuse and adaptation with attribution under CC BY-NC 3.0. Exact-pixel panel crops preserve panel letters, arrows, source symbols, scale bars, and full microscopic fields and remain linked to complete Figure 4. The locally retained JATS contains conflicting CC BY and CC BY-NC labels. The copyright statement and article citation explicitly identify CC BY-NC 3.0, so the more restrictive CC BY-NC 3.0 interpretation is used. Figure 4 has no separate third-party credit line.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-NC-RAT-CP-RJ-F04-E.png", "preview_path": "previews/BM-CC-NC-RAT-CP-RJ-F04-E.jpg", "sha256": "c29794cf80a39748e2152dcf1234d5f5df8baccebd3ac84f88df2e0c4b2a55bd", "processing_note": "Exact-pixel crop of Figure 4E at parent coordinates [0,596,352,870]. The panel letter, complete microscopic field, and 100 µm scale bar are retained; no resampling, retouching, visual enhancement, or generative modification was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC6947013-FIGURE-4", "parent_sha256": "f43a66a1021e4ff0447075c673cd71dc745afaee4e5f2d380ffde6182154eedc", "parent_asset_path": "images/PMC6947013-FIGURE-4.jpg", "crop_coordinates": [ 0, 596, 352, 870 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-NC-RAT-CP-RJ-F04-F", "map_image_id": "NR", "source_id": "LEGACY-RPBM-002", "title_cn": "Royal Jelly 200 mg/kg预处理加环磷酰胺：骨髓保护性对照", "title_en": "Royal jelly 200 mg/kg pretreatment plus cyclophosphamide: marrow-protection comparator", "description_cn": "Panel F为Royal Jelly 200 mg/kg预处理后再给予环磷酰胺的代表性股骨骨髓视野。原作者将其与CP单独组比较并报告保护作用；网站保留该作者解释，同时提示图像不能独立证明剂量反应、完全恢复或临床可转化性。", "description_en": "Panel F is a representative femoral marrow field after royal jelly 200 mg/kg pretreatment followed by cyclophosphamide. The authors report protection relative to CP alone. The atlas preserves that interpretation while noting that the image cannot independently establish dose response, complete recovery, or clinical translatability.", "species": "Rat", "strain": "Male Wistar rat, 200 ± 20 g", "specimen_type": "Histology_HE", "stain": "H&E; objective 40×; scale bar 100 µm", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Protective_cotreatment_author_interpretation", "Hematopoietic_architecture_partly_preserved" ], "evidence_role": "Treatment_associated_response", "causality_level": "Author_attributed", "figure_label": "Figure 4", "panel_label": "F — royal jelly 200 mg/kg pretreatment plus cyclophosphamide", "source_page": "Figure 4, panel F", "caption_original_en": "Hisopathological changes of femoral bone marrow in different groups. A. The Control, B. R100, C. R200 groups, showing no pathological changes, megakaryocytes (ð). D. The CP group with decreased cellularity in hematopoietic cells (&), severe hemorrhage (∑) and adipose-like cells (α), E. CP+100 group, and F. CP+200 group (H&E, ×40) (scale bar: 100 µm). CP; Cyclophosphamide and R; Royal Jelly.", "article_title": "Protective Effect of Royal Jelly against Cyclophosphamide-Induced Thrombocytopenia and Spleen and Bone Marrow Damages in Rats", "authors": "Khazaei F, Ghanbari E, Khazaei M", "journal": "Cell Journal (Yakhteh)", "year": "2020", "doi": "10.22074/cellj.2020.6703", "pmid": "31863655", "pmcid": "PMC6947013", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6947013/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b0c6/6947013/bde8fefefac4/Cell-J-22-302-g04.jpg", "license": "CC BY-NC 3.0", "license_url": "https://creativecommons.org/licenses/by-nc/3.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Khazaei F, Ghanbari E, Khazaei M. Protective Effect of Royal Jelly against Cyclophosphamide-Induced Thrombocytopenia and Spleen and Bone Marrow Damages in Rats. Cell Journal (Yakhteh). 2020. doi:10.22074/cellj.2020.6703. Figure 4, F — royal jelly 200 mg/kg pretreatment plus cyclophosphamide. CC BY-NC 3.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 4 legend", "rights_basis": "The article copyright statement permits noncommercial reuse and adaptation with attribution under CC BY-NC 3.0. Exact-pixel panel crops preserve panel letters, arrows, source symbols, scale bars, and full microscopic fields and remain linked to complete Figure 4. The locally retained JATS contains conflicting CC BY and CC BY-NC labels. The copyright statement and article citation explicitly identify CC BY-NC 3.0, so the more restrictive CC BY-NC 3.0 interpretation is used. Figure 4 has no separate third-party credit line.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-NC-RAT-CP-RJ-F04-F.png", "preview_path": "previews/BM-CC-NC-RAT-CP-RJ-F04-F.jpg", "sha256": "00a444245a0bbf67a45536d01e8a7de9306862dbec1ecd6edde78c7c3f4a9159", "processing_note": "Exact-pixel crop of Figure 4F at parent coordinates [352,596,722,870]. The panel letter, complete microscopic field, and 100 µm scale bar are retained; no resampling, retouching, visual enhancement, or generative modification was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC6947013-FIGURE-4", "parent_sha256": "f43a66a1021e4ff0447075c673cd71dc745afaee4e5f2d380ffde6182154eedc", "parent_asset_path": "images/PMC6947013-FIGURE-4.jpg", "crop_coordinates": [ 352, 596, 722, 870 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-DOG-LEISHMANIASIS-F01-A", "map_image_id": "BMPM-IMG-0076", "source_id": "PMC3972870", "title_cn": "犬内脏利什曼病骨髓：巨核细胞胞穿入与作者描述的核异常", "title_en": "Canine visceral leishmaniasis marrow: megakaryocytic emperipolesis and author-described nuclear abnormalities", "description_cn": "Figure 1的panel a来自少症状组（group O），显示骨髓肉芽肿；插图a1箭头指示巨核细胞胞穿入，a2为原作者归入巨核细胞发育异常的形态，正文将其特征描述为核碎裂或异常分叶。该图用于感染性疾病鉴别，不是处理相关骨髓毒性证据；这些核改变也不应改写为多个表观独立核，单个代表视野不能提供发生频率。", "description_en": "Figure 1 panel a is from the oligosymptomatic group O and shows a marrow granuloma; inset a1 identifies megakaryocytic emperipolesis, while inset a2 shows a form the authors classified as megakaryocytic dysplasia and characterized in the text as nuclear fragmentation or abnormal lobulation. This is an infectious-disease differential, not treatment-related marrow toxicity. These nuclear changes must not be relabeled as multiple apparently separate nuclei, and one representative field does not establish frequency.", "species": "Dog", "strain": "Naturally infected dog; oligosymptomatic group O", "specimen_type": "Histology_HE", "stain": "H&E; objective 40×", "lineage": "Megakaryocytic", "maturation_stage": "Mature_megakaryocyte", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Granuloma", "Emperipolesis", "Megakaryocyte_nuclear_fragmentation_author_reported", "Megakaryocyte_abnormal_lobulation_author_reported" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "a with insets a1-a2 — granuloma, emperipolesis, and author-described megakaryocyte nuclear abnormalities", "source_page": "Figure 1, panels a, a1, and a2", "caption_original_en": "Photomicrographs of the bone marrow of dogs with visceral leishmaniasis. (a) Granuloma (∗), megakaryocytic emperipolesis (arrow, (a1), group O), and dysplastic megakaryocytes ((a2), group O). (b) Bone marrow with severe aplasia (group A); hematoxylin and eosin, objective 40x. (c) Immunolabeling of amastigote forms of L. chagasi in macrophages (∗); detail of megakaryocytic emperipolesis with an immunolabeled amastigote form (arrow, (c1); symptomatic dog); streptavidin-biotin-peroxidase complex, objective 40x.", "article_title": "Morphological Changes in the Bone Marrow of the Dogs with Visceral Leishmaniasis", "authors": "Momo C, Jacintho APP, Moreira PRR, Munari DP, Machado GF, Vasconcelos RO", "journal": "Veterinary Medicine International", "year": "2014", "doi": "10.1155/2014/150582", "pmid": "24744957", "pmcid": "PMC3972870", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3972870/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3972870/figure/fig1/", "license": "Creative Commons Attribution License (version not stated)", "license_url": "https://creativecommons.org/licenses/by/", "reuse_status": "cc_reuse_allowed", "attribution": "Momo C, Jacintho APP, Moreira PRR, Munari DP, Machado GF, Vasconcelos RO. Morphological Changes in the Bone Marrow of the Dogs with Visceral Leishmaniasis. Veterinary Medicine International. 2014. doi:10.1155/2014/150582. Figure 1, a with insets a1-a2 — granuloma, emperipolesis, and author-described megakaryocyte nuclear abnormalities. Creative Commons Attribution License (version not stated); cropped teaching panel.", "third_party_credit_line": "None reported for Figure 1", "rights_basis": "The article explicitly permits unrestricted use, distribution, and reproduction with attribution. The exact-pixel crop preserves panel a, insets a1-a2, arrows, labels, and the complete field and remains linked to complete Figure 1. The locally retained PMC JATS permissions block grants unrestricted use, distribution, and reproduction under the Creative Commons Attribution License with attribution. The license version is not stated in the article, and no separate third-party credit line was observed for Figure 1.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-LEISHMANIASIS-F01-A.png", "preview_path": "previews/BM-CC-DOG-LEISHMANIASIS-F01-A.jpg", "sha256": "83b762efffec151b84b04710cd42690053cb80a78c39f9e52cb3d7e96af6078c", "processing_note": "Exact-pixel crop of panel a with insets a1-a2 from the Creative Commons Attribution complete Figure 1 at parent coordinates [0,0,600,405]. The panel label, insets, arrows, asterisk, and complete field are retained; no resampling, retouching, or visual enhancement was applied.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC3972870-FIGURE-1", "parent_sha256": "65604a9d0bfbfc53aa424b7f02054110554df7f004f8ba419124e76d6909546e", "parent_asset_path": "images/PMC3972870-FIGURE-1.jpg", "crop_coordinates": [ 0, 0, 600, 405 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-5FU-F02-A", "map_image_id": "BMPM-IMG-0140", "source_id": "PMC4837595-MOUSE-5FU-TIMECOURSE", "title_cn": "5-FU时序对照：未处理小鼠骨髓", "title_en": "5-FU time-course control: untreated mouse marrow", "description_cn": "6–8周龄Swiss小鼠股骨骨髓H&E切片对照。造血组织细胞性保存，作为D2、D4和D10处理后变化的同研究参照。", "description_en": "Untreated H&E-stained femoral marrow from 6–8-week-old Swiss mice. Hematopoietic cellularity is preserved and provides the within-study comparator for days 2, 4, and 10 after treatment.", "species": "Mouse", "strain": "Swiss; 6–8 weeks", "specimen_type": "Bone_marrow_histology_section", "stain": "H&E", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Normal_maturation", "secondary_features": [ "Normal_cellularity_comparator" ], "evidence_role": "Normal_comparator", "causality_level": "Differential_only", "figure_label": "Fig. 2", "panel_label": "a — untreated control", "source_page": "Figure 2, panel a", "caption_original_en": "Effect of 5-FU on bone marrow cellularity. Hematoxylin and eosin-stained sections of decalcified femur ( a ) and affected histology on D2, D4, and D10 ( b – d ) after 5-FU treatment. Gradual decrease in bone marrow cells is observed on D2 ( b ) and D4 ( c ) with lowest cellularity on D4 ( c ) compared with control ( a ). By D10, endogenous recovery of hematopoiesis is seen ( d ). Note an influx of RBCs on D2 and D4. Scale bar = 20 μm. All images are taken on the Nikon 90i microscope. D2-5-FU , D4-5-FU , D10-5-FU days post 5-fluorouracil treatment", "article_title": "Delineating the effects of 5-fluorouracil and follicle-stimulating hormone on mouse bone marrow stem/progenitor cells", "authors": "Shaikh A, Bhartiya D, Kapoor S, Nimkar H", "journal": "Stem Cell Research & Therapy", "year": "2016", "doi": "10.1186/s13287-016-0311-6", "pmid": "27095238", "pmcid": "PMC4837595", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4837595/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faf1/4837595/e899cc6df667/13287_2016_311_Fig2_HTML.jpg", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Shaikh A, Bhartiya D, Kapoor S, Nimkar H. Delineating the effects of 5-fluorouracil and follicle-stimulating hormone on mouse bone marrow stem/progenitor cells. Stem Cell Research & Therapy. 2016. doi:10.1186/s13287-016-0311-6. Fig. 2, a — untreated control. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0 International License.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-5FU-F02-A.png", "preview_path": "previews/BM-CC-5FU-F02-A.jpg", "sha256": "acddb8a06b0fef62bc97243f8930cdeb30aa9e164a23f3181a2d9799d4dad888", "processing_note": "Panel a was cropped from the CC BY 4.0 composite Figure 2. The embedded Control label, panel letter, bone/marrow labels, and scale bar are retained; no tissue structures were altered.", "source_mode": "canonical_map_image", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-5FU-F02-B", "map_image_id": "BMPM-IMG-0155", "source_id": "PMC4837595-MOUSE-5FU-TIMECOURSE", "title_cn": "5-FU后第2天：骨髓造血细胞开始减少", "title_en": "Day 2 after 5-FU: early reduction in marrow hematopoietic cells", "description_cn": "与同研究对照相比，D2股骨骨髓造血细胞开始减少，并出现红细胞流入。该图表示早期损伤时点，不等同于最低点。", "description_en": "Relative to the study control, femoral marrow on day 2 shows an early decrease in hematopoietic cells with an influx of erythrocytes. This is an early injury time point, not the nadir.", "species": "Mouse", "strain": "Swiss; 6–8 weeks", "specimen_type": "Bone_marrow_histology_section", "stain": "H&E", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Cytotoxic_change", "secondary_features": [ "Hypocellularity", "Erythrocyte_influx" ], "evidence_role": "Toxicity_image", "causality_level": "Author_attributed", "figure_label": "Fig. 2", "panel_label": "b — day 2 after 5-FU", "source_page": "Figure 2, panel b", "caption_original_en": "Effect of 5-FU on bone marrow cellularity. Hematoxylin and eosin-stained sections of decalcified femur ( a ) and affected histology on D2, D4, and D10 ( b – d ) after 5-FU treatment. Gradual decrease in bone marrow cells is observed on D2 ( b ) and D4 ( c ) with lowest cellularity on D4 ( c ) compared with control ( a ). By D10, endogenous recovery of hematopoiesis is seen ( d ). Note an influx of RBCs on D2 and D4. Scale bar = 20 μm. All images are taken on the Nikon 90i microscope. D2-5-FU , D4-5-FU , D10-5-FU days post 5-fluorouracil treatment", "article_title": "Delineating the effects of 5-fluorouracil and follicle-stimulating hormone on mouse bone marrow stem/progenitor cells", "authors": "Shaikh A, Bhartiya D, Kapoor S, Nimkar H", "journal": "Stem Cell Research & Therapy", "year": "2016", "doi": "10.1186/s13287-016-0311-6", "pmid": "27095238", "pmcid": "PMC4837595", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4837595/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faf1/4837595/e899cc6df667/13287_2016_311_Fig2_HTML.jpg", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Shaikh A, Bhartiya D, Kapoor S, Nimkar H. Delineating the effects of 5-fluorouracil and follicle-stimulating hormone on mouse bone marrow stem/progenitor cells. Stem Cell Research & Therapy. 2016. doi:10.1186/s13287-016-0311-6. Fig. 2, b — day 2 after 5-FU. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0 International License.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-5FU-F02-B.png", "preview_path": "previews/BM-CC-5FU-F02-B.jpg", "sha256": "8d953888b606d364f0e3d7cd390d33a3c3a62927da0bcc8f36db886c2c0a0e0d", "processing_note": "Panel b was cropped from the CC BY 4.0 composite Figure 2. The embedded D2-5-FU label, panel letter, bone/marrow labels, and scale bar are retained; no tissue structures were altered.", "source_mode": "canonical_map_image", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-5FU-F02-D", "map_image_id": "BMPM-IMG-0171", "source_id": "PMC4837595-MOUSE-5FU-TIMECOURSE", "title_cn": "5-FU后第10天：内源性造血恢复", "title_en": "Day 10 after 5-FU: endogenous hematopoietic recovery", "description_cn": "D10骨髓组织结构和细胞性接近对照，原作者据此描述内源性造血恢复。该图应与D4最低点并列阅读，不代表完全功能恢复已被单张切片证明。", "description_en": "By day 10, marrow histoarchitecture and cellularity approach the control appearance, supporting the authors' description of endogenous hematopoietic recovery. It should be read beside the day 4 nadir and does not by itself prove complete functional recovery.", "species": "Mouse", "strain": "Swiss; 6–8 weeks", "specimen_type": "Bone_marrow_histology_section", "stain": "H&E", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Recovery_response", "Repopulation" ], "evidence_role": "Recovery_response", "causality_level": "Author_attributed", "figure_label": "Fig. 2", "panel_label": "d — day 10 recovery after 5-FU", "source_page": "Figure 2, panel d", "caption_original_en": "Effect of 5-FU on bone marrow cellularity. Hematoxylin and eosin-stained sections of decalcified femur ( a ) and affected histology on D2, D4, and D10 ( b – d ) after 5-FU treatment. Gradual decrease in bone marrow cells is observed on D2 ( b ) and D4 ( c ) with lowest cellularity on D4 ( c ) compared with control ( a ). By D10, endogenous recovery of hematopoiesis is seen ( d ). Note an influx of RBCs on D2 and D4. Scale bar = 20 μm. All images are taken on the Nikon 90i microscope. D2-5-FU , D4-5-FU , D10-5-FU days post 5-fluorouracil treatment", "article_title": "Delineating the effects of 5-fluorouracil and follicle-stimulating hormone on mouse bone marrow stem/progenitor cells", "authors": "Shaikh A, Bhartiya D, Kapoor S, Nimkar H", "journal": "Stem Cell Research & Therapy", "year": "2016", "doi": "10.1186/s13287-016-0311-6", "pmid": "27095238", "pmcid": "PMC4837595", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4837595/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/faf1/4837595/e899cc6df667/13287_2016_311_Fig2_HTML.jpg", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Shaikh A, Bhartiya D, Kapoor S, Nimkar H. Delineating the effects of 5-fluorouracil and follicle-stimulating hormone on mouse bone marrow stem/progenitor cells. Stem Cell Research & Therapy. 2016. doi:10.1186/s13287-016-0311-6. Fig. 2, d — day 10 recovery after 5-FU. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0 International License.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-5FU-F02-D.png", "preview_path": "previews/BM-CC-5FU-F02-D.jpg", "sha256": "b5aef701ed07b1f47ba8699a155ce5bb1594ec4bb1ac4bfaabccc6386720d4df", "processing_note": "Panel d was cropped from the CC BY 4.0 composite Figure 2. The embedded D10-5-FU label, panel letter, bone/marrow labels, and scale bar are retained; no tissue structures were altered.", "source_mode": "canonical_map_image", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-RHESUS-TBI-F03-5P8GY", "map_image_id": "BMPM-IMG-0337", "source_id": "PMC13135069-RHESUS-RADIATION-DEPLETION", "title_cn": "恒河猴5.8 Gy全身辐射后胸骨骨髓显著细胞耗竭", "title_en": "Marked sternal marrow cellular depletion after 5.8 Gy total-body irradiation in a rhesus macaque", "description_cn": "雄性恒河猴RA1272M胸骨骨髓造血细胞显著耗竭，仅残留少量不同类型有核细胞。该动物与6.5 Gy图和健康图不是同一只动物。", "description_en": "Sternal marrow from male rhesus macaque RA1272M shows marked cellular depletion with only minimal nucleated cells of various types. This animal is distinct from the 6.5 Gy and healthy examples.", "species": "Rhesus_monkey", "strain": "Macaca mulatta; NHP ID RA1272M", "specimen_type": "Sternum_bone_marrow_histology", "stain": "H&E", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Cytotoxic_change", "secondary_features": [ "Marked_cellular_depletion", "Hypocellularity" ], "evidence_role": "Toxicity_image", "causality_level": "Treatment_associated", "figure_label": "Fig. 3", "panel_label": "a — sternum marrow, 5.8 Gy", "source_page": "Figure 3a, marrow image labeled 5.8 Gy", "caption_original_en": "Comparison of sternum and spleen tissue sections collected from male and female rhesus macaques exposed to 5.8 or 6.5 Gy, as well as healthy tissue. ( a ) 5.8 Gy (NHP ID RA1272M, scale bar = 100 μm) There is marked cellular depletion with minimal nucleated cells of various types; 6.5 Gy (NHP ID RA2693M, scale bar = 1000 μm) There is marked cellular loss throughout the marrow space with minimal cellular presence (stars); Healthy (NHP ID 14041532F, scale bar = 1000 μm) There are no abnormalities noted. ( b ) 5.8 Gy (NHP ID RA1671F, scale bar = 100 μm) There is severe depletion of white cellular components throughout the spleen parenchyma (stars); 6.5 Gy (NHP ID RA2688M, scale bar = 100 μm) There is severe cellular depletion of the white pulp (star); Healthy (NHP ID 14041532F, scale bar = 1000 μm) The spleen is characterized by well-formed white pulp (stars), indicative of normal lymphoid tissue.", "article_title": "Comparative study of pathology of various organs of rhesus macaques exposed to two different doses of acute total-body radiation", "authors": "Brink MW, Petrus SA, Carpenter AD, Fatanmi OO, Wise SY, Seed TM, Lee S-H, Singh VK", "journal": "Scientific Reports", "year": "2026", "doi": "10.1038/s41598-026-49844-x", "pmid": "42034724", "pmcid": "PMC13135069", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13135069/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe09/13135069/670b25a63892/41598_2026_49844_Fig3_HTML.jpg", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Brink MW, Petrus SA, Carpenter AD, Fatanmi OO, Wise SY, Seed TM, Lee S-H, Singh VK. Comparative study of pathology of various organs of rhesus macaques exposed to two different doses of acute total-body radiation. Scientific Reports. 2026. doi:10.1038/s41598-026-49844-x. Fig. 3, a — sternum marrow, 5.8 Gy. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0 International License; article images are included unless a separate credit line states otherwise.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-RHESUS-TBI-F03-5P8GY.png", "preview_path": "previews/BM-CC-RHESUS-TBI-F03-5P8GY.jpg", "sha256": "9b284682a74935b82cff3badf5ef8528b83eb861a2cb0dbcd27e7200b4fb4d82", "processing_note": "The 5.8 Gy sternal marrow field was cropped from row a of the CC BY 4.0 composite Figure 3. The dose label and scale bar are retained; no tissue structures were altered.", "source_mode": "canonical_map_image", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-RHESUS-TBI-F03-6P5GY", "map_image_id": "BMPM-IMG-0336", "source_id": "PMC13135069-RHESUS-RADIATION-DEPLETION", "title_cn": "恒河猴6.5 Gy全身辐射后胸骨骨髓显著细胞丢失", "title_en": "Marked sternal marrow cellular loss after 6.5 Gy total-body irradiation in a rhesus macaque", "description_cn": "雄性恒河猴RA2693M胸骨髓腔内广泛造血细胞丢失，仅有极少细胞残留。该图与5.8 Gy图分属不同动物，不能按同一动物剂量递增解释。", "description_en": "Sternal marrow from male rhesus macaque RA2693M shows marked cellular loss throughout the marrow space with minimal cellular presence. It is from a different animal than the 5.8 Gy example and is not a within-animal dose escalation.", "species": "Rhesus_monkey", "strain": "Macaca mulatta; NHP ID RA2693M", "specimen_type": "Sternum_bone_marrow_histology", "stain": "H&E", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Cytotoxic_change", "secondary_features": [ "Marked_cellular_depletion", "Hypocellularity" ], "evidence_role": "Toxicity_image", "causality_level": "Treatment_associated", "figure_label": "Fig. 3", "panel_label": "a — sternum marrow, 6.5 Gy", "source_page": "Figure 3a, marrow image labeled 6.5 Gy", "caption_original_en": "Comparison of sternum and spleen tissue sections collected from male and female rhesus macaques exposed to 5.8 or 6.5 Gy, as well as healthy tissue. ( a ) 5.8 Gy (NHP ID RA1272M, scale bar = 100 μm) There is marked cellular depletion with minimal nucleated cells of various types; 6.5 Gy (NHP ID RA2693M, scale bar = 1000 μm) There is marked cellular loss throughout the marrow space with minimal cellular presence (stars); Healthy (NHP ID 14041532F, scale bar = 1000 μm) There are no abnormalities noted. ( b ) 5.8 Gy (NHP ID RA1671F, scale bar = 100 μm) There is severe depletion of white cellular components throughout the spleen parenchyma (stars); 6.5 Gy (NHP ID RA2688M, scale bar = 100 μm) There is severe cellular depletion of the white pulp (star); Healthy (NHP ID 14041532F, scale bar = 1000 μm) The spleen is characterized by well-formed white pulp (stars), indicative of normal lymphoid tissue.", "article_title": "Comparative study of pathology of various organs of rhesus macaques exposed to two different doses of acute total-body radiation", "authors": "Brink MW, Petrus SA, Carpenter AD, Fatanmi OO, Wise SY, Seed TM, Lee S-H, Singh VK", "journal": "Scientific Reports", "year": "2026", "doi": "10.1038/s41598-026-49844-x", "pmid": "42034724", "pmcid": "PMC13135069", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13135069/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe09/13135069/670b25a63892/41598_2026_49844_Fig3_HTML.jpg", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Brink MW, Petrus SA, Carpenter AD, Fatanmi OO, Wise SY, Seed TM, Lee S-H, Singh VK. Comparative study of pathology of various organs of rhesus macaques exposed to two different doses of acute total-body radiation. Scientific Reports. 2026. doi:10.1038/s41598-026-49844-x. Fig. 3, a — sternum marrow, 6.5 Gy. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0 International License; article images are included unless a separate credit line states otherwise.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-RHESUS-TBI-F03-6P5GY.png", "preview_path": "previews/BM-CC-RHESUS-TBI-F03-6P5GY.jpg", "sha256": "00c7c95b381addaf48f0186f87d3b83ef276c894cc1e67467791a75351e15182", "processing_note": "The 6.5 Gy sternal marrow field was cropped from row a of the CC BY 4.0 composite Figure 3. The dose label, stars, and scale bar are retained; no tissue structures were altered.", "source_mode": "canonical_map_image", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-RHESUS-TBI-F03-HEALTHY", "map_image_id": "BMPM-IMG-0330", "source_id": "PMC13135069-RHESUS-RADIATION-DEPLETION", "title_cn": "健康恒河猴胸骨骨髓组织学对照", "title_en": "Healthy rhesus macaque sternal marrow histology comparator", "description_cn": "健康雌性恒河猴14041532F胸骨骨髓未见来源所述异常，为5.8 Gy和6.5 Gy辐射组的跨动物组织学参照。", "description_en": "Sternal marrow from healthy female rhesus macaque 14041532F was described as having no abnormalities and provides a cross-animal histologic comparator for the 5.8 and 6.5 Gy examples.", "species": "Rhesus_monkey", "strain": "Macaca mulatta; NHP ID 14041532F", "specimen_type": "Sternum_bone_marrow_histology", "stain": "H&E", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Normal_maturation", "secondary_features": [ "Normal_cellularity_comparator" ], "evidence_role": "Normal_comparator", "causality_level": "Differential_only", "figure_label": "Fig. 3", "panel_label": "a — healthy sternum marrow", "source_page": "Figure 3a, marrow image labeled Healthy", "caption_original_en": "Comparison of sternum and spleen tissue sections collected from male and female rhesus macaques exposed to 5.8 or 6.5 Gy, as well as healthy tissue. ( a ) 5.8 Gy (NHP ID RA1272M, scale bar = 100 μm) There is marked cellular depletion with minimal nucleated cells of various types; 6.5 Gy (NHP ID RA2693M, scale bar = 1000 μm) There is marked cellular loss throughout the marrow space with minimal cellular presence (stars); Healthy (NHP ID 14041532F, scale bar = 1000 μm) There are no abnormalities noted. ( b ) 5.8 Gy (NHP ID RA1671F, scale bar = 100 μm) There is severe depletion of white cellular components throughout the spleen parenchyma (stars); 6.5 Gy (NHP ID RA2688M, scale bar = 100 μm) There is severe cellular depletion of the white pulp (star); Healthy (NHP ID 14041532F, scale bar = 1000 μm) The spleen is characterized by well-formed white pulp (stars), indicative of normal lymphoid tissue.", "article_title": "Comparative study of pathology of various organs of rhesus macaques exposed to two different doses of acute total-body radiation", "authors": "Brink MW, Petrus SA, Carpenter AD, Fatanmi OO, Wise SY, Seed TM, Lee S-H, Singh VK", "journal": "Scientific Reports", "year": "2026", "doi": "10.1038/s41598-026-49844-x", "pmid": "42034724", "pmcid": "PMC13135069", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13135069/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fe09/13135069/670b25a63892/41598_2026_49844_Fig3_HTML.jpg", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Brink MW, Petrus SA, Carpenter AD, Fatanmi OO, Wise SY, Seed TM, Lee S-H, Singh VK. Comparative study of pathology of various organs of rhesus macaques exposed to two different doses of acute total-body radiation. Scientific Reports. 2026. doi:10.1038/s41598-026-49844-x. Fig. 3, a — healthy sternum marrow. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0 International License; article images are included unless a separate credit line states otherwise.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-RHESUS-TBI-F03-HEALTHY.png", "preview_path": "previews/BM-CC-RHESUS-TBI-F03-HEALTHY.jpg", "sha256": "a98321b662123594720fd92ab09963414f37a4cefc970d4700fa8ed0f9f92f30", "processing_note": "The healthy sternal marrow field was cropped from row a of the CC BY 4.0 composite Figure 3. The Healthy label and scale bar are retained; no tissue structures were altered.", "source_mode": "canonical_map_image", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-RHESUS-EBOV-F02", "map_image_id": "NR", "source_id": "PMC10699128-RHESUS-EBOV-CELLULARITY", "title_cn": "恒河猴EBOV疾病鉴别：巨核细胞病毒抗原、核酸与超微结构证据", "title_en": "Rhesus macaque EBOV disease differential: viral antigen, RNA, and ultrastructural evidence in megakaryocytes", "description_cn": "完整Figure 2以IHC、RNAscope原位杂交、共聚焦显微镜和透射电镜展示EBOV感染恒河猴骨髓巨核细胞。原作者在5–8天观察到病毒抗原或基因组RNA阳性巨核细胞、伴细胞伸入现象的巨核细胞，以及去分界管道中的丝状病毒颗粒。该图用于感染性疾病鉴别和机制学习，不属于药物性骨髓毒性。", "description_en": "Complete Figure 2 uses IHC, RNAscope in situ hybridization, confocal microscopy, and transmission electron microscopy to examine marrow megakaryocytes in EBOV-infected rhesus macaques. The authors show viral antigen or genomic RNA-positive megakaryocytes, a megakaryocyte with emperipolesis, and filamentous viral particles within demarcation channels at representative 5- to 8-day observations. This is an infectious-disease differential and mechanistic reference, not drug-related marrow toxicity.", "species": "Rhesus_monkey", "strain": "Macaca mulatta", "specimen_type": "Bone_marrow_multimodal_microscopy", "stain": "IHC; RNAscope ISH; confocal immunofluorescence; TEM", "lineage": "Megakaryocytic", "maturation_stage": "Mature_megakaryocyte", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Emperipolesis", "EBOV_antigen_positive", "EBOV_genomic_RNA_positive", "Intracytoplasmic_viral_particles" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 2", "panel_label": "A–F (complete figure)", "source_page": "Figure 2, complete six-panel figure", "caption_original_en": "Immunohistochemical (IHC) analysis, RNAscope in situ hybridization (ISH), confocal microscopy (CM), and transmission electron microscopy (TEM) of bone marrow (BM) megakaryocytes (MKs) from Ebolavirus (EBOV)-infected RhMs. A: On IHC analysis at 5 days post exposure (dpe), an MK in the BM sinusoid of a terminal control rhesus macaque (RhM) is positive for EBOV-VP40 antigen (arrow). B: At 6 dpe, two MKs adjacent to the BM sinusoids in a terminal control macaque are positive for EBOV-GP antigen (arrows). C: At 8 dpe, an MK with emperipolesis (arrow) from a terminal control rhesus macaque (RhM) is positive for EBOV-VP35 antigen (>). D: On ISH at 5 dpe, an MK is positive for EBOV genomic RNA (arrow). E: On CM at 6 dpe, EBOV-VP35 (green, arrows) is present in the cytoplasm of an MK (CD41+, red) from a terminal control macaque. DAPI stains the cell nucleus (N) in blue. F: On TEM at 5 dpe, mature, filamentous, intracytoplasmic EBOV particles in the demarcation channels of an MK in BM from a terminal control RhM. The boxed region corresponds to the EBOV particle (arrow) in the inset at higher magnification. Scale bars: 20 μm (A–D); 100 μm (E); 4 μm (F).", "article_title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "authors": "Liu DX et al.", "journal": "The American Journal of Pathology", "year": "2023", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe7/10699128/6dbcb4d3d8c6/gr2.jpg", "license": "CC BY-NC-ND 4.0", "license_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Liu DX et al.. Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease. The American Journal of Pathology. 2023. doi:10.1016/j.ajpath.2023.08.010. Figure 2, A–F (complete figure). CC BY-NC-ND 4.0; complete figure reproduced without adaptation for noncommercial learning.", "third_party_credit_line": "None reported in the Figure 1 or Figure 2 legends", "rights_basis": "The article permits noncommercial sharing with attribution and without distribution of adapted material. Only byte-identical complete source figures are used. PMC full-text copyright and license block: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0; complete Figures 1 and 2 are reproduced without cropping, annotation, retouching, or other adaptation.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-RHESUS-EBOV-F02.jpg", "preview_path": "images/BM-CC-RHESUS-EBOV-F02.jpg", "sha256": "a6c7e3f5fc9de1a1cc4d32fe58b6c954c9fb97ff4e2adce21682cae112989602", "processing_note": "Byte-identical complete Figure 2 copied from the PMC source media. All six microscopy panels, arrows, panel letters, inset, stain signals, and scale bars are retained; no crop, annotation, color change, retouching, or other adaptation was applied.", "source_mode": "verbatim_full_figure", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-DOG-MDS-F01-F", "map_image_id": "BMPM-IMG-0090", "source_id": "SUP-PMC11697499", "title_cn": "犬MDS骨髓切片：原始细胞增加、巨核细胞核异常和巨型杆状核中性粒细胞", "title_en": "Canine MDS marrow histology: increased blasts, abnormal megakaryocytic nuclei, and giant band neutrophils", "description_cn": "高倍骨髓切片同时显示原始细胞比例增加、核分叶异常且染色质开放并有核仁的巨核细胞，以及巨型异常杆状核中性粒细胞。该图展示多谱系形态，但不能由单视野替代系统分类计数。", "description_en": "The high-power marrow section shows an increased proportion of blasts, a megakaryocyte with abnormal lobulation, open chromatin and nucleoli, and dysplastic giant band neutrophils. It illustrates multilineage morphology but cannot replace a systematic differential count.", "species": "Dog", "strain": "Clinical canine MDS cohort; case-specific breed NR in legend", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_myeloid_and_megakaryocytic", "primary_morphology_class": "Dysplastic_change", "secondary_features": [ "Increased_blasts", "Megakaryocyte_abnormal_lobulation", "Giant_band_neutrophils" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "f", "source_page": "Figure 1, panel f", "caption_original_en": "Myelodysplastic syndrome, dog. (a) Blood film with dysplastic neutrophils (*) that have unevenly sized nuclear lobes and giant red blood cells (^) reflecting increased red cell distribution width. Case 1. Wright stain (WS). (b) The marrow aspirate is highly cellular and has a predominance of granulocytes. There are approximately 10% blasts (arrowheads). Of total, 15% of segmented neutrophils have dysplastic changes (*), and there are dysplastic band neutrophils (arrows). Case 2. WS. (c) An immature megakaryocyte with abnormal nuclear lobulation (left) and an abnormally small megakaryocyte with mature cytoplasm and a hypolobulated nucleus (right). Case 2. WS. (d) A micromegakaryocyte, ~24 µm in diameter with multiple, widely separated nuclei (arrow). Case 2. WS. (e) The marrow core is hypercellular despite chronic marked anemia, and megakaryocytes are clustered (arrows). Case 3. Hematoxylin and eosin (HE). (f) Higher magnification of (e) illustrating an increased proportion of blasts (arrowheads) in the center of the intertrabecular space; a megakaryocyte with abnormal nuclear lobulation, open chromatin, and nucleoli (arrow); and dysplastic giant band neutrophils (*). Case 3. HE.", "article_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "authors": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D", "journal": "Veterinary Pathology", "year": "2024", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D. Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia. Veterinary Pathology. 2024. doi:10.1177/03009858241277982. Figure 1, f. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 1-4 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-MDS-F01-F.jpg", "preview_path": "previews/BM-CC-DOG-MDS-F01-F.jpg", "sha256": "c2a2f5e6a8b58e30e46db6967926aef10ee666d9efdd7c0174fb72ac59b54b36", "processing_note": "Exact-pixel panel f crop from the CC BY 4.0 composite Figure 1 at parent coordinates [395,240,712,480]. Arrowheads, arrow, asterisks, and the complete field are retained.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC11697499-FIGURE-1", "parent_sha256": "5a483add2bbc9fd987d7603436aa2e972a9b71b8d8889bb981fb4c5fc5834d50", "parent_asset_path": "images/PMC11697499-FIGURE-1.jpg", "crop_coordinates": [ 395, 240, 712, 480 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-DOG-MDS-F02-C", "map_image_id": "BMPM-IMG-0089", "source_id": "SUP-PMC11697499", "title_cn": "犬MDS骨髓切片：造血细胞间胶原束及约5%原始细胞", "title_en": "Canine MDS marrow histology: collagen bundles among hematopoietic cells and approximately 5% blasts", "description_cn": "高倍切片可见纤细胶原束穿插于造血细胞之间，原作者报告原始细胞约占5%。纤维化应结合低倍分布、特殊染色及取材部位评价，单个高倍视野不能确定全骨髓程度。", "description_en": "The high-power section shows slender collagen bundles among hematopoietic cells, with approximately 5% blasts reported by the authors. Fibrosis requires low-power distribution, special stains, and site context; one high-power field cannot establish whole-marrow extent.", "species": "Dog", "strain": "Clinical canine MDS cohort; case-specific breed NR in legend", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Stromal_nonhematopoietic", "maturation_stage": "NR", "primary_morphology_class": "Stromal_or_microenvironment_change", "secondary_features": [ "Paratrabecular_fibrosis", "Collagen_bundles", "Blasts_approximately_5_percent" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 2", "panel_label": "c", "source_page": "Figure 2, panel c", "caption_original_en": "Myelodysplastic syndrome, dog. (a) The blood film has dysplastic neutrophils (*) characterized by incomplete and uneven nuclear segmentation. Note also frequent platelets. The dog had chronic nonregenerative anemia, a normal leukocyte count, and thrombocytosis (554 × 10^9/L; reference interval 117-418 × 10^9/L). The marrow aspirate had no particles. Case 4. Wright stain. (b) The marrow core is nearly devoid of adipocytes is densely cellular with paratrabecular fibrosis (arrow). Case 5. Hematoxylin and eosin (HE). (c) At higher magnification, there are slender bundles of collagen interspersed among hematopoietic cells (arrow). Blasts comprise approximately 5% of cells (arrowheads). Case 5. HE.", "article_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "authors": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D", "journal": "Veterinary Pathology", "year": "2024", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D. Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia. Veterinary Pathology. 2024. doi:10.1177/03009858241277982. Figure 2, c. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 1-4 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-MDS-F02-C.jpg", "preview_path": "previews/BM-CC-DOG-MDS-F02-C.jpg", "sha256": "ae1fcc655594e9db680ef376e86fb73bef5bb4ab2af7e435f446a7d6a12ef59c", "processing_note": "Exact-pixel panel c crop from the CC BY 4.0 composite Figure 2 at parent coordinates [492,0,738,122]. Arrow, arrowheads, and complete histologic field are retained.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC11697499-FIGURE-2", "parent_sha256": "4975bf669afe4e403ff36cdf8c82bfd67d975ef016207a0f41c60def1f74ae0c", "parent_asset_path": "images/PMC11697499-FIGURE-2.jpg", "crop_coordinates": [ 492, 0, 738, 122 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-DOG-MDS-F01-E", "map_image_id": "NR", "source_id": "SUP-PMC11697499", "title_cn": "犬MDS骨髓芯样本：高细胞性与巨核细胞聚集", "title_en": "Canine MDS marrow core: hypercellularity with megakaryocyte clustering", "description_cn": "骨髓芯样本在慢性重度贫血背景下仍呈高细胞性，并可见巨核细胞成簇。该panel用于观察组织学细胞量和空间分布；不能由此直接推断涂片分类比例或处理相关性。", "description_en": "The marrow core remains hypercellular despite chronic marked anemia and contains clustered megakaryocytes. This panel supports assessment of histologic cellularity and spatial distribution; it does not establish smear differential proportions or treatment relationship.", "species": "Dog", "strain": "Clinical canine MDS cohort; case-specific breed NR in legend", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Megakaryocytic", "maturation_stage": "Mixed_megakaryocytic_population", "primary_morphology_class": "Proliferative_change", "secondary_features": [ "Hypercellularity", "Megakaryocyte_clustering", "Chronic_marked_anemia_context" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "e", "source_page": "Figure 1, panel e", "caption_original_en": "Myelodysplastic syndrome, dog. (a) Blood film with dysplastic neutrophils (*) that have unevenly sized nuclear lobes and giant red blood cells (^) reflecting increased red cell distribution width. Case 1. Wright stain (WS). (b) The marrow aspirate is highly cellular and has a predominance of granulocytes. There are approximately 10% blasts (arrowheads). Of total, 15% of segmented neutrophils have dysplastic changes (*), and there are dysplastic band neutrophils (arrows). Case 2. WS. (c) An immature megakaryocyte with abnormal nuclear lobulation (left) and an abnormally small megakaryocyte with mature cytoplasm and a hypolobulated nucleus (right). Case 2. WS. (d) A micromegakaryocyte, ~24 µm in diameter with multiple, widely separated nuclei (arrow). Case 2. WS. (e) The marrow core is hypercellular despite chronic marked anemia, and megakaryocytes are clustered (arrows). Case 3. Hematoxylin and eosin (HE). (f) Higher magnification of (e) illustrating an increased proportion of blasts (arrowheads) in the center of the intertrabecular space; a megakaryocyte with abnormal nuclear lobulation, open chromatin, and nucleoli (arrow); and dysplastic giant band neutrophils (*). Case 3. HE.", "article_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "authors": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D", "journal": "Veterinary Pathology", "year": "2024", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D. Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia. Veterinary Pathology. 2024. doi:10.1177/03009858241277982. Figure 1, e. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 1-4 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-MDS-F01-E.png", "preview_path": "previews/BM-CC-DOG-MDS-F01-E.jpg", "sha256": "266ac9d465422341a0fe3d3509f5d7f747ccdb93573e362260d1143cfd3c4c0c", "processing_note": "Exact-pixel panel e crop from the CC BY 4.0 composite Figure 1 at parent coordinates [180,240,395,480]. The panel letter, arrows, complete marrow-core field, and surrounding tissue are retained; no resampling or visual enhancement was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC11697499-FIGURE-1", "parent_sha256": "5a483add2bbc9fd987d7603436aa2e972a9b71b8d8889bb981fb4c5fc5834d50", "parent_asset_path": "images/PMC11697499-FIGURE-1.jpg", "crop_coordinates": [ 180, 240, 395, 480 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-DOG-MDS-F02-B", "map_image_id": "NR", "source_id": "SUP-PMC11697499", "title_cn": "犬MDS骨髓芯样本：致密高细胞性与小梁旁纤维化", "title_en": "Canine MDS marrow core: dense hypercellularity with paratrabecular fibrosis", "description_cn": "低倍骨髓芯样本几乎无脂肪细胞，造血组织致密，并见小梁旁纤维化。该视野适合与高倍胶原束panel并列观察；纤维化程度仍应结合完整切片和特殊染色。", "description_en": "At low power, the marrow core is nearly devoid of adipocytes, densely cellular, and shows paratrabecular fibrosis. It is intended for comparison with the higher-power collagen-bundle panel; fibrosis severity still requires the complete section and appropriate special stains.", "species": "Dog", "strain": "Clinical canine MDS cohort; case-specific breed NR in legend", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Stromal_nonhematopoietic", "maturation_stage": "NR", "primary_morphology_class": "Stromal_or_microenvironment_change", "secondary_features": [ "Hypercellularity", "Paratrabecular_fibrosis", "Adipocyte_depletion" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 2", "panel_label": "b", "source_page": "Figure 2, panel b", "caption_original_en": "Myelodysplastic syndrome, dog. (a) The blood film has dysplastic neutrophils (*) characterized by incomplete and uneven nuclear segmentation. Note also frequent platelets. The dog had chronic nonregenerative anemia, a normal leukocyte count, and thrombocytosis (554 × 10^9/L; reference interval 117-418 × 10^9/L). The marrow aspirate had no particles. Case 4. Wright stain. (b) The marrow core is nearly devoid of adipocytes is densely cellular with paratrabecular fibrosis (arrow). Case 5. Hematoxylin and eosin (HE). (c) At higher magnification, there are slender bundles of collagen interspersed among hematopoietic cells (arrow). Blasts comprise approximately 5% of cells (arrowheads). Case 5. HE.", "article_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "authors": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D", "journal": "Veterinary Pathology", "year": "2024", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D. Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia. Veterinary Pathology. 2024. doi:10.1177/03009858241277982. Figure 2, b. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 1-4 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-MDS-F02-B.png", "preview_path": "previews/BM-CC-DOG-MDS-F02-B.jpg", "sha256": "597e7bccd9995a3c2bfed64fae369904c3471edff87dc657f124db2d9414047e", "processing_note": "Exact-pixel panel b crop from the CC BY 4.0 composite Figure 2 at parent coordinates [245,0,492,122]. The panel letter, arrow, complete core profile, and trabecular context are retained; no resampling or visual enhancement was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC11697499-FIGURE-2", "parent_sha256": "4975bf669afe4e403ff36cdf8c82bfd67d975ef016207a0f41c60def1f74ae0c", "parent_asset_path": "images/PMC11697499-FIGURE-2.jpg", "crop_coordinates": [ 245, 0, 492, 122 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-DOG-AML-F03-B", "map_image_id": "NR", "source_id": "SUP-PMC11697499", "title_cn": "犬AML骨髓切片：近全细胞性并见核形不规则、核仁明显的细胞群", "title_en": "Canine AML marrow histology: near-total cellularity with irregular nuclei and prominent nucleoli", "description_cn": "同一AML病例的死后骨髓切片接近100%细胞性，可见多量核形不规则、核仁较大且有时呈双染性的细胞。谱系和原始细胞比例来自整合诊断背景，不应仅凭该H&E视野重新判定。", "description_en": "The postmortem marrow section from the same AML case is nearly 100% cellular and contains many cells with irregular nuclei and large, sometimes amphophilic nucleoli. Lineage and blast proportion depend on the integrated diagnostic context and should not be reassigned from this H&E field alone.", "species": "Dog", "strain": "Clinical canine AML cohort; case-specific breed NR in legend", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Mixed_or_uncertain", "maturation_stage": "Blast_rich_population", "primary_morphology_class": "Proliferative_change", "secondary_features": [ "Near_100_percent_cellularity", "Irregular_nuclear_shapes", "Large_nucleoli" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 3", "panel_label": "b", "source_page": "Figure 3, panel b", "caption_original_en": "Acute myeloid leukemia, dog. Case 6. (a) The blood film contains occasional blasts (arrowhead), numerous large myelomonocytes with irregular nuclear shapes, and occasional cytoplasmic vacuoles. Neutrophils are dysplastic with irregular nuclear lobes and incomplete segmentation (*). The dog had a leukocytosis of 157 × 10^9/L (reference interval = 4.9-15.4 × 10^9/L), thrombocytopenia, and anemia. Wright stain. (b) The postmortem marrow section is nearly 100% cellular and includes many cells with irregular nuclear shapes and large, sometimes amphophilic, nucleoli (arrowheads). Hematoxylin and eosin.", "article_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "authors": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D", "journal": "Veterinary Pathology", "year": "2024", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Meredith AM, Beeler-Marfisi J, Berke O, Mutsaers AJ, Bienzle D. Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia. Veterinary Pathology. 2024. doi:10.1177/03009858241277982. Figure 3, b. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the relevant figure legend", "rights_basis": "The locally retained PMC full text explicitly states a Creative Commons Attribution 4.0 license. No figure-specific third-party credit line was observed for the screened figure. Cropped panels are identified as adaptations and remain linked to the complete original caption. PMC full-text copyright and license block: Creative Commons Attribution 4.0; no separate third-party credit line was observed in the screened Figure 1-4 legends.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-AML-F03-B.png", "preview_path": "previews/BM-CC-DOG-AML-F03-B.jpg", "sha256": "1e3b2d441a6ce2f2963ec4c05b11d6d08e296469f38498c3dd4e1d891a6881ab", "processing_note": "Exact-pixel panel b crop from the CC BY 4.0 composite Figure 3 at parent coordinates [370,0,738,241]. The panel letter, arrowheads, adipocyte profiles, and complete marrow field are retained; no resampling or visual enhancement was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC11697499-FIGURE-3", "parent_sha256": "e5f2ecb1a5292c5932df9fb937819c6841bd385c271c8009f1f5ee561d50b1cd", "parent_asset_path": "images/PMC11697499-FIGURE-3.jpg", "crop_coordinates": [ 370, 0, 738, 241 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-DOG-MARROW-FIBROSIS-F03", "map_image_id": "NR", "source_id": "PMC7324823", "title_cn": "犬骨髓芯活检：重度骨髓纤维化", "title_en": "Canine bone marrow core biopsy: severe marrow fibrosis", "description_cn": "H&E骨髓芯活检显示原作者判定的重度纤维化。该图应与骨髓涂片代表性、胶原/网状纤维特殊染色及全切片分布共同解释。", "description_en": "An H&E-stained marrow core biopsy shows severe fibrosis as reported by the authors. Interpretation should be integrated with smear representativeness, collagen or reticulin stains, and whole-section distribution.", "species": "Dog", "strain": "Miniature Dachshund", "specimen_type": "Bone_marrow_core_biopsy", "stain": "H&E", "lineage": "Stromal_nonhematopoietic", "maturation_stage": "NR", "primary_morphology_class": "Stromal_or_microenvironment_change", "secondary_features": [ "Severe_fibrosis", "Core_biopsy" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Fig. 3", "panel_label": "Complete figure", "source_page": "Figure 3, complete figure", "caption_original_en": "Severe fibrosis observed in bone marrow core biopsy stained by hematoxylin-eosin stain. Bar=50 µm.", "article_title": "Clinical and clinicopathological features and outcomes of Miniature Dachshunds with bone marrow disorders", "authors": "Tani A, Tomiyasu H, Ohmi A, Ohno K, Tsujimoto H", "journal": "The Journal of Veterinary Medical Science", "year": "2020", "doi": "10.1292/jvms.19-0439", "pmid": "32307340", "pmcid": "PMC7324823", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7324823/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/20c5/7324823/c8b1c3e33c38/jvms-82-771-g003.jpg", "license": "CC BY-NC-ND 4.0", "license_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Tani A, Tomiyasu H, Ohmi A, Ohno K, Tsujimoto H. Clinical and clinicopathological features and outcomes of Miniature Dachshunds with bone marrow disorders. The Journal of Veterinary Medical Science. 2020. doi:10.1292/jvms.19-0439. Fig. 3, Complete figure. CC BY-NC-ND 4.0; complete figure reproduced without adaptation for noncommercial learning.", "third_party_credit_line": "None reported in the relevant figure legends", "rights_basis": "The article permits noncommercial sharing with attribution and without distribution of adapted material. Only byte-identical complete source figures are used. PMC full-text copyright and license block: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0; complete Figures 2 and 3 are reproduced without cropping, annotation, retouching, or other adaptation.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-DOG-MARROW-FIBROSIS-F03.jpg", "preview_path": "images/BM-CC-DOG-MARROW-FIBROSIS-F03.jpg", "sha256": "d2519af18a8e468e9b1488d5995147cc6975a176b6ccacecdb5775a910871a29", "processing_note": "Byte-identical complete Figure 3 copied from the PMC source media. The complete histologic field and scale bar are retained; no crop, annotation, color change, retouching, or other adaptation was applied.", "source_mode": "verbatim_full_figure", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-MOUSE-TELSYK-F03", "map_image_id": "NR", "source_id": "PMC4219468", "title_cn": "小鼠TEL-SYK模型：APMF样AML、多系发育异常与骨髓纤维化", "title_en": "Mouse TEL-SYK model: APMF-like AML with multilineage dysplasia and myelofibrosis", "description_cn": "完整Figure 3比较对照及SYK模型小鼠的骨髓、脾和肝H&E，以及骨髓/脾PAS和网状纤维染色。TEL-SYK组可见未成熟或发育异常巨核细胞/巨核母细胞浸润及II-III级纤维化。该图是疾病模型鉴别，不是一般药物毒性图。", "description_en": "Complete Figure 3 compares H&E-stained marrow, spleen, and liver and PAS/reticulin-stained marrow and spleen across control and SYK models. TEL-SYK mice show infiltrating immature or dysplastic megakaryocytes/megakaryoblasts and grade II-III fibrosis. This is a disease-model differential, not a general drug-toxicity image.", "species": "Mouse", "strain": "Balb/c transplantation model", "specimen_type": "Mixed_bone_marrow_spleen_liver_histology", "stain": "H&E; PAS; reticulin", "lineage": "Megakaryocytic_and_stromal", "maturation_stage": "Megakaryoblast_and_immature_megakaryocyte", "primary_morphology_class": "Proliferative_change", "secondary_features": [ "APMF_like_AML", "Multilineage_dysplasia", "Megakaryoblast_infiltration", "Myelofibrosis_grade_II_III" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 3", "panel_label": "a-c (complete figure)", "source_page": "Figure 3, complete composite figure", "caption_original_en": "TEL-SYK induces an AML with features of human APMF in mice. (a) Images from hematoxylin and eosin-stained BM, spleen and liver slides from control, SYKwt, TEL-SYK and ITK-SYK mice. Arrowheads show dysplastic and immature megakaryocytes/megakaryoblasts infiltrating BM, spleens and the liver of TEL-SYK mice. Bars, 50 µm. (b) Periodic acid-Schiff (PAS) stain of BM and spleens from control and TEL-SYK mice highlight the infiltrating megakaryoblasts in TEL-SYK mice. (c) Reticulin stain of BM and spleens of diseased TEL-SYK mice compared with controls display a strong fibrosis (II-III) in both organs (right panel). Bars, 50 µm.", "article_title": "Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice", "authors": "Sprissler C, Belenki D, Maurer H, Aumann K, Pfeifer D, Klein C, Müller TA, Kissel S, Hülsdünker J, Alexandrovski J, Brummer T, Jumaa H, Duyster J, Dierks C", "journal": "Blood Cancer Journal", "year": "2014", "doi": "10.1038/bcj.2014.53", "pmid": "25148222", "pmcid": "PMC4219468", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4219468/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c804/4219468/0f91755d98f3/bcj201453f3.jpg", "license": "CC BY-NC-ND 4.0", "license_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Sprissler C, Belenki D, Maurer H, Aumann K, Pfeifer D, Klein C, Müller TA, Kissel S, Hülsdünker J, Alexandrovski J, Brummer T, Jumaa H, Duyster J, Dierks C. Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice. Blood Cancer Journal. 2014. doi:10.1038/bcj.2014.53. Figure 3, a-c (complete figure). CC BY-NC-ND 4.0; complete figure reproduced without adaptation for noncommercial learning.", "third_party_credit_line": "None reported in the Figure 3 legend", "rights_basis": "The article permits noncommercial sharing with attribution and without distribution of adapted material. Only the byte-identical complete Figure 3 is used. PMC full-text copyright and license block: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0; complete Figure 3 is reproduced without cropping, annotation, retouching, or other adaptation.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-MOUSE-TELSYK-F03.jpg", "preview_path": "images/BM-CC-MOUSE-TELSYK-F03.jpg", "sha256": "78094061504bc15a6f23c9c957d4424c9e8abe5c1110fa62c35497d269147e64", "processing_note": "Byte-identical complete Figure 3 copied from the PMC source media. All marrow and comparator-tissue panels, panel labels, arrowheads, and scale bars are retained; no crop, annotation, color change, retouching, or other adaptation was applied.", "source_mode": "verbatim_full_figure", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-RHESUS-EBOV-F01", "map_image_id": "NR", "source_id": "PMC10699128-RHESUS-EBOV-CELLULARITY", "title_cn": "恒河猴EBOV疾病鉴别：骨髓感染细胞与CD68阳性单核/巨噬细胞", "title_en": "Rhesus macaque EBOV disease differential: infected marrow cells and CD68-positive monocytes/macrophages", "description_cn": "完整Figure 1以IHC、RNAscope原位杂交和共聚焦显微镜显示EBOV感染恒河猴骨髓细胞。图中包括病毒抗原或RNA阳性骨髓细胞、阳性巨核细胞及与CD68阳性单核/巨噬细胞共定位的信号。该图用于感染性疾病鉴别和机制学习。", "description_en": "Complete Figure 1 uses IHC, RNAscope in situ hybridization, and confocal microscopy to demonstrate EBOV-positive marrow cells in rhesus macaques, including a positive megakaryocyte and viral signal colocalizing with CD68-positive monocytes/macrophages. It is an infectious-disease differential and mechanistic reference.", "species": "Rhesus_monkey", "strain": "Macaca mulatta", "specimen_type": "Bone_marrow_multimodal_microscopy", "stain": "IHC; RNAscope ISH; confocal immunofluorescence", "lineage": "Monocytic_macrophagic_and_megakaryocytic", "maturation_stage": "Mixed", "primary_morphology_class": "Reactive_change", "secondary_features": [ "EBOV_antigen_positive", "EBOV_genomic_RNA_positive", "EBOV_antigenomic_RNA_positive", "CD68_colocalization" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 1", "panel_label": "A-F (complete figure)", "source_page": "Figure 1, complete six-panel figure", "caption_original_en": "Immunohistochemical (IHC) analysis, RNAscope in situ hybridization (ISH), and confocal microscopy (CM) of bone marrow (BM) cells from Ebolavirus (EBOV)-infected RhMs. A and B: On IHC analysis at 3 days post exposure (dpe) to EBOV, EBOV-VP40 antigens (A) and EBOV-GP antigens (B) (arrow) are detected in a single BM cell from an RhM. C: On IHC analysis at 4 dpe, many BM cells (arrows) and a megakaryocyte (MK) (arrowhead) are positive for EBOV-VP40 antigen. D: On ISH analysis at 4 dpe, many BM cells are positive for EBOV genomic RNA (arrows). E: On ISH at 6 dpe, many BM cells from a terminal control RhM are positive for EBOV antigenomic (replicative intermediate) RNA (arrows). F: On CM at 6 dpe, EBOV-VP35 (green) colocalizes with CD68-positive (red) monocytes/macrophages (arrows) in BM cells from a terminal control RhM. The boxed region corresponds to the inset at higher magnification. DAPI stains the cell nucleus in blue. Scale bars: 20 µm (A, B, and D); 50 µm (C and E); 100 µm (F).", "article_title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "authors": "Liu DX et al.", "journal": "The American Journal of Pathology", "year": "2023", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfe7/10699128/88c01e19e566/gr1.jpg", "license": "CC BY-NC-ND 4.0", "license_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Liu DX et al.. Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease. The American Journal of Pathology. 2023. doi:10.1016/j.ajpath.2023.08.010. Figure 1, A-F (complete figure). CC BY-NC-ND 4.0; complete figure reproduced without adaptation for noncommercial learning.", "third_party_credit_line": "None reported in the Figure 1 or Figure 2 legends", "rights_basis": "The article permits noncommercial sharing with attribution and without distribution of adapted material. Only byte-identical complete source figures are used. PMC full-text copyright and license block: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0; complete Figures 1 and 2 are reproduced without cropping, annotation, retouching, or other adaptation.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-RHESUS-EBOV-F01.jpg", "preview_path": "images/BM-CC-RHESUS-EBOV-F01.jpg", "sha256": "869bdf8528df894b1d849497b7022488103d4fefaf2032b416fc80063039b6e6", "processing_note": "Byte-identical complete Figure 1 copied from the PMC source media. All six microscopy panels, arrows, arrowhead, boxed inset, stain signals, and scale bars are retained; no crop, annotation, color change, retouching, or other adaptation was applied.", "source_mode": "verbatim_full_figure", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC0-RHESUS-ENTOLIMOD-F03-VEH", "map_image_id": "BMPM-IMG-0344", "source_id": "S2M-PMC4569586", "title_cn": "恒河猴全身照射后载体组：第40天骨髓仍相对低细胞性", "title_en": "Rhesus macaque after total-body irradiation: persistent relative marrow hypocellularity in the day-40 vehicle group", "description_cn": "6.5 Gy全身照射后第40天，载体组代表性胸骨骨髓切片较entolimod组细胞较少、脂肪成分较多。该图是照射后载体对照，不是未处理正常骨髓，也不能单独量化个体恢复程度。", "description_en": "At day 40 after 6.5 Gy total-body irradiation, this representative vehicle-group sternal marrow field is less cellular and contains more adipose tissue than the entolimod-treated fields. It is an irradiated vehicle comparator, not untreated normal marrow, and it does not quantify recovery in an individual animal.", "species": "Rhesus_monkey", "strain": "Rhesus macaque (Macaca mulatta); study cohort Rs-06", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Cytotoxic_change", "secondary_features": [ "Hypocellularity", "Adipocyte_replacement", "Post_irradiation_persistent_depletion" ], "evidence_role": "Toxicity_image", "causality_level": "Treatment_associated", "figure_label": "Fig 3. Enhanced morphological recovery of hematopoietic and lymphoid organs in NHPs treated with entolimod post-irradiation", "panel_label": "Vehicle — irradiated vehicle comparator", "source_page": "Figure 3, sternum bone marrow row, Vehicle panel", "caption_original_en": "NHPs were treated with a single injection of 40 μg/kg entolimod 16, 25 or 48 hours after LD75/40 total body irradiation (TBI). Tissue morphology was assessed 40 days post-irradiation and compared to that in control NHPs treated with vehicle 16 hours after LD75/40 TBI. Representative histological images (hematoxylin-eosin staining) of sternum bone marrow sections, thymuses, spleens and mesenteric lymph nodes of animals that survived to study termination on Day 40 post-TBI (study Rs-06) are shown. Scale bars: 100 μm for bone marrow, 200 μm for thymus, spleen, and lymph node.", "article_title": "The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates", "authors": "Krivokrysenko VI, Toshkov IA, Gleiberman AS, Krasnov P, Shyshynova I, Bespalov I, Maitra RK, Narizhneva NV, Singh VK, Whitnall MH, Purmal AA, Shakhov AN, Gudkov AV, Feinstein E", "journal": "PLoS ONE", "year": "2015", "doi": "10.1371/journal.pone.0135388", "pmid": "26367124", "pmcid": "PMC4569586", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4569586/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fad/4569586/3541f0ad7743/pone.0135388.g003.jpg", "license": "CC0 1.0 Universal", "license_url": "https://creativecommons.org/publicdomain/zero/1.0/", "reuse_status": "public_domain", "attribution": "Krivokrysenko VI, Toshkov IA, Gleiberman AS, Krasnov P, Shyshynova I, Bespalov I, Maitra RK, Narizhneva NV, Singh VK, Whitnall MH, Purmal AA, Shakhov AN, Gudkov AV, Feinstein E. The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates. PLoS ONE. 2015. doi:10.1371/journal.pone.0135388. Fig 3. Enhanced morphological recovery of hematopoietic and lymphoid organs in NHPs treated with entolimod post-irradiation, Vehicle — irradiated vehicle comparator. CC0 1.0 Universal; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 3 legend", "rights_basis": "The article is dedicated to the public domain under CC0. Figure 3 has no separate third-party credit line; exact-pixel marrow-panel crops remain linked to the complete figure and original legend. The PMC Open Access service records the article as CC0, and the locally retained full text states that the work is distributed under the Creative Commons Public Domain declaration.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC0-RHESUS-ENTOLIMOD-F03-VEH.png", "preview_path": "previews/BM-CC0-RHESUS-ENTOLIMOD-F03-VEH.jpg", "sha256": "022e0da82393f56ebba8b4f19366537a7442f319b3ccf95ca5bbd98c730ca263", "processing_note": "Exact-pixel crop of the top-row Vehicle marrow panel from the CC0 Figure 3 at parent coordinates [0,44,196,188]. The group label, complete marrow field, bone edge, and 100 μm scale bar are preserved; no resampling or visual enhancement was applied.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC4569586-FIGURE-3", "parent_sha256": "8bce24bd6a55899133fc1d3bc5a6e76307f4d8890a5a767e0c49e65378b75103", "parent_asset_path": "images/PMC4569586-FIGURE-3.jpg", "crop_coordinates": [ 0, 44, 196, 188 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC0-RHESUS-ENTOLIMOD-F03-16H", "map_image_id": "BMPM-IMG-0347", "source_id": "S2M-PMC4569586", "title_cn": "恒河猴辐射后恢复：16小时给予entolimod的第40天骨髓", "title_en": "Rhesus macaque post-irradiation recovery: day-40 marrow after entolimod at 16 hours", "description_cn": "原作者报告照射后16小时给予entolimod的代表性胸骨骨髓较载体组显示更充分的形态恢复，造血细胞增多并呈较密集簇状分布。该图属于组水平恢复反应，不证明同一动物的纵向变化或完全功能恢复。", "description_en": "The authors report greater morphological recovery than in the irradiated vehicle group, with more numerous hematopoietic cells arranged in denser clusters, after entolimod at 16 hours. This is a group-level recovery response and does not demonstrate within-animal longitudinal change or complete functional recovery.", "species": "Rhesus_monkey", "strain": "Rhesus macaque (Macaca mulatta); study cohort Rs-06", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Hematopoietic_repopulation", "Post_irradiation_recovery" ], "evidence_role": "Recovery_response", "causality_level": "Author_attributed", "figure_label": "Fig 3. Enhanced morphological recovery of hematopoietic and lymphoid organs in NHPs treated with entolimod post-irradiation", "panel_label": "+16h — entolimod after irradiation", "source_page": "Figure 3, sternum bone marrow row, +16h panel", "caption_original_en": "NHPs were treated with a single injection of 40 μg/kg entolimod 16, 25 or 48 hours after LD75/40 total body irradiation (TBI). Tissue morphology was assessed 40 days post-irradiation and compared to that in control NHPs treated with vehicle 16 hours after LD75/40 TBI. Representative histological images (hematoxylin-eosin staining) of sternum bone marrow sections, thymuses, spleens and mesenteric lymph nodes of animals that survived to study termination on Day 40 post-TBI (study Rs-06) are shown. Scale bars: 100 μm for bone marrow, 200 μm for thymus, spleen, and lymph node.", "article_title": "The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates", "authors": "Krivokrysenko VI, Toshkov IA, Gleiberman AS, Krasnov P, Shyshynova I, Bespalov I, Maitra RK, Narizhneva NV, Singh VK, Whitnall MH, Purmal AA, Shakhov AN, Gudkov AV, Feinstein E", "journal": "PLoS ONE", "year": "2015", "doi": "10.1371/journal.pone.0135388", "pmid": "26367124", "pmcid": "PMC4569586", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4569586/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fad/4569586/3541f0ad7743/pone.0135388.g003.jpg", "license": "CC0 1.0 Universal", "license_url": "https://creativecommons.org/publicdomain/zero/1.0/", "reuse_status": "public_domain", "attribution": "Krivokrysenko VI, Toshkov IA, Gleiberman AS, Krasnov P, Shyshynova I, Bespalov I, Maitra RK, Narizhneva NV, Singh VK, Whitnall MH, Purmal AA, Shakhov AN, Gudkov AV, Feinstein E. The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates. PLoS ONE. 2015. doi:10.1371/journal.pone.0135388. Fig 3. Enhanced morphological recovery of hematopoietic and lymphoid organs in NHPs treated with entolimod post-irradiation, +16h — entolimod after irradiation. CC0 1.0 Universal; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 3 legend", "rights_basis": "The article is dedicated to the public domain under CC0. Figure 3 has no separate third-party credit line; exact-pixel marrow-panel crops remain linked to the complete figure and original legend. The PMC Open Access service records the article as CC0, and the locally retained full text states that the work is distributed under the Creative Commons Public Domain declaration.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC0-RHESUS-ENTOLIMOD-F03-16H.png", "preview_path": "previews/BM-CC0-RHESUS-ENTOLIMOD-F03-16H.jpg", "sha256": "e97ed1c26a8363007eaba352f64b7e470e6a823f27aa9002806be8b0bd8f5cd8", "processing_note": "Exact-pixel crop of the top-row +16h marrow panel from the CC0 Figure 3 at parent coordinates [196,44,392,188]. The treatment-time label, complete marrow field, bone edge, and 100 μm scale bar are preserved; no resampling or visual enhancement was applied.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC4569586-FIGURE-3", "parent_sha256": "8bce24bd6a55899133fc1d3bc5a6e76307f4d8890a5a767e0c49e65378b75103", "parent_asset_path": "images/PMC4569586-FIGURE-3.jpg", "crop_coordinates": [ 196, 44, 392, 188 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC0-RHESUS-ENTOLIMOD-F03-25H", "map_image_id": "BMPM-IMG-0345", "source_id": "S2M-PMC4569586", "title_cn": "恒河猴辐射后恢复：25小时给予entolimod的第40天骨髓", "title_en": "Rhesus macaque post-irradiation recovery: day-40 marrow after entolimod at 25 hours", "description_cn": "照射后25小时给予entolimod的代表性胸骨骨髓显示较载体组更丰富、更致密的造血组织，支持原作者所述的加速形态恢复。该panel不应用于在缺乏定量评分时比较三个给药时点的优劣。", "description_en": "This representative sternal marrow field after entolimod at 25 hours contains more abundant and densely arranged hematopoietic tissue than the vehicle field, supporting the authors' description of accelerated morphological recovery. The panel should not be used to rank treatment times without quantitative scores.", "species": "Rhesus_monkey", "strain": "Rhesus macaque (Macaca mulatta); study cohort Rs-06", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Hematopoietic_repopulation", "Post_irradiation_recovery" ], "evidence_role": "Recovery_response", "causality_level": "Author_attributed", "figure_label": "Fig 3. Enhanced morphological recovery of hematopoietic and lymphoid organs in NHPs treated with entolimod post-irradiation", "panel_label": "+25h — entolimod after irradiation", "source_page": "Figure 3, sternum bone marrow row, +25h panel", "caption_original_en": "NHPs were treated with a single injection of 40 μg/kg entolimod 16, 25 or 48 hours after LD75/40 total body irradiation (TBI). Tissue morphology was assessed 40 days post-irradiation and compared to that in control NHPs treated with vehicle 16 hours after LD75/40 TBI. Representative histological images (hematoxylin-eosin staining) of sternum bone marrow sections, thymuses, spleens and mesenteric lymph nodes of animals that survived to study termination on Day 40 post-TBI (study Rs-06) are shown. Scale bars: 100 μm for bone marrow, 200 μm for thymus, spleen, and lymph node.", "article_title": "The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates", "authors": "Krivokrysenko VI, Toshkov IA, Gleiberman AS, Krasnov P, Shyshynova I, Bespalov I, Maitra RK, Narizhneva NV, Singh VK, Whitnall MH, Purmal AA, Shakhov AN, Gudkov AV, Feinstein E", "journal": "PLoS ONE", "year": "2015", "doi": "10.1371/journal.pone.0135388", "pmid": "26367124", "pmcid": "PMC4569586", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4569586/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fad/4569586/3541f0ad7743/pone.0135388.g003.jpg", "license": "CC0 1.0 Universal", "license_url": "https://creativecommons.org/publicdomain/zero/1.0/", "reuse_status": "public_domain", "attribution": "Krivokrysenko VI, Toshkov IA, Gleiberman AS, Krasnov P, Shyshynova I, Bespalov I, Maitra RK, Narizhneva NV, Singh VK, Whitnall MH, Purmal AA, Shakhov AN, Gudkov AV, Feinstein E. The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates. PLoS ONE. 2015. doi:10.1371/journal.pone.0135388. Fig 3. Enhanced morphological recovery of hematopoietic and lymphoid organs in NHPs treated with entolimod post-irradiation, +25h — entolimod after irradiation. CC0 1.0 Universal; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 3 legend", "rights_basis": "The article is dedicated to the public domain under CC0. Figure 3 has no separate third-party credit line; exact-pixel marrow-panel crops remain linked to the complete figure and original legend. The PMC Open Access service records the article as CC0, and the locally retained full text states that the work is distributed under the Creative Commons Public Domain declaration.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC0-RHESUS-ENTOLIMOD-F03-25H.png", "preview_path": "previews/BM-CC0-RHESUS-ENTOLIMOD-F03-25H.jpg", "sha256": "3e12b0f9dc07dd96ccf856b37ccdf544bc88ed7b48cb7d3f1172270e2ba43731", "processing_note": "Exact-pixel crop of the top-row +25h marrow panel from the CC0 Figure 3 at parent coordinates [392,44,587,188]. The treatment-time label, complete marrow field, bone edge, and 100 μm scale bar are preserved; no resampling or visual enhancement was applied.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC4569586-FIGURE-3", "parent_sha256": "8bce24bd6a55899133fc1d3bc5a6e76307f4d8890a5a767e0c49e65378b75103", "parent_asset_path": "images/PMC4569586-FIGURE-3.jpg", "crop_coordinates": [ 392, 44, 587, 188 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC0-RHESUS-ENTOLIMOD-F03-48H", "map_image_id": "BMPM-IMG-0346", "source_id": "S2M-PMC4569586", "title_cn": "恒河猴辐射后恢复：48小时给予entolimod的第40天骨髓", "title_en": "Rhesus macaque post-irradiation recovery: day-40 marrow after entolimod at 48 hours", "description_cn": "照射后48小时给予entolimod的代表性胸骨骨髓较载体组显示更充分的造血组织重建。原文指出部分动物接近正常、部分仍有轻至中度低形成，因此单一代表图不能外推为全部动物完全恢复。", "description_en": "This representative sternal marrow field after entolimod at 48 hours shows greater hematopoietic repopulation than the vehicle field. The text notes that some animals were near normal whereas others remained mildly or moderately hypoplastic, so one field cannot be generalized as complete recovery in every animal.", "species": "Rhesus_monkey", "strain": "Rhesus macaque (Macaca mulatta); study cohort Rs-06", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Hematopoietic_repopulation", "Post_irradiation_recovery" ], "evidence_role": "Recovery_response", "causality_level": "Author_attributed", "figure_label": "Fig 3. Enhanced morphological recovery of hematopoietic and lymphoid organs in NHPs treated with entolimod post-irradiation", "panel_label": "+48h — entolimod after irradiation", "source_page": "Figure 3, sternum bone marrow row, +48h panel", "caption_original_en": "NHPs were treated with a single injection of 40 μg/kg entolimod 16, 25 or 48 hours after LD75/40 total body irradiation (TBI). Tissue morphology was assessed 40 days post-irradiation and compared to that in control NHPs treated with vehicle 16 hours after LD75/40 TBI. Representative histological images (hematoxylin-eosin staining) of sternum bone marrow sections, thymuses, spleens and mesenteric lymph nodes of animals that survived to study termination on Day 40 post-TBI (study Rs-06) are shown. Scale bars: 100 μm for bone marrow, 200 μm for thymus, spleen, and lymph node.", "article_title": "The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates", "authors": "Krivokrysenko VI, Toshkov IA, Gleiberman AS, Krasnov P, Shyshynova I, Bespalov I, Maitra RK, Narizhneva NV, Singh VK, Whitnall MH, Purmal AA, Shakhov AN, Gudkov AV, Feinstein E", "journal": "PLoS ONE", "year": "2015", "doi": "10.1371/journal.pone.0135388", "pmid": "26367124", "pmcid": "PMC4569586", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4569586/", "source_media_url": "https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0fad/4569586/3541f0ad7743/pone.0135388.g003.jpg", "license": "CC0 1.0 Universal", "license_url": "https://creativecommons.org/publicdomain/zero/1.0/", "reuse_status": "public_domain", "attribution": "Krivokrysenko VI, Toshkov IA, Gleiberman AS, Krasnov P, Shyshynova I, Bespalov I, Maitra RK, Narizhneva NV, Singh VK, Whitnall MH, Purmal AA, Shakhov AN, Gudkov AV, Feinstein E. The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates. PLoS ONE. 2015. doi:10.1371/journal.pone.0135388. Fig 3. Enhanced morphological recovery of hematopoietic and lymphoid organs in NHPs treated with entolimod post-irradiation, +48h — entolimod after irradiation. CC0 1.0 Universal; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 3 legend", "rights_basis": "The article is dedicated to the public domain under CC0. Figure 3 has no separate third-party credit line; exact-pixel marrow-panel crops remain linked to the complete figure and original legend. The PMC Open Access service records the article as CC0, and the locally retained full text states that the work is distributed under the Creative Commons Public Domain declaration.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC0-RHESUS-ENTOLIMOD-F03-48H.png", "preview_path": "previews/BM-CC0-RHESUS-ENTOLIMOD-F03-48H.jpg", "sha256": "6ded14b889e1ae7a05f08373aa4587cacce6b44a1a42951450d04c15b76cd63c", "processing_note": "Exact-pixel crop of the top-row +48h marrow panel from the CC0 Figure 3 at parent coordinates [587,44,783,188]. The treatment-time label, complete marrow field, bone edge, and 100 μm scale bar are preserved; no resampling or visual enhancement was applied.", "source_mode": "canonical_map_panel", "parent_figure_id": "PMC4569586-FIGURE-3", "parent_sha256": "8bce24bd6a55899133fc1d3bc5a6e76307f4d8890a5a767e0c49e65378b75103", "parent_asset_path": "images/PMC4569586-FIGURE-3.jpg", "crop_coordinates": [ 587, 44, 783, 188 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-JAPANESE-MACAQUE-FUKUSHIMA-F03-A", "map_image_id": "NR", "source_id": "PMC6233195-JAPANESE-MACAQUE-MARROW", "title_cn": "日本猴骨髓环境暴露研究：低内照射剂量率代表视野", "title_en": "Japanese macaque marrow in an environmental-exposure study: representative lower internal dose-rate field", "description_cn": "Figure 3a来自1只9岁雄性日本猴，作者估算内照射剂量率为4.90 μGy/day、外照射剂量率为24.8 μGy/day。该视野用于理解横断面环境暴露队列中的骨髓组织学外观；原文的细胞计数与剂量率相关性是群体层面结果，不能从这一代表视野诊断个体骨髓毒性或确证因果关系。", "description_en": "Figure 3a is from one 9-year-old male Japanese macaque with an estimated internal dose-rate of 4.90 μGy/day and external dose-rate of 24.8 μGy/day. The field supports visual study of marrow histology in a cross-sectional environmental-exposure cohort. The article's dose-rate correlations with cell counts are population-level findings and cannot be converted into an individual diagnosis of marrow toxicity or causality from this representative field.", "species": "Japanese_macaque", "strain": "Macaca fuscata; 9-year-old male", "specimen_type": "Histology_Giemsa", "stain": "Giemsa; 100 µm scale bar", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Expected_background_variation", "secondary_features": [ "Environmental_exposure_context", "Representative_histology", "Population_level_correlation_only" ], "evidence_role": "Disease_differential", "causality_level": "Uncertain", "figure_label": "Figure 3", "panel_label": "a", "source_page": "Figure 3, panel a", "caption_original_en": "Representative histology of bone marrow of the exposed macaques. (a) A 9-year-old male captured on August 27, 2013 with 479 Bq/kg (134Cs + 137Cs) of the skeletal muscle, of which the estimated internal dose-rate was 4.90 μGy/day and the external dose-rate was 24.8 μGy/day. (b) An 8-year-old female captured on January 24, 2014 with 11,400 Bq/kg (137Cs + 134Cs) of the skeletal muscle, of which the estimated internal dose-rate was 74.5 μGy/day and the external dose-rate was 24.9 μGy/day.", "article_title": "Haematological analysis of Japanese macaques (Macaca fuscata) in the area affected by the Fukushima Daiichi Nuclear Power Plant accident", "authors": "Urushihara Y, Suzuki T, Shimizu Y, Ohtaki M, Kuwahara Y, Suzuki M, Uno T, Fujita S, Saito A, Yamashiro H, Kino Y, Sekine T, Shinoda H, Fukumoto M", "journal": "Scientific Reports", "year": "2018", "doi": "10.1038/s41598-018-35104-0", "pmid": "30425289", "pmcid": "PMC6233195", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6233195/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6233195/figure/Fig3/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Urushihara Y, Suzuki T, Shimizu Y, Ohtaki M, Kuwahara Y, Suzuki M, Uno T, Fujita S, Saito A, Yamashiro H, Kino Y, Sekine T, Shinoda H, Fukumoto M. Haematological analysis of Japanese macaques (Macaca fuscata) in the area affected by the Fukushima Daiichi Nuclear Power Plant accident. Scientific Reports. 2018. doi:10.1038/s41598-018-35104-0. Figure 3, a. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 3 legend", "rights_basis": "CC BY 4.0 permits adaptation with attribution. The two exact-pixel panel crops retain panel letters, full microscopic fields, and 100 µm scale bars and remain linked to the complete Figure 3 caption. The locally retained JATS permissions block applies CC BY 4.0 to the article and its images unless a separate credit line states otherwise. Figure 3 contains no separate third-party credit line.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-JAPANESE-MACAQUE-FUKUSHIMA-F03-A.png", "preview_path": "previews/BM-CC-JAPANESE-MACAQUE-FUKUSHIMA-F03-A.jpg", "sha256": "6f7148bc2e05fe4b5043f190eba261604df4f818a822e84cafcc16c99fd2ab67", "processing_note": "Exact-pixel panel a crop from complete CC BY 4.0 Figure 3 at parent coordinates [0,0,375,375]. The panel letter, complete field, and 100 µm scale bar are retained; no resampling, retouching, enhancement, or generative modification was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC6233195-FIGURE-3", "parent_sha256": "7f1ed8c03e55021db390c1593c94c298af6fa18f73ff235c23466d5f0ccf71c8", "parent_asset_path": "images/PMC6233195-FIGURE-3.jpg", "crop_coordinates": [ 0, 0, 375, 375 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-JAPANESE-MACAQUE-FUKUSHIMA-F03-B", "map_image_id": "NR", "source_id": "PMC6233195-JAPANESE-MACAQUE-MARROW", "title_cn": "日本猴骨髓环境暴露研究：高内照射剂量率代表视野", "title_en": "Japanese macaque marrow in an environmental-exposure study: representative higher internal dose-rate field", "description_cn": "Figure 3b来自1只8岁雌性日本猴，作者估算内照射剂量率为74.5 μGy/day、外照射剂量率为24.9 μGy/day。图中可见较多脂肪间隙和较少的造血细胞区，但这只是单个代表视野；原文报告的脂肪占比与造血细胞计数相关性来自群体分析，不应单独解读为个体骨髓毒性。", "description_en": "Figure 3b is from one 8-year-old female Japanese macaque with an estimated internal dose-rate of 74.5 μGy/day and external dose-rate of 24.9 μGy/day. More adipose spaces and less hematopoietic tissue are visible in this representative field, but it is a single field. The article's correlations between adipose occupancy, hematopoietic counts, and dose-rate derive from cohort-level analyses and should not be read as an individual toxicity diagnosis.", "species": "Japanese_macaque", "strain": "Macaca fuscata; 8-year-old female", "specimen_type": "Histology_Giemsa", "stain": "Giemsa; 100 µm scale bar", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Stromal_or_microenvironment_change", "secondary_features": [ "Environmental_exposure_context", "Increased_adipose_spaces_visible", "Reduced_hematopoietic_area_visible", "Population_level_correlation_only" ], "evidence_role": "Disease_differential", "causality_level": "Uncertain", "figure_label": "Figure 3", "panel_label": "b", "source_page": "Figure 3, panel b", "caption_original_en": "Representative histology of bone marrow of the exposed macaques. (a) A 9-year-old male captured on August 27, 2013 with 479 Bq/kg (134Cs + 137Cs) of the skeletal muscle, of which the estimated internal dose-rate was 4.90 μGy/day and the external dose-rate was 24.8 μGy/day. (b) An 8-year-old female captured on January 24, 2014 with 11,400 Bq/kg (137Cs + 134Cs) of the skeletal muscle, of which the estimated internal dose-rate was 74.5 μGy/day and the external dose-rate was 24.9 μGy/day.", "article_title": "Haematological analysis of Japanese macaques (Macaca fuscata) in the area affected by the Fukushima Daiichi Nuclear Power Plant accident", "authors": "Urushihara Y, Suzuki T, Shimizu Y, Ohtaki M, Kuwahara Y, Suzuki M, Uno T, Fujita S, Saito A, Yamashiro H, Kino Y, Sekine T, Shinoda H, Fukumoto M", "journal": "Scientific Reports", "year": "2018", "doi": "10.1038/s41598-018-35104-0", "pmid": "30425289", "pmcid": "PMC6233195", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6233195/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6233195/figure/Fig3/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Urushihara Y, Suzuki T, Shimizu Y, Ohtaki M, Kuwahara Y, Suzuki M, Uno T, Fujita S, Saito A, Yamashiro H, Kino Y, Sekine T, Shinoda H, Fukumoto M. Haematological analysis of Japanese macaques (Macaca fuscata) in the area affected by the Fukushima Daiichi Nuclear Power Plant accident. Scientific Reports. 2018. doi:10.1038/s41598-018-35104-0. Figure 3, b. CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 3 legend", "rights_basis": "CC BY 4.0 permits adaptation with attribution. The two exact-pixel panel crops retain panel letters, full microscopic fields, and 100 µm scale bars and remain linked to the complete Figure 3 caption. The locally retained JATS permissions block applies CC BY 4.0 to the article and its images unless a separate credit line states otherwise. Figure 3 contains no separate third-party credit line.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-JAPANESE-MACAQUE-FUKUSHIMA-F03-B.png", "preview_path": "previews/BM-CC-JAPANESE-MACAQUE-FUKUSHIMA-F03-B.jpg", "sha256": "a933b3a272c22317c92b425f7d374d6fa02cb5fa48e627bab34815e31cbfeeee", "processing_note": "Exact-pixel panel b crop from complete CC BY 4.0 Figure 3 at parent coordinates [375,0,750,375]. The panel letter, complete field, and 100 µm scale bar are retained; no resampling, retouching, enhancement, or generative modification was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC6233195-FIGURE-3", "parent_sha256": "7f1ed8c03e55021db390c1593c94c298af6fa18f73ff235c23466d5f0ccf71c8", "parent_asset_path": "images/PMC6233195-FIGURE-3.jpg", "crop_coordinates": [ 375, 0, 750, 375 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-NC-ND-CYNO-INHAND-F015", "map_image_id": "NR", "source_id": "AUTH-PMC8544165", "title_cn": "INHAND食蟹猴骨髓：猴细小病毒性核内包涵体", "title_en": "INHAND cynomolgus marrow: simian parvovirus-associated intranuclear inclusions", "description_cn": "INHAND完整Figure 15展示骨髓细胞核内包涵体，原图归因于猴细小病毒。该图是感染性病变和毒理研究混杂因素的鉴别案例，不应自动标记为试验物相关骨髓毒性。", "description_en": "Complete INHAND Figure 15 shows intranuclear inclusions in marrow attributed by the source to simian parvovirus. It is an infectious-disease differential and a potential toxicology-study confounder, not an automatically treatment-related marrow toxicity finding.", "species": "Cynomolgus_monkey", "strain": "Macaca fascicularis; study context NR", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Mixed_or_uncertain", "maturation_stage": "NR", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Intranuclear_inclusions", "Simian_parvovirus_author_attributed", "Infectious_disease_differential" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 15", "panel_label": "Complete figure", "source_page": "Figure 15", "caption_original_en": "Cynomolgus, Bone marrow, Intranuclear inclusions, simian parvovirus, H&E.", "article_title": "International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis)", "authors": "Colman K, Andrews RN, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A, Capobianco R, Caudell D, Cline M, Doi T, et al.", "journal": "Journal of Toxicologic Pathology", "year": "2021", "doi": "10.1293/tox.34.1S", "pmid": "34712008", "pmcid": "PMC8544165", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "license": "CC BY-NC-ND 4.0", "license_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Colman K, Andrews RN, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A, Capobianco R, Caudell D, Cline M, Doi T, et al.. International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis). Journal of Toxicologic Pathology. 2021. doi:10.1293/tox.34.1S. Figure 15, Complete figure. CC BY-NC-ND 4.0; complete figure reproduced without adaptation for noncommercial learning.", "third_party_credit_line": "None reported in the screened figure legends", "rights_basis": "The complete figures are reproduced byte-for-byte for noncommercial education with attribution. No crop, annotation, resampling, color change, retouching, or other adaptation is distributed. The locally retained JATS permissions block grants CC BY-NC-ND 4.0. Figures 15, 16, 74, 75, 79, and 80 have no separate third-party credit lines. Because derivatives are not permitted, only byte-identical complete figure files are distributed.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-NC-ND-CYNO-INHAND-F015.jpg", "preview_path": "images/BM-CC-NC-ND-CYNO-INHAND-F015.jpg", "sha256": "dee0c8300b44e25cb6c219dfc62313b8f1ede93153b2de95dd0e938c6b9b09a2", "processing_note": "Byte-identical complete Figure 15 reproduced under CC BY-NC-ND 4.0 for noncommercial education. No crop, annotation, resampling, color change, retouching, enhancement, or generative modification was applied.", "source_mode": "verbatim_full_figure", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-NC-ND-CYNO-INHAND-F016", "map_image_id": "NR", "source_id": "AUTH-PMC8544165", "title_cn": "INHAND食蟹猴骨髓：幼红细胞病毒性包涵体", "title_en": "INHAND cynomolgus marrow: viral inclusions in erythroid blasts", "description_cn": "INHAND完整Figure 16展示幼红细胞中的病毒性包涵体，原图归因于猴细小病毒。它可用于识别感染导致的红系异常，但不能脱离病毒学和研究背景转译为直接骨髓毒性。", "description_en": "Complete INHAND Figure 16 shows viral inclusions in erythroid blasts attributed by the source to simian parvovirus. It teaches an infectious erythroid differential and must not be converted into direct marrow toxicity without virologic and study-context support.", "species": "Cynomolgus_monkey", "strain": "Macaca fascicularis; study context NR", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Erythroid", "maturation_stage": "Erythroid_blasts", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Viral_inclusions", "Erythroid_blasts", "Simian_parvovirus_author_attributed", "Infectious_disease_differential" ], "evidence_role": "Disease_differential", "causality_level": "Differential_only", "figure_label": "Figure 16", "panel_label": "Complete figure", "source_page": "Figure 16", "caption_original_en": "Cynomolgus, Bone marrow, Erythroid blasts with viral inclusions, simian parvovirus, H&E.", "article_title": "International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis)", "authors": "Colman K, Andrews RN, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A, Capobianco R, Caudell D, Cline M, Doi T, et al.", "journal": "Journal of Toxicologic Pathology", "year": "2021", "doi": "10.1293/tox.34.1S", "pmid": "34712008", "pmcid": "PMC8544165", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "license": "CC BY-NC-ND 4.0", "license_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Colman K, Andrews RN, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A, Capobianco R, Caudell D, Cline M, Doi T, et al.. International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis). Journal of Toxicologic Pathology. 2021. doi:10.1293/tox.34.1S. Figure 16, Complete figure. CC BY-NC-ND 4.0; complete figure reproduced without adaptation for noncommercial learning.", "third_party_credit_line": "None reported in the screened figure legends", "rights_basis": "The complete figures are reproduced byte-for-byte for noncommercial education with attribution. No crop, annotation, resampling, color change, retouching, or other adaptation is distributed. The locally retained JATS permissions block grants CC BY-NC-ND 4.0. Figures 15, 16, 74, 75, 79, and 80 have no separate third-party credit lines. Because derivatives are not permitted, only byte-identical complete figure files are distributed.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-NC-ND-CYNO-INHAND-F016.jpg", "preview_path": "images/BM-CC-NC-ND-CYNO-INHAND-F016.jpg", "sha256": "b4bb8f7c44a8407adcb50ecb2b50c7400c8ec9424e0e24d7d9c18cffd0b4af01", "processing_note": "Byte-identical complete Figure 16 reproduced under CC BY-NC-ND 4.0 for noncommercial education. No crop, annotation, resampling, color change, retouching, enhancement, or generative modification was applied.", "source_mode": "verbatim_full_figure", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-NC-ND-CYNO-INHAND-F074", "map_image_id": "NR", "source_id": "AUTH-PMC8544165", "title_cn": "INHAND食蟹猴骨髓：淋巴滤泡形成低倍视野", "title_en": "INHAND cynomolgus marrow: lymphoid follicle formation at low magnification", "description_cn": "INHAND完整Figure 74为骨髓淋巴滤泡形成的低倍视野。这是具组织化结构的滤泡样反应；来源指出持续抗原刺激可能与其有关，但是否超出背景范围应结合对照、发生率和研究背景判断。", "description_en": "Complete INHAND Figure 74 is a low-magnification view of marrow lymphoid follicle formation. It represents an organized follicular response; persistent antigen exposure may be associated according to the source, but an increase beyond background requires concurrent controls, incidence, and study context.", "species": "Cynomolgus_monkey", "strain": "Macaca fascicularis; study context NR", "specimen_type": "Histology_HE", "stain": "H&E; low magnification", "lineage": "Lymphoid", "maturation_stage": "Mixed_lymphoid_population", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Lymphoid_follicle_formation", "Organized_follicular_structure", "Antigenic_stimulation_differential" ], "evidence_role": "Background_comparator", "causality_level": "Differential_only", "figure_label": "Figure 74", "panel_label": "Complete figure", "source_page": "Figure 74", "caption_original_en": "Cynomolgus, Bone marrow, Lymphoid follicle formation, H&E, Low magnification.", "article_title": "International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis)", "authors": "Colman K, Andrews RN, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A, Capobianco R, Caudell D, Cline M, Doi T, et al.", "journal": "Journal of Toxicologic Pathology", "year": "2021", "doi": "10.1293/tox.34.1S", "pmid": "34712008", "pmcid": "PMC8544165", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "license": "CC BY-NC-ND 4.0", "license_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Colman K, Andrews RN, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A, Capobianco R, Caudell D, Cline M, Doi T, et al.. International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis). Journal of Toxicologic Pathology. 2021. doi:10.1293/tox.34.1S. Figure 74, Complete figure. CC BY-NC-ND 4.0; complete figure reproduced without adaptation for noncommercial learning.", "third_party_credit_line": "None reported in the screened figure legends", "rights_basis": "The complete figures are reproduced byte-for-byte for noncommercial education with attribution. No crop, annotation, resampling, color change, retouching, or other adaptation is distributed. The locally retained JATS permissions block grants CC BY-NC-ND 4.0. Figures 15, 16, 74, 75, 79, and 80 have no separate third-party credit lines. Because derivatives are not permitted, only byte-identical complete figure files are distributed.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-NC-ND-CYNO-INHAND-F074.jpg", "preview_path": "images/BM-CC-NC-ND-CYNO-INHAND-F074.jpg", "sha256": "fef1b5829703a47bcaf27fe4bf3646b512451f0526213b0eeea0ead5e65da43c", "processing_note": "Byte-identical complete Figure 74 reproduced under CC BY-NC-ND 4.0 for noncommercial education. No crop, annotation, resampling, color change, retouching, enhancement, or generative modification was applied.", "source_mode": "verbatim_full_figure", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-NC-ND-CYNO-INHAND-F075", "map_image_id": "NR", "source_id": "AUTH-PMC8544165", "title_cn": "INHAND食蟹猴骨髓：淋巴滤泡形成高倍视野", "title_en": "INHAND cynomolgus marrow: lymphoid follicle formation at high magnification", "description_cn": "INHAND完整Figure 75是与低倍图配套的高倍视野，用于观察滤泡内的淋巴细胞构成。该图属背景反应和免疫刺激的教学鉴别，不能仅凭单一视野判定处理相关性。", "description_en": "Complete INHAND Figure 75 is the high-magnification companion view for examining the cellular composition of a marrow lymphoid follicle. It is a teaching differential for background reactivity and immune stimulation; one field cannot establish treatment association.", "species": "Cynomolgus_monkey", "strain": "Macaca fascicularis; study context NR", "specimen_type": "Histology_HE", "stain": "H&E; high magnification", "lineage": "Lymphoid", "maturation_stage": "Mixed_lymphoid_population", "primary_morphology_class": "Reactive_change", "secondary_features": [ "Lymphoid_follicle_formation", "Organized_follicular_structure", "High_magnification_companion" ], "evidence_role": "Background_comparator", "causality_level": "Differential_only", "figure_label": "Figure 75", "panel_label": "Complete figure", "source_page": "Figure 75", "caption_original_en": "Cynomolgus, Bone marrow, Lymphoid follicle formation, H&E, High magnification.", "article_title": "International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis)", "authors": "Colman K, Andrews RN, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A, Capobianco R, Caudell D, Cline M, Doi T, et al.", "journal": "Journal of Toxicologic Pathology", "year": "2021", "doi": "10.1293/tox.34.1S", "pmid": "34712008", "pmcid": "PMC8544165", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "license": "CC BY-NC-ND 4.0", "license_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Colman K, Andrews RN, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A, Capobianco R, Caudell D, Cline M, Doi T, et al.. International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis). Journal of Toxicologic Pathology. 2021. doi:10.1293/tox.34.1S. Figure 75, Complete figure. CC BY-NC-ND 4.0; complete figure reproduced without adaptation for noncommercial learning.", "third_party_credit_line": "None reported in the screened figure legends", "rights_basis": "The complete figures are reproduced byte-for-byte for noncommercial education with attribution. No crop, annotation, resampling, color change, retouching, or other adaptation is distributed. The locally retained JATS permissions block grants CC BY-NC-ND 4.0. Figures 15, 16, 74, 75, 79, and 80 have no separate third-party credit lines. Because derivatives are not permitted, only byte-identical complete figure files are distributed.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-NC-ND-CYNO-INHAND-F075.jpg", "preview_path": "images/BM-CC-NC-ND-CYNO-INHAND-F075.jpg", "sha256": "1b52bfa8a5f677fb09af841c0120e00386eff202c8834741ec2e2b2554739077", "processing_note": "Byte-identical complete Figure 75 reproduced under CC BY-NC-ND 4.0 for noncommercial education. No crop, annotation, resampling, color change, retouching, enhancement, or generative modification was applied.", "source_mode": "verbatim_full_figure", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-NC-ND-CYNO-INHAND-F079", "map_image_id": "NR", "source_id": "AUTH-PMC8544165", "title_cn": "INHAND食蟹猴骨髓：淋巴细胞聚集", "title_en": "INHAND cynomolgus marrow: lymphoid aggregate", "description_cn": "INHAND完整Figure 79展示骨髓内局灶性淋巴细胞聚集，其缺少成熟淋巴滤泡的组织化结构。来源资料提示此类聚集可在股骨或胸骨骨髓中观察到；应与滤泡形成、弥漫性浸润和肿瘤性增殖分开。", "description_en": "Complete INHAND Figure 79 shows a focal marrow lymphoid aggregate lacking the organized architecture of a mature lymphoid follicle. Such aggregates can be encountered in femoral or sternal marrow according to the source and should be distinguished from follicle formation, diffuse infiltration, and neoplastic proliferation.", "species": "Cynomolgus_monkey", "strain": "Macaca fascicularis; study context NR", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Lymphoid", "maturation_stage": "Mixed_lymphoid_population", "primary_morphology_class": "Expected_background_variation", "secondary_features": [ "Lymphoid_aggregate", "Focal_accumulation", "Unorganized_architecture" ], "evidence_role": "Background_comparator", "causality_level": "Differential_only", "figure_label": "Figure 79", "panel_label": "Complete figure", "source_page": "Figure 79", "caption_original_en": "Cynomolgus, Bone marrow, Lymphoid aggregate, H&E.", "article_title": "International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis)", "authors": "Colman K, Andrews RN, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A, Capobianco R, Caudell D, Cline M, Doi T, et al.", "journal": "Journal of Toxicologic Pathology", "year": "2021", "doi": "10.1293/tox.34.1S", "pmid": "34712008", "pmcid": "PMC8544165", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "license": "CC BY-NC-ND 4.0", "license_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Colman K, Andrews RN, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A, Capobianco R, Caudell D, Cline M, Doi T, et al.. International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis). Journal of Toxicologic Pathology. 2021. doi:10.1293/tox.34.1S. Figure 79, Complete figure. CC BY-NC-ND 4.0; complete figure reproduced without adaptation for noncommercial learning.", "third_party_credit_line": "None reported in the screened figure legends", "rights_basis": "The complete figures are reproduced byte-for-byte for noncommercial education with attribution. No crop, annotation, resampling, color change, retouching, or other adaptation is distributed. The locally retained JATS permissions block grants CC BY-NC-ND 4.0. Figures 15, 16, 74, 75, 79, and 80 have no separate third-party credit lines. Because derivatives are not permitted, only byte-identical complete figure files are distributed.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-NC-ND-CYNO-INHAND-F079.jpg", "preview_path": "images/BM-CC-NC-ND-CYNO-INHAND-F079.jpg", "sha256": "5196787c8221fa69eac68f4900ec9a033a6add12c45cc97b863e6a7e90fe6d29", "processing_note": "Byte-identical complete Figure 79 reproduced under CC BY-NC-ND 4.0 for noncommercial education. No crop, annotation, resampling, color change, retouching, enhancement, or generative modification was applied.", "source_mode": "verbatim_full_figure", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-NC-ND-CYNO-INHAND-F080", "map_image_id": "NR", "source_id": "AUTH-PMC8544165", "title_cn": "INHAND食蟹猴骨髓：增加的巨核细胞胞穿入", "title_en": "INHAND cynomolgus marrow: increased megakaryocytic emperipolesis", "description_cn": "INHAND完整Figure 80展示巨核细胞胞质内完整细胞的胞穿入（emperipolesis）。胞穿入是完整细胞穿过另一细胞胞质的现象，不同于吞噬；它可见于健康骨髓，也可在压力或疾病状态中增加，正常食蟹猴中的意义仍不明确。", "description_en": "Complete INHAND Figure 80 shows intact cells within megakaryocyte cytoplasm, termed emperipolesis. Emperipolesis is passage of intact cells through another cell's cytoplasm and differs from phagocytosis. It can occur in healthy marrow and may increase during stress or disease; its significance in normal cynomolgus marrow remains unclear.", "species": "Cynomolgus_monkey", "strain": "Macaca fascicularis; study context NR", "specimen_type": "Histology_HE", "stain": "H&E", "lineage": "Megakaryocytic", "maturation_stage": "Mature_megakaryocyte", "primary_morphology_class": "Expected_background_variation", "secondary_features": [ "Emperipolesis", "Intact_cells_within_megakaryocyte", "Not_phagocytosis", "Significance_uncertain" ], "evidence_role": "Teaching_pattern", "causality_level": "Differential_only", "figure_label": "Figure 80", "panel_label": "Complete figure", "source_page": "Figure 80", "caption_original_en": "Cynomolgus, Bone marrow, Emperipolesis, increased, megakaryocyte, H&E.", "article_title": "International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis)", "authors": "Colman K, Andrews RN, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A, Capobianco R, Caudell D, Cline M, Doi T, et al.", "journal": "Journal of Toxicologic Pathology", "year": "2021", "doi": "10.1293/tox.34.1S", "pmid": "34712008", "pmcid": "PMC8544165", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "license": "CC BY-NC-ND 4.0", "license_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/", "reuse_status": "cc_noncommercial_only", "attribution": "Colman K, Andrews RN, Atkins H, Boulineau T, Bradley A, Braendli-Baiocco A, Capobianco R, Caudell D, Cline M, Doi T, et al.. International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis). Journal of Toxicologic Pathology. 2021. doi:10.1293/tox.34.1S. Figure 80, Complete figure. CC BY-NC-ND 4.0; complete figure reproduced without adaptation for noncommercial learning.", "third_party_credit_line": "None reported in the screened figure legends", "rights_basis": "The complete figures are reproduced byte-for-byte for noncommercial education with attribution. No crop, annotation, resampling, color change, retouching, or other adaptation is distributed. The locally retained JATS permissions block grants CC BY-NC-ND 4.0. Figures 15, 16, 74, 75, 79, and 80 have no separate third-party credit lines. Because derivatives are not permitted, only byte-identical complete figure files are distributed.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-NC-ND-CYNO-INHAND-F080.jpg", "preview_path": "images/BM-CC-NC-ND-CYNO-INHAND-F080.jpg", "sha256": "0e6f89f4199c2430035593d3d7c6740bbed33801a25586e642c283116c7af265", "processing_note": "Byte-identical complete Figure 80 reproduced under CC BY-NC-ND 4.0 for noncommercial education. No crop, annotation, resampling, color change, retouching, enhancement, or generative modification was applied.", "source_mode": "verbatim_full_figure", "parent_figure_id": "NR", "parent_sha256": "NR", "parent_asset_path": "NR", "crop_coordinates": "NR", "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" }, { "image_id": "BM-CC-RHESUS-12GY-GT3-F03-STERNUM", "map_image_id": "NR", "source_id": "PMC10923821-RHESUS-RADIATION-HISTOPATH", "title_cn": "恒河猴12 Gy辐射后第7天：胸骨骨髓重度低生成和造血细胞耗竭", "title_en": "Rhesus macaque day 7 after 12 Gy irradiation: severe sternal marrow hypoplasia and hematopoietic depletion", "description_cn": "Figure 3胸骨行并列展示12 Gy全身或部分身体辐射后第7天的GT3处理组、载体组和健康对照。原作者报告所有辐射组胸骨存在显著造血细胞耗竭和重度低生成，造血成分大量丧失并被脂肪细胞取代；超致死剂量下GT3保护有限。各列来自不同动物或组别，不是同一动物的连续活检。", "description_en": "The sternum rows of Figure 3 compare GT3-treated, vehicle-treated, and healthy rhesus macaques seven days after 12 Gy total- or partial-body irradiation. The authors report pronounced hematopoietic-cell depletion and severe hypoplasia in all irradiated sternum sections, with extensive loss of hematopoietic elements and adipocyte replacement; GT3 provided limited protection at this supralethal dose. Columns represent different animals or groups, not serial biopsies from one animal.", "species": "Rhesus_monkey", "strain": "Macaca mulatta; 32 naive animals in study; representative animals identified in caption", "specimen_type": "Histology_HE", "stain": "H&E; 40× and 200× source rows", "lineage": "Mixed_or_uncertain", "maturation_stage": "Mixed_hematopoietic_population", "primary_morphology_class": "Cytotoxic_change", "secondary_features": [ "Severe_hypoplasia", "Hematopoietic_cell_depletion", "Adipocyte_replacement", "Healthy_comparator", "GT3_limited_protection_author_reported" ], "evidence_role": "Toxicity_image", "causality_level": "Author_attributed", "figure_label": "Figure 3", "panel_label": "Sternum rows (40× and 200×)", "source_page": "Figure 3, sternum rows", "caption_original_en": "Comparison of lymphohematopoietic organs collected from vehicle- and GT3-treated NHPs day 7 post-irradiation with 12 Gy. Radiation exposure was either partial-body (PBI) or total-body (TBI). GT3 Sternum: TBI RA2528F, PBI 1603158F, Vehicle Sternum: TBI RA3238F, PBI 1607024F, Healthy 14041532F. GT3 Spleen: TBI RA2528F, PBI 1603158F, Vehicle Spleen: TBI RA3291F, PBI 1603103M, Healthy 14041532F.", "article_title": "Histopathological studies of nonhuman primates exposed to supralethal doses of total- or partial-body radiation: influence of a medical countermeasure, gamma-tocotrienol", "authors": "Singh VK, Wise SY, Fatanmi OO, Petrus SA, Carpenter AD, Lee SH, Hauer-Jensen M, Seed TM", "journal": "Scientific Reports", "year": "2024", "doi": "10.1038/s41598-024-56135-w", "pmid": "38459144", "pmcid": "PMC10923821", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10923821/", "source_media_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10923821/figure/Fig3/", "license": "CC BY 4.0", "license_url": "https://creativecommons.org/licenses/by/4.0/", "reuse_status": "cc_reuse_allowed", "attribution": "Singh VK, Wise SY, Fatanmi OO, Petrus SA, Carpenter AD, Lee SH, Hauer-Jensen M, Seed TM. Histopathological studies of nonhuman primates exposed to supralethal doses of total- or partial-body radiation: influence of a medical countermeasure, gamma-tocotrienol. Scientific Reports. 2024. doi:10.1038/s41598-024-56135-w. Figure 3, Sternum rows (40× and 200×). CC BY 4.0; cropped teaching panel.", "third_party_credit_line": "None reported in the Figure 3 legend", "rights_basis": "CC BY 4.0 permits adaptation with attribution. The exact-pixel crop retains the complete column headings, 40× and 200× sternum row labels, and all five group fields; the spleen rows are excluded without altering marrow pixels. The JATS permissions block applies CC BY 4.0 to the article and images unless separately credited. Figure 3 has no separate third-party credit line; the article also identifies the work as a U.S. Government work in the United States.", "rights_reviewed_at": "2026-08-12", "expert_review_status": "Pending", "asset_path": "images/BM-CC-RHESUS-12GY-GT3-F03-STERNUM.png", "preview_path": "previews/BM-CC-RHESUS-12GY-GT3-F03-STERNUM.jpg", "sha256": "79860df05bb6193af669bca3b02b2ab9c7dc36674545e07c35726b47e819d6e6", "processing_note": "Exact-pixel crop of the complete 40× and 200× sternum rows from CC BY 4.0 Figure 3 at parent coordinates [0,0,708,198]. All group headers, row labels, and five marrow fields are retained; the spleen rows are excluded without modifying marrow pixels. No resampling, retouching, enhancement, or generative modification was applied.", "source_mode": "audited_parent_crop", "parent_figure_id": "PMC10923821-FIGURE-3", "parent_sha256": "6d3669af34af1475b10966c211d2e910bfaee8b75041dd914e7117674f4d6931", "parent_asset_path": "images/PMC10923821-FIGURE-3.jpg", "crop_coordinates": [ 0, 0, 708, 198 ], "display_surface": "Linked_pathology_evidence", "pathology_atlas_url": "../public-atlas/?system=bone_marrow" } ] }