{ "meta": { "title_cn": "非临床骨髓典型案例库", "title_en": "Representative Nonclinical Bone Marrow Case Library", "version": "1.0.0", "generated_at": "2026-08-11", "canonical_url": "https://toxpathmap.cn/bone-marrow/cases/", "notice_cn": "公开案例卡为可追溯摘要，不等同于专家诊断或因果性结论。" }, "stats": { "local_cases_audited": 440, "public_traceable_cases": 326, "featured_cases": 75, "sources": 130, "species": 9, "toxicity_types": 12, "public_linked_cases": 32, "public_linked_case_images": 48, "pathology_routed_cases": 32, "pathology_routed_case_images": 81, "local_images_audited": 372, "public_allowlisted_images": 86, "public_equivalent_images": 6, "nonreleasable_no_derivatives_crops": 7, "images_pending_release_review": 273 }, "exclusion_summary": { "Duplicate_case_summary": 46, "Source_URL_missing": 10, "Species_uncertain": 89 }, "controlled_values": { "publication_level": [ "Featured_case", "Traceable_case_index" ], "image_status": [ "Public_image_linked", "Pathology_evidence_routed", "Source_reports_image_not_republished", "Metadata_only" ], "expert_review_status": [ "Pending" ] }, "toxicity_types": [ { "id": "T01", "title_cn": "骨髓低细胞性、全系减少和再生障碍", "title_en": "Hypocellularity, pancytopenia and aplasia", "definition_cn": "造血细胞总体减少，可局灶或弥漫，并可伴脂肪组织相对增加；严重时表现为全系耗竭或再生障碍。", "definition_en": "A global reduction in hematopoietic cells, focal or diffuse, sometimes with relative adipose replacement; severe forms may include multilineage depletion or aplasia.", "expert_review_status": "Pending" }, { "id": "T02", "title_cn": "红系、粒系或巨核系选择性减少", "title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "definition_cn": "一个主要造血谱系选择性减少，而其他谱系相对保留。比例变化本身不能证明绝对减少。", "definition_en": "Preferential reduction of one hematopoietic lineage with relative preservation of others. A proportional change alone does not establish an absolute decrease.", "expert_review_status": "Pending" }, { "id": "T03", "title_cn": "成熟阻滞和发育异常", "title_en": "Maturation arrest and dysmaturation", "definition_cn": "成熟序列在特定阶段前聚集、后续阶段减少，或出现核/胞质成熟不同步及群体性发育异常。", "definition_en": "Accumulation before a maturation stage with reduction beyond it, or population-level asynchronous nuclear/cytoplasmic maturation and abnormal development.", "expert_review_status": "Pending" }, { "id": "T04", "title_cn": "细胞凋亡、变性和骨髓坏死", "title_en": "Apoptosis, degeneration and marrow necrosis", "definition_cn": "造血细胞出现凋亡、变性、碎裂或较大片骨髓坏死，可为直接损伤或继发改变。", "definition_en": "Apoptosis, degeneration, fragmentation, or confluent marrow necrosis involving hematopoietic cells; the change may be direct or secondary.", "expert_review_status": "Pending" }, { "id": "T05", "title_cn": "骨髓纤维化和基质改变", "title_en": "Fibrosis and stromal or microenvironment change", "definition_cn": "网状纤维/胶原增加、基质成分改变或造血微环境受损。", "definition_en": "Increased reticulin/collagen, altered stromal components, or injury to the hematopoietic microenvironment.", "expert_review_status": "Pending" }, { "id": "T06", "title_cn": "反应性增生、恢复期反跳和高细胞性", "title_en": "Reactive hyperplasia, rebound and hypercellularity", "definition_cn": "某一或多个造血谱系增加，包括治疗期反应性增生、骨髓抑制后反跳或总体高细胞性。", "definition_en": "Expansion of one or more hematopoietic lineages, including treatment-period reactive hyperplasia, post-suppression rebound, or global hypercellularity.", "expert_review_status": "Pending" }, { "id": "T07", "title_cn": "巨核细胞损伤、减少及血小板毒性", "title_en": "Megakaryocyte injury, decrease and platelet toxicity", "definition_cn": "巨核细胞数量、成熟、核形、胞质成熟或产板表现改变，并与血小板毒性证据关联。", "definition_en": "Changes in megakaryocyte quantity, maturation, nuclear morphology, cytoplasmic maturation, or platelet shedding, correlated with platelet toxicity evidence.", "expert_review_status": "Pending" }, { "id": "T08", "title_cn": "嗜血、红细胞吞噬和巨噬细胞改变", "title_en": "Hemophagocytosis, erythrophagocytosis and macrophage change", "definition_cn": "巨噬细胞吞噬红细胞、红系前体或其他血细胞，或伴巨噬细胞数量/活化形态改变。", "definition_en": "Macrophage ingestion of erythrocytes, erythroid precursors, or other blood cells, with or without altered macrophage quantity or activation morphology.", "expert_review_status": "Pending" }, { "id": "T09", "title_cn": "色素、含铁血黄素及异物蓄积", "title_en": "Pigment, hemosiderin and foreign material accumulation", "definition_cn": "巨噬细胞或基质中出现含铁血黄素、其他内源性色素或外源性物质蓄积。", "definition_en": "Accumulation of hemosiderin, other endogenous pigment, or exogenous material in macrophages or marrow stroma.", "expert_review_status": "Pending" }, { "id": "T10", "title_cn": "血管扩张、缺血和骨髓微环境损伤", "title_en": "Angiectasis, ischemia and marrow vascular injury", "definition_cn": "骨髓血窦/血管扩张、充血、出血、缺血性损伤或血管相关微环境改变。", "definition_en": "Sinusoidal or vascular dilation, congestion, hemorrhage, ischemic injury, or vascular-associated microenvironment change.", "expert_review_status": "Pending" }, { "id": "T11", "title_cn": "炎症、感染性改变和异常细胞浸润", "title_en": "Inflammation, infection and abnormal cellular infiltration", "definition_cn": "骨髓炎症、感染性病原体、反应性炎细胞或异常细胞群浸润。", "definition_en": "Marrow inflammation, infectious organisms, reactive inflammatory cells, or infiltration by an abnormal cell population.", "expert_review_status": "Pending" }, { "id": "T12", "title_cn": "MDS、AML及增殖性病变鉴别对照", "title_en": "MDS, AML and proliferative disease differentials", "definition_cn": "MDS、AML及其他增殖性病变的疾病鉴别层，用于避免把克隆性/自发病变误称为药物毒性。", "definition_en": "Disease-differential layer for MDS, AML, and other proliferative disorders, preventing clonal or spontaneous disease from being mislabeled as drug toxicity.", "expert_review_status": "Pending" } ], "cases": [ { "case_id": "S2E-CASE-MOUSE-NTP-HYPER", "featured": true, "featured_reason_cn": "NTP小鼠骨髓高细胞性组织学模式", "module_id": "neutrophilia", "source_id": "NTP-BONE-MARROW-HYPERCELLULARITY", "source_title": "Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "NR", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "NTP小鼠骨髓高细胞性组织学模式", "display_title_cn": "NTP小鼠骨髓高细胞性组织学模式", "title_en": "NTP mouse marrow hypercellularity pattern", "factor": "Sustained_inflammatory_response", "dose": "NR", "timecourse": "NR", "evidence_role": "Teaching_pattern", "causality_level": "NR", "observation_summary_cn": "NTP小鼠骨髓高细胞性组织学模式", "author_conclusion_summary_cn": "教学性模式对应，不声称来自同一动物或同一研究中的CBC—骨髓配对。", "author_conclusion_summary_en": "Teaching correspondence only; not presented as a paired CBC-marrow observation from the same animal or study group.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-HYPER-F05" ], "pathology_evidence_count": 1, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-HYPER-F05", "title_cn": "小鼠骨髓高细胞性组织学模式", "title_en": "Histologic pattern of bone marrow hypercellularity in mouse", "figure_label": "Figure 5", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-CASE-PMC4566160", "featured": true, "featured_reason_cn": "食蟹猴辐射后第5天多系骨髓耗竭", "module_id": "toxicity_atlas", "source_id": "PMC4566160-CYNO-RADIATION-MARROW", "source_title": "Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4566160/", "doi": "10.3109/09553002.2015.1028597", "pmid": "25786585", "pmcid": "PMC4566160", "source_page": "Figure 2, panels A-C; Results paragraphs 20-21", "species": "Cynomolgus_monkey", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "食蟹猴全身照射后第5天骨髓严重低细胞性、坏死和多系造血细胞丢失。", "display_title_cn": "食蟹猴辐射后第5天多系骨髓耗竭", "title_en": "Day-5 marrow after total-body irradiation showed severe hypocellularity, necrosis, and multilineage hematopoietic cell loss.", "factor": "Single total-body irradiation", "dose": "0, 2, or 5 Gy", "timecourse": "Bone marrow histology on day 5; peripheral-blood nadirs occurred later", "evidence_role": "Toxicity_image", "causality_level": "Author_attributed", "observation_summary_cn": "食蟹猴全身照射后第5天骨髓严重低细胞性、坏死和多系造血细胞丢失。", "author_conclusion_summary_cn": "原作者报告2 Gy和5 Gy照射动物第5天骨髓均见严重造血细胞耗竭，涉及全部造血谱系，并伴低细胞性和坏死。同期研究还记录了血小板、白细胞和红细胞下降，但各外周血最低点多发生在第5天之后。单张代表性视野不能单独量化各谱系耗竭、证明2 Gy与5 Gy之间的严格形态剂量梯度，或判定恢复、机制和不良性。", "author_conclusion_summary_en": "The authors reported severe day-5 depletion across all hematopoietic lineages after 2 or 5 Gy, with hypocellularity and necrosis. Blood-cell nadirs mostly occurred later. Representative fields do not quantify lineage-specific loss or establish a strict 2-versus-5 Gy morphologic gradient.", "pairing_note_cn": "Figure 2的A、B、C分别为0、2、5 Gy组第5天的骨髓切片代表视野；D-F为脾脏，不计入骨髓形态图。三个骨髓panel来自不同动物/组别，不是同一动物连续取样。Figure 1的外周血曲线来自同研究，但其最低点与第5天组织学并不同步，因此属于同研究支持证据，不是同一时间点严格配对。", "pairing_note_en": "Figure 2 panels A, B, and C are representative day-5 marrow sections from the 0-, 2-, and 5-Gy groups; panels D-F are spleen and are excluded from marrow morphology. The marrow panels are different animals/groups, not serial samples. Figure 1 blood curves are same-study support but not a same-time-point strict pair.", "rights_note_cn": "PMC可公开阅读不等于允许转载图片。核对的文章页面未显示明确Creative Commons或Figure 2专属再利用许可，因此本站仅提供来源链接和双语证据卡，不复制原图。", "rights_note_en": "Public readability in PMC is not image-reuse permission. No explicit Creative Commons or Figure 2-specific reuse license was identified in the inspected article page, so the website links the source without republishing the figure.", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2O-CASE-PMC6233195", "featured": true, "featured_reason_cn": "日本猴环境辐射暴露研究：骨髓造血细胞与脂肪占比对照", "module_id": "bone-marrow-cases", "source_id": "PMC6233195-JAPANESE-MACAQUE-MARROW", "source_title": "Haematological analysis of Japanese macaques (Macaca fuscata) in the area affected by the Fukushima Daiichi Nuclear Power Plant accident", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6233195/", "doi": "10.1038/s41598-018-35104-0", "pmid": "30425289", "pmcid": "PMC6233195", "source_page": "Figure 3 and marrow-correlation results", "species": "Japanese_macaque", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "福岛周边日本猴横断面研究报告，成熟个体的内照射剂量率与骨髓髓系、巨核系和总造血细胞计数呈负相关，与脂肪占比呈正相关。", "display_title_cn": "日本猴环境辐射暴露研究：骨髓造血细胞与脂肪占比对照", "title_en": "Japanese_macaque: Hypocellularity, pancytopenia and aplasia associated with Environmental radiocesium exposure after the Fukushima Daiichi accident", "factor": "Environmental radiocesium exposure after the Fukushima Daiichi accident", "dose": "Representative Figure 3 animals: estimated internal dose-rates 4.90 and 74.5 μGy/day; external dose-rates 24.8 and 24.9 μGy/day", "timecourse": "Cross-sectional captures from 2013-2014; not a controlled longitudinal toxicity study", "evidence_role": "Disease_differential", "causality_level": "Uncertain", "observation_summary_cn": "福岛周边日本猴横断面研究报告，成熟个体的内照射剂量率与骨髓髓系、巨核系和总造血细胞计数呈负相关，与脂肪占比呈正相关。", "author_conclusion_summary_cn": "作者认为结果提示长期低剂量内照射可能影响骨髓造血细胞。网站将这一解释与可见组织学分开：环境暴露横断面相关性不能等同于受控试验的剂量-反应因果证据。", "author_conclusion_summary_en": "The authors interpreted the findings as suggesting that chronic low-dose internal exposure may affect marrow hematopoietic cells. The atlas separates that interpretation from the visible histology: a cross-sectional environmental-exposure correlation is not equivalent to a controlled dose-response causality demonstration.", "pairing_note_cn": "Panels a和b来自两只不同动物；它们是代表性视野，不是同一动物的暴露前后配对或严格对照。", "pairing_note_en": "Panels a and b are from two different animals. They are representative fields, not pre/post samples from one animal or a strict matched comparison.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-CC-JAPANESE-MACAQUE-FUKUSHIMA-F03-A", "BM-CC-JAPANESE-MACAQUE-FUKUSHIMA-F03-B" ], "pathology_evidence_count": 2, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-CC-JAPANESE-MACAQUE-FUKUSHIMA-F03-A", "title_cn": "日本猴骨髓环境暴露研究：低内照射剂量率代表视野", "title_en": "Japanese macaque marrow in an environmental-exposure study: representative lower internal dose-rate field", "figure_label": "Figure 3", "specimen_type": "Histology_Giemsa", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6233195/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-JAPANESE-MACAQUE-FUKUSHIMA-F03-B", "title_cn": "日本猴骨髓环境暴露研究：高内照射剂量率代表视野", "title_en": "Japanese macaque marrow in an environmental-exposure study: representative higher internal dose-rate field", "figure_label": "Figure 3", "specimen_type": "Histology_Giemsa", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6233195/", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "AUTH-CASE-PMC2974595", "featured": true, "featured_reason_cn": "小鼠再生障碍模型：进行性脂肪置换", "module_id": "toxicity_library", "source_id": "AUTH-PMC2974595", "source_title": "Hematopoiesis in 3 dimensions: human and murine bone marrow architecture visualized by confocal microscopy", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2974595/", "doi": "10.1182/blood-2010-02-268466", "pmid": "20647571", "pmcid": "PMC2974595", "source_page": "NR", "species": "Mouse", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "权威候选来源记录：Immune-mediated aplastic anemia architecture with progressive adipose replacement。具体图像与处理相关性仍需逐图专家复核。", "display_title_cn": "小鼠再生障碍模型：进行性脂肪置换", "title_en": "Immune-mediated aplastic anemia architecture with progressive adipose replacement", "factor": "Three-dimensional microenvironment comparator", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "权威候选来源记录：Immune-mediated aplastic anemia architecture with progressive adipose replacement。具体图像与处理相关性仍需逐图专家复核。", "author_conclusion_summary_cn": "NR", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "NTP-CASE-MOUSE-SEVERE-HYPOCELLULARITY", "featured": true, "featured_reason_cn": "小鼠重度骨髓低细胞性：低/高倍对照", "module_id": "bone-marrow-cases", "source_id": "NTP-BONE-MARROW-HYPOCELLULARITY", "source_title": "Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "Figures 5-6", "species": "Mouse", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "亚慢性研究雄性B6C3F1小鼠出现重度骨髓低细胞性，髓腔大部分由脂肪组织和血管窦占据。", "display_title_cn": "小鼠重度骨髓低细胞性：低/高倍对照", "title_en": "Severe marrow hypocellularity in a male B6C3F1 mouse, with marrow spaces largely occupied by adipose tissue and vascular sinuses.", "factor": "Treatment-induced aplastic anemia context", "dose": "NR", "timecourse": "Subchronic study", "evidence_role": "Treatment_associated_pair", "causality_level": "Author_attributed", "observation_summary_cn": "亚慢性研究雄性B6C3F1小鼠出现重度骨髓低细胞性，髓腔大部分由脂肪组织和血管窦占据。", "author_conclusion_summary_cn": "原来源将该重度造血细胞丢失置于处理诱导再生障碍性贫血背景；仍需结合血液学及研究设计判断毒理学意义。", "author_conclusion_summary_en": "The source places the severe loss of hematopoietic cells in the context of treatment-induced aplastic anemia; hematology and study design remain necessary for toxicologic interpretation.", "pairing_note_cn": "Figures 5与6为同一重度病变的低倍和高倍视图。", "pairing_note_en": "Figures 5 and 6 are low- and higher-magnification views of the same severe lesion pattern.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-HYPO-F05", "BM-NTP-HYPO-F06" ], "pathology_evidence_count": 2, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-HYPO-F05", "title_cn": "小鼠骨髓重度低细胞性（低倍）", "title_en": "Severe bone marrow hypocellularity in mouse, low power", "figure_label": "Figure 5", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-HYPO-F06", "title_cn": "小鼠骨髓重度低细胞性（高倍）", "title_en": "Severe bone marrow hypocellularity in mouse, higher magnification", "figure_label": "Figure 6", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC2807276-CASE-MOUSE-BMT-SEVERE-DEPLETION", "featured": true, "featured_reason_cn": "小鼠骨髓移植后严重造血细胞丢失与近乎完全粒系耗竭", "module_id": "bone-marrow-cases", "source_id": "S2M-PMC2807276", "source_title": "Pathological features of bone marrow transplantation-related toxicity in a mouse", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2807276/", "doi": "10.4142/jvs.2009.10.4.361", "pmid": "19934605", "pmcid": "PMC2807276", "source_page": "Figure 1 and Tables 1-2", "species": "Mouse", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "C57BL/6小鼠骨髓移植后第19天濒死：严重造血细胞丢失与近乎完全粒系耗竭。", "display_title_cn": "小鼠骨髓移植后严重造血细胞丢失与近乎完全粒系耗竭", "title_en": "Moribund C57BL/6 mouse 19 days after bone marrow transplantation: severe hematopoietic-cell loss and near-complete myeloid depletion.", "factor": "7.5 Gy irradiation followed by mock-transduced bone marrow transplantation", "dose": "7.5 Gy irradiation; mock-transduced marrow cells 35 × 10^6 cells/kg by tail-vein injection", "timecourse": "Moribund sacrifice 19 days after transplantation; planned experimental duration 53 days", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "C57BL/6小鼠骨髓移植后第19天濒死：严重造血细胞丢失与近乎完全粒系耗竭。", "author_conclusion_summary_cn": "原作者报告骨髓造血细胞严重耗竭、粒系细胞近乎完全耗竭，同时外周血WBC、RBC、HCT、HGB和PLT降低而网织红细胞增加，并在组织学中观察到骨髓、胸腺和脾萎缩。作者将多器官表现解释为骨髓移植相关的autoimmune-like complications；图谱保留该解释，但单只濒死动物且缺少严格同期对照，不能分离照射、植入失败、移植相关免疫反应或其他机制，也不能作为一般药物性骨髓抑制的频率或剂量反应证据。", "author_conclusion_summary_en": "See the cited source for the complete author interpretation.", "pairing_note_cn": "Figure 1的A、B为同一只小鼠、同一第19天终末评价中的两个代表性骨髓细胞学视野，Tables 1-2提供同病例血液学和分类计数支持。两张图不是处理前后序列，也没有同期未处理动物的图像对照；视野内残存细胞不代表其绝对数量或发生率。", "pairing_note_en": "Panels A and B are two representative marrow-cytology fields from the same mouse at the same day-19 terminal evaluation, with Tables 1-2 providing same-case hematology and differential-count support. They are not a before-after sequence and lack an imaged concurrent untreated control; residual cells within the fields do not establish absolute abundance or frequency.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-NC-MOUSE-BMT-DEPLETION-F01-A", "BM-CC-NC-MOUSE-BMT-DEPLETION-F01-B" ], "public_image_paths": [ "../images/BM-CC-NC-MOUSE-BMT-DEPLETION-F01-A.png", "../images/BM-CC-NC-MOUSE-BMT-DEPLETION-F01-B.png" ], "public_image_preview_paths": [ "../previews/BM-CC-NC-MOUSE-BMT-DEPLETION-F01-A.jpg", "../previews/BM-CC-NC-MOUSE-BMT-DEPLETION-F01-B.jpg" ], "public_images": [ { "image_id": "BM-CC-NC-MOUSE-BMT-DEPLETION-F01-A", "title_cn": "小鼠骨髓移植后严重造血细胞丢失：残存混合细胞群", "title_en": "Severe hematopoietic-cell loss after mouse BMT: residual mixed marrow cells", "figure_label": "Fig. 1", "species": "Mouse", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-NC-MOUSE-BMT-DEPLETION-F01-A.png", "preview_path": "../previews/BM-CC-NC-MOUSE-BMT-DEPLETION-F01-A.jpg", "caption_original_en": "Bone marrow (BM) cytology from the mouse found moribund 19 days after BM transplantation (BMT). BM cytology showed a severe loss of hematopoietic cells. (A) Few basophilic erythroblasts, basophils, macrophages, plasma cells, and lymphoblasts. (B) Proerythroblasts, polychromatic erythroblasts, and lymphocytes are present. Wright-Geimsa stain.", "reuse_status": "cc_noncommercial_only", "expert_review_status": "Pending" }, { "image_id": "BM-CC-NC-MOUSE-BMT-DEPLETION-F01-B", "title_cn": "小鼠骨髓移植后严重造血细胞丢失：残存红系前体与淋巴细胞", "title_en": "Severe hematopoietic-cell loss after mouse BMT: residual erythroid precursors and lymphocytes", "figure_label": "Fig. 1", "species": "Mouse", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-NC-MOUSE-BMT-DEPLETION-F01-B.png", "preview_path": "../previews/BM-CC-NC-MOUSE-BMT-DEPLETION-F01-B.jpg", "caption_original_en": "Bone marrow (BM) cytology from the mouse found moribund 19 days after BM transplantation (BMT). BM cytology showed a severe loss of hematopoietic cells. (A) Few basophilic erythroblasts, basophils, macrophages, plasma cells, and lymphoblasts. (B) Proerythroblasts, polychromatic erythroblasts, and lymphocytes are present. Wright-Geimsa stain.", "reuse_status": "cc_noncommercial_only", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-CASE-PMC10752361", "featured": true, "featured_reason_cn": "兔正常骨髓细胞量对照", "module_id": "toxicity_atlas", "source_id": "PMC10752361-RABBIT-EPO-MARROW", "source_title": "Effects of Exogenous Erythropoietin on Rabbit (Oryctolagus cuniculus) Hematological and Biochemical Parameters", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10752361/", "doi": "10.30802/AALAS-CM-22-000107", "pmid": "37967856", "pmcid": "PMC10752361", "source_page": "Figure 2 and Table 1; Results: postmortem marrow at week 4", "species": "Rabbit", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "新西兰白兔EPO研究第4周骨髓保持正常细胞量，铁储存存在且组间无明显差异。", "display_title_cn": "兔正常骨髓细胞量对照", "title_en": "At week 4 in the rabbit EPO study, marrow remained normocellular with detectable iron and no obvious group difference.", "factor": "Subcutaneous erythropoietin", "dose": "150 or 1,000 IU/kg; one dose or three doses 24 hours apart", "timecourse": "Necropsy and marrow evaluation 4 weeks after initial dosing", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "新西兰白兔EPO研究第4周骨髓保持正常细胞量，铁储存存在且组间无明显差异。", "author_conclusion_summary_cn": "Figure 2图注明确所有兔骨髓造血成分约占30%-50%，均为正常细胞量；普鲁士蓝染色显示铁从少量至中等量，组间无明显差异。原文另报告4只兔有红系成分扩增，但未见随EPO剂量增加的明确剂量反应；所有兔巨核细胞数量及成熟均在该研究采用的范围内。该小样本、特定实验条件下的结果可作为处理情境中的正常/背景对照，不能直接建立跨实验室兔参考区间。", "author_conclusion_summary_en": "Figure 2 reports 30%-50% hematopoietic content with normal cellularity and rare-to-moderate iron without an obvious group difference. Four rabbits had erythroid expansion without a clear dose response. This small study is a context-specific comparator, not a universal rabbit reference interval.", "pairing_note_cn": "Figure 2将对照、150 IU/kg及1,000 IU/kg的单次或连续3次给药组代表性H&E（10×）和普鲁士蓝（40×）视野组合在一张图中。各panel来自不同兔和不同染色，不是同一动物的多时点配对；第4周组织学也不能替代给药后第1周短暂CBC变化的同期骨髓证据。", "pairing_note_en": "Figure 2 combines representative H&E (10×) and Prussian-blue (40×) fields from control and single- or three-dose 150- and 1,000-IU/kg groups. Panels are different rabbits/stains, not serial samples. Week-4 histology is not synchronous marrow evidence for the transient week-1 CBC response.", "rights_note_cn": "文章版权页标示© American Association for Laboratory Animal Science，未见明确Creative Commons图片再利用许可；Figure 2仅作来源链接和案例摘要，不在公开站点复制。", "rights_note_en": "The article page identifies copyright by the American Association for Laboratory Animal Science and no explicit Creative Commons image-reuse license. Figure 2 remains source-linked and is not republished.", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "NTP-CASE-RAT-HYPOCELLULARITY", "featured": true, "featured_reason_cn": "大鼠轻度骨髓低细胞性：同期对照与低/高倍配对", "module_id": "bone-marrow-cases", "source_id": "NTP-BONE-MARROW-HYPOCELLULARITY", "source_title": "Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "Figures 1-4", "species": "Rat", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "亚慢性研究中，处理雌性F344/N大鼠骨髓较同期对照呈轻度低细胞性；低倍和高倍视图均支持该比较。", "display_title_cn": "大鼠轻度骨髓低细胞性：同期对照与低/高倍配对", "title_en": "Mild marrow hypocellularity in a treated female F344/N rat relative to the concurrent control, supported at low and higher magnification.", "factor": "Treatment; test article NR", "dose": "NR", "timecourse": "Subchronic study", "evidence_role": "Treatment_associated_pair", "causality_level": "Author_attributed", "observation_summary_cn": "亚慢性研究中，处理雌性F344/N大鼠骨髓较同期对照呈轻度低细胞性；低倍和高倍视图均支持该比较。", "author_conclusion_summary_cn": "原来源将该改变描述为与同期对照相比的轻度骨髓低细胞性；组织学图像本身不能确定具体受影响细胞系。", "author_conclusion_summary_en": "The source describes mild marrow hypocellularity relative to the concurrent control; histology alone does not identify a selectively affected lineage.", "pairing_note_cn": "Figures 1与2为同期对照和处理动物的低倍比较，Figures 3与4为相应高倍比较；不是同一动物的连续时序。", "pairing_note_en": "Figures 1 and 2 provide the concurrent-control versus treated low-power comparison; Figures 3 and 4 provide the corresponding higher-power comparison. This is not a longitudinal sequence from one animal.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-HYPO-F01", "BM-NTP-HYPO-F02", "BM-NTP-HYPO-F03", "BM-NTP-HYPO-F04" ], "pathology_evidence_count": 4, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-HYPO-F01", "title_cn": "对照大鼠骨髓细胞量（低倍）", "title_en": "Control rat bone marrow cellularity, low power", "figure_label": "Figure 1", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-HYPO-F02", "title_cn": "大鼠骨髓轻度低细胞性（低倍）", "title_en": "Mild bone marrow hypocellularity in rat, low power", "figure_label": "Figure 2", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-HYPO-F03", "title_cn": "对照大鼠骨髓细胞量（高倍）", "title_en": "Control rat bone marrow cellularity, higher magnification", "figure_label": "Figure 3", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-HYPO-F04", "title_cn": "大鼠骨髓轻度低细胞性（高倍）", "title_en": "Mild bone marrow hypocellularity in rat, higher magnification", "figure_label": "Figure 4", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC6947013-CASE-RAT-CYCLOPHOSPHAMIDE-MARROW-INJURY", "featured": true, "featured_reason_cn": "大鼠环磷酰胺骨髓损伤与Royal Jelly预处理对照", "module_id": "bone-marrow-cases", "source_id": "LEGACY-RPBM-002", "source_title": "Protective Effect of Royal Jelly against Cyclophosphamide-Induced Thrombocytopenia and Spleen and Bone Marrow Damages in Rats", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6947013/", "doi": "10.22074/cellj.2020.6703", "pmid": "31863655", "pmcid": "PMC6947013", "source_page": "Figure 4, panels A, D, E, and F; Figure 3B; Results: Histological changes", "species": "Rat", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "Wistar大鼠环磷酰胺骨髓损伤图组：对照、造血细胞减少伴出血及脂肪样空隙增加，以及Royal Jelly预处理组。", "display_title_cn": "大鼠环磷酰胺骨髓损伤与Royal Jelly预处理对照", "title_en": "Wistar rat cyclophosphamide marrow-injury set: control, reduced hematopoietic cells with hemorrhage and adipose-like spaces, and royal-jelly pretreatment groups.", "factor": "Cyclophosphamide with or without royal jelly pretreatment", "dose": "Royal jelly 100 or 200 mg/kg orally for 14 days; cyclophosphamide 100, 50, and 50 mg/kg intraperitoneally on days 15-17", "timecourse": "Terminal evaluation 3 days after the last cyclophosphamide injection", "evidence_role": "Treatment_associated_pair", "causality_level": "Author_attributed", "observation_summary_cn": "Wistar大鼠环磷酰胺骨髓损伤图组：对照、造血细胞减少伴出血及脂肪样空隙增加，以及Royal Jelly预处理组。", "author_conclusion_summary_cn": "原作者报告CP组PLT、WBC和RBC降低，股骨骨髓造血细胞减少、重度出血、脂肪样细胞增加且巨核细胞数降低；RJ预处理组的血液学和组织学改变减轻。图谱把这些原文观察与作者的保护性解释分开保存。该高剂量短期模型支持环磷酰胺相关多系骨髓损伤的教学识别，但不能由代表性视野单独量化细胞量、证明谱系选择性、推导临床等效剂量或判断不良性。", "author_conclusion_summary_en": "See the cited source for the complete author interpretation.", "pairing_note_cn": "Panels A、D、E和F来自同一研究、同一终末时间点的不同处理组代表视野，不是同一动物的连续骨髓取样。Figure图注明确D为CP组并以符号标示造血细胞减少、出血和脂肪样细胞，而正文一处误写为Fig.4B；网站按图注和图内标记映射，同时保留该来源内冲突。Figure 1和Figure 3为组水平统计图，仅作案例证据，不计入形态图数量。", "pairing_note_en": "Panels A, D, E, and F are representative fields from different treatment groups at one terminal time point in the same study, not serial marrow samples from one animal. The legend and in-image symbols identify D as the CP group, whereas one prose sentence inconsistently cites Fig. 4B; the atlas follows the legend and annotations while preserving the conflict. Figures 1 and 3 are group-level statistical plots used as case evidence and are not counted as morphology images.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-CC-NC-RAT-CP-RJ-F04-A", "BM-CC-NC-RAT-CP-RJ-F04-D", "BM-CC-NC-RAT-CP-RJ-F04-E", "BM-CC-NC-RAT-CP-RJ-F04-F" ], "pathology_evidence_count": 4, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-CC-NC-RAT-CP-RJ-F04-A", "title_cn": "Wistar大鼠股骨骨髓对照：保留的造血组织结构", "title_en": "Wistar rat femoral marrow control: preserved hematopoietic architecture", "figure_label": "Figure 4", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6947013/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-NC-RAT-CP-RJ-F04-D", "title_cn": "环磷酰胺处理大鼠骨髓：造血细胞减少、出血和脂肪样空隙增加", "title_en": "Cyclophosphamide-treated rat marrow: reduced hematopoietic cells, hemorrhage, and increased adipose-like spaces", "figure_label": "Figure 4", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6947013/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-NC-RAT-CP-RJ-F04-E", "title_cn": "Royal Jelly 100 mg/kg预处理加环磷酰胺：骨髓保护性对照", "title_en": "Royal jelly 100 mg/kg pretreatment plus cyclophosphamide: marrow-protection comparator", "figure_label": "Figure 4", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6947013/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-NC-RAT-CP-RJ-F04-F", "title_cn": "Royal Jelly 200 mg/kg预处理加环磷酰胺：骨髓保护性对照", "title_en": "Royal jelly 200 mg/kg pretreatment plus cyclophosphamide: marrow-protection comparator", "figure_label": "Figure 4", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6947013/", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-CASE-PMC13135069", "featured": true, "featured_reason_cn": "恒河猴辐射性造血细胞耗竭", "module_id": "toxicity_atlas", "source_id": "PMC13135069-RHESUS-RADIATION-DEPLETION", "source_title": "Comparative study of pathology of various organs of rhesus macaques exposed to two different doses of acute total-body radiation", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13135069/", "doi": "10.1038/s41598-026-49844-x", "pmid": "42034724", "pmcid": "PMC13135069", "source_page": "Figure 3a, sternum marrow row", "species": "Rhesus_monkey", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "与健康对照相比，辐射后胸骨骨髓呈明显造血细胞耗竭。", "display_title_cn": "恒河猴辐射性造血细胞耗竭", "title_en": "Irradiated sternum marrow showed marked hematopoietic depletion compared with healthy marrow.", "factor": "Acute total-body irradiation", "dose": "5.8 or 6.5 Gy", "timecourse": "Terminal sternum histopathology within a 60-day study", "evidence_role": "Treatment_associated_pair", "causality_level": "Treatment_associated", "observation_summary_cn": "与健康对照相比，辐射后胸骨骨髓呈明显造血细胞耗竭。", "author_conclusion_summary_cn": "两个辐射剂量示例均显示显著骨髓造血细胞耗竭，并以健康恒河猴胸骨骨髓作为形态参照；研究中5.8 Gy组的耗竭评分反而略高，不能将三图简单解释为单调剂量反应。", "author_conclusion_summary_en": "Both irradiated examples show marked hematopoietic depletion relative to healthy sternum marrow. Depletion scores were unexpectedly somewhat greater in the 5.8 Gy group, so the three fields should not be read as a simple monotonic dose response.", "pairing_note_cn": "5.8 Gy（RA1272M）、6.5 Gy（RA2693M）和健康对照（14041532F）来自三只不同恒河猴，比例尺也不同；仅构成跨动物教学比较。", "pairing_note_en": "The 5.8 Gy (RA1272M), 6.5 Gy (RA2693M), and healthy (14041532F) fields are from three different rhesus macaques and use different scale bars. They form a cross-animal teaching comparison only.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-CC-RHESUS-TBI-F03-5P8GY", "BM-CC-RHESUS-TBI-F03-6P5GY", "BM-CC-RHESUS-TBI-F03-HEALTHY" ], "pathology_evidence_count": 3, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-CC-RHESUS-TBI-F03-5P8GY", "title_cn": "恒河猴5.8 Gy全身辐射后胸骨骨髓显著细胞耗竭", "title_en": "Marked sternal marrow cellular depletion after 5.8 Gy total-body irradiation in a rhesus macaque", "figure_label": "Fig. 3", "specimen_type": "Sternum_bone_marrow_histology", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13135069/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-RHESUS-TBI-F03-6P5GY", "title_cn": "恒河猴6.5 Gy全身辐射后胸骨骨髓显著细胞丢失", "title_en": "Marked sternal marrow cellular loss after 6.5 Gy total-body irradiation in a rhesus macaque", "figure_label": "Fig. 3", "specimen_type": "Sternum_bone_marrow_histology", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13135069/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-RHESUS-TBI-F03-HEALTHY", "title_cn": "健康恒河猴胸骨骨髓组织学对照", "title_en": "Healthy rhesus macaque sternal marrow histology comparator", "figure_label": "Fig. 3", "specimen_type": "Sternum_bone_marrow_histology", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13135069/", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2O-CASE-PMC10923821", "featured": true, "featured_reason_cn": "恒河猴12 Gy辐射后第7天：重度骨髓低生成与造血细胞耗竭", "module_id": "bone-marrow-cases", "source_id": "PMC10923821-RHESUS-RADIATION-HISTOPATH", "source_title": "Histopathological studies of nonhuman primates exposed to supralethal doses of total- or partial-body radiation: influence of a medical countermeasure, gamma-tocotrienol", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10923821/", "doi": "10.1038/s41598-024-56135-w", "pmid": "38459144", "pmcid": "PMC10923821", "source_page": "Figure 3, sternum rows; day-7 histopathology results", "species": "Rhesus_monkey", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "恒河猴接受12 Gy全身或部分身体辐射后第7天，胸骨骨髓出现显著造血细胞耗竭和重度低生成，并见脂肪细胞取代。", "display_title_cn": "恒河猴12 Gy辐射后第7天：重度骨髓低生成与造血细胞耗竭", "title_en": "Seven days after 12 Gy total- or partial-body irradiation, rhesus macaque sternum showed pronounced hematopoietic-cell depletion, severe hypoplasia, and adipocyte replacement.", "factor": "12 Gy total-body or partial-body irradiation; gamma-tocotrienol medical countermeasure", "dose": "12 Gy; GT3 37.5 mg/kg or vehicle administered 24 hours before irradiation", "timecourse": "Necropsy and histopathology on day 7", "evidence_role": "Toxicity_image", "causality_level": "Author_attributed", "observation_summary_cn": "恒河猴接受12 Gy全身或部分身体辐射后第7天，胸骨骨髓出现显著造血细胞耗竭和重度低生成，并见脂肪细胞取代。", "author_conclusion_summary_cn": "原作者将重度骨髓低生成与超致死剂量辐射相关联，并报告GT3在该剂量下对骨髓的保护有限。该图是辐射性骨髓耗竭的高价值恒河猴组织学对照，但不能类推至所有药物性骨髓抑制。", "author_conclusion_summary_en": "The authors associated the severe marrow hypoplasia with supralethal irradiation and reported limited GT3 protection at this dose. The image is a high-value rhesus histology comparator for radiation-induced depletion but should not be generalized to every form of drug-induced marrow suppression.", "pairing_note_cn": "各列来自不同动物和处理组；是同研究、同时点的支持性组比较，不是同一动物的连续活检。", "pairing_note_en": "Columns represent different animals and treatment groups. This is a same-study, same-time-point supportive group comparison, not serial biopsy evidence from one animal.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-CC-RHESUS-12GY-GT3-F03-STERNUM" ], "pathology_evidence_count": 1, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-CC-RHESUS-12GY-GT3-F03-STERNUM", "title_cn": "恒河猴12 Gy辐射后第7天：胸骨骨髓重度低生成和造血细胞耗竭", "title_en": "Rhesus macaque day 7 after 12 Gy irradiation: severe sternal marrow hypoplasia and hematopoietic depletion", "figure_label": "Figure 3", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10923821/", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "AUTH-CASE-PMC2517354", "featured": true, "featured_reason_cn": "小鼠氯霉素骨髓毒性：红系耗竭和前体空泡", "module_id": "toxicity_library", "source_id": "AUTH-PMC2517354", "source_title": "Characterization of the myelotoxicity of chloramphenicol succinate in the B6C3F1 mouse", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2517354/", "doi": "10.1111/j.0959-9673.2006.00460.x", "pmid": "16623754", "pmcid": "PMC2517354", "source_page": "NR", "species": "Mouse", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "权威候选来源记录：Normal marrow comparator; erythroid depletion/vacuolation; myeloid and monocytic precursor vacuolation。具体图像与处理相关性仍需逐图专家复核。", "display_title_cn": "小鼠氯霉素骨髓毒性：红系耗竭和前体空泡", "title_en": "Normal marrow comparator; erythroid depletion/vacuolation; myeloid and monocytic precursor vacuolation", "factor": "Treatment-associated cytology and normal comparator", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "权威候选来源记录：Normal marrow comparator; erythroid depletion/vacuolation; myeloid and monocytic precursor vacuolation。具体图像与处理相关性仍需逐图专家复核。", "author_conclusion_summary_cn": "NR", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC11697499-CASE-MDS-GRANULOCYTIC-DYSPLASIA", "featured": true, "featured_reason_cn": "犬MDS鉴别：外周血与骨髓粒系发育异常", "module_id": "bone-marrow-cases", "source_id": "SUP-PMC11697499", "source_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_page": "Figure 1, panels a-b; Figure 2, panel a", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "犬MDS疾病鉴别图组：外周血中性粒细胞核分节异常，以及骨髓吸取物中原始细胞增加和粒系发育异常。", "display_title_cn": "犬MDS鉴别：外周血与骨髓粒系发育异常", "title_en": "Canine MDS disease-differential set showing abnormal neutrophil segmentation in blood and increased blasts with granulocytic dysplasia in marrow aspirate.", "factor": "Spontaneous/clinical canine myelodysplastic syndrome", "dose": "Not applicable", "timecourse": "Diagnostic evaluation; figures include Cases 1, 2, and 4", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬MDS疾病鉴别图组：外周血中性粒细胞核分节异常，以及骨髓吸取物中原始细胞增加和粒系发育异常。", "author_conclusion_summary_cn": "原作者用外周血核叶大小不均、核分节不全，以及骨髓粒系占优、约10%原始细胞和异常中性粒细胞展示犬MDS粒系异常。该图组是疾病鉴别，不是处理相关骨髓毒性。", "author_conclusion_summary_en": "The authors illustrate canine MDS with uneven or incomplete neutrophil segmentation in blood and a granulocyte-predominant marrow containing approximately 10% blasts and dysplastic neutrophils. This is a disease differential, not treatment-related marrow toxicity.", "pairing_note_cn": "三个panel来自同一研究但涉及Case 1、Case 2和Case 4；它们是跨病例教学对照，不是同一动物的血液—骨髓严格配对。", "pairing_note_en": "The three panels come from one study but represent Cases 1, 2, and 4. They are a cross-case teaching comparison, not a strict same-animal blood-marrow pair.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-MDS-F01-A", "BM-CC-DOG-MDS-F01-B", "BM-CC-DOG-MDS-F02-A" ], "public_image_paths": [ "../images/BM-CC-DOG-MDS-F01-A.jpg", "../images/BM-CC-DOG-MDS-F01-B.jpg", "../images/BM-CC-DOG-MDS-F02-A.jpg" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-MDS-F01-A.jpg", "../previews/BM-CC-DOG-MDS-F01-B.jpg", "../previews/BM-CC-DOG-MDS-F02-A.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-MDS-F01-A", "title_cn": "犬MDS鉴别：外周血中性粒细胞核叶大小不均", "title_en": "Canine MDS differential: neutrophils with unevenly sized nuclear lobes", "figure_label": "Figure 1", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-MDS-F01-A.jpg", "preview_path": "../previews/BM-CC-DOG-MDS-F01-A.jpg", "caption_original_en": "Myelodysplastic syndrome, dog. (a) Blood film with dysplastic neutrophils (*) that have unevenly sized nuclear lobes and giant red blood cells (^) reflecting increased red cell distribution width. Case 1. Wright stain (WS). (b) The marrow aspirate is highly cellular and has a predominance of granulocytes. There are approximately 10% blasts (arrowheads). Of total, 15% of segmented neutrophils have dysplastic changes (*), and there are dysplastic band neutrophils (arrows). Case 2. WS. (c) An immature megakaryocyte with abnormal nuclear lobulation (left) and an abnormally small megakaryocyte with mature cytoplasm and a hypolobulated nucleus (right). Case 2. WS. (d) A micromegakaryocyte, ~24 µm in diameter with multiple, widely separated nuclei (arrow). Case 2. WS. (e) The marrow core is hypercellular despite chronic marked anemia, and megakaryocytes are clustered (arrows). Case 3. Hematoxylin and eosin (HE). (f) Higher magnification of (e) illustrating an increased proportion of blasts (arrowheads) in the center of the intertrabecular space; a megakaryocyte with abnormal nuclear lobulation, open chromatin, and nucleoli (arrow); and dysplastic giant band neutrophils (*). Case 3. HE.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" }, { "image_id": "BM-CC-DOG-MDS-F01-B", "title_cn": "犬MDS骨髓吸取物：粒系占优、原始细胞增加与中性粒细胞发育异常", "title_en": "Canine MDS marrow aspirate: granulocytic predominance, increased blasts, and neutrophil dysplasia", "figure_label": "Figure 1", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-MDS-F01-B.jpg", "preview_path": "../previews/BM-CC-DOG-MDS-F01-B.jpg", "caption_original_en": "Myelodysplastic syndrome, dog. (a) Blood film with dysplastic neutrophils (*) that have unevenly sized nuclear lobes and giant red blood cells (^) reflecting increased red cell distribution width. Case 1. Wright stain (WS). (b) The marrow aspirate is highly cellular and has a predominance of granulocytes. There are approximately 10% blasts (arrowheads). Of total, 15% of segmented neutrophils have dysplastic changes (*), and there are dysplastic band neutrophils (arrows). Case 2. WS. (c) An immature megakaryocyte with abnormal nuclear lobulation (left) and an abnormally small megakaryocyte with mature cytoplasm and a hypolobulated nucleus (right). Case 2. WS. (d) A micromegakaryocyte, ~24 µm in diameter with multiple, widely separated nuclei (arrow). Case 2. WS. (e) The marrow core is hypercellular despite chronic marked anemia, and megakaryocytes are clustered (arrows). Case 3. Hematoxylin and eosin (HE). (f) Higher magnification of (e) illustrating an increased proportion of blasts (arrowheads) in the center of the intertrabecular space; a megakaryocyte with abnormal nuclear lobulation, open chromatin, and nucleoli (arrow); and dysplastic giant band neutrophils (*). Case 3. HE.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" }, { "image_id": "BM-CC-DOG-MDS-F02-A", "title_cn": "犬MDS鉴别：外周血中性粒细胞核分节不全且不均", "title_en": "Canine MDS differential: incomplete and uneven neutrophil nuclear segmentation", "figure_label": "Figure 2", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-MDS-F02-A.jpg", "preview_path": "../previews/BM-CC-DOG-MDS-F02-A.jpg", "caption_original_en": "Myelodysplastic syndrome, dog. (a) The blood film has dysplastic neutrophils (*) characterized by incomplete and uneven nuclear segmentation. Note also frequent platelets. The dog had chronic nonregenerative anemia, a normal leukocyte count, and thrombocytosis (554 × 10^9/L; reference interval 117-418 × 10^9/L). The marrow aspirate had no particles. Case 4. Wright stain. (b) The marrow core is nearly devoid of adipocytes is densely cellular with paratrabecular fibrosis (arrow). Case 5. Hematoxylin and eosin (HE). (c) At higher magnification, there are slender bundles of collagen interspersed among hematopoietic cells (arrow). Blasts comprise approximately 5% of cells (arrowheads). Case 5. HE.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC11697499-CASE-SAMPLE-QUALITY", "featured": true, "featured_reason_cn": "犬MDS样本质量：骨髓吸取物无颗粒的解释限制", "module_id": "bone-marrow-cases", "source_id": "SUP-PMC11697499", "source_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_page": "Figure 2, panel a and legend", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "犬MDS样本质量案例：外周血有异常粒系形态，但骨髓吸取物无颗粒。", "display_title_cn": "犬MDS样本质量：骨髓吸取物无颗粒的解释限制", "title_en": "Canine MDS sample-quality case: abnormal granulocytic morphology in blood with a marrow aspirate lacking particles.", "factor": "Spontaneous/clinical canine myelodysplastic syndrome", "dose": "Not applicable", "timecourse": "Diagnostic evaluation; Case 4", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬MDS样本质量案例：外周血有异常粒系形态，但骨髓吸取物无颗粒。", "author_conclusion_summary_cn": "“吸取物无颗粒”是重要的可评价性限制。即使外周血存在异常细胞，也不应在缺乏代表性骨髓颗粒时生成过度确定的骨髓细胞量或完整分类结论。", "author_conclusion_summary_en": "A marrow aspirate without particles is an important evaluability limitation. Abnormal blood cells do not justify definitive marrow cellularity or complete differential conclusions when representative marrow particles are absent.", "pairing_note_cn": "该条目复用Figure 2a外周血图并引用图注中的骨髓样本质量信息；它不是一张独立的不合格涂片图。", "pairing_note_en": "This item reuses the Figure 2a blood image and the legend's marrow-quality statement; it is not a separate image of an inadequate marrow smear.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-MDS-F02-A" ], "public_image_paths": [ "../images/BM-CC-DOG-MDS-F02-A.jpg" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-MDS-F02-A.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-MDS-F02-A", "title_cn": "犬MDS鉴别：外周血中性粒细胞核分节不全且不均", "title_en": "Canine MDS differential: incomplete and uneven neutrophil nuclear segmentation", "figure_label": "Figure 2", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-MDS-F02-A.jpg", "preview_path": "../previews/BM-CC-DOG-MDS-F02-A.jpg", "caption_original_en": "Myelodysplastic syndrome, dog. (a) The blood film has dysplastic neutrophils (*) characterized by incomplete and uneven nuclear segmentation. Note also frequent platelets. The dog had chronic nonregenerative anemia, a normal leukocyte count, and thrombocytosis (554 × 10^9/L; reference interval 117-418 × 10^9/L). The marrow aspirate had no particles. Case 4. Wright stain. (b) The marrow core is nearly devoid of adipocytes is densely cellular with paratrabecular fibrosis (arrow). Case 5. Hematoxylin and eosin (HE). (c) At higher magnification, there are slender bundles of collagen interspersed among hematopoietic cells (arrow). Blasts comprise approximately 5% of cells (arrowheads). Case 5. HE.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC12910396-CASE-DOG-PIMA-ERYTHROID-ARREST", "featured": true, "featured_reason_cn": "犬PIMA鉴别：红系低生成、成熟阻滞及M:E升高", "module_id": "bone-marrow-cases", "source_id": "S2M-PMC12910396", "source_title": "First Case Report of Precursor‐Targeted Immune‐Mediated Anaemia in a Dog From Italy Lacking Rubriphagocytosis and With Severe Hyperferraemia: Diagnosis, Treatment, and Clinical Outcome", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12910396/", "doi": "10.1002/vms3.70852", "pmid": "41700447", "pmcid": "PMC12910396", "source_page": "Figure 2, Table 1, and case-history marrow description", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "犬前体靶向免疫介导性贫血鉴别：红系低生成与成熟阻滞导致M:E升高，未见红系前体吞噬。", "display_title_cn": "犬PIMA鉴别：红系低生成、成熟阻滞及M:E升高", "title_en": "Canine precursor-targeted immune-mediated anemia differential: increased M:E from erythroid hypoplasia with maturation arrest, without observed rubriphagocytosis.", "factor": "Precursor-targeted immune-mediated anemia (PIMA) disease differential", "dose": "Diagnostic marrow obtained before the reported immunosuppressive response; treatment was prednisolone 2 mg/kg/day with later mycophenolate mofetil", "timecourse": "Seventy-day progressive non-regenerative anemia; diagnostic marrow at referral; serial blood follow-up after treatment without serial marrow imaging", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬前体靶向免疫介导性贫血鉴别：红系低生成与成熟阻滞导致M:E升高，未见红系前体吞噬。", "author_conclusion_summary_cn": "原作者报告骨髓颗粒低细胞性、M:E显著升高（归因于红系低生成伴成熟阻滞）、粒系有序成熟、红系核质不同步和未见红系前体吞噬；结合持续非再生性贫血、抗红细胞抗体阳性及免疫抑制治疗反应，作者支持PIMA诊断。图谱保留该病例解释，但缺少骨髓组织学，单个代表视野不能量化M:E，也不能把未见吞噬等同于排除PIMA。", "author_conclusion_summary_en": "See the cited source for the complete author interpretation.", "pairing_note_cn": "Figure 2与Table 1来自同一病例，但图像仅为诊断时单个代表性骨髓视野；后续疗效依据连续外周血数据，不是连续骨髓采样。原文没有提供可由该图独立复算的固定分母分类计数，因此图像用于形态构成教学，而非定量M:E测量。", "pairing_note_en": "Figure 2 and Table 1 are from the same case, but the image is one representative diagnostic marrow field. Treatment response was followed with serial peripheral blood data rather than serial marrow sampling. The paper does not provide a denominator-based differential that can be recalculated from this image, so it is used for teaching lineage composition, not quantitative M:E measurement.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-NC-DOG-PIMA-F02" ], "public_image_paths": [ "../images/BM-CC-NC-DOG-PIMA-F02.png" ], "public_image_preview_paths": [ "../previews/BM-CC-NC-DOG-PIMA-F02.jpg" ], "public_images": [ { "image_id": "BM-CC-NC-DOG-PIMA-F02", "title_cn": "犬PIMA鉴别：红系低生成与成熟阻滞背景中的髓系占优势", "title_en": "Canine PIMA differential: myeloid predominance in erythroid hypoplasia with maturation arrest", "figure_label": "FIGURE 2", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-NC-DOG-PIMA-F02.png", "preview_path": "../previews/BM-CC-NC-DOG-PIMA-F02.jpg", "caption_original_en": "Fine‐needle aspiration smear of bone marrow. May–Grunwald–Giemsa Wright. 400×. Predominance of myeloid over erythroid elements (increased myeloid‐to‐erythroid ratio).", "reuse_status": "cc_noncommercial_only", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC4261574-CASE-ATYPICAL-MITOSIS", "featured": true, "featured_reason_cn": "犬疾病鉴别：谱系未明的异常有丝分裂", "module_id": "bone-marrow-cases", "source_id": "S2M-PMC4261574", "source_title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "doi": "10.1186/s13071-014-0534-2", "pmid": "25441458", "pmcid": "PMC4261574", "source_page": "Figure 6", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "犬骨髓异常有丝分裂代表视野；原图注未明确所属细胞谱系。", "display_title_cn": "犬疾病鉴别：谱系未明的异常有丝分裂", "title_en": "Representative canine marrow atypical mitosis; the original legend does not identify the cell lineage.", "factor": "Naturally acquired canine vector-borne disease; exact pathogen for the figure not stated", "dose": "Not applicable", "timecourse": "Diagnostic marrow examination; exact time point NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬骨髓异常有丝分裂代表视野；原图注未明确所属细胞谱系。", "author_conclusion_summary_cn": "该图可作为异常有丝分裂的识别案例。由于图注未给出谱系，网站保持Mixed_or_uncertain，不依据视觉猜测红系或粒系来源。", "author_conclusion_summary_en": "The image is useful for recognizing an atypical mitosis. Because the legend does not specify lineage, the atlas retains Mixed_or_uncertain and does not infer erythroid or myeloid origin from appearance alone.", "pairing_note_cn": "Figure 6为单个代表视野；具体动物、病原体和发生频率均未由图注明确。", "pairing_note_en": "Figure 6 is one representative field; the exact animal, pathogen, and frequency are not specified in the legend.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-CVBD-F06" ], "public_image_paths": [ "../images/BM-CC-DOG-CVBD-F06.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-CVBD-F06.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-CVBD-F06", "title_cn": "犬骨髓疾病鉴别：异常有丝分裂", "title_en": "Canine marrow disease differential: atypical mitosis", "figure_label": "Figure 6", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-CVBD-F06.png", "preview_path": "../previews/BM-CC-DOG-CVBD-F06.jpg", "caption_original_en": "Atypical mitosis. Bone marrow. Quick Stain, 100×.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC4261574-CASE-ERYTHROID-MULTINUCLEATION", "featured": true, "featured_reason_cn": "犬疾病鉴别：多核巨幼样红系前体", "module_id": "bone-marrow-cases", "source_id": "S2M-PMC4261574", "source_title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "doi": "10.1186/s13071-014-0534-2", "pmid": "25441458", "pmcid": "PMC4261574", "source_page": "Figure 2", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "自然感染犬骨髓中可见具有多个细胞核的巨幼样红系前体，旁见其他红系前体。", "display_title_cn": "犬疾病鉴别：多核巨幼样红系前体", "title_en": "A multinucleated megaloblastic erythroid precursor in marrow from a naturally infected dog, with additional erythroid precursors nearby.", "factor": "Naturally acquired canine vector-borne disease; exact pathogen for the figure not stated", "dose": "Not applicable", "timecourse": "Diagnostic marrow examination; exact time point NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "自然感染犬骨髓中可见具有多个细胞核的巨幼样红系前体，旁见其他红系前体。", "author_conclusion_summary_cn": "原作者将该细胞纳入犬媒介传播疾病队列中的红系发育异常形态。它适合作为多核红系前体鉴别图，不可自动迁移为给药相关骨髓毒性或群体性发育异常结论。", "author_conclusion_summary_en": "The authors include this cell among dysplastic erythroid findings in a canine vector-borne disease cohort. It is a differential example of a multinucleated erythroid precursor and must not be transferred automatically into drug-toxicity or population-level dysplasia conclusions.", "pairing_note_cn": "Figure 2为单个代表视野；图注未提供具体动物、病原体或该形态发生频率。", "pairing_note_en": "Figure 2 is one representative field; the legend does not identify the exact animal, pathogen, or frequency of the finding.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-CVBD-F02" ], "public_image_paths": [ "../images/BM-CC-DOG-CVBD-F02.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-CVBD-F02.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-CVBD-F02", "title_cn": "犬骨髓疾病鉴别：多核巨幼样红系前体", "title_en": "Canine marrow disease differential: multinucleated megaloblastic erythroid precursor", "figure_label": "Figure 2", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-CVBD-F02.png", "preview_path": "../previews/BM-CC-DOG-CVBD-F02.jpg", "caption_original_en": "A megaloblastic erythroid precursor with multiple nuclei (arrow); two other eryhtroid precursors are also present. Bone marrow. Quick Stain, 100×.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC4261574-CASE-MYELOID-DYSPLASIA", "featured": true, "featured_reason_cn": "犬疾病鉴别：过分叶中性粒细胞与巨型晚幼粒细胞", "module_id": "bone-marrow-cases", "source_id": "S2M-PMC4261574", "source_title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "doi": "10.1186/s13071-014-0534-2", "pmid": "25441458", "pmcid": "PMC4261574", "source_page": "Figure 3, panels A-B", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "犬骨髓粒系发育异常图组：Panel A为过分叶成熟中性粒细胞，Panel B为巨型晚幼粒细胞。", "display_title_cn": "犬疾病鉴别：过分叶中性粒细胞与巨型晚幼粒细胞", "title_en": "Canine marrow dysgranulopoiesis set: a hypersegmented mature neutrophil in panel A and a giant metamyelocyte in panel B.", "factor": "Naturally acquired canine vector-borne disease; exact pathogen for the figure not stated", "dose": "Not applicable", "timecourse": "Diagnostic marrow examination; exact time point NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬骨髓粒系发育异常图组：Panel A为过分叶成熟中性粒细胞，Panel B为巨型晚幼粒细胞。", "author_conclusion_summary_cn": "原作者将过分叶成熟中性粒细胞和巨型晚幼粒细胞归入myeloid dysplasia。网站同时保留可见观察与作者解释，并提示需以全片频率、成熟序列和CBC复核。", "author_conclusion_summary_en": "The authors categorize the hypersegmented mature neutrophil and giant metamyelocyte as myeloid dysplasia. The atlas separates the visible observations from that interpretation and requires whole-smear frequency, maturation sequence, and CBC review.", "pairing_note_cn": "Panels A和B来自同一复合Figure，但图注未确认来自同一动物或同一病原体；按同来源教学对应展示。", "pairing_note_en": "Panels A and B are from one composite figure, but the legend does not confirm one animal or one pathogen. They are displayed as a same-source teaching correspondence.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-CVBD-F03-A", "BM-CC-DOG-CVBD-F03-B" ], "public_image_paths": [ "../images/BM-CC-DOG-CVBD-F03-A.png", "../images/BM-CC-DOG-CVBD-F03-B.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-CVBD-F03-A.jpg", "../previews/BM-CC-DOG-CVBD-F03-B.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-CVBD-F03-A", "title_cn": "犬粒系发育异常鉴别：成熟中性粒细胞过分叶", "title_en": "Canine dysgranulopoiesis differential: hypersegmented mature neutrophil", "figure_label": "Figure 3", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-CVBD-F03-A.png", "preview_path": "../previews/BM-CC-DOG-CVBD-F03-A.jpg", "caption_original_en": "Myeloid dysplasia. A. A hypersegmented mature neutrophil (arrow); myeloid precursors in different maturation stages are also present. B. A giant metamyelocyte (arrow) with two erythroid precursors. Bone marrow. Quick Stain, 100×.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" }, { "image_id": "BM-CC-DOG-CVBD-F03-B", "title_cn": "犬粒系发育异常鉴别：巨型晚幼粒细胞", "title_en": "Canine dysgranulopoiesis differential: giant metamyelocyte", "figure_label": "Figure 3", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-CVBD-F03-B.png", "preview_path": "../previews/BM-CC-DOG-CVBD-F03-B.jpg", "caption_original_en": "Myeloid dysplasia. A. A hypersegmented mature neutrophil (arrow); myeloid precursors in different maturation stages are also present. B. A giant metamyelocyte (arrow) with two erythroid precursors. Bone marrow. Quick Stain, 100×.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC7324823-CASE-MULTILINEAGE-DYSPLASIA", "featured": true, "featured_reason_cn": "犬多系骨髓异常：红系核碎裂、环形中性粒细胞与多核巨核细胞", "module_id": "bone-marrow-cases", "source_id": "PMC7324823", "source_title": "Clinical and clinicopathological features and outcomes of Miniature Dachshunds with bone marrow disorders", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7324823/", "doi": "10.1292/jvms.19-0439", "pmid": "32307340", "pmcid": "PMC7324823", "source_page": "Figure 2, panels a-c", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "Miniature Dachshund骨髓涂片完整图组展示红系核碎裂、环形中性粒细胞和具有多个核的形态异常巨核细胞。", "display_title_cn": "犬多系骨髓异常：红系核碎裂、环形中性粒细胞与多核巨核细胞", "title_en": "A complete Miniature Dachshund marrow-smear figure showing erythroid nuclear fragmentation, a ringed neutrophil, and a dysmorphic megakaryocyte with multiple nuclei.", "factor": "Spontaneous/clinical bone marrow disorder", "dose": "Not applicable", "timecourse": "Diagnostic marrow examination; exact animal-level timing NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "Miniature Dachshund骨髓涂片完整图组展示红系核碎裂、环形中性粒细胞和具有多个核的形态异常巨核细胞。", "author_conclusion_summary_cn": "该图组提示多系异常应按可见形态分别记录，再结合固定分母计数、CBC、骨髓芯活检和临床背景判断。多个核是观察描述，不应由网站自动升级为药物相关dysplasia。", "author_conclusion_summary_en": "The set supports recording each visible lineage abnormality separately before integrating denominator-based counts, CBC, core-biopsy findings, and clinical context. Multiple nuclei are an observation and are not automatically promoted by the website to drug-related dysplasia.", "pairing_note_cn": "Figure 2的a-c为同一来源的完整复合图，但图注未确认三个panel来自同一动物；属于同研究教学对应，而非严格同一动物配对。", "pairing_note_en": "Panels a-c are retained as one complete source figure, but the legend does not confirm that all three panels come from one animal. This is a same-study teaching correspondence, not a strict same-animal pair.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-MARROW-DISORDERS-F02" ], "public_image_paths": [ "../images/BM-CC-DOG-MARROW-DISORDERS-F02.jpg" ], "public_image_preview_paths": [ "../images/BM-CC-DOG-MARROW-DISORDERS-F02.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-MARROW-DISORDERS-F02", "title_cn": "犬多系骨髓异常：红系核碎裂、环形中性粒细胞与多核巨核细胞", "title_en": "Canine multilineage marrow abnormalities: erythroid nuclear fragmentation, ringed neutrophil, and multinucleated megakaryocyte", "figure_label": "Fig. 2", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-MARROW-DISORDERS-F02.jpg", "preview_path": "../images/BM-CC-DOG-MARROW-DISORDERS-F02.jpg", "caption_original_en": "Fragmented nucleus in the erythroid lineage (a), ringed neutrophil in the myeloid linage (b), and dysmorphic megakaryocyte with multiple nuclei (c) observed in bone marrow smears stained with Wright-Giemsa stain. Bar=10 µm.", "reuse_status": "cc_noncommercial_only", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-017", "featured": true, "featured_reason_cn": "犬先天性红系发育异常：外周血异形红细胞与晚幼红细胞", "module_id": "lineage", "source_id": "PMC9407898", "source_title": "An EHPB1L1 Nonsense Mutation Associated with Congenital Dyserythropoietic Anemia and Polymyopathy in Labrador Retriever Littermates", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9407898/", "doi": "10.3390/genes13081427", "pmid": "36011338", "pmcid": "PMC9407898", "source_page": "Figure 1, panel A", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "外周血异形红细胞增多并见晚幼红细胞。", "display_title_cn": "犬先天性红系发育异常：外周血异形红细胞与晚幼红细胞", "title_en": "Peripheral blood poikilocytosis and a metarubricyte.", "factor": "Disease_differential", "dose": "NR", "timecourse": "NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "外周血异形红细胞增多并见晚幼红细胞。", "author_conclusion_summary_cn": "疾病相关形态，作为毒性评价鉴别参考，不等同于处理相关毒性。", "author_conclusion_summary_en": "Disease-associated morphology; differential reference rather than treatment toxicity.", "pairing_note_cn": "Panel A为外周血，Panels B-D为同一复合Figure中的骨髓细胞学；它们来自同一研究但图注未确认全部来自同一只犬。", "pairing_note_en": "Panel A is peripheral blood and panels B-D are marrow cytology in the same composite figure. They come from one study, but the legend does not confirm that all panels are from one dog.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-EHBP1L1-F01-A" ], "public_image_paths": [ "../images/BM-CC-DOG-EHBP1L1-F01-A.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-EHBP1L1-F01-A.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-EHBP1L1-F01-A", "title_cn": "犬先天性红系发育异常：外周血异形红细胞与晚幼红细胞", "title_en": "Canine congenital dyserythropoiesis: peripheral poikilocytosis and a metarubricyte", "figure_label": "Figure 1", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-EHBP1L1-F01-A.png", "preview_path": "../previews/BM-CC-DOG-EHBP1L1-F01-A.jpg", "caption_original_en": "Review of histopathological changes in red blood cells, bone marrow and muscle in Labrador Retrievers with an EHBP1L1 variant. (A) Review of Wrights Giemsa stained peripheral blood from an affected Labrador Retriever demonstrating poikilocytosis and a metarubricyte (arrow). (B) Review of Wrights Giemsa stained bone marrow cytology demonstrating cytoplasmic bridging (arrow). (C) Review of Wrights Giemsa stained bone marrow cytology demonstrating an atypical mitotic figure (arrow). (D) Review of Wrights Giemsa stained bone marrow cytology demonstrating rubriphagocytosis (arrow) and increased proportion of metarubricytes. (E) Review of the biceps femoris muscle biopsy from one dog showing myofiber size variation, pale, floccular sarcoplasmic inclusions (arrows) and endomysial fibrosis. (F) In severely affected biceps femoris muscle biopsies, endomysial fibrosis (asterisk) and numerous pale, floccular sarcoplasmic inclusions are present. H&E. Bar=10 µm for A-D and 50 µm for E-F.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-018", "featured": true, "featured_reason_cn": "犬先天性红系发育异常：红系前体间胞质桥", "module_id": "lineage", "source_id": "PMC9407898", "source_title": "An EHPB1L1 Nonsense Mutation Associated with Congenital Dyserythropoietic Anemia and Polymyopathy in Labrador Retriever Littermates", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9407898/", "doi": "10.3390/genes13081427", "pmid": "36011338", "pmcid": "PMC9407898", "source_page": "Figure 1, panel B", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "骨髓红系前体间可见胞质桥。", "display_title_cn": "犬先天性红系发育异常：红系前体间胞质桥", "title_en": "Bone marrow cytoplasmic bridging between erythroid precursors.", "factor": "Disease_differential", "dose": "NR", "timecourse": "NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "骨髓红系前体间可见胞质桥。", "author_conclusion_summary_cn": "疾病相关形态，作为毒性评价鉴别参考，不等同于处理相关毒性。", "author_conclusion_summary_en": "Disease-associated morphology; differential reference rather than treatment toxicity.", "pairing_note_cn": "Panel B与Panels A、C、D同属完整Figure 1；仅构成同研究形态对照，不是经图注明确的同一动物严格配对。", "pairing_note_en": "Panel B belongs to complete Figure 1 with panels A, C, and D. It is a same-study morphology comparison, not a legend-confirmed strict same-animal pair.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-EHBP1L1-F01-B" ], "public_image_paths": [ "../images/BM-CC-DOG-EHBP1L1-F01-B.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-EHBP1L1-F01-B.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-EHBP1L1-F01-B", "title_cn": "犬先天性红系发育异常：红系前体间胞质桥", "title_en": "Canine congenital dyserythropoiesis: cytoplasmic bridging between erythroid precursors", "figure_label": "Figure 1", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-EHBP1L1-F01-B.png", "preview_path": "../previews/BM-CC-DOG-EHBP1L1-F01-B.jpg", "caption_original_en": "Review of histopathological changes in red blood cells, bone marrow and muscle in Labrador Retrievers with an EHBP1L1 variant. (A) Review of Wrights Giemsa stained peripheral blood from an affected Labrador Retriever demonstrating poikilocytosis and a metarubricyte (arrow). (B) Review of Wrights Giemsa stained bone marrow cytology demonstrating cytoplasmic bridging (arrow). (C) Review of Wrights Giemsa stained bone marrow cytology demonstrating an atypical mitotic figure (arrow). (D) Review of Wrights Giemsa stained bone marrow cytology demonstrating rubriphagocytosis (arrow) and increased proportion of metarubricytes. (E) Review of the biceps femoris muscle biopsy from one dog showing myofiber size variation, pale, floccular sarcoplasmic inclusions (arrows) and endomysial fibrosis. (F) In severely affected biceps femoris muscle biopsies, endomysial fibrosis (asterisk) and numerous pale, floccular sarcoplasmic inclusions are present. H&E. Bar=10 µm for A-D and 50 µm for E-F.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-019", "featured": true, "featured_reason_cn": "犬先天性红系发育异常：红系前体异型有丝分裂", "module_id": "lineage", "source_id": "PMC9407898", "source_title": "An EHPB1L1 Nonsense Mutation Associated with Congenital Dyserythropoietic Anemia and Polymyopathy in Labrador Retriever Littermates", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9407898/", "doi": "10.3390/genes13081427", "pmid": "36011338", "pmcid": "PMC9407898", "source_page": "Figure 1, panel C", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "骨髓红系前体可见异型有丝分裂象。", "display_title_cn": "犬先天性红系发育异常：红系前体异型有丝分裂", "title_en": "Bone marrow atypical mitotic figure in an erythroid precursor.", "factor": "Disease_differential", "dose": "NR", "timecourse": "NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "骨髓红系前体可见异型有丝分裂象。", "author_conclusion_summary_cn": "疾病相关形态，作为毒性评价鉴别参考，不等同于处理相关毒性。", "author_conclusion_summary_en": "Disease-associated morphology; differential reference rather than treatment toxicity.", "pairing_note_cn": "Panel C为单个代表性异型有丝分裂象；图注未提供固定分母、发生频率或个体层级计数。", "pairing_note_en": "Panel C is one representative atypical mitotic figure; the legend does not provide a fixed denominator, frequency, or animal-level count.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-EHBP1L1-F01-C" ], "public_image_paths": [ "../images/BM-CC-DOG-EHBP1L1-F01-C.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-EHBP1L1-F01-C.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-EHBP1L1-F01-C", "title_cn": "犬先天性红系发育异常：红系前体异型有丝分裂", "title_en": "Canine congenital dyserythropoiesis: atypical erythroid mitosis", "figure_label": "Figure 1", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-EHBP1L1-F01-C.png", "preview_path": "../previews/BM-CC-DOG-EHBP1L1-F01-C.jpg", "caption_original_en": "Review of histopathological changes in red blood cells, bone marrow and muscle in Labrador Retrievers with an EHBP1L1 variant. (A) Review of Wrights Giemsa stained peripheral blood from an affected Labrador Retriever demonstrating poikilocytosis and a metarubricyte (arrow). (B) Review of Wrights Giemsa stained bone marrow cytology demonstrating cytoplasmic bridging (arrow). (C) Review of Wrights Giemsa stained bone marrow cytology demonstrating an atypical mitotic figure (arrow). (D) Review of Wrights Giemsa stained bone marrow cytology demonstrating rubriphagocytosis (arrow) and increased proportion of metarubricytes. (E) Review of the biceps femoris muscle biopsy from one dog showing myofiber size variation, pale, floccular sarcoplasmic inclusions (arrows) and endomysial fibrosis. (F) In severely affected biceps femoris muscle biopsies, endomysial fibrosis (asterisk) and numerous pale, floccular sarcoplasmic inclusions are present. H&E. Bar=10 µm for A-D and 50 µm for E-F.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-021", "featured": true, "featured_reason_cn": "犬红系发育异常鉴别：异型有丝分裂", "module_id": "lineage", "source_id": "PMC8478025", "source_title": "Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8478025/", "doi": "10.1111/jvim.16214", "pmid": "34227150", "pmcid": "PMC8478025", "source_page": "Figure 2, panel A", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "红系前体异型有丝分裂。", "display_title_cn": "犬红系发育异常鉴别：异型有丝分裂", "title_en": "Atypical mitosis in an erythroid precursor.", "factor": "Suspected congenital dyserythropoiesis", "dose": "Not applicable", "timecourse": "Diagnostic marrow aspirate from case 1", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "红系前体异型有丝分裂。", "author_conclusion_summary_cn": "原作者将该细胞描述为红系前体异型有丝分裂。它是疾病性红系发育异常的鉴别参考，不等同于处理相关骨髓毒性。", "author_conclusion_summary_en": "The authors describe an atypical mitotic figure in an erythroid precursor. It is a disease differential for dyserythropoiesis and not treatment-related marrow toxicity.", "pairing_note_cn": "Figure 2 A–F均来自同一病例的骨髓细胞学复合图；各panel为单个代表视野，不能由此推断该形态的发生频率。", "pairing_note_en": "Figure 2 panels A-F are from one composite marrow-cytology figure from the same case. Each is a representative field and does not establish the frequency of the finding.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-DYSERYTHRO-F02-A" ], "public_image_paths": [ "../images/BM-CC-DOG-DYSERYTHRO-F02-A.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-DYSERYTHRO-F02-A.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-DYSERYTHRO-F02-A", "title_cn": "犬红系发育异常鉴别：红系前体异型有丝分裂", "title_en": "Canine dyserythropoiesis differential: atypical mitosis in an erythroid precursor", "figure_label": "Figure 2", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-DYSERYTHRO-F02-A.png", "preview_path": "../previews/BM-CC-DOG-DYSERYTHRO-F02-A.jpg", "caption_original_en": "Representative cytologic bone marrow images of case 1 illustrating dysplastic changes and erythrophagocytosis. Wright‐Giemsa, ×100 objective. A, Atypical mitotic figure; B, cytoplasmic vacuolation of metarubricytes. Note the contrast of vacuolation (left metarubricyte) compared to water artifact (adjacent right metarubricyte), C, binucleated erythroid precursor; D, nuclear blebbing within a metarubricyte; E, cytoplasmic bridging of rubricytes; F, macrophage displaying metarubricyte phagocytosis.", "reuse_status": "cc_noncommercial_only", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-022", "featured": true, "featured_reason_cn": "犬红系发育异常鉴别：胞质空泡与水伪影", "module_id": "lineage", "source_id": "PMC8478025", "source_title": "Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8478025/", "doi": "10.1111/jvim.16214", "pmid": "34227150", "pmcid": "PMC8478025", "source_page": "Figure 2, panel B", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "红系前体胞质空泡；需与水伪影鉴别。", "display_title_cn": "犬红系发育异常鉴别：胞质空泡与水伪影", "title_en": "Cytoplasmic vacuolation in erythroid precursors; water artifact is a differential.", "factor": "Suspected congenital dyserythropoiesis", "dose": "Not applicable", "timecourse": "Diagnostic marrow aspirate from case 1", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "红系前体胞质空泡；需与水伪影鉴别。", "author_conclusion_summary_cn": "Panel B将晚幼红细胞胞质空泡与相邻细胞的水伪影直接并列，用于提醒真性形态改变与制片伪影的鉴别。", "author_conclusion_summary_en": "Panel B directly contrasts metarubricyte cytoplasmic vacuolation with water artifact in an adjacent cell, supporting an artifact differential.", "pairing_note_cn": "Figure 2 A–F均来自同一病例的骨髓细胞学复合图；各panel为单个代表视野，不能由此推断该形态的发生频率。", "pairing_note_en": "Figure 2 panels A-F are from one composite marrow-cytology figure from the same case. Each is a representative field and does not establish the frequency of the finding.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-DYSERYTHRO-F02-B" ], "public_image_paths": [ "../images/BM-CC-DOG-DYSERYTHRO-F02-B.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-DYSERYTHRO-F02-B.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-DYSERYTHRO-F02-B", "title_cn": "犬红系发育异常鉴别：晚幼红细胞胞质空泡与水伪影", "title_en": "Canine dyserythropoiesis differential: metarubricyte vacuolation versus water artifact", "figure_label": "Figure 2", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-DYSERYTHRO-F02-B.png", "preview_path": "../previews/BM-CC-DOG-DYSERYTHRO-F02-B.jpg", "caption_original_en": "Representative cytologic bone marrow images of case 1 illustrating dysplastic changes and erythrophagocytosis. Wright‐Giemsa, ×100 objective. A, Atypical mitotic figure; B, cytoplasmic vacuolation of metarubricytes. Note the contrast of vacuolation (left metarubricyte) compared to water artifact (adjacent right metarubricyte), C, binucleated erythroid precursor; D, nuclear blebbing within a metarubricyte; E, cytoplasmic bridging of rubricytes; F, macrophage displaying metarubricyte phagocytosis.", "reuse_status": "cc_noncommercial_only", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-023", "featured": true, "featured_reason_cn": "犬红系发育异常鉴别：双核红系前体", "module_id": "lineage", "source_id": "PMC8478025", "source_title": "Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8478025/", "doi": "10.1111/jvim.16214", "pmid": "34227150", "pmcid": "PMC8478025", "source_page": "Figure 2, panel C", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "双核红系前体。", "display_title_cn": "犬红系发育异常鉴别：双核红系前体", "title_en": "Binucleated erythroid precursor.", "factor": "Suspected congenital dyserythropoiesis", "dose": "Not applicable", "timecourse": "Diagnostic marrow aspirate from case 1", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "双核红系前体。", "author_conclusion_summary_cn": "原作者描述为双核红系前体。单个细胞不足以诊断群体性发育异常，需结合频率、其他形态及CBC。", "author_conclusion_summary_en": "The authors describe a binucleated erythroid precursor. One cell is insufficient to diagnose a population-level dysplastic process; frequency, other morphology, and CBC data are required.", "pairing_note_cn": "Figure 2 A–F均来自同一病例的骨髓细胞学复合图；各panel为单个代表视野，不能由此推断该形态的发生频率。", "pairing_note_en": "Figure 2 panels A-F are from one composite marrow-cytology figure from the same case. Each is a representative field and does not establish the frequency of the finding.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-DYSERYTHRO-F02-C" ], "public_image_paths": [ "../images/BM-CC-DOG-DYSERYTHRO-F02-C.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-DYSERYTHRO-F02-C.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-DYSERYTHRO-F02-C", "title_cn": "犬红系发育异常鉴别：双核红系前体", "title_en": "Canine dyserythropoiesis differential: binucleated erythroid precursor", "figure_label": "Figure 2", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-DYSERYTHRO-F02-C.png", "preview_path": "../previews/BM-CC-DOG-DYSERYTHRO-F02-C.jpg", "caption_original_en": "Representative cytologic bone marrow images of case 1 illustrating dysplastic changes and erythrophagocytosis. Wright‐Giemsa, ×100 objective. A, Atypical mitotic figure; B, cytoplasmic vacuolation of metarubricytes. Note the contrast of vacuolation (left metarubricyte) compared to water artifact (adjacent right metarubricyte), C, binucleated erythroid precursor; D, nuclear blebbing within a metarubricyte; E, cytoplasmic bridging of rubricytes; F, macrophage displaying metarubricyte phagocytosis.", "reuse_status": "cc_noncommercial_only", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-024", "featured": true, "featured_reason_cn": "犬红系发育异常鉴别：核出芽", "module_id": "lineage", "source_id": "PMC8478025", "source_title": "Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8478025/", "doi": "10.1111/jvim.16214", "pmid": "34227150", "pmcid": "PMC8478025", "source_page": "Figure 2, panel D", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "红系前体核出芽。", "display_title_cn": "犬红系发育异常鉴别：核出芽", "title_en": "Nuclear blebbing in an erythroid precursor.", "factor": "Suspected congenital dyserythropoiesis", "dose": "Not applicable", "timecourse": "Diagnostic marrow aspirate from case 1", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "红系前体核出芽。", "author_conclusion_summary_cn": "原作者描述为晚幼红细胞核出芽。该词先表达观察事实，不由网站自动转换为毒性机制或处理相关性。", "author_conclusion_summary_en": "The authors describe nuclear blebbing in a metarubricyte. The term records an observation and is not automatically converted into a toxic mechanism or treatment relationship.", "pairing_note_cn": "Figure 2 A–F均来自同一病例的骨髓细胞学复合图；各panel为单个代表视野，不能由此推断该形态的发生频率。", "pairing_note_en": "Figure 2 panels A-F are from one composite marrow-cytology figure from the same case. Each is a representative field and does not establish the frequency of the finding.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-DYSERYTHRO-F02-D" ], "public_image_paths": [ "../images/BM-CC-DOG-DYSERYTHRO-F02-D.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-DYSERYTHRO-F02-D.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-DYSERYTHRO-F02-D", "title_cn": "犬红系发育异常鉴别：晚幼红细胞核出芽", "title_en": "Canine dyserythropoiesis differential: nuclear blebbing in a metarubricyte", "figure_label": "Figure 2", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-DYSERYTHRO-F02-D.png", "preview_path": "../previews/BM-CC-DOG-DYSERYTHRO-F02-D.jpg", "caption_original_en": "Representative cytologic bone marrow images of case 1 illustrating dysplastic changes and erythrophagocytosis. Wright‐Giemsa, ×100 objective. A, Atypical mitotic figure; B, cytoplasmic vacuolation of metarubricytes. Note the contrast of vacuolation (left metarubricyte) compared to water artifact (adjacent right metarubricyte), C, binucleated erythroid precursor; D, nuclear blebbing within a metarubricyte; E, cytoplasmic bridging of rubricytes; F, macrophage displaying metarubricyte phagocytosis.", "reuse_status": "cc_noncommercial_only", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-025", "featured": true, "featured_reason_cn": "犬红系发育异常鉴别：胞质桥", "module_id": "lineage", "source_id": "PMC8478025", "source_title": "Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8478025/", "doi": "10.1111/jvim.16214", "pmid": "34227150", "pmcid": "PMC8478025", "source_page": "Figure 2, panel E", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "红系前体间胞质桥。", "display_title_cn": "犬红系发育异常鉴别：胞质桥", "title_en": "Cytoplasmic bridging between erythroid precursors.", "factor": "Suspected congenital dyserythropoiesis", "dose": "Not applicable", "timecourse": "Diagnostic marrow aspirate from case 1", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "红系前体间胞质桥。", "author_conclusion_summary_cn": "原作者描述为幼红细胞之间的胞质桥。该特征应与频率、红系成熟模式和血液学改变联合解读。", "author_conclusion_summary_en": "The authors describe cytoplasmic bridging between rubricytes. Interpretation requires frequency data, the erythroid maturation pattern, and correlated hematology findings.", "pairing_note_cn": "Figure 2 A–F均来自同一病例的骨髓细胞学复合图；各panel为单个代表视野，不能由此推断该形态的发生频率。", "pairing_note_en": "Figure 2 panels A-F are from one composite marrow-cytology figure from the same case. Each is a representative field and does not establish the frequency of the finding.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-DYSERYTHRO-F02-E" ], "public_image_paths": [ "../images/BM-CC-DOG-DYSERYTHRO-F02-E.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-DYSERYTHRO-F02-E.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-DYSERYTHRO-F02-E", "title_cn": "犬红系发育异常鉴别：幼红细胞间胞质桥", "title_en": "Canine dyserythropoiesis differential: cytoplasmic bridging between rubricytes", "figure_label": "Figure 2", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-DYSERYTHRO-F02-E.png", "preview_path": "../previews/BM-CC-DOG-DYSERYTHRO-F02-E.jpg", "caption_original_en": "Representative cytologic bone marrow images of case 1 illustrating dysplastic changes and erythrophagocytosis. Wright‐Giemsa, ×100 objective. A, Atypical mitotic figure; B, cytoplasmic vacuolation of metarubricytes. Note the contrast of vacuolation (left metarubricyte) compared to water artifact (adjacent right metarubricyte), C, binucleated erythroid precursor; D, nuclear blebbing within a metarubricyte; E, cytoplasmic bridging of rubricytes; F, macrophage displaying metarubricyte phagocytosis.", "reuse_status": "cc_noncommercial_only", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-020", "featured": true, "featured_reason_cn": "犬内脏利什曼病鉴别：巨核细胞胞穿入、核碎裂与异常分叶", "module_id": "lineage", "source_id": "PMC3972870", "source_title": "Morphological Changes in the Bone Marrow of the Dogs with Visceral Leishmaniasis", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3972870/", "doi": "10.1155/2014/150582", "pmid": "24744957", "pmcid": "PMC3972870", "source_page": "Figure 1, panels a, a1, and a2", "species": "Dog", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "犬内脏利什曼病骨髓切片显示肉芽肿、巨核细胞胞穿入，以及原作者描述为核碎裂或异常分叶的巨核细胞核异常。", "display_title_cn": "犬内脏利什曼病鉴别：巨核细胞胞穿入、核碎裂与异常分叶", "title_en": "Canine visceral leishmaniasis marrow histology showed granuloma, megakaryocytic emperipolesis, and author-described nuclear fragmentation or abnormal lobulation.", "factor": "Canine visceral leishmaniasis", "dose": "Not applicable", "timecourse": "Cross-sectional necropsy study of 33 naturally infected dogs", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬内脏利什曼病骨髓切片显示肉芽肿、巨核细胞胞穿入，以及原作者描述为核碎裂或异常分叶的巨核细胞核异常。", "author_conclusion_summary_cn": "直接形态证据为少症状组Figure 1 panel a及插图a1-a2中的肉芽肿、巨核细胞胞穿入和巨核细胞核异常；原作者将后者解释为巨核细胞发育异常，并提出寄生或活化巨噬细胞及异常细胞因子环境可能参与。机制联系属于作者假说，正文明确指出仍需进一步研究。本案例仅作感染性疾病鉴别，不作为药物性骨髓毒性、发生频率或多个表观独立核的证据。", "author_conclusion_summary_en": "Figure 1a and insets a1-a2 directly show granuloma, emperipolesis, and author-described megakaryocytic nuclear abnormalities. The authors interpreted the latter as dysplasia and proposed macrophage or cytokine involvement, but called for further study. This is an infectious-disease differential, not drug-toxicity, frequency, or separate-nuclei evidence.", "pairing_note_cn": "Panel a、a1和a2属于同一完整Figure，并由图注明确归于少症状组O；图注未提供具体犬只编号，也未建立个体CBC与该图像的一一对应。它是同研究复合图内的形态证据，不是同一动物的血液—骨髓严格配对。", "pairing_note_en": "Panel a and insets a1-a2 belong to the same complete figure and are assigned by the legend to oligosymptomatic group O. The legend provides no individual dog identifier and no case-level CBC-to-image mapping. This is morphology evidence within one composite figure, not a strict same-animal blood-marrow pair.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-CC-DOG-LEISHMANIASIS-F01-A" ], "pathology_evidence_count": 1, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-CC-DOG-LEISHMANIASIS-F01-A", "title_cn": "犬内脏利什曼病骨髓：巨核细胞胞穿入与作者描述的核异常", "title_en": "Canine visceral leishmaniasis marrow: megakaryocytic emperipolesis and author-described nuclear abnormalities", "figure_label": "Figure 1", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3972870/", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC4948781-CASE-MOUSE-ENU-MDS-MEGAKARYOCYTE", "featured": true, "featured_reason_cn": "小鼠ENU诱导MDS模型：巨核细胞多枚表观分离核", "module_id": "bone-marrow-cases", "source_id": "PMC4948781", "source_title": "Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4948781/", "doi": "10.1371/journal.pone.0159189", "pmid": "27428079", "pmcid": "PMC4948781", "source_page": "Figure 3, panel k", "species": "Mouse", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "ENU诱导小鼠MDS模型骨髓涂片中，巨核细胞呈多枚表观分离核。", "display_title_cn": "小鼠ENU诱导MDS模型：巨核细胞多枚表观分离核", "title_en": "A megakaryocyte with multiple apparently separated nuclei in an ENU-induced mouse MDS marrow smear.", "factor": "N-ethyl-N-nitrosourea (ENU) alkylator-induced MDS model", "dose": "Two weekly intraperitoneal doses totaling 100-300 mg/kg; exact panel-k animal dose NR", "timecourse": "At moribund sacrifice; exact interval for the panel-k animal NR", "evidence_role": "Treatment_associated_model", "causality_level": "Author_attributed", "observation_summary_cn": "ENU诱导小鼠MDS模型骨髓涂片中，巨核细胞呈多枚表观分离核。", "author_conclusion_summary_cn": "原作者将骨髓巨核细胞异常核形态列为ENU诱导MDS的巨核系发育异常，并在正文中提到多枚分离核。图谱先记录可见的多枚表观分离核，再保留原作者解释。", "author_conclusion_summary_en": "The authors identified abnormal megakaryocyte nuclear morphology in ENU-induced MDS and included multiple separated nuclei among megakaryocytic dysplastic changes. The atlas records the visible nuclear form separately from that source interpretation.", "pairing_note_cn": "Panel k是复合Figure中MDS行的单个1000×代表性骨髓视野；它不是同一动物的处理前后对照，也不提供异常发生频率或该个体的确切ENU剂量。", "pairing_note_en": "Panel k is one representative 1000x marrow field in the MDS row of a composite figure. It is not a within-animal before-after comparison and does not establish abnormality frequency or the exact ENU dose for that animal.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC0-MOUSE-ENU-MDS-F03-K" ], "public_image_paths": [ "../images/BM-CC0-MOUSE-ENU-MDS-F03-K.png" ], "public_image_preview_paths": [ "../previews/BM-CC0-MOUSE-ENU-MDS-F03-K.jpg" ], "public_images": [ { "image_id": "BM-CC0-MOUSE-ENU-MDS-F03-K", "title_cn": "ENU诱导小鼠MDS模型：骨髓涂片中巨核细胞核形态异常", "title_en": "ENU-induced mouse MDS model: abnormal megakaryocyte nuclear morphology in a marrow smear", "figure_label": "Figure 3", "species": "Mouse", "evidence_role": "Treatment_associated_model", "asset_path": "../images/BM-CC0-MOUSE-ENU-MDS-F03-K.png", "preview_path": "../previews/BM-CC0-MOUSE-ENU-MDS-F03-K.jpg", "caption_original_en": "Smears from peripheral blood, bone marrow, spleen, and liver were prepared from mice at sacrifice and stained with Wright-Giemsa stain. Samples of tibia, spleen, liver, kidney, and brain were fixed in formalin, paraffin-embedded, sectioned, and stained with hematoxylin and eosin. Representative smears (1000x) from an AML case show circulating peripheral blood blasts (a) and blasts infiltrating the bone marrow (b), spleen (c), and liver (d). Representative images (400x) show infiltrates of blasts in bone marrow (e), spleen (f), liver (g), kidney (h), and brain (i) sections from a mouse with AML. Representative smears (1000x) from the peripheral blood (j), bone marrow (k), and spleen (l) from a mouse with MDS show dysplastic hematopoiesis including abnormal neutrophil nuclear maturation, target cells, basophilic stippling, and large platelets in the peripheral blood, abnormal megakaryocyte nuclear morphology in the bone marrow, and bi-nucleated red cell precursors in the spleen. Examples are highlighted with arrows.", "reuse_status": "public_domain", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "AUTH-CASE-PMC3252037", "featured": true, "featured_reason_cn": "大鼠5-FU后超分叶或多倍体粒系细胞", "module_id": "toxicity_library", "source_id": "AUTH-PMC3252037", "source_title": "Importance of Starting Age for Myelotoxicity Study in Dietary Restricted Rats", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3252037/", "doi": "10.1293/tox.22.153", "pmid": "22271989", "pmcid": "PMC3252037", "source_page": "NR", "species": "Rat", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "权威候选来源记录：5-FU-associated hypersegmented or polyploid granulocytes; untreated comparator。具体图像与处理相关性仍需逐图专家复核。", "display_title_cn": "大鼠5-FU后超分叶或多倍体粒系细胞", "title_en": "Rat: Maturation arrest and dysmaturation associated with Rare abnormal granulocytic morphology at x1000", "factor": "Rare abnormal granulocytic morphology at x1000", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "权威候选来源记录：5-FU-associated hypersegmented or polyploid granulocytes; untreated comparator。具体图像与处理相关性仍需逐图专家复核。", "author_conclusion_summary_cn": "NR", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "AUTH-CASE-PMC6398341", "featured": true, "featured_reason_cn": "恒河猴粒系成熟序列对照", "module_id": "toxicity_library", "source_id": "AUTH-PMC6398341", "source_title": "Neutrophil Progenitor Populations of Rhesus Macaques", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6398341/", "doi": "10.1002/JLB.1TA1117-431RR", "pmid": "30395351", "pmcid": "PMC6398341", "source_page": "NR", "species": "Rhesus_monkey", "toxicity_type": "T03", "toxicity_title_cn": "成熟阻滞和发育异常", "toxicity_title_en": "Maturation arrest and dysmaturation", "title_cn": "权威候选来源记录：Myelocytes, metamyelocytes, bands and segmented neutrophils in sorted rhesus marrow populations。具体图像与处理相关性仍需逐图专家复核。", "display_title_cn": "恒河猴粒系成熟序列对照", "title_en": "Myelocytes, metamyelocytes, bands and segmented neutrophils in sorted rhesus marrow populations", "factor": "Normal granulocytic maturation comparator", "dose": "NR", "timecourse": "NR", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "权威候选来源记录：Myelocytes, metamyelocytes, bands and segmented neutrophils in sorted rhesus marrow populations。具体图像与处理相关性仍需逐图专家复核。", "author_conclusion_summary_cn": "NR", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "NTP-CASE-MOUSE-MARROW-NECROSIS", "featured": true, "featured_reason_cn": "小鼠骨髓坏死：范围、细胞细节与过渡区", "module_id": "bone-marrow-cases", "source_id": "NTP-BONE-MARROW-NECROSIS", "source_title": "Bone marrow - Necrosis - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "Figures 1-5", "species": "Mouse", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "B6C3F1小鼠骨髓坏死教学图组，展示病灶范围、核固缩/核溶解/核碎裂、存活与坏死组织分界及过渡区。", "display_title_cn": "小鼠骨髓坏死：范围、细胞细节与过渡区", "title_en": "Teaching set of B6C3F1 mouse marrow necrosis showing lesion extent, pyknosis, karyolysis, karyorrhexis, demarcation, and transition zones.", "factor": "NR", "dose": "NR", "timecourse": "Chronic studies", "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "observation_summary_cn": "B6C3F1小鼠骨髓坏死教学图组，展示病灶范围、核固缩/核溶解/核碎裂、存活与坏死组织分界及过渡区。", "author_conclusion_summary_cn": "这些图支持骨髓坏死的形态识别，但不能单独确定病因或给药相关性；死后自溶是重要鉴别。", "author_conclusion_summary_en": "The figures support recognition of marrow necrosis but do not by themselves establish cause or treatment relationship; postmortem autolysis is an important differential.", "pairing_note_cn": "Figures 1-2构成一组低/高倍，Figures 3-4构成另一组低/高倍，Figure 5为独立的正常区向坏死区过渡示例。", "pairing_note_en": "Figures 1-2 form one low/high-power pair, Figures 3-4 form a second pair, and Figure 5 is a separate example of transition from viable to necrotic marrow.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-NECROSIS-F01", "BM-NTP-NECROSIS-F02", "BM-NTP-NECROSIS-F03", "BM-NTP-NECROSIS-F04", "BM-NTP-NECROSIS-F05" ], "pathology_evidence_count": 5, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-NECROSIS-F01", "title_cn": "小鼠骨髓坏死（低倍）", "title_en": "Bone marrow necrosis in mouse, low power", "figure_label": "Figure 1", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-NECROSIS-F02", "title_cn": "小鼠骨髓坏死的细胞学特征（高倍）", "title_en": "Cellular features of bone marrow necrosis in mouse, higher magnification", "figure_label": "Figure 2", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-NECROSIS-F03", "title_cn": "界限清楚的骨髓坏死区（低倍）", "title_en": "Well-demarcated bone marrow necrosis, low power", "figure_label": "Figure 3", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-NECROSIS-F04", "title_cn": "骨髓坏死与存活组织分界（高倍）", "title_en": "Interface between viable marrow and necrosis, higher magnification", "figure_label": "Figure 4", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-NECROSIS-F05", "title_cn": "正常骨髓向坏死区的过渡", "title_en": "Transition from viable marrow to necrosis", "figure_label": "Figure 5", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC11697499-CASE-MDS-HISTOLOGY", "featured": true, "featured_reason_cn": "犬MDS鉴别：骨髓切片多谱系异常与纤维化", "module_id": "bone-marrow-cases", "source_id": "SUP-PMC11697499", "source_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_page": "Figure 1, panels e-f; Figure 2, panels b-c", "species": "Dog", "toxicity_type": "T05", "toxicity_title_cn": "骨髓纤维化和基质改变", "toxicity_title_en": "Fibrosis and stromal or microenvironment change", "title_cn": "犬MDS骨髓组织学谱：高细胞性、巨核细胞聚集、多谱系核异常与纤维化。", "display_title_cn": "犬MDS鉴别：骨髓切片多谱系异常与纤维化", "title_en": "Canine MDS histologic spectrum with hypercellularity, megakaryocyte clustering, multilineage nuclear abnormalities, and fibrosis.", "factor": "Spontaneous/clinical canine myelodysplastic syndrome", "dose": "Not applicable", "timecourse": "Diagnostic marrow cores; Cases 3 and 5", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬MDS骨髓组织学谱：高细胞性、巨核细胞聚集、多谱系核异常与纤维化。", "author_conclusion_summary_cn": "Figure 1e-f展示高细胞性、巨核细胞聚集、原始细胞和多谱系核异常；Figure 2b-c由低倍到高倍展示小梁旁纤维化、胶原束和约5%原始细胞。组织学细胞量与涂片分类比例必须保持为不同终点。", "author_conclusion_summary_en": "Figure 1e-f shows hypercellularity, megakaryocyte clustering, blasts, and multilineage nuclear abnormalities; Figure 2b-c shows paratrabecular fibrosis, collagen bundles, and approximately 5% blasts from low to high power. Histologic cellularity and smear differential proportions must remain distinct endpoints.", "pairing_note_cn": "Figure 1e-f同属Case 3，Figure 2b-c同属Case 5；两组各自构成同病例的低高倍支持性对照，但Case 3和Case 5之间仅是跨病例教学对照。", "pairing_note_en": "Figure 1e-f belongs to Case 3 and Figure 2b-c to Case 5; each pair is a same-case low/high-power supportive comparison, whereas the two cases together are only a cross-case teaching comparison.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-CC-DOG-MDS-F01-E", "BM-CC-DOG-MDS-F01-F", "BM-CC-DOG-MDS-F02-B", "BM-CC-DOG-MDS-F02-C" ], "pathology_evidence_count": 4, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-CC-DOG-MDS-F01-E", "title_cn": "犬MDS骨髓芯样本：高细胞性与巨核细胞聚集", "title_en": "Canine MDS marrow core: hypercellularity with megakaryocyte clustering", "figure_label": "Figure 1", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-DOG-MDS-F01-F", "title_cn": "犬MDS骨髓切片：原始细胞增加、巨核细胞核异常和巨型杆状核中性粒细胞", "title_en": "Canine MDS marrow histology: increased blasts, abnormal megakaryocytic nuclei, and giant band neutrophils", "figure_label": "Figure 1", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-DOG-MDS-F02-B", "title_cn": "犬MDS骨髓芯样本：致密高细胞性与小梁旁纤维化", "title_en": "Canine MDS marrow core: dense hypercellularity with paratrabecular fibrosis", "figure_label": "Figure 2", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-DOG-MDS-F02-C", "title_cn": "犬MDS骨髓切片：造血细胞间胶原束及约5%原始细胞", "title_en": "Canine MDS marrow histology: collagen bundles among hematopoietic cells and approximately 5% blasts", "figure_label": "Figure 2", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC7324823-CASE-MYELOFIBROSIS", "featured": true, "featured_reason_cn": "犬骨髓芯活检：重度骨髓纤维化", "module_id": "bone-marrow-cases", "source_id": "PMC7324823", "source_title": "Clinical and clinicopathological features and outcomes of Miniature Dachshunds with bone marrow disorders", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7324823/", "doi": "10.1292/jvms.19-0439", "pmid": "32307340", "pmcid": "PMC7324823", "source_page": "Figure 3", "species": "Dog", "toxicity_type": "T05", "toxicity_title_cn": "骨髓纤维化和基质改变", "toxicity_title_en": "Fibrosis and stromal or microenvironment change", "title_cn": "Miniature Dachshund骨髓芯活检H&E图显示原作者判定的重度骨髓纤维化。", "display_title_cn": "犬骨髓芯活检：重度骨髓纤维化", "title_en": "An H&E-stained Miniature Dachshund marrow core biopsy showing severe fibrosis as reported by the authors.", "factor": "Spontaneous/clinical bone marrow disorder", "dose": "Not applicable", "timecourse": "Diagnostic core biopsy; exact time point NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "Miniature Dachshund骨髓芯活检H&E图显示原作者判定的重度骨髓纤维化。", "author_conclusion_summary_cn": "该图适合作为犬骨髓纤维化疾病鉴别。严重度为原作者结论；实际毒理研究应结合全切片分布、网状纤维或胶原染色、涂片可评价性及同期血液学。", "author_conclusion_summary_en": "The figure is useful as a canine myelofibrosis disease differential. Severity is source-reported; toxicology interpretation should integrate whole-section distribution, reticulin or collagen stains, smear evaluability, and concurrent hematology.", "pairing_note_cn": "Figure 3是单张完整芯活检视野；不能与同文Figure 2默认视为同一动物或同一时间点。", "pairing_note_en": "Figure 3 is one complete core-biopsy field and must not be assumed to represent the same animal or time point as Figure 2.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-CC-DOG-MARROW-FIBROSIS-F03" ], "pathology_evidence_count": 1, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-CC-DOG-MARROW-FIBROSIS-F03", "title_cn": "犬骨髓芯活检：重度骨髓纤维化", "title_en": "Canine bone marrow core biopsy: severe marrow fibrosis", "figure_label": "Fig. 3", "specimen_type": "Bone_marrow_core_biopsy", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7324823/", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-CASE-PMC6298844", "featured": true, "featured_reason_cn": "小型猪骨髓脂肪浆液性萎缩", "module_id": "toxicity_atlas", "source_id": "PMC6298844-MINIPIG-SEROUS-ATROPHY", "source_title": "Proceedings of the 2018 National Toxicology Program Satellite Symposium", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6298844/", "doi": "10.1177/0192623318800734", "pmid": "30282530", "pmcid": "PMC6298844", "source_page": "Figure 11, panels C-E; Case 2 discussion", "species": "Minipig", "toxicity_type": "T05", "toxicity_title_cn": "骨髓纤维化和基质改变", "toxicity_title_en": "Fibrosis and stromal or microenvironment change", "title_cn": "哥廷根小型猪股骨骨髓脂肪浆液性萎缩：造血细胞减少、脂肪细胞退变及酸性黏多糖基质。", "display_title_cn": "小型猪骨髓脂肪浆液性萎缩", "title_en": "Göttingen minipig serous atrophy of marrow fat showed hematopoietic loss, adipocyte degeneration, and acidic mucopolysaccharide matrix.", "factor": "Background/nutritional serous atrophy in a Göttingen minipig", "dose": "Not applicable; no test article attribution in the presented case", "timecourse": "Single case presented at necropsy", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "哥廷根小型猪股骨骨髓脂肪浆液性萎缩：造血细胞减少、脂肪细胞退变及酸性黏多糖基质。", "author_conclusion_summary_cn": "原作者将该背景性改变描述为骨髓脂肪细胞萎缩/退变，伴细胞间酸性黏多糖增加，并常伴造血细胞密度降低。Figure 11C为股骨远端低倍H&E，D显示退变脂肪细胞间少量残存造血细胞及均质嗜酸性物，E以pH 2.5阿利新蓝证实基质的黏多糖性质。文献认为其常与限制饲喂和能量动员有关、可见于临床无异常的小型猪；因此它是药物毒性评价的重要背景/营养性鉴别，而不是本例已证明的试验物质效应或骨髓纤维化。", "author_conclusion_summary_en": "The authors described marrow adipocyte atrophy/degeneration with increased acidic mucopolysaccharides and often reduced hematopoietic density. H&E and alcian blue support serous atrophy of fat. It is an important background/nutritional differential, not demonstrated test-article toxicity or marrow fibrosis.", "pairing_note_cn": "Figure 11C-E为同一Case 2的多倍率/多染色证据：C为股骨远端低倍H&E，D为较高倍H&E，E为pH 2.5阿利新蓝。它们不是同一视野的连续染色，也没有与CBC、体重曲线或处理组构成严格配对。Figure 11A-B及F-M属于其他器官/病例，不纳入本骨髓案例。", "pairing_note_en": "Figure 11C-E is multimagnification/multistain evidence from Case 2: distal-femur H&E at low and higher power plus alcian blue at pH 2.5. These are not serial stains of one identical field and are not strictly paired to CBC or treatment data. Panels A-B and F-M are other cases and are excluded.", "rights_note_cn": "该综述性会议论文可在PMC阅读，但核对页面未见明确Creative Commons或Figure 11C-E专属图片许可；公开站点仅保留精确图号、双语摘要和来源链接。", "rights_note_en": "The symposium proceedings are publicly readable in PMC, but no explicit Creative Commons or Figure 11C-E-specific image license was identified. The public site retains the exact figure reference and summary without republishing the image.", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-CASE-PMC8546475", "featured": true, "featured_reason_cn": "兔骨髓基质改变的疾病性鉴别", "module_id": "toxicity_atlas", "source_id": "PMC8546475-RABBIT-GELATINOUS-MARROW", "source_title": "Gelatinous transformation of bone marrow in a rabbit", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8546475/", "doi": "10.1177/10406387211029916", "pmid": "34250866", "pmcid": "PMC8546475", "source_page": "Figure 1, panels A-D; journal pages 1185-1186", "species": "Rabbit", "toxicity_type": "T05", "toxicity_title_cn": "骨髓纤维化和基质改变", "toxicity_title_en": "Fibrosis and stromal or microenvironment change", "title_cn": "兔骨髓直接涂片可见丰富粉红基质、印戒样脂肪细胞及保留的三系成熟。", "display_title_cn": "兔骨髓基质改变的疾病性鉴别", "title_en": "Rabbit marrow direct smears showed abundant pink matrix, signet-ring adipocytes, and preserved trilineage maturation.", "factor": "Severe gastrointestinal disease with anorexia and malnutrition", "dose": "Not applicable", "timecourse": "Day 11 proximal right humerus marrow aspirate from a clinical rabbit case", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "兔骨髓直接涂片可见丰富粉红基质、印戒样脂肪细胞及保留的三系成熟。", "author_conclusion_summary_cn": "原作者结合PAS强阳性、阿利新蓝弱阳性的基质，将该病例诊断为骨髓胶样转化（脂肪浆液性萎缩），并认为其很可能与厌食和营养不良相关。直接观察还包括颗粒内细胞量估计30%–40%、巨核细胞成熟且数量适当、粒红比1.0和完整正常成熟；病例未进行骨髓芯活检，部分附加染色也未完成，因此不能仅凭图像外推机制、发生率或药物相关性。原文未授予明确的公开图片再利用许可，网页仅保留可追溯案例卡。", "author_conclusion_summary_en": "See the cited source for the complete author interpretation.", "pairing_note_cn": "Figure 1的A-D均来自同一病例第11天近端右肱骨骨髓吸取物：A为Wright-Giemsa直接涂片，B为高倍印戒样脂肪细胞，C-D为PAS和阿利新蓝细胞块染色。它是同病例多方法支持，不是治疗前后时序配对；网站不公开原图。", "pairing_note_en": "Figure 1 panels A-D derive from the same day-11 proximal right humerus aspirate: panel A is a Wright-Giemsa direct smear, panel B is a higher-power signet-ring adipocyte field, and panels C-D are PAS- and alcian-blue-stained cell-block sections. This is same-case multimethod support, not a before-after time course; the website does not republish the source figure.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "NTP-CASE-RAT-GELATINOUS-TRANSFORMATION", "featured": true, "featured_reason_cn": "大鼠骨髓胶样变：低细胞性、脂肪萎缩与基质改变", "module_id": "bone-marrow-cases", "source_id": "NTP-BONE-MARROW-GELATINOUSTRANSFORMATION", "source_title": "Bone marrow - Gelatinous Transformation - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/GelatinousTransformation", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "Figures 1-3", "species": "Rat", "toxicity_type": "T05", "toxicity_title_cn": "骨髓纤维化和基质改变", "toxicity_title_en": "Fibrosis and stromal or microenvironment change", "title_cn": "亚慢性研究雌性F344/N大鼠骨髓胶样变，表现为重度低细胞性、脂肪细胞萎缩和嗜酸性颗粒状基质。", "display_title_cn": "大鼠骨髓胶样变：低细胞性、脂肪萎缩与基质改变", "title_en": "Gelatinous transformation in female F344/N rat marrow with severe hypocellularity, atrophied adipocytes, and eosinophilic granular ground substance.", "factor": "Advanced illness or nutritional depletion differential", "dose": "NR", "timecourse": "Subchronic study", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "亚慢性研究雌性F344/N大鼠骨髓胶样变，表现为重度低细胞性、脂肪细胞萎缩和嗜酸性颗粒状基质。", "author_conclusion_summary_cn": "该少见模式常与恶病质、严重营养不足或晚期疾病相关；应与单纯低细胞性及脂肪性替代区分，不能仅凭图像归因于试验物质。", "author_conclusion_summary_en": "This uncommon pattern is associated with cachexia, severe undernutrition, or advanced illness and should be distinguished from simple hypocellularity or fatty replacement; the image alone cannot attribute it to a test article.", "pairing_note_cn": "Figures 1-2展示相同诊断模式的低/中倍视野，Figure 3为高倍视图；来源未确认全部图片来自同一动物。", "pairing_note_en": "Figures 1-2 show low/intermediate views of the diagnostic pattern and Figure 3 is a higher-magnification view; the source does not confirm that all images are from one animal.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-GELATINOUS-F01", "BM-NTP-GELATINOUS-F02", "BM-NTP-GELATINOUS-F03" ], "pathology_evidence_count": 3, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-GELATINOUS-F01", "title_cn": "大鼠骨髓胶样变（低倍）", "title_en": "Gelatinous transformation of rat bone marrow, low power", "figure_label": "Figure 1", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/GelatinousTransformation", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-GELATINOUS-F02", "title_cn": "大鼠骨髓胶样变（中倍）", "title_en": "Gelatinous transformation of rat bone marrow, intermediate view", "figure_label": "Figure 2", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/GelatinousTransformation", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-GELATINOUS-F03", "title_cn": "大鼠骨髓胶样变（高倍）", "title_en": "Gelatinous transformation of rat bone marrow, higher magnification", "figure_label": "Figure 3", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/GelatinousTransformation", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "NTP-CASE-RAT-MARROW-FIBROSIS", "featured": true, "featured_reason_cn": "大鼠骨髓纤维化：低倍定位与高倍形态", "module_id": "bone-marrow-cases", "source_id": "NTP-BONE-MARROW-FIBROSIS", "source_title": "Bone marrow - Fibrosis - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Fibrosis", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "Figures 1-3", "species": "Rat", "toxicity_type": "T05", "toxicity_title_cn": "骨髓纤维化和基质改变", "toxicity_title_en": "Fibrosis and stromal or microenvironment change", "title_cn": "慢性研究雄性F344/N大鼠骨髓致密纤维组织伴血管扩张，提供低倍定位和两个高倍形态视野。", "display_title_cn": "大鼠骨髓纤维化：低倍定位与高倍形态", "title_en": "Dense fibrous marrow tissue with angiectasis in a male F344/N rat, shown at low power and in two higher-magnification fields.", "factor": "NR", "dose": "NR", "timecourse": "Chronic study", "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "observation_summary_cn": "慢性研究雄性F344/N大鼠骨髓致密纤维组织伴血管扩张，提供低倍定位和两个高倍形态视野。", "author_conclusion_summary_cn": "HE图支持纤维化形态识别，但不能单独诊断原发性髓纤维化或确定病因；必要时应结合网状纤维或三色染色。", "author_conclusion_summary_en": "H&E supports recognition of fibrosis but does not alone diagnose primary myelofibrosis or establish cause; reticulin or trichrome stains may be needed.", "pairing_note_cn": "Figure 1为病灶低倍定位，Figures 2-3为同一病变的两个高倍视野。", "pairing_note_en": "Figure 1 localizes the lesion at low power; Figures 2-3 provide two higher-magnification views of the same lesion pattern.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-FIBROSIS-F01", "BM-NTP-FIBROSIS-F02", "BM-NTP-FIBROSIS-F03" ], "pathology_evidence_count": 3, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-FIBROSIS-F01", "title_cn": "大鼠骨髓致密纤维化伴血管扩张（低倍）", "title_en": "Dense marrow fibrosis with angiectasis in rat, low power", "figure_label": "Figure 1", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Fibrosis", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-FIBROSIS-F02", "title_cn": "大鼠骨髓致密纤维化（高倍）", "title_en": "Dense marrow fibrosis in rat, higher magnification", "figure_label": "Figure 2", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Fibrosis", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-FIBROSIS-F03", "title_cn": "大鼠骨髓致密纤维化（另一高倍视野）", "title_en": "Dense marrow fibrosis in rat, alternate higher-power field", "figure_label": "Figure 3", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Fibrosis", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-DOG-ESTROGEN-STAGE2", "featured": true, "featured_reason_cn": "犬雌激素髓毒性时序：中性粒细胞与骨髓粒系反应", "module_id": "neutrophilia", "source_id": "PMC2748286-DOG-ESTROGEN-MYELOTOXICITY", "source_title": "Canine estrogen myelotoxicity stage 2: neutrophilia with granulocytic hyperplasia", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2748286/", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "NR", "species": "Dog", "toxicity_type": "T06", "toxicity_title_cn": "反应性增生、恢复期反跳和高细胞性", "toxicity_title_en": "Reactive hyperplasia, rebound and hypercellularity", "title_cn": "犬雌激素髓毒性第二阶段：中性粒细胞增多伴粒系增生", "display_title_cn": "犬雌激素髓毒性时序：中性粒细胞与骨髓粒系反应", "title_en": "Canine estrogen myelotoxicity stage 2: neutrophilia with granulocytic hyperplasia", "factor": "Drug_phase_response", "dose": "NR", "timecourse": "Days 13-20", "evidence_role": "Treatment_associated_pair", "causality_level": "Treatment_associated", "observation_summary_cn": "犬雌激素髓毒性第二阶段：中性粒细胞增多伴粒系增生", "author_conclusion_summary_cn": "重要犬种属和时相特异性髓毒性模式。", "author_conclusion_summary_en": "Important canine and phase-specific myelotoxicity pattern.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "AUTH-CASE-PMC4408895", "featured": true, "featured_reason_cn": "小鼠骨髓增生、含铁巨噬细胞和骨髓纤维化对照", "module_id": "toxicity_library", "source_id": "AUTH-PMC4408895", "source_title": "Practical Murine Hematopathology: A Comparative Review and Implications for Research", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4408895/", "doi": "NR", "pmid": "25926395", "pmcid": "PMC4408895", "source_page": "NR", "species": "Mouse", "toxicity_type": "T06", "toxicity_title_cn": "反应性增生、恢复期反跳和高细胞性", "toxicity_title_en": "Reactive hyperplasia, rebound and hypercellularity", "title_cn": "权威候选来源记录：Normal marrow, emperipolesis, megakaryocyte, myeloid hyperplasia, iron-laden macrophages and myelofibrosis。具体图像与处理相关性仍需逐图专家复核。", "display_title_cn": "小鼠骨髓增生、含铁巨噬细胞和骨髓纤维化对照", "title_en": "Normal marrow, emperipolesis, megakaryocyte, myeloid hyperplasia, iron-laden macrophages and myelofibrosis", "factor": "Core mouse cytology/histology methods and differential atlas", "dose": "NR", "timecourse": "NR", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "权威候选来源记录：Normal marrow, emperipolesis, megakaryocyte, myeloid hyperplasia, iron-laden macrophages and myelofibrosis。具体图像与处理相关性仍需逐图专家复核。", "author_conclusion_summary_cn": "NR", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-CASE-PMC3996654", "featured": true, "featured_reason_cn": "小鼠5-FU骨髓损伤与恢复性干预", "module_id": "toxicity_atlas", "source_id": "PMC3996654-MOUSE-5FU-ENTOLIMOD", "source_title": "Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3996654/", "doi": "10.18632/oncotarget.1773", "pmid": "24583651", "pmcid": "PMC3996654", "source_page": "NR", "species": "Mouse", "toxicity_type": "T06", "toxicity_title_cn": "反应性增生、恢复期反跳和高细胞性", "toxicity_title_en": "Reactive hyperplasia, rebound and hypercellularity", "title_cn": "与5-FU单用相比，entolimod减轻损伤或促进骨髓恢复。", "display_title_cn": "小鼠5-FU骨髓损伤与恢复性干预", "title_en": "Entolimod reduced or accelerated recovery from 5-FU-associated marrow injury.", "factor": "5-fluorouracil with or without entolimod", "dose": "200 mg/kg 5-FU in source caption", "timecourse": "Day 3 and day 7", "evidence_role": "Toxicity_image", "causality_level": "Author_attributed", "observation_summary_cn": "与5-FU单用相比，entolimod减轻损伤或促进骨髓恢复。", "author_conclusion_summary_cn": "该对照支持处理相关的保护或恢复作用。", "author_conclusion_summary_en": "The comparison supports a treatment-associated protective or restorative effect.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-CASE-PMC4837595", "featured": true, "featured_reason_cn": "小鼠5-FU低细胞性最低点与内源性恢复", "module_id": "toxicity_atlas", "source_id": "PMC4837595-MOUSE-5FU-TIMECOURSE", "source_title": "Delineating the effects of 5-fluorouracil and follicle-stimulating hormone on mouse bone marrow stem/progenitor cells", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4837595/", "doi": "10.1186/s13287-016-0311-6", "pmid": "27095238", "pmcid": "PMC4837595", "source_page": "Figure 2, panels a-d", "species": "Mouse", "toxicity_type": "T06", "toxicity_title_cn": "反应性增生、恢复期反跳和高细胞性", "toxicity_title_en": "Reactive hyperplasia, rebound and hypercellularity", "title_cn": "5-FU引起明显骨髓低细胞性，随后出现造血恢复。", "display_title_cn": "小鼠5-FU低细胞性最低点与内源性恢复", "title_en": "Mouse: Reactive hyperplasia, rebound and hypercellularity associated with 5-fluorouracil", "factor": "5-fluorouracil", "dose": "150 mg/kg", "timecourse": "Untreated control; day 2 injury; day 4 nadir; day 10 recovery", "evidence_role": "Treatment_associated_pair", "causality_level": "Author_attributed", "observation_summary_cn": "5-FU引起明显骨髓低细胞性，随后出现造血恢复。", "author_conclusion_summary_cn": "原作者报告5-FU后骨髓细胞数逐步下降，D4达到最低点，并在D10出现内源性造血恢复；单张切片不能单独证明恢复已完全或判定不良性。", "author_conclusion_summary_en": "The authors reported progressive marrow cell loss after 5-FU, a day 4 nadir, and endogenous hematopoietic recovery by day 10. A single section does not by itself establish complete functional recovery or adversity.", "pairing_note_cn": "四张图来自同一研究的Figure 2，但为未处理对照及D2、D4、D10各时点的代表性不同动物/样本；是同研究时序对照，不是同一动物纵向活检。", "pairing_note_en": "All four panels are from Figure 2 of the same study, but they represent the untreated control and samples at days 2, 4, and 10. This is a same-study time-course comparison, not serial biopsies from one animal.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-CC-5FU-F02-A", "BM-CC-5FU-F02-B", "BM-CC-5FU-F02-D" ], "pathology_evidence_count": 3, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-CC-5FU-F02-A", "title_cn": "5-FU时序对照：未处理小鼠骨髓", "title_en": "5-FU time-course control: untreated mouse marrow", "figure_label": "Fig. 2", "specimen_type": "Bone_marrow_histology_section", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4837595/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-5FU-F02-B", "title_cn": "5-FU后第2天：骨髓造血细胞开始减少", "title_en": "Day 2 after 5-FU: early reduction in marrow hematopoietic cells", "figure_label": "Fig. 2", "specimen_type": "Bone_marrow_histology_section", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4837595/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-5FU-F02-D", "title_cn": "5-FU后第10天：内源性造血恢复", "title_en": "Day 10 after 5-FU: endogenous hematopoietic recovery", "figure_label": "Fig. 2", "specimen_type": "Bone_marrow_histology_section", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4837595/", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-MOUSE-GCSF-D9", "featured": true, "featured_reason_cn": "小鼠G-CSF作用下外周血与骨髓粒系的配对反应", "module_id": "neutrophilia", "source_id": "PMC7723243-MOUSE-GCSF-GRANULOPOIESIS", "source_title": "G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7723243/", "doi": "10.26508/lsa.202000737", "pmid": "33234677", "pmcid": "PMC7723243", "source_page": "Supplementary Figure S3, panels C-E", "species": "Mouse", "toxicity_type": "T06", "toxicity_title_cn": "反应性增生、恢复期反跳和高细胞性", "toxicity_title_en": "Reactive hyperplasia, rebound and hypercellularity", "title_cn": "小鼠G-CSF处理：外周中性粒细胞增多与骨髓粒系生成增强", "display_title_cn": "小鼠G-CSF作用下外周血与骨髓粒系的配对反应", "title_en": "Mouse G-CSF treatment with peripheral neutrophilia and enhanced marrow granulopoiesis", "factor": "G-CSF", "dose": "50 μg/kg subcutaneous, twice daily", "timecourse": "Day 9 after repeated administration", "evidence_role": "Mechanistic_reference", "causality_level": "Treatment_associated", "observation_summary_cn": "小鼠G-CSF处理：外周中性粒细胞增多与骨髓粒系生成增强", "author_conclusion_summary_cn": "原作者报告G-CSF处理后骨髓粒细胞生成增强，外周中性粒细胞计数升高；同时该研究主线还显示骨髓红系受抑。该案例用于说明药理性细胞因子反应，不应自动等同于不良骨髓毒性。", "author_conclusion_summary_en": "The authors reported enhanced marrow granulopoiesis and increased peripheral neutrophil counts after G-CSF treatment; the broader study also showed suppression of marrow erythropoiesis. This is a pharmacologic cytokine-response example and should not automatically be classified as adverse marrow toxicity.", "pairing_note_cn": "Panel D骨髓涂片、Panel E外周血涂片和Panel C计数来自同一研究、同组别和第9天时点（n=5/组）的代表性证据；原文未说明每个图像视野均来自同一只动物，因此按同研究支持性配对展示。", "pairing_note_en": "Panel D marrow smears, panel E peripheral-blood smears, and panel C counts are representative evidence from the same study, groups, and day-9 time point (n=5/group). The source does not state that every displayed field came from the same animal, so the set is presented as same-study supportive pairing.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-GCSF-FS3-D", "BM-CC-GCSF-FS3-E" ], "public_image_paths": [ "../images/BM-CC-GCSF-FS3-D.png", "../images/BM-CC-GCSF-FS3-E.png" ], "public_image_preview_paths": [ "../previews/BM-CC-GCSF-FS3-D.jpg", "../previews/BM-CC-GCSF-FS3-E.jpg" ], "public_images": [ { "image_id": "BM-CC-GCSF-FS3-D", "title_cn": "小鼠G-CSF反应：骨髓粒细胞生成增强的低倍与高倍对照", "title_en": "Mouse G-CSF response: low- and high-power comparison of enhanced marrow granulopoiesis", "figure_label": "Figure S3", "species": "Mouse", "evidence_role": "Mechanistic_reference", "asset_path": "../images/BM-CC-GCSF-FS3-D.png", "preview_path": "../previews/BM-CC-GCSF-FS3-D.jpg", "caption_original_en": "G-CSF treatment enhances granulopoiesis in the BM of mice. (A, B) Flow cytometric analysis of the BM neutrophils (CD11b+Ly6G+) in control and G-CSF–treated mice. (A) Representative flow cytometric plots of CD11b+Ly6G+ cells in the BMs of control and G-CSF–treated mice. (B) Flow cytometric quantification of CD11b+Ly6G+ neutrophils in the BMs of control and G-CSF–treated mice. (C) Peripheral neutrophil counts in control and G-CSF–treated mice. (D) Wright–Giemsa staining of BM cells from control and G-CSF–treated mice. Original magnification ×100 (upper panels); ×1,000 (lower panels) (E) Wright–Giemsa staining of peripheral blood cells from control and G-CSF–treated mice. (F) Representative fields of CFU-GM–derived colonies in BM cultures from control and G-CSF–treated mice (×100 magnification; scale bar = 200 μm). (G) Quantification of the number of CFU-GM–derived colonies in BM cultures from control and G-CSF treated mice. n = 5/group (A, B, C, D, E), n = 3/group (F, G). ***P < 0.001.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" }, { "image_id": "BM-CC-GCSF-FS3-E", "title_cn": "小鼠G-CSF反应：外周血中性粒细胞增多的涂片对照", "title_en": "Mouse G-CSF response: peripheral-blood smear comparison accompanying neutrophilia", "figure_label": "Figure S3", "species": "Mouse", "evidence_role": "Mechanistic_reference", "asset_path": "../images/BM-CC-GCSF-FS3-E.png", "preview_path": "../previews/BM-CC-GCSF-FS3-E.jpg", "caption_original_en": "G-CSF treatment enhances granulopoiesis in the BM of mice. (A, B) Flow cytometric analysis of the BM neutrophils (CD11b+Ly6G+) in control and G-CSF–treated mice. (A) Representative flow cytometric plots of CD11b+Ly6G+ cells in the BMs of control and G-CSF–treated mice. (B) Flow cytometric quantification of CD11b+Ly6G+ neutrophils in the BMs of control and G-CSF–treated mice. (C) Peripheral neutrophil counts in control and G-CSF–treated mice. (D) Wright–Giemsa staining of BM cells from control and G-CSF–treated mice. Original magnification ×100 (upper panels); ×1,000 (lower panels) (E) Wright–Giemsa staining of peripheral blood cells from control and G-CSF–treated mice. (F) Representative fields of CFU-GM–derived colonies in BM cultures from control and G-CSF–treated mice (×100 magnification; scale bar = 200 μm). (G) Quantification of the number of CFU-GM–derived colonies in BM cultures from control and G-CSF treated mice. n = 5/group (A, B, C, D, E), n = 3/group (F, G). ***P < 0.001.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC4427713-CASE-RAT-CYPERMETHRIN-TIMECOURSE", "featured": true, "featured_reason_cn": "大鼠氯氰菊酯骨髓红系反应与恢复时序", "module_id": "bone-marrow-cases", "source_id": "PMC4427713-RAT-CYPERMETHRIN", "source_title": "Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/", "doi": "10.2478/intox-2014-0006", "pmid": "26038674", "pmcid": "PMC4427713", "source_page": "Plates XI-XVII and Tables 8-10", "species": "Rat", "toxicity_type": "T06", "toxicity_title_cn": "反应性增生、恢复期反跳和高细胞性", "toxicity_title_en": "Reactive hyperplasia, rebound and hypercellularity", "title_cn": "大鼠氯氰菊酯骨髓涂片时序：对照、急性处理、亚慢性红系比例变化及停药恢复。", "display_title_cn": "大鼠氯氰菊酯骨髓红系反应与恢复时序", "title_en": "Rat marrow-smear time course after cypermethrin: control, acute exposure, subchronic erythroid proportional changes, and post-treatment recovery.", "factor": "Cypermethrin", "dose": "Acute 300 mg/kg once; subchronic 10.7 mg/kg/day for 7-28 days by oral gavage", "timecourse": "Control; acute day 1; subchronic days 7, 14, 21, and 28; recovery day 60 after 22 untreated days", "evidence_role": "Treatment_associated_pair", "causality_level": "Author_attributed", "observation_summary_cn": "大鼠氯氰菊酯骨髓涂片时序：对照、急性处理、亚慢性红系比例变化及停药恢复。", "author_conclusion_summary_cn": "原作者报告亚慢性处理期间红系前体相对比例逐步增加、M:E下降，并在停药恢复期趋于正常。图谱保留这一作者解释，同时强调涂片比例升高不等同于红系绝对增生，单个代表视野也不能替代固定分母分类计数、同期CBC或组织学评价。", "author_conclusion_summary_en": "See the cited source for the complete author interpretation.", "pairing_note_cn": "Plates XI-XVII来自同一研究中不同处理组和时间点的代表视野，并非同一动物的连续骨髓采样。Plate XI是来源标注的对照视野，但原文未证明它与每个处理panel构成严格同一动物或严格配对对照，因此属于同研究、组水平支持性时序。", "pairing_note_en": "Plates XI-XVII are representative fields from different groups and time points in one study, not serial marrow samples from one animal. Plate XI is source-labeled as control, but the article does not establish a strict animal-level pair for every treated panel; the set therefore provides same-study, group-level supportive time-course evidence.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-RAT-CYPERMETHRIN-P11-CONTROL", "BM-CC-RAT-CYPERMETHRIN-P12-DAY1", "BM-CC-RAT-CYPERMETHRIN-P13-DAY7", "BM-CC-RAT-CYPERMETHRIN-P14-DAY14", "BM-CC-RAT-CYPERMETHRIN-P15-DAY21", "BM-CC-RAT-CYPERMETHRIN-P16-DAY28", "BM-CC-RAT-CYPERMETHRIN-P17-RECOVERY" ], "public_image_paths": [ "../images/BM-CC-RAT-CYPERMETHRIN-P11-CONTROL.png", "../images/BM-CC-RAT-CYPERMETHRIN-P12-DAY1.png", "../images/BM-CC-RAT-CYPERMETHRIN-P13-DAY7.png", "../images/BM-CC-RAT-CYPERMETHRIN-P14-DAY14.png", "../images/BM-CC-RAT-CYPERMETHRIN-P15-DAY21.png", "../images/BM-CC-RAT-CYPERMETHRIN-P16-DAY28.png", "../images/BM-CC-RAT-CYPERMETHRIN-P17-RECOVERY.png" ], "public_image_preview_paths": [ "../previews/BM-CC-RAT-CYPERMETHRIN-P11-CONTROL.jpg", "../previews/BM-CC-RAT-CYPERMETHRIN-P12-DAY1.jpg", "../previews/BM-CC-RAT-CYPERMETHRIN-P13-DAY7.jpg", "../previews/BM-CC-RAT-CYPERMETHRIN-P14-DAY14.jpg", "../previews/BM-CC-RAT-CYPERMETHRIN-P15-DAY21.jpg", "../previews/BM-CC-RAT-CYPERMETHRIN-P16-DAY28.jpg", "../previews/BM-CC-RAT-CYPERMETHRIN-P17-RECOVERY.jpg" ], "public_images": [ { "image_id": "BM-CC-RAT-CYPERMETHRIN-P11-CONTROL", "title_cn": "同期对照大鼠骨髓涂片：早幼粒细胞与多染性幼红细胞", "title_en": "Concurrent-control rat marrow smear: promyelocyte and polychromatic erythroblast", "figure_label": "Plates XI-XVII", "species": "Rat", "evidence_role": "Normal_comparator", "asset_path": "../images/BM-CC-RAT-CYPERMETHRIN-P11-CONTROL.png", "preview_path": "../previews/BM-CC-RAT-CYPERMETHRIN-P11-CONTROL.jpg", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus of control group depicting promyelocyte (PMC) and polychromatic erythroblast (PE).", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" }, { "image_id": "BM-CC-RAT-CYPERMETHRIN-P12-DAY1", "title_cn": "氯氰菊酯急性处理后大鼠骨髓：正染性幼红细胞", "title_en": "Rat marrow after acute cypermethrin exposure: orthochromatic erythroblast", "figure_label": "Plates XI-XVII", "species": "Rat", "evidence_role": "Treatment_context_reference", "asset_path": "../images/BM-CC-RAT-CYPERMETHRIN-P12-DAY1.png", "preview_path": "../previews/BM-CC-RAT-CYPERMETHRIN-P12-DAY1.jpg", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus after acute cypermethrin treatment showing orthochromatic erythroblast (OE).", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" }, { "image_id": "BM-CC-RAT-CYPERMETHRIN-P13-DAY7", "title_cn": "氯氰菊酯处理7天：原作者标注巨幼样细胞及轻度红系增加", "title_en": "Cypermethrin day 7: source-labeled megaloblast and slight erythroid increase", "figure_label": "Plates XI-XVII", "species": "Rat", "evidence_role": "Treatment_associated_response", "asset_path": "../images/BM-CC-RAT-CYPERMETHRIN-P13-DAY7.png", "preview_path": "../previews/BM-CC-RAT-CYPERMETHRIN-P13-DAY7.jpg", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus after 7 days of cypermethrin treatment showing megaloblast (MB) and slight increase in cells of erythroid series.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" }, { "image_id": "BM-CC-RAT-CYPERMETHRIN-P14-DAY14", "title_cn": "氯氰菊酯处理14天：红系前体增加", "title_en": "Cypermethrin day 14: increased erythroid precursors", "figure_label": "Plates XI-XVII", "species": "Rat", "evidence_role": "Treatment_associated_response", "asset_path": "../images/BM-CC-RAT-CYPERMETHRIN-P14-DAY14.png", "preview_path": "../previews/BM-CC-RAT-CYPERMETHRIN-P14-DAY14.jpg", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus after subchronic (14 days) cypermethrin treatment showing polychromatic erythroblast (PE) and increase in erythroid precursors.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" }, { "image_id": "BM-CC-RAT-CYPERMETHRIN-P15-DAY21", "title_cn": "氯氰菊酯处理21天：中幼粒细胞与中度红系前体增加", "title_en": "Cypermethrin day 21: myelocyte and moderate erythroid-precursor increase", "figure_label": "Plates XI-XVII", "species": "Rat", "evidence_role": "Treatment_associated_response", "asset_path": "../images/BM-CC-RAT-CYPERMETHRIN-P15-DAY21.png", "preview_path": "../previews/BM-CC-RAT-CYPERMETHRIN-P15-DAY21.jpg", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus after subchronic (21 days) cypermethrin treatment depicting myelocyte (MC) and moderate increase in erythroid precursors.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" }, { "image_id": "BM-CC-RAT-CYPERMETHRIN-P16-DAY28", "title_cn": "氯氰菊酯处理28天：粒系成熟阶段与高度红系比例增加", "title_en": "Cypermethrin day 28: granulocytic maturation stages and markedly increased erythroid proportion", "figure_label": "Plates XI-XVII", "species": "Rat", "evidence_role": "Treatment_associated_response", "asset_path": "../images/BM-CC-RAT-CYPERMETHRIN-P16-DAY28.png", "preview_path": "../previews/BM-CC-RAT-CYPERMETHRIN-P16-DAY28.jpg", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus after subchronic (28 days) treatment showing metamyelocyte (MMC) band stage (B), polymorphonuclear neutrophils (PMN) and highly increased proportion of erythroid cells.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" }, { "image_id": "BM-CC-RAT-CYPERMETHRIN-P17-RECOVERY", "title_cn": "氯氰菊酯恢复期大鼠骨髓：粒系成熟序列", "title_en": "Rat marrow during cypermethrin recovery: granulocytic maturation sequence", "figure_label": "Plates XI-XVII", "species": "Rat", "evidence_role": "Recovery_response", "asset_path": "../images/BM-CC-RAT-CYPERMETHRIN-P17-RECOVERY.png", "preview_path": "../previews/BM-CC-RAT-CYPERMETHRIN-P17-RECOVERY.jpg", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus of recovery group (60 days) showing developing neutrophils (NP), polymorphonuclear eosinophil (PNE) and polymorphonuclear basophil (PNB).", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-RAT-CYP-D14", "featured": true, "featured_reason_cn": "大鼠氯氰菊酯第14天：外周中性粒细胞与红系前体增加", "module_id": "neutrophilia", "source_id": "PMC4427713-RAT-CYPERMETHRIN", "source_title": "Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/", "doi": "10.2478/intox-2014-0006", "pmid": "26038674", "pmcid": "PMC4427713", "source_page": "Plate XIV and Tables 8-10", "species": "Rat", "toxicity_type": "T06", "toxicity_title_cn": "反应性增生、恢复期反跳和高细胞性", "toxicity_title_en": "Reactive hyperplasia, rebound and hypercellularity", "title_cn": "大鼠氯氰菊酯处理14天：外周中性粒细胞增加与骨髓组成改变", "display_title_cn": "大鼠氯氰菊酯第14天：外周中性粒细胞与红系前体增加", "title_en": "Rat cypermethrin day 14: increased circulating neutrophils with marrow composition change", "factor": "Cypermethrin", "dose": "10.7 mg/kg/day by oral gavage", "timecourse": "Day 14", "evidence_role": "Treatment_associated_pair", "causality_level": "Treatment_associated", "observation_summary_cn": "大鼠氯氰菊酯处理14天：外周中性粒细胞增加与骨髓组成改变", "author_conclusion_summary_cn": "处理相关血液—骨髓配对证据；ANC由原文TLC均值和中性粒细胞百分比透明计算，未对派生ANC另行统计检验。", "author_conclusion_summary_en": "Treatment-associated paired evidence; ANC is transparently derived from reported mean TLC and neutrophil percentage and was not separately tested statistically.", "pairing_note_cn": "Plate XIV和第14天血液学表是同研究同时点的组水平支持性对照，不是已证明的同一动物严格配对。ANC为派生值，图中红系增加也不自动说明中性粒细胞增多的具体机制。", "pairing_note_en": "Plate XIV and day-14 hematology tables are same-study, same-time-point group-level supportive evidence, not a proven strict same-animal pair. ANC is derived, and the erythroid increase in the image does not by itself establish the mechanism of neutrophilia.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-RAT-CYPERMETHRIN-P14-DAY14" ], "public_image_paths": [ "../images/BM-CC-RAT-CYPERMETHRIN-P14-DAY14.png" ], "public_image_preview_paths": [ "../previews/BM-CC-RAT-CYPERMETHRIN-P14-DAY14.jpg" ], "public_images": [ { "image_id": "BM-CC-RAT-CYPERMETHRIN-P14-DAY14", "title_cn": "氯氰菊酯处理14天：红系前体增加", "title_en": "Cypermethrin day 14: increased erythroid precursors", "figure_label": "Plates XI-XVII", "species": "Rat", "evidence_role": "Treatment_associated_response", "asset_path": "../images/BM-CC-RAT-CYPERMETHRIN-P14-DAY14.png", "preview_path": "../previews/BM-CC-RAT-CYPERMETHRIN-P14-DAY14.jpg", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus after subchronic (14 days) cypermethrin treatment showing polychromatic erythroblast (PE) and increase in erythroid precursors.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-RAT-CYP-D21", "featured": true, "featured_reason_cn": "大鼠氯氰菊酯第21天：外周中性粒细胞与中度红系增加", "module_id": "neutrophilia", "source_id": "PMC4427713-RAT-CYPERMETHRIN", "source_title": "Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/", "doi": "10.2478/intox-2014-0006", "pmid": "26038674", "pmcid": "PMC4427713", "source_page": "Plate XV and Tables 8-10", "species": "Rat", "toxicity_type": "T06", "toxicity_title_cn": "反应性增生、恢复期反跳和高细胞性", "toxicity_title_en": "Reactive hyperplasia, rebound and hypercellularity", "title_cn": "大鼠氯氰菊酯处理21天：外周中性粒细胞增加与骨髓组成改变", "display_title_cn": "大鼠氯氰菊酯第21天：外周中性粒细胞与中度红系增加", "title_en": "Rat cypermethrin day 21: increased circulating neutrophils with marrow composition change", "factor": "Cypermethrin", "dose": "10.7 mg/kg/day by oral gavage", "timecourse": "Day 21", "evidence_role": "Treatment_associated_pair", "causality_level": "Treatment_associated", "observation_summary_cn": "大鼠氯氰菊酯处理21天：外周中性粒细胞增加与骨髓组成改变", "author_conclusion_summary_cn": "处理相关血液—骨髓配对证据；ANC由原文TLC均值和中性粒细胞百分比透明计算，未对派生ANC另行统计检验。", "author_conclusion_summary_en": "Treatment-associated paired evidence; ANC is transparently derived from reported mean TLC and neutrophil percentage and was not separately tested statistically.", "pairing_note_cn": "Plate XV与第21天表格为同组别、同时点的组水平证据，但原文未提供同一动物图像—CBC身份映射。单个中幼粒细胞不证明粒系增生或成熟阻滞。", "pairing_note_en": "Plate XV and day-21 tables are group-level evidence from the same group and time point, but the source provides no same-animal image-CBC identity mapping. One myelocyte does not establish myeloid hyperplasia or maturation arrest.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-RAT-CYPERMETHRIN-P15-DAY21" ], "public_image_paths": [ "../images/BM-CC-RAT-CYPERMETHRIN-P15-DAY21.png" ], "public_image_preview_paths": [ "../previews/BM-CC-RAT-CYPERMETHRIN-P15-DAY21.jpg" ], "public_images": [ { "image_id": "BM-CC-RAT-CYPERMETHRIN-P15-DAY21", "title_cn": "氯氰菊酯处理21天：中幼粒细胞与中度红系前体增加", "title_en": "Cypermethrin day 21: myelocyte and moderate erythroid-precursor increase", "figure_label": "Plates XI-XVII", "species": "Rat", "evidence_role": "Treatment_associated_response", "asset_path": "../images/BM-CC-RAT-CYPERMETHRIN-P15-DAY21.png", "preview_path": "../previews/BM-CC-RAT-CYPERMETHRIN-P15-DAY21.jpg", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus after subchronic (21 days) cypermethrin treatment depicting myelocyte (MC) and moderate increase in erythroid precursors.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-RAT-CYP-D28", "featured": true, "featured_reason_cn": "大鼠氯氰菊酯第28天：红系比例增加与粒系成熟阶段", "module_id": "neutrophilia", "source_id": "PMC4427713-RAT-CYPERMETHRIN", "source_title": "Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/", "doi": "10.2478/intox-2014-0006", "pmid": "26038674", "pmcid": "PMC4427713", "source_page": "Plate XVI and Tables 8-10", "species": "Rat", "toxicity_type": "T06", "toxicity_title_cn": "反应性增生、恢复期反跳和高细胞性", "toxicity_title_en": "Reactive hyperplasia, rebound and hypercellularity", "title_cn": "大鼠氯氰菊酯处理28天：外周中性粒细胞增加与骨髓组成改变", "display_title_cn": "大鼠氯氰菊酯第28天：红系比例增加与粒系成熟阶段", "title_en": "Rat cypermethrin day 28: increased circulating neutrophils with marrow composition change", "factor": "Cypermethrin", "dose": "10.7 mg/kg/day by oral gavage", "timecourse": "Day 28", "evidence_role": "Treatment_associated_pair", "causality_level": "Treatment_associated", "observation_summary_cn": "大鼠氯氰菊酯处理28天：外周中性粒细胞增加与骨髓组成改变", "author_conclusion_summary_cn": "处理相关血液—骨髓配对证据；ANC由原文TLC均值和中性粒细胞百分比透明计算，未对派生ANC另行统计检验。", "author_conclusion_summary_en": "Treatment-associated paired evidence; ANC is transparently derived from reported mean TLC and neutrophil percentage and was not separately tested statistically.", "pairing_note_cn": "Plate XVI与第28天数据是同研究组水平的同时点证据，不是严格同一动物配对。原文报告的红系“proportion”增加不应直接改写为绝对红系增生。", "pairing_note_en": "Plate XVI and day-28 data provide same-time-point group-level evidence within one study, not a strict same-animal pair. The reported increase in erythroid proportion should not be rewritten as absolute erythroid hyperplasia without supporting cellularity data.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-RAT-CYPERMETHRIN-P16-DAY28" ], "public_image_paths": [ "../images/BM-CC-RAT-CYPERMETHRIN-P16-DAY28.png" ], "public_image_preview_paths": [ "../previews/BM-CC-RAT-CYPERMETHRIN-P16-DAY28.jpg" ], "public_images": [ { "image_id": "BM-CC-RAT-CYPERMETHRIN-P16-DAY28", "title_cn": "氯氰菊酯处理28天：粒系成熟阶段与高度红系比例增加", "title_en": "Cypermethrin day 28: granulocytic maturation stages and markedly increased erythroid proportion", "figure_label": "Plates XI-XVII", "species": "Rat", "evidence_role": "Treatment_associated_response", "asset_path": "../images/BM-CC-RAT-CYPERMETHRIN-P16-DAY28.png", "preview_path": "../previews/BM-CC-RAT-CYPERMETHRIN-P16-DAY28.jpg", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus after subchronic (28 days) treatment showing metamyelocyte (MMC) band stage (B), polymorphonuclear neutrophils (PMN) and highly increased proportion of erythroid cells.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-RAT-CYP-D7", "featured": true, "featured_reason_cn": "大鼠氯氰菊酯第7天：外周中性粒细胞与轻度红系增加", "module_id": "neutrophilia", "source_id": "PMC4427713-RAT-CYPERMETHRIN", "source_title": "Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/", "doi": "10.2478/intox-2014-0006", "pmid": "26038674", "pmcid": "PMC4427713", "source_page": "Plate XIII and Tables 8-10", "species": "Rat", "toxicity_type": "T06", "toxicity_title_cn": "反应性增生、恢复期反跳和高细胞性", "toxicity_title_en": "Reactive hyperplasia, rebound and hypercellularity", "title_cn": "大鼠氯氰菊酯处理7天：外周中性粒细胞增加与骨髓组成改变", "display_title_cn": "大鼠氯氰菊酯第7天：外周中性粒细胞与轻度红系增加", "title_en": "Rat cypermethrin day 7: increased circulating neutrophils with marrow composition change", "factor": "Cypermethrin", "dose": "10.7 mg/kg/day by oral gavage", "timecourse": "Day 7", "evidence_role": "Treatment_associated_pair", "causality_level": "Treatment_associated", "observation_summary_cn": "大鼠氯氰菊酯处理7天：外周中性粒细胞增加与骨髓组成改变", "author_conclusion_summary_cn": "处理相关血液—骨髓配对证据；ANC由原文TLC均值和中性粒细胞百分比透明计算，未对派生ANC另行统计检验。", "author_conclusion_summary_en": "Treatment-associated paired evidence; ANC is transparently derived from reported mean TLC and neutrophil percentage and was not separately tested statistically.", "pairing_note_cn": "Plate XIII和第7天血液学表来自同研究、同处理时点的组水平证据；原文未证明图像与表中数值来自同一只动物。ANC为由组均TLC和中性粒细胞百分比派生，未单独统计检验。", "pairing_note_en": "Plate XIII and day-7 hematology tables provide same-study, same-time-point group-level evidence. The source does not establish that the image and table values came from one animal. ANC is derived from group-mean TLC and neutrophil percentage and was not separately tested.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-RAT-CYPERMETHRIN-P13-DAY7" ], "public_image_paths": [ "../images/BM-CC-RAT-CYPERMETHRIN-P13-DAY7.png" ], "public_image_preview_paths": [ "../previews/BM-CC-RAT-CYPERMETHRIN-P13-DAY7.jpg" ], "public_images": [ { "image_id": "BM-CC-RAT-CYPERMETHRIN-P13-DAY7", "title_cn": "氯氰菊酯处理7天：原作者标注巨幼样细胞及轻度红系增加", "title_en": "Cypermethrin day 7: source-labeled megaloblast and slight erythroid increase", "figure_label": "Plates XI-XVII", "species": "Rat", "evidence_role": "Treatment_associated_response", "asset_path": "../images/BM-CC-RAT-CYPERMETHRIN-P13-DAY7.png", "preview_path": "../previews/BM-CC-RAT-CYPERMETHRIN-P13-DAY7.jpg", "caption_original_en": "Photomicrograph of bone marrow smear of Rattus norvegicus after 7 days of cypermethrin treatment showing megaloblast (MB) and slight increase in cells of erythroid series.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-RAT-GCSF-KINETICS", "featured": true, "featured_reason_cn": "大鼠G-CSF早期动员与骨髓增殖时序", "module_id": "neutrophilia", "source_id": "PMC1880821-RAT-GCSF-KINETICS", "source_title": "Rat G-CSF early mobilization-to-proliferation sequence", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC1880821/", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "NR", "species": "Rat", "toxicity_type": "T06", "toxicity_title_cn": "反应性增生、恢复期反跳和高细胞性", "toxicity_title_en": "Reactive hyperplasia, rebound and hypercellularity", "title_cn": "大鼠G-CSF早期动员—增殖时序", "display_title_cn": "大鼠G-CSF早期动员与骨髓增殖时序", "title_en": "Rat G-CSF early mobilization-to-proliferation sequence", "factor": "GCSF_or_cytokine_driven", "dose": "NR", "timecourse": "0.5-48 hours after IV G-CSF", "evidence_role": "Mechanistic_reference", "causality_level": "Treatment_associated", "observation_summary_cn": "大鼠G-CSF早期动员—增殖时序", "author_conclusion_summary_cn": "说明外周升高和骨髓成熟池变化可方向不同，必须按时相解释。", "author_conclusion_summary_en": "Shows that circulating neutrophilia and the mature marrow pool can change in opposite directions depending on time.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-RAT-NTP-HYPER", "featured": true, "featured_reason_cn": "NTP大鼠骨髓高细胞性组织学模式", "module_id": "neutrophilia", "source_id": "NTP-BONE-MARROW-HYPERCELLULARITY", "source_title": "Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "NR", "species": "Rat", "toxicity_type": "T06", "toxicity_title_cn": "反应性增生、恢复期反跳和高细胞性", "toxicity_title_en": "Reactive hyperplasia, rebound and hypercellularity", "title_cn": "NTP大鼠骨髓高细胞性组织学模式", "display_title_cn": "NTP大鼠骨髓高细胞性组织学模式", "title_en": "NTP rat marrow hypercellularity pattern", "factor": "Sustained_inflammatory_response", "dose": "NR", "timecourse": "NR", "evidence_role": "Teaching_pattern", "causality_level": "Differential_only", "observation_summary_cn": "NTP大鼠骨髓高细胞性组织学模式", "author_conclusion_summary_cn": "教学性模式对应，不声称来自同一动物或同一研究中的CBC—骨髓配对。", "author_conclusion_summary_en": "Teaching correspondence only; not presented as a paired CBC-marrow observation from the same animal or study group.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-HYPER-F01", "BM-NTP-HYPER-F02", "BM-NTP-HYPER-F03", "BM-NTP-HYPER-F04" ], "pathology_evidence_count": 4, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-HYPER-F01", "title_cn": "对照大鼠骨髓细胞量（低倍）", "title_en": "Control rat bone marrow cellularity, low power", "figure_label": "Figure 1", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-HYPER-F02", "title_cn": "处理相关贫血后的红系高细胞性（大鼠，低倍）", "title_en": "Erythroid hypercellularity after treatment-related anemia in rat, low power", "figure_label": "Figure 2", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-HYPER-F03", "title_cn": "对照大鼠骨髓细胞量（高倍）", "title_en": "Control rat bone marrow cellularity, higher magnification", "figure_label": "Figure 3", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-HYPER-F04", "title_cn": "处理相关贫血后的红系高细胞性（大鼠，高倍）", "title_en": "Erythroid hypercellularity after treatment-related anemia in rat, higher magnification", "figure_label": "Figure 4", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC4569586-CASE-RHESUS-RADIATION-RECOVERY", "featured": true, "featured_reason_cn": "恒河猴辐射后骨髓耗竭与entolimod相关恢复", "module_id": "bone-marrow-cases", "source_id": "S2M-PMC4569586", "source_title": "The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4569586/", "doi": "10.1371/journal.pone.0135388", "pmid": "26367124", "pmcid": "PMC4569586", "source_page": "Figure 3, sternum bone marrow row (Vehicle, +16h, +25h, +48h)", "species": "Rhesus_monkey", "toxicity_type": "T06", "toxicity_title_cn": "反应性增生、恢复期反跳和高细胞性", "toxicity_title_en": "Reactive hyperplasia, rebound and hypercellularity", "title_cn": "恒河猴6.5 Gy全身照射后第40天：载体组持续相对低细胞性，与16、25或48小时给予entolimod后的骨髓形态恢复对照。", "display_title_cn": "恒河猴辐射后骨髓耗竭与entolimod相关恢复", "title_en": "Day-40 rhesus macaque marrow after 6.5 Gy total-body irradiation: persistent relative hypocellularity in the vehicle group compared with morphological recovery after entolimod at 16, 25, or 48 hours.", "factor": "Acute total-body irradiation with entolimod radiomitigation", "dose": "6.5 Gy TBI; entolimod 40 µg/kg intramuscularly at 16, 25, or 48 hours", "timecourse": "Representative sternum sections from day-40 survivors", "evidence_role": "Treatment_associated_pair", "causality_level": "Author_attributed", "observation_summary_cn": "恒河猴6.5 Gy全身照射后第40天：载体组持续相对低细胞性，与16、25或48小时给予entolimod后的骨髓形态恢复对照。", "author_conclusion_summary_cn": "原作者报告entolimod组骨髓较照射后载体组显示加速形态恢复，造血细胞更多、簇状排列更致密且脂肪成分较少；部分动物接近正常，部分仍轻至中度低形成。单张代表图不能证明个体完全功能恢复，也不能替代盲法半定量评分和同期血液学。", "author_conclusion_summary_en": "The authors reported accelerated marrow recovery after entolimod, with more numerous, densely clustered hematopoietic cells and less adipose tissue than in irradiated vehicle controls. Some animals remained hypoplastic; representative fields do not prove complete individual recovery or replace blinded scores and hematology.", "pairing_note_cn": "四个panel来自同一研究、同一第40天终点的不同处理组代表性存活动物/视野；原文未证明为同一动物，也不是纵向连续活检。它们属于组水平同研究支持性对照，不能按图片外观直接对三个给药时点排序。", "pairing_note_en": "The four panels are representative day-40 fields from surviving animals in different groups within one study. The source does not establish one animal across panels, and these are not serial biopsies. They provide a same-study, group-level supportive comparison and should not be used to rank the three treatment times by appearance alone.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-CC0-RHESUS-ENTOLIMOD-F03-VEH", "BM-CC0-RHESUS-ENTOLIMOD-F03-16H", "BM-CC0-RHESUS-ENTOLIMOD-F03-25H", "BM-CC0-RHESUS-ENTOLIMOD-F03-48H" ], "pathology_evidence_count": 4, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-CC0-RHESUS-ENTOLIMOD-F03-VEH", "title_cn": "恒河猴全身照射后载体组：第40天骨髓仍相对低细胞性", "title_en": "Rhesus macaque after total-body irradiation: persistent relative marrow hypocellularity in the day-40 vehicle group", "figure_label": "Fig 3. Enhanced morphological recovery of hematopoietic and lymphoid organs in NHPs treated with entolimod post-irradiation", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4569586/", "expert_review_status": "Pending" }, { "image_id": "BM-CC0-RHESUS-ENTOLIMOD-F03-16H", "title_cn": "恒河猴辐射后恢复：16小时给予entolimod的第40天骨髓", "title_en": "Rhesus macaque post-irradiation recovery: day-40 marrow after entolimod at 16 hours", "figure_label": "Fig 3. Enhanced morphological recovery of hematopoietic and lymphoid organs in NHPs treated with entolimod post-irradiation", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4569586/", "expert_review_status": "Pending" }, { "image_id": "BM-CC0-RHESUS-ENTOLIMOD-F03-25H", "title_cn": "恒河猴辐射后恢复：25小时给予entolimod的第40天骨髓", "title_en": "Rhesus macaque post-irradiation recovery: day-40 marrow after entolimod at 25 hours", "figure_label": "Fig 3. Enhanced morphological recovery of hematopoietic and lymphoid organs in NHPs treated with entolimod post-irradiation", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4569586/", "expert_review_status": "Pending" }, { "image_id": "BM-CC0-RHESUS-ENTOLIMOD-F03-48H", "title_cn": "恒河猴辐射后恢复：48小时给予entolimod的第40天骨髓", "title_en": "Rhesus macaque post-irradiation recovery: day-40 marrow after entolimod at 48 hours", "figure_label": "Fig 3. Enhanced morphological recovery of hematopoietic and lymphoid organs in NHPs treated with entolimod post-irradiation", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4569586/", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC11697499-CASE-MDS-MEGAKARYOCYTE-ATYPIA", "featured": true, "featured_reason_cn": "犬MDS鉴别：微巨核细胞与核分离异常", "module_id": "bone-marrow-cases", "source_id": "SUP-PMC11697499", "source_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_page": "Figure 1, panels c-d", "species": "Dog", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "犬MDS巨核系鉴别图组：核分叶异常、低分叶小巨核细胞与含多枚广泛分离核的微巨核细胞。", "display_title_cn": "犬MDS鉴别：微巨核细胞与核分离异常", "title_en": "Canine MDS megakaryocytic differential showing abnormal lobulation, a hypolobulated small megakaryocyte, and a micromegakaryocyte with multiple widely separated nuclei.", "factor": "Spontaneous/clinical canine myelodysplastic syndrome", "dose": "Not applicable", "timecourse": "Diagnostic marrow aspirate; Case 2", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬MDS巨核系鉴别图组：核分叶异常、低分叶小巨核细胞与含多枚广泛分离核的微巨核细胞。", "author_conclusion_summary_cn": "这组图强调巨核细胞的数量、体积、成熟度和核形应分开记录。“多枚广泛分离核”是可见观察，dysplasia是结合病例背景的原作者解释。", "author_conclusion_summary_en": "The set emphasizes separate recording of megakaryocyte quantity, size, maturation, and nuclear form. Multiple widely separated nuclei are the visible observation; dysplasia is the source interpretation in the MDS context.", "pairing_note_cn": "Panels c和d均为Case 2的Wright染色骨髓吸取物代表视野，但原文未给出该形态的分母或发生频率。", "pairing_note_en": "Panels c and d are representative Wright-stained marrow-aspirate fields from Case 2, but the source does not provide a denominator or frequency for these forms.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-MDS-F01-C", "BM-CC-DOG-MDS-F01-D" ], "public_image_paths": [ "../images/BM-CC-DOG-MDS-F01-C.jpg", "../images/BM-CC-DOG-MDS-F01-D.jpg" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-MDS-F01-C.jpg", "../previews/BM-CC-DOG-MDS-F01-D.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-MDS-F01-C", "title_cn": "犬MDS巨核细胞鉴别：核分叶异常与低分叶微小巨核细胞", "title_en": "Canine MDS megakaryocyte differential: abnormal lobulation and a hypolobulated small megakaryocyte", "figure_label": "Figure 1", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-MDS-F01-C.jpg", "preview_path": "../previews/BM-CC-DOG-MDS-F01-C.jpg", "caption_original_en": "Myelodysplastic syndrome, dog. (a) Blood film with dysplastic neutrophils (*) that have unevenly sized nuclear lobes and giant red blood cells (^) reflecting increased red cell distribution width. Case 1. Wright stain (WS). (b) The marrow aspirate is highly cellular and has a predominance of granulocytes. There are approximately 10% blasts (arrowheads). Of total, 15% of segmented neutrophils have dysplastic changes (*), and there are dysplastic band neutrophils (arrows). Case 2. WS. (c) An immature megakaryocyte with abnormal nuclear lobulation (left) and an abnormally small megakaryocyte with mature cytoplasm and a hypolobulated nucleus (right). Case 2. WS. (d) A micromegakaryocyte, ~24 µm in diameter with multiple, widely separated nuclei (arrow). Case 2. WS. (e) The marrow core is hypercellular despite chronic marked anemia, and megakaryocytes are clustered (arrows). Case 3. Hematoxylin and eosin (HE). (f) Higher magnification of (e) illustrating an increased proportion of blasts (arrowheads) in the center of the intertrabecular space; a megakaryocyte with abnormal nuclear lobulation, open chromatin, and nucleoli (arrow); and dysplastic giant band neutrophils (*). Case 3. HE.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" }, { "image_id": "BM-CC-DOG-MDS-F01-D", "title_cn": "犬MDS鉴别：伴多枚广泛分离核的微巨核细胞", "title_en": "Canine MDS differential: micromegakaryocyte with multiple widely separated nuclei", "figure_label": "Figure 1", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-MDS-F01-D.jpg", "preview_path": "../previews/BM-CC-DOG-MDS-F01-D.jpg", "caption_original_en": "Myelodysplastic syndrome, dog. (a) Blood film with dysplastic neutrophils (*) that have unevenly sized nuclear lobes and giant red blood cells (^) reflecting increased red cell distribution width. Case 1. Wright stain (WS). (b) The marrow aspirate is highly cellular and has a predominance of granulocytes. There are approximately 10% blasts (arrowheads). Of total, 15% of segmented neutrophils have dysplastic changes (*), and there are dysplastic band neutrophils (arrows). Case 2. WS. (c) An immature megakaryocyte with abnormal nuclear lobulation (left) and an abnormally small megakaryocyte with mature cytoplasm and a hypolobulated nucleus (right). Case 2. WS. (d) A micromegakaryocyte, ~24 µm in diameter with multiple, widely separated nuclei (arrow). Case 2. WS. (e) The marrow core is hypercellular despite chronic marked anemia, and megakaryocytes are clustered (arrows). Case 3. Hematoxylin and eosin (HE). (f) Higher magnification of (e) illustrating an increased proportion of blasts (arrowheads) in the center of the intertrabecular space; a megakaryocyte with abnormal nuclear lobulation, open chromatin, and nucleoli (arrow); and dysplastic giant band neutrophils (*). Case 3. HE.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC4261574-CASE-MEGAKARYOCYTE-ATYPIA", "featured": true, "featured_reason_cn": "犬疾病鉴别：巨核细胞多个表观分离核与胞穿入", "module_id": "bone-marrow-cases", "source_id": "S2M-PMC4261574", "source_title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "doi": "10.1186/s13071-014-0534-2", "pmid": "25441458", "pmcid": "PMC4261574", "source_page": "Figure 5, panels A-B", "species": "Dog", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "犬巨核细胞异常图组：具有四个表观分离核的巨核系前体，以及核形异常伴胞穿入的巨核细胞。", "display_title_cn": "犬疾病鉴别：巨核细胞多个表观分离核与胞穿入", "title_en": "Canine megakaryocytic-abnormality set showing a precursor with four apparently separate nuclei and a megakaryocyte with abnormal nuclear shape and emperipolesis.", "factor": "Naturally acquired canine vector-borne disease; exact pathogen for the figure not stated", "dose": "Not applicable", "timecourse": "Diagnostic marrow examination; exact time point NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬巨核细胞异常图组：具有四个表观分离核的巨核系前体，以及核形异常伴胞穿入的巨核细胞。", "author_conclusion_summary_cn": "原作者将该组图解释为megakaryocytic dysplasia。网站先记录多个表观分离核、核形异常和胞穿入，再保留作者解释；不把观察性核形自动等同于药物性发育异常。", "author_conclusion_summary_en": "The authors interpret the set as megakaryocytic dysplasia. The atlas first records the observations—apparently separate nuclei, abnormal nuclear shape, and emperipolesis—and then preserves the author interpretation; an observed nuclear form is not automatically drug-related dysplasia.", "pairing_note_cn": "Panels A和B来自同一复合Figure，分别展示不同巨核系细胞；图注未确认来自同一动物。", "pairing_note_en": "Panels A and B are from one composite figure and show different megakaryocytic cells; the legend does not confirm that they are from one animal.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-CVBD-F05-A", "BM-CC-DOG-CVBD-F05-B" ], "public_image_paths": [ "../images/BM-CC-DOG-CVBD-F05-A.png", "../images/BM-CC-DOG-CVBD-F05-B.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-CVBD-F05-A.jpg", "../previews/BM-CC-DOG-CVBD-F05-B.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-CVBD-F05-A", "title_cn": "犬巨核细胞核异常鉴别：四个表观分离核的巨核系前体", "title_en": "Canine megakaryocytic nuclear abnormality: precursor with four apparently separate nuclei", "figure_label": "Figure 5", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-CVBD-F05-A.png", "preview_path": "../previews/BM-CC-DOG-CVBD-F05-A.jpg", "caption_original_en": "Megakaryocytic dysplasia. A. Megakaryocytic precursor with four divided nuclei. B. A megakaryocyte presenting morphologic abnormalities in nucleus shape and emperipolesis (arrow). Bone marrow. Quick Stain, 100×.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" }, { "image_id": "BM-CC-DOG-CVBD-F05-B", "title_cn": "犬巨核细胞异常鉴别：核形异常伴胞穿入", "title_en": "Canine megakaryocytic abnormality: abnormal nuclear shape with emperipolesis", "figure_label": "Figure 5", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-CVBD-F05-B.png", "preview_path": "../previews/BM-CC-DOG-CVBD-F05-B.jpg", "caption_original_en": "Megakaryocytic dysplasia. A. Megakaryocytic precursor with four divided nuclei. B. A megakaryocyte presenting morphologic abnormalities in nucleus shape and emperipolesis (arrow). Bone marrow. Quick Stain, 100×.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-007", "featured": true, "featured_reason_cn": "卡铂后巨核细胞减少：组织学与血小板时序对照", "module_id": "lineage", "source_id": "LEGACY-RPBM-001", "source_title": "Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9181531/", "doi": "10.3390/ijms23116290", "pmid": "35682967", "pmcid": "PMC9181531", "source_page": "NR", "species": "Rat", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "大鼠骨髓H&E切片对照：卡铂35 mg/kg处理后第6天，与对照相比黄色箭头所示巨核细胞减少。", "display_title_cn": "卡铂后巨核细胞减少：组织学与血小板时序对照", "title_en": "Rat: Megakaryocyte injury, decrease and platelet toxicity associated with Carboplatin", "factor": "Carboplatin", "dose": "35 mg/kg intraperitoneal", "timecourse": "Day 6", "evidence_role": "Toxicity_image", "causality_level": "Author_attributed", "observation_summary_cn": "大鼠骨髓H&E切片对照：卡铂35 mg/kg处理后第6天，与对照相比黄色箭头所示巨核细胞减少。", "author_conclusion_summary_cn": "原作者报告卡铂处理后第6天血小板和骨髓巨核细胞减少。", "author_conclusion_summary_en": "The authors reported reduced platelet counts and marrow megakaryocytes on day 6 after carboplatin treatment.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BMAT-0001-MORPH-B" ], "pathology_evidence_count": 1, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BMAT-0001-MORPH-B", "title_cn": "卡铂处理后大鼠骨髓巨核细胞减少", "title_en": "Reduced rat marrow megakaryocytes after carboplatin", "figure_label": "Figure 1B", "specimen_type": "Bone_marrow_histology_section", "source_url": "https://www.mdpi.com/1422-0067/23/11/6290", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-008", "featured": true, "featured_reason_cn": "卡铂后巨核细胞减少：骨髓洗出细胞学", "module_id": "lineage", "source_id": "LEGACY-RPBM-001", "source_title": "Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9181531/", "doi": "10.3390/ijms23116290", "pmid": "35682967", "pmcid": "PMC9181531", "source_page": "NR", "species": "Rat", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "大鼠骨髓洗脱物Liu染色对照：35 mg/kg卡铂处理后第6天巨核细胞减少，图中保留箭头和比例尺。", "display_title_cn": "卡铂后巨核细胞减少：骨髓洗出细胞学", "title_en": "Rat: Megakaryocyte injury, decrease and platelet toxicity associated with Carboplatin", "factor": "Carboplatin", "dose": "35 mg/kg intraperitoneal", "timecourse": "Day 6", "evidence_role": "Toxicity_image", "causality_level": "Author_attributed", "observation_summary_cn": "大鼠骨髓洗脱物Liu染色对照：35 mg/kg卡铂处理后第6天巨核细胞减少，图中保留箭头和比例尺。", "author_conclusion_summary_cn": "骨髓洗出细胞学支持卡铂处理后巨核细胞减少。", "author_conclusion_summary_en": "Bone marrow washout cytology supported a reduction in megakaryocytes after carboplatin treatment.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BMAT-0002-MORPH-A" ], "public_image_paths": [ "../images/BMAT-0002-MORPH-A.jpg" ], "public_image_preview_paths": [ "../previews/BMAT-0002-MORPH-A.jpg" ], "public_images": [ { "image_id": "BMAT-0002-MORPH-A", "title_cn": "卡铂处理后大鼠骨髓冲洗物巨核细胞减少", "title_en": "Reduced megakaryocytes in rat marrow washout after carboplatin", "figure_label": "Figure 2A", "species": "Rat", "evidence_role": "Toxicity_image", "asset_path": "../images/BMAT-0002-MORPH-A.jpg", "preview_path": "../previews/BMAT-0002-MORPH-A.jpg", "caption_original_en": "Number of megakaryocytes decreased after carboplatin treatment in vivo. Bone marrow washout from control and 35 mg/kg carboplatin-treated rat at the sixth day were used for the analysis. ( A ) After fixation and Liu’s staining, the megakaryocyte number was determined by counting. Scale bar = 120 μm. ( B ) Experiment was carried out in three different rats and result was statistically significant. ( C ) The CD61+ cells in the bone marrow washout were analyzed by flow cytometry. ( D ) A representative image from the flow cytometry was shown. Cells in the green square with the increased green fluorescence by the binding with FITC-conjugated annexin V were characterized as early apoptotic cells. On the other hand, cells in the red square with the increase of green fluorescence by the binding with FITC-conjugated annexin V and also the increase of red fluorescence from the PI inside the cytosol were characterized as late apoptotic cells. ( E ) Percentage of the early and late apoptotic cells in bone marrow washout was analyzed based on the results of flow cytometry. (* p -value < 0.05, ** p -value < 0.01, three independent experiments were performed).", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-009", "featured": true, "featured_reason_cn": "卡铂后巨核细胞JAK2信号下降", "module_id": "lineage", "source_id": "LEGACY-RPBM-001", "source_title": "Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9181531/", "doi": "10.3390/ijms23116290", "pmid": "35682967", "pmcid": "PMC9181531", "source_page": "NR", "species": "Rat", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "大鼠骨髓切片免疫荧光：卡铂处理后第6天，黄色箭头所示巨核细胞JAK2红色信号降低。", "display_title_cn": "卡铂后巨核细胞JAK2信号下降", "title_en": "Rat: Megakaryocyte injury, decrease and platelet toxicity associated with Carboplatin", "factor": "Carboplatin", "dose": "35 mg/kg intraperitoneal", "timecourse": "Day 6", "evidence_role": "Mechanistic_reference", "causality_level": "Author_attributed", "observation_summary_cn": "大鼠骨髓切片免疫荧光：卡铂处理后第6天，黄色箭头所示巨核细胞JAK2红色信号降低。", "author_conclusion_summary_cn": "原作者将巨核细胞JAK2信号下降与卡铂相关血小板减少联系起来。", "author_conclusion_summary_en": "The authors associated reduced megakaryocytic JAK2 signal with carboplatin-related thrombocytopenia.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BMAT-0003-MORPH-D" ], "pathology_evidence_count": 1, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BMAT-0003-MORPH-D", "title_cn": "卡铂处理后大鼠骨髓巨核细胞JAK2信号降低", "title_en": "Reduced JAK2 signal in rat marrow megakaryocytes after carboplatin", "figure_label": "Figure 5D", "specimen_type": "Bone_marrow_section_immunofluorescence", "source_url": "https://www.mdpi.com/1422-0067/23/11/6290", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC4261574-CASE-ERYTHROPHAGOCYTOSIS", "featured": true, "featured_reason_cn": "犬疾病鉴别：红系前体、血小板和细胞碎片吞噬", "module_id": "bone-marrow-cases", "source_id": "S2M-PMC4261574", "source_title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "doi": "10.1186/s13071-014-0534-2", "pmid": "25441458", "pmcid": "PMC4261574", "source_page": "Figure 4, panels A-B", "species": "Dog", "toxicity_type": "T08", "toxicity_title_cn": "嗜血、红细胞吞噬和巨噬细胞改变", "toxicity_title_en": "Hemophagocytosis, erythrophagocytosis and macrophage change", "title_cn": "犬骨髓吞噬性改变图组：巨噬细胞内含红系前体、血小板及细胞碎片。", "display_title_cn": "犬疾病鉴别：红系前体、血小板和细胞碎片吞噬", "title_en": "Canine marrow phagocytic-change set showing macrophages containing erythroid precursors, platelets, and cellular debris.", "factor": "Naturally acquired canine vector-borne disease; exact pathogen for the figure not stated", "dose": "Not applicable", "timecourse": "Diagnostic marrow examination; exact time point NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬骨髓吞噬性改变图组：巨噬细胞内含红系前体、血小板及细胞碎片。", "author_conclusion_summary_cn": "图注明确指出红系前体、血小板和细胞碎片被吞噬。报告时应逐项描述对象，避免仅凭该图扩大为广义嗜血细胞现象或毒性机制。", "author_conclusion_summary_en": "The legend explicitly identifies phagocytosed erythroid precursors, platelets, and cellular debris. Reporting should name the ingested components and avoid broadening the image alone to generalized hemophagocytosis or a toxic mechanism.", "pairing_note_cn": "Panel A显示单个巨噬细胞，Panel B显示两个具有相同特征的巨噬细胞；两图支持现象复现，但不提供全片发生率。", "pairing_note_en": "Panel A shows one macrophage and panel B shows two macrophages with the same features. Together they support repeat observation but do not provide whole-smear frequency.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-CVBD-F04-A", "BM-CC-DOG-CVBD-F04-B" ], "public_image_paths": [ "../images/BM-CC-DOG-CVBD-F04-A.png", "../images/BM-CC-DOG-CVBD-F04-B.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-CVBD-F04-A.jpg", "../previews/BM-CC-DOG-CVBD-F04-B.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-CVBD-F04-A", "title_cn": "犬骨髓吞噬性改变：红系前体、血小板与细胞碎片被吞噬", "title_en": "Canine marrow phagocytic change: erythroid precursors, platelets, and cellular debris", "figure_label": "Figure 4", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-CVBD-F04-A.png", "preview_path": "../previews/BM-CC-DOG-CVBD-F04-A.jpg", "caption_original_en": "Platelets and erythrophagocytosis. A. A macrophage phagocyting erythroid precursors (red arrow), platelets (black arrow) and cellular debris. B. Two macrophages with the same features described in A. Bone marrow. Quick Stain, 100×.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" }, { "image_id": "BM-CC-DOG-CVBD-F04-B", "title_cn": "犬骨髓吞噬性改变：两个具有复合吞噬表现的巨噬细胞", "title_en": "Canine marrow phagocytic change: two macrophages with composite phagocytic features", "figure_label": "Figure 4", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-CVBD-F04-B.png", "preview_path": "../previews/BM-CC-DOG-CVBD-F04-B.jpg", "caption_original_en": "Platelets and erythrophagocytosis. A. A macrophage phagocyting erythroid precursors (red arrow), platelets (black arrow) and cellular debris. B. Two macrophages with the same features described in A. Bone marrow. Quick Stain, 100×.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-020", "featured": true, "featured_reason_cn": "犬先天性红系发育异常：红系前体吞噬与晚幼红细胞增加", "module_id": "lineage", "source_id": "PMC9407898", "source_title": "An EHPB1L1 Nonsense Mutation Associated with Congenital Dyserythropoietic Anemia and Polymyopathy in Labrador Retriever Littermates", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9407898/", "doi": "10.3390/genes13081427", "pmid": "36011338", "pmcid": "PMC9407898", "source_page": "Figure 1, panel D", "species": "Dog", "toxicity_type": "T08", "toxicity_title_cn": "嗜血、红细胞吞噬和巨噬细胞改变", "toxicity_title_en": "Hemophagocytosis, erythrophagocytosis and macrophage change", "title_cn": "骨髓可见红系前体吞噬现象并伴晚幼红细胞增加。", "display_title_cn": "犬先天性红系发育异常：红系前体吞噬与晚幼红细胞增加", "title_en": "Bone marrow rubriphagocytosis with increased metarubricytes.", "factor": "Disease_differential", "dose": "NR", "timecourse": "NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "骨髓可见红系前体吞噬现象并伴晚幼红细胞增加。", "author_conclusion_summary_cn": "疾病相关形态，作为毒性评价鉴别参考，不等同于处理相关毒性。", "author_conclusion_summary_en": "Disease-associated morphology; differential reference rather than treatment toxicity.", "pairing_note_cn": "Panel D为红系前体吞噬和晚幼红细胞增加的代表视野；不能由单个视野推断群体发生率或嗜血细胞综合征。", "pairing_note_en": "Panel D is a representative field of rubriphagocytosis and increased metarubricytes. One field cannot establish population frequency or a hemophagocytic syndrome.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-EHBP1L1-F01-D" ], "public_image_paths": [ "../images/BM-CC-DOG-EHBP1L1-F01-D.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-EHBP1L1-F01-D.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-EHBP1L1-F01-D", "title_cn": "犬先天性红系发育异常：红系前体吞噬与晚幼红细胞增加", "title_en": "Canine congenital dyserythropoiesis: rubriphagocytosis and increased metarubricytes", "figure_label": "Figure 1", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-EHBP1L1-F01-D.png", "preview_path": "../previews/BM-CC-DOG-EHBP1L1-F01-D.jpg", "caption_original_en": "Review of histopathological changes in red blood cells, bone marrow and muscle in Labrador Retrievers with an EHBP1L1 variant. (A) Review of Wrights Giemsa stained peripheral blood from an affected Labrador Retriever demonstrating poikilocytosis and a metarubricyte (arrow). (B) Review of Wrights Giemsa stained bone marrow cytology demonstrating cytoplasmic bridging (arrow). (C) Review of Wrights Giemsa stained bone marrow cytology demonstrating an atypical mitotic figure (arrow). (D) Review of Wrights Giemsa stained bone marrow cytology demonstrating rubriphagocytosis (arrow) and increased proportion of metarubricytes. (E) Review of the biceps femoris muscle biopsy from one dog showing myofiber size variation, pale, floccular sarcoplasmic inclusions (arrows) and endomysial fibrosis. (F) In severely affected biceps femoris muscle biopsies, endomysial fibrosis (asterisk) and numerous pale, floccular sarcoplasmic inclusions are present. H&E. Bar=10 µm for A-D and 50 µm for E-F.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-026", "featured": true, "featured_reason_cn": "犬红系发育异常鉴别：晚幼红细胞吞噬", "module_id": "lineage", "source_id": "PMC8478025", "source_title": "Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8478025/", "doi": "10.1111/jvim.16214", "pmid": "34227150", "pmcid": "PMC8478025", "source_page": "Figure 2, panel F", "species": "Dog", "toxicity_type": "T08", "toxicity_title_cn": "嗜血、红细胞吞噬和巨噬细胞改变", "toxicity_title_en": "Hemophagocytosis, erythrophagocytosis and macrophage change", "title_cn": "巨噬细胞吞噬晚幼红细胞。", "display_title_cn": "犬红系发育异常鉴别：晚幼红细胞吞噬", "title_en": "Macrophage phagocytosis of a metarubricyte.", "factor": "Suspected congenital dyserythropoiesis", "dose": "Not applicable", "timecourse": "Diagnostic marrow aspirate from case 1", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "巨噬细胞吞噬晚幼红细胞。", "author_conclusion_summary_cn": "原作者描述为巨噬细胞吞噬晚幼红细胞。这一观察可称为红细胞吞噬或rubriphagocytosis，不自动等同于广义嗜血细胞现象。", "author_conclusion_summary_en": "The authors describe macrophage phagocytosis of a metarubricyte. This supports erythrophagocytosis or rubriphagocytosis and is not automatically equivalent to generalized hemophagocytosis.", "pairing_note_cn": "Figure 2 A–F均来自同一病例的骨髓细胞学复合图；各panel为单个代表视野，不能由此推断该形态的发生频率。", "pairing_note_en": "Figure 2 panels A-F are from one composite marrow-cytology figure from the same case. Each is a representative field and does not establish the frequency of the finding.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-DYSERYTHRO-F02-F" ], "public_image_paths": [ "../images/BM-CC-DOG-DYSERYTHRO-F02-F.png" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-DYSERYTHRO-F02-F.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-DYSERYTHRO-F02-F", "title_cn": "犬骨髓吞噬性改变鉴别：巨噬细胞吞噬晚幼红细胞", "title_en": "Canine marrow phagocytic differential: macrophage phagocytosis of a metarubricyte", "figure_label": "Figure 2", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-DYSERYTHRO-F02-F.png", "preview_path": "../previews/BM-CC-DOG-DYSERYTHRO-F02-F.jpg", "caption_original_en": "Representative cytologic bone marrow images of case 1 illustrating dysplastic changes and erythrophagocytosis. Wright‐Giemsa, ×100 objective. A, Atypical mitotic figure; B, cytoplasmic vacuolation of metarubricytes. Note the contrast of vacuolation (left metarubricyte) compared to water artifact (adjacent right metarubricyte), C, binucleated erythroid precursor; D, nuclear blebbing within a metarubricyte; E, cytoplasmic bridging of rubricytes; F, macrophage displaying metarubricyte phagocytosis.", "reuse_status": "cc_noncommercial_only", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-CASE-PMC10699128", "featured": true, "featured_reason_cn": "恒河猴感染相关骨髓耗竭与巨噬细胞改变", "module_id": "toxicity_atlas", "source_id": "PMC10699128-RHESUS-EBOV-CELLULARITY", "source_title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "source_page": "Figure 2, panels A-F", "species": "Rhesus_monkey", "toxicity_type": "T08", "toxicity_title_cn": "嗜血、红细胞吞噬和巨噬细胞改变", "toxicity_title_en": "Hemophagocytosis, erythrophagocytosis and macrophage change", "title_cn": "埃博拉病毒病伴进行性骨髓耗竭、谱系改变、巨噬细胞增多和伸入运动。", "display_title_cn": "恒河猴感染相关骨髓耗竭与巨噬细胞改变", "title_en": "Ebolavirus disease was associated with progressive marrow depletion, lineage changes, macrophage expansion and emperipolesis.", "factor": "Ebolavirus infection", "dose": "Not applicable", "timecourse": "Representative marrow observations at 5, 6, and 8 days post exposure", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "埃博拉病毒病伴进行性骨髓耗竭、谱系改变、巨噬细胞增多和伸入运动。", "author_conclusion_summary_cn": "原作者在EBOV感染恒河猴骨髓巨核细胞中检出病毒抗原、基因组RNA和超微结构病毒颗粒，并记录伴细胞伸入现象的巨核细胞。该证据用于感染性疾病鉴别与机制学习，不作为药物性骨髓毒性归因。", "author_conclusion_summary_en": "The authors detected viral antigen, genomic RNA, and ultrastructural viral particles in marrow megakaryocytes from EBOV-infected rhesus macaques and documented a megakaryocyte with emperipolesis. This evidence is used as an infectious-disease differential and mechanistic reference, not as drug-toxicity attribution.", "pairing_note_cn": "完整Figure 2汇集5、6和8天的不同代表性动物/视野及IHC、原位杂交、共聚焦和电镜方法；它是同研究多方法证据组，不是同一动物同一时间点配对。", "pairing_note_en": "Complete Figure 2 combines representative 5-, 6-, and 8-day observations and multiple methods (IHC, in situ hybridization, confocal microscopy, and TEM). It is a same-study multimethod evidence set, not a same-animal/same-time-point pair.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-CC-RHESUS-EBOV-F01", "BM-CC-RHESUS-EBOV-F02" ], "pathology_evidence_count": 2, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-CC-RHESUS-EBOV-F01", "title_cn": "恒河猴EBOV疾病鉴别：骨髓感染细胞与CD68阳性单核/巨噬细胞", "title_en": "Rhesus macaque EBOV disease differential: infected marrow cells and CD68-positive monocytes/macrophages", "figure_label": "Figure 1", "specimen_type": "Bone_marrow_multimodal_microscopy", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-RHESUS-EBOV-F02", "title_cn": "恒河猴EBOV疾病鉴别：巨核细胞病毒抗原、核酸与超微结构证据", "title_en": "Rhesus macaque EBOV disease differential: viral antigen, RNA, and ultrastructural evidence in megakaryocytes", "figure_label": "Figure 2", "specimen_type": "Bone_marrow_multimodal_microscopy", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "AUTH-CASE-PMC7040758", "featured": true, "featured_reason_cn": "小鼠骨髓细胞内外铁沉积", "module_id": "toxicity_library", "source_id": "AUTH-PMC7040758", "source_title": "Effect of cyclophosphamide on hematopoietic stem cells in mice with iron overload", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7040758/", "doi": "10.12122/j.issn.1673-4254.2020.01.18", "pmid": "32376555", "pmcid": "PMC7040758", "source_page": "NR", "species": "Mouse", "toxicity_type": "T09", "toxicity_title_cn": "色素、含铁血黄素及异物蓄积", "toxicity_title_en": "Pigment, hemosiderin and foreign material accumulation", "title_cn": "权威候选来源记录：Extracellular and intracellular marrow iron deposition。具体图像与处理相关性仍需逐图专家复核。", "display_title_cn": "小鼠骨髓细胞内外铁沉积", "title_en": "Extracellular and intracellular marrow iron deposition", "factor": "Pigment/iron accumulation comparator", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "权威候选来源记录：Extracellular and intracellular marrow iron deposition。具体图像与处理相关性仍需逐图专家复核。", "author_conclusion_summary_cn": "NR", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "NTP-CASE-MOUSE-MARROW-PIGMENT", "featured": true, "featured_reason_cn": "小鼠骨髓金棕色色素：未确认含铁血黄素的程度示例", "module_id": "bone-marrow-cases", "source_id": "NTP-BONE-MARROW-PIGMENT", "source_title": "Bone marrow - Pigment - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Pigment", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "Figures 1-2", "species": "Mouse", "toxicity_type": "T09", "toxicity_title_cn": "色素、含铁血黄素及异物蓄积", "toxicity_title_en": "Pigment, hemosiderin and foreign material accumulation", "title_cn": "雄性B6C3F1小鼠骨髓金棕色色素的少量和中等量教学示例。", "display_title_cn": "小鼠骨髓金棕色色素：未确认含铁血黄素的程度示例", "title_en": "Teaching examples of low and moderate amounts of golden-brown pigment in male B6C3F1 mouse marrow.", "factor": "NR", "dose": "NR", "timecourse": "Subchronic and chronic studies", "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "observation_summary_cn": "雄性B6C3F1小鼠骨髓金棕色色素的少量和中等量教学示例。", "author_conclusion_summary_cn": "在Prussian blue等铁染色确认前，推荐诊断为pigment而非hemosiderin；程度评价应与同部位同期对照比较。", "author_conclusion_summary_en": "Before confirmation with an iron stain such as Prussian blue, the preferred diagnosis is pigment rather than hemosiderin; severity should be assessed against concurrent controls at the same site.", "pairing_note_cn": "Figure 1来自亚慢性研究，Figure 2来自慢性研究；仅用于少量与中等量的教学比较，不是同一研究、同一动物或时间序列。", "pairing_note_en": "Figure 1 is from a subchronic study and Figure 2 from a chronic study. They provide a low-versus-moderate teaching comparison, not a same-study, same-animal, or longitudinal pair.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-PIGMENT-F01", "BM-NTP-PIGMENT-F02" ], "pathology_evidence_count": 2, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-PIGMENT-F01", "title_cn": "小鼠骨髓少量金棕色色素", "title_en": "Low amount of golden-brown pigment in mouse bone marrow", "figure_label": "Figure 1", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Pigment", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-PIGMENT-F02", "title_cn": "小鼠骨髓中等量金棕色色素", "title_en": "Moderate amount of golden-brown pigment in mouse bone marrow", "figure_label": "Figure 2", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Pigment", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-CASE-PMC10754359", "featured": true, "featured_reason_cn": "恒河猴辐射后色素和铁沉积", "module_id": "toxicity_atlas", "source_id": "PMC10754359-RHESUS-RADIATION-IRON", "source_title": "Iron Deposition in the Bone Marrow and Spleen of Nonhuman Primates with Acute Radiation Syndrome", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10754359/", "doi": "10.1667/RADE-23-00107.1", "pmid": "37967581", "pmcid": "PMC10754359", "source_page": "Figure 1, panels A-F; Results paragraphs 10-12 and Discussion", "species": "Rhesus_monkey", "toxicity_type": "T09", "toxicity_title_cn": "色素、含铁血黄素及异物蓄积", "toxicity_title_en": "Pigment, hemosiderin and foreign material accumulation", "title_cn": "恒河猴急性辐射综合征：骨髓细胞量丢失、恢复时序及棕色色素/铁相关改变。", "display_title_cn": "恒河猴辐射后色素和铁沉积", "title_en": "Rhesus acute radiation syndrome showed time-dependent marrow cell loss, recovery, and brown-pigment/iron-associated changes.", "factor": "Total-body cobalt-60 gamma irradiation", "dose": "Sham; 4.0; 5.8-8.5; or 12.0 Gy in Figure 1", "timecourse": "Day 4-7, 13-60, or day 30, depending on dose/group", "evidence_role": "Toxicity_image", "causality_level": "Treatment_associated", "observation_summary_cn": "恒河猴急性辐射综合征：骨髓细胞量丢失、恢复时序及棕色色素/铁相关改变。", "author_conclusion_summary_cn": "Figure 1同时展示胸骨骨髓H&E细胞量和普鲁士蓝/核固红染色。原作者报告6.0-8.5 Gy后第13-15天显著至重度细胞再生障碍并丢失全部前体谱系，第20天出现早期再生，第30天存活动物有轻至中度造血细胞增殖；12 Gy后第4-7天几乎完全丧失正常细胞量。骨髓棕色色素在辐射后有增加趋势，但组间差异未达统计学显著，且作者提出部分色素可能为不含铁的血红素衍生物，不能把所有棕色色素自动标为含铁血黄素。", "author_conclusion_summary_en": "The authors reported marked-to-severe aplasia at days 13-15 after 6.0-8.5 Gy, early regeneration by day 20, proliferation in day-30 survivors, and near-complete cell loss at days 4-7 after 12 Gy. Marrow brown pigment only trended upward and may include iron-free pigment; it should not all be labeled hemosiderin.", "pairing_note_cn": "Figure 1A为假照射，B为4 Gy第30天，C汇集5.8-8.5 Gy第13-60天，D为12 Gy第4-7天；E-F为组水平定量图。各代表图来自不同动物、剂量和终末时间点，不是同一动物连续活检。C/D内部还覆盖多个剂量/时间，不能仅按画面顺序推定单调剂量反应或精确恢复轨迹。", "pairing_note_en": "Figure 1A is sham, B is 4 Gy/day 30, C spans 5.8-8.5 Gy/days 13-60, D is 12 Gy/days 4-7, and E-F are group-level quantification. Images are different animals, doses, and terminal time points, not serial biopsies. Panel order cannot establish a monotonic dose response or exact recovery path.", "rights_note_cn": "文章未提供可覆盖完整Figure 1的明确Creative Commons或Figure级再利用许可。虽有部分作者为美国政府雇员，但不能据此把多作者完成的整张Figure自动认定为公有领域；因此只发布案例卡和来源链接。", "rights_note_en": "No explicit Creative Commons or figure-level license covering complete Figure 1 was identified. Some authors' U.S.-Government status does not establish public-domain status for a multi-author figure, so only the case card and source link are published.", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "NTP-CASE-MOUSE-MARROW-ANGIECTASIS", "featured": true, "featured_reason_cn": "小鼠骨髓血管扩张：两组低倍与高倍识别", "module_id": "bone-marrow-cases", "source_id": "NTP-BONE-MARROW-ANGIECTASIS", "source_title": "Bone marrow - Angiectasis - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "Figures 1-4", "species": "Mouse", "toxicity_type": "T10", "toxicity_title_cn": "血管扩张、缺血和骨髓微环境损伤", "toxicity_title_en": "Angiectasis, ischemia and marrow vascular injury", "title_cn": "慢性研究雌性B6C3F1小鼠骨髓窦血管扩张教学图组，展示两组低倍与高倍视野。", "display_title_cn": "小鼠骨髓血管扩张：两组低倍与高倍识别", "title_en": "Teaching set of marrow sinus angiectasis in female B6C3F1 mice, shown as two low- and higher-magnification groups.", "factor": "NR", "dose": "NR", "timecourse": "Chronic studies", "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "observation_summary_cn": "慢性研究雌性B6C3F1小鼠骨髓窦血管扩张教学图组，展示两组低倍与高倍视野。", "author_conclusion_summary_cn": "完整内皮衬里有助于将血管扩张与出血鉴别；形成边界清楚肿块时应考虑血管瘤。图片本身不能确定病因或处理相关性。", "author_conclusion_summary_en": "An intact endothelial lining helps distinguish angiectasis from hemorrhage; a well-demarcated mass raises hemangioma as a differential. The images alone do not establish cause or treatment relationship.", "pairing_note_cn": "Figures 1-2构成第一组低/高倍视图，Figures 3-4构成第二组低/高倍视图；两组为教学对应，不是同一动物的连续时序。", "pairing_note_en": "Figures 1-2 form the first low/high-power pair and Figures 3-4 form the second. The pairs are teaching correspondences, not a longitudinal series from one animal.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-ANGIECTASIS-F01", "BM-NTP-ANGIECTASIS-F02", "BM-NTP-ANGIECTASIS-F03", "BM-NTP-ANGIECTASIS-F04" ], "pathology_evidence_count": 4, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-ANGIECTASIS-F01", "title_cn": "小鼠骨髓血管扩张（第一组，低倍）", "title_en": "Bone marrow angiectasis in mouse, first low-power example", "figure_label": "Figure 1", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-ANGIECTASIS-F02", "title_cn": "小鼠骨髓血管扩张（第一组，高倍）", "title_en": "Bone marrow angiectasis in mouse, first higher-power example", "figure_label": "Figure 2", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-ANGIECTASIS-F03", "title_cn": "小鼠骨髓血管扩张（第二组，低倍）", "title_en": "Bone marrow angiectasis in mouse, second low-power example", "figure_label": "Figure 3", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-ANGIECTASIS-F04", "title_cn": "小鼠骨髓血管扩张（第二组，高倍）", "title_en": "Bone marrow angiectasis in mouse, second higher-power example", "figure_label": "Figure 4", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "AUTH-CASE-PMC3320159", "featured": true, "featured_reason_cn": "食蟹猴自发性和背景性造血淋巴组织变化", "module_id": "toxicity_library", "source_id": "AUTH-PMC3320159", "source_title": "Histopathology of Incidental Findings in Cynomolgus Monkeys (Macaca Fascicularis) Used in Toxicity Studies", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3320159/", "doi": "10.1293/tox.25.63", "pmid": "22481861", "pmcid": "PMC3320159", "source_page": "NR", "species": "Cynomolgus_monkey", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "权威候选来源记录：Spontaneous/background histopathology。具体图像与处理相关性仍需逐图专家复核。", "display_title_cn": "食蟹猴自发性和背景性造血淋巴组织变化", "title_en": "Spontaneous/background histopathology", "factor": "Background comparator", "dose": "NR", "timecourse": "NR", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "权威候选来源记录：Spontaneous/background histopathology。具体图像与处理相关性仍需逐图专家复核。", "author_conclusion_summary_cn": "NR", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "AUTH-CASE-PMC8544165", "featured": true, "featured_reason_cn": "INHAND食蟹猴骨髓：背景、反应性与感染性鉴别组图", "module_id": "toxicity_library", "source_id": "AUTH-PMC8544165", "source_title": "International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis)", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "doi": "10.1293/tox.34.1S", "pmid": "34712008", "pmcid": "PMC8544165", "source_page": "Figures 15, 16, 74, 75, 79, and 80", "species": "Cynomolgus_monkey", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "INHAND食蟹猴骨髓组图同时展示猴细小病毒包涵体、淋巴滤泡、淋巴聚集和巨核细胞胞穿入。", "display_title_cn": "INHAND食蟹猴骨髓：背景、反应性与感染性鉴别组图", "title_en": "INHAND cynomolgus marrow set covering simian-parvovirus inclusions, lymphoid follicles, a lymphoid aggregate, and megakaryocytic emperipolesis.", "factor": "INHAND nomenclature and diagnostic-criteria reference", "dose": "Not applicable", "timecourse": "Background, reactive, and infectious-disease reference; exact study time points NR", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "INHAND食蟹猴骨髓组图同时展示猴细小病毒包涵体、淋巴滤泡、淋巴聚集和巨核细胞胞穿入。", "author_conclusion_summary_cn": "该组图将感染性鉴别、免疫反应性改变和可见于背景骨髓的形态放在同一学习框架中。胞穿入不等于吞噬；背景发现是否超出正常变异必须结合同期对照和发生率，不得自动写成试验物相关毒性。", "author_conclusion_summary_en": "The set places infectious differentials, immune-reactive changes, and morphologies that may occur in background marrow into one learning framework. Emperipolesis is not phagocytosis, and any increase beyond normal variation requires concurrent controls and incidence data rather than automatic attribution to a test article.", "pairing_note_cn": "6张图来自同一INHAND出版物的不同代表性案例，不是同一动物、同一试验或同一时点的配对证据。", "pairing_note_en": "The six figures are separate representative examples from one INHAND publication, not matched observations from one animal, one study, or one time point.", "rights_note_cn": "文章为CC BY-NC-ND 4.0；网站仅分发字节完全一致的完整Figure，未裁剪、缩放、重采样或加注。", "rights_note_en": "The article is CC BY-NC-ND 4.0. The website distributes only byte-identical complete figures without cropping, resampling, annotation, or other adaptation.", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-CC-NC-ND-CYNO-INHAND-F015", "BM-CC-NC-ND-CYNO-INHAND-F016", "BM-CC-NC-ND-CYNO-INHAND-F074", "BM-CC-NC-ND-CYNO-INHAND-F075", "BM-CC-NC-ND-CYNO-INHAND-F079", "BM-CC-NC-ND-CYNO-INHAND-F080" ], "pathology_evidence_count": 6, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-CC-NC-ND-CYNO-INHAND-F015", "title_cn": "INHAND食蟹猴骨髓：猴细小病毒性核内包涵体", "title_en": "INHAND cynomolgus marrow: simian parvovirus-associated intranuclear inclusions", "figure_label": "Figure 15", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-NC-ND-CYNO-INHAND-F016", "title_cn": "INHAND食蟹猴骨髓：幼红细胞病毒性包涵体", "title_en": "INHAND cynomolgus marrow: viral inclusions in erythroid blasts", "figure_label": "Figure 16", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-NC-ND-CYNO-INHAND-F074", "title_cn": "INHAND食蟹猴骨髓：淋巴滤泡形成低倍视野", "title_en": "INHAND cynomolgus marrow: lymphoid follicle formation at low magnification", "figure_label": "Figure 74", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-NC-ND-CYNO-INHAND-F075", "title_cn": "INHAND食蟹猴骨髓：淋巴滤泡形成高倍视野", "title_en": "INHAND cynomolgus marrow: lymphoid follicle formation at high magnification", "figure_label": "Figure 75", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-NC-ND-CYNO-INHAND-F079", "title_cn": "INHAND食蟹猴骨髓：淋巴细胞聚集", "title_en": "INHAND cynomolgus marrow: lymphoid aggregate", "figure_label": "Figure 79", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "expert_review_status": "Pending" }, { "image_id": "BM-CC-NC-ND-CYNO-INHAND-F080", "title_cn": "INHAND食蟹猴骨髓：增加的巨核细胞胞穿入", "title_en": "INHAND cynomolgus marrow: increased megakaryocytic emperipolesis", "figure_label": "Figure 80", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-MOUSE-INFLAMMATION", "featured": true, "featured_reason_cn": "小鼠骨髓化脓性炎症与退变中性粒细胞", "module_id": "neutrophilia", "source_id": "NTP-BONE-MARROW-INFLAMMATION", "source_title": "Bone marrow - Inflammation - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "NR", "species": "Mouse", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "小鼠骨髓化脓性炎症中的退变中性粒细胞", "display_title_cn": "小鼠骨髓化脓性炎症与退变中性粒细胞", "title_en": "Degenerating neutrophils in suppurative mouse marrow inflammation", "factor": "Acute_inflammation_emergency_granulopoiesis", "dose": "NR", "timecourse": "NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "小鼠骨髓化脓性炎症中的退变中性粒细胞", "author_conclusion_summary_cn": "教学性模式对应，不声称来自同一动物或同一研究中的CBC—骨髓配对。", "author_conclusion_summary_en": "Teaching correspondence only; not presented as a paired CBC-marrow observation from the same animal or study group.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-INFLAM-F03", "BM-NTP-INFLAM-F04", "BM-NTP-INFLAM-F05", "BM-NTP-INFLAM-F06" ], "pathology_evidence_count": 4, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-INFLAM-F03", "title_cn": "小鼠骨髓肉芽肿", "title_en": "Bone marrow granuloma in mouse", "figure_label": "Figure 3", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-INFLAM-F04", "title_cn": "小鼠骨髓肉芽肿（高倍）", "title_en": "Bone marrow granuloma in mouse, higher magnification", "figure_label": "Figure 4", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-INFLAM-F05", "title_cn": "小鼠骨髓重度化脓性炎症", "title_en": "Severe suppurative inflammation in mouse bone marrow", "figure_label": "Figure 5", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-INFLAM-F06", "title_cn": "小鼠骨髓重度化脓性炎症（高倍）", "title_en": "Severe suppurative inflammation in mouse bone marrow, higher magnification", "figure_label": "Figure 6", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "NTP-CASE-RAT-HISTIOCYTIC-INFILTRATION", "featured": true, "featured_reason_cn": "大鼠骨髓组织细胞浸润：空泡化与胆固醇结晶", "module_id": "bone-marrow-cases", "source_id": "NTP-BONE-MARROW-INFILTRATIONCELLULARHISTIOCYTE", "source_title": "Bone marrow - Histiocytic Infiltration - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "Figures 1-4", "species": "Rat", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "2年研究雌性F344/N大鼠骨髓组织细胞浸润图组，显示淡染空泡化组织细胞及含胆固醇结晶的示例。", "display_title_cn": "大鼠骨髓组织细胞浸润：空泡化与胆固醇结晶", "title_en": "Histiocytic infiltration in female F344/N rat marrow, including pale vacuolated histiocytes and an example containing cholesterol crystals.", "factor": "NR", "dose": "NR", "timecourse": "2-year studies", "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "observation_summary_cn": "2年研究雌性F344/N大鼠骨髓组织细胞浸润图组，显示淡染空泡化组织细胞及含胆固醇结晶的示例。", "author_conclusion_summary_cn": "组织细胞浸润通常为反应性改变；若存在上皮样或多核巨噬细胞、其他炎细胞或水肿，应考虑肉芽肿性炎症。具体病因可能不明确。", "author_conclusion_summary_en": "Histiocytic infiltration is generally reactive. Epithelioid or multinucleated macrophages, other inflammatory cells, or edema favor granulomatous inflammation; the specific cause may remain unclear.", "pairing_note_cn": "Figures 1-4为同一术语的四个代表性视野；Figure 3特异展示含胆固醇结晶的组织细胞。来源未说明它们来自同一动物。", "pairing_note_en": "Figures 1-4 are representative fields for the same diagnostic term; Figure 3 specifically shows histiocytes containing cholesterol crystals. The source does not establish that they are from one animal.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-HISTIOCYTE-F01", "BM-NTP-HISTIOCYTE-F02", "BM-NTP-HISTIOCYTE-F03", "BM-NTP-HISTIOCYTE-F04" ], "pathology_evidence_count": 4, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-HISTIOCYTE-F01", "title_cn": "大鼠骨髓组织细胞浸润（箭头示例）", "title_en": "Histiocytic infiltration in rat bone marrow, arrowed example", "figure_label": "Figure 1", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-HISTIOCYTE-F02", "title_cn": "大鼠骨髓淡染空泡化组织细胞增加", "title_en": "Increased pale vacuolated histiocytes in rat bone marrow", "figure_label": "Figure 2", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-HISTIOCYTE-F03", "title_cn": "大鼠骨髓含胆固醇结晶的组织细胞浸润", "title_en": "Histiocytic infiltration with cholesterol crystals in rat bone marrow", "figure_label": "Figure 3", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-HISTIOCYTE-F04", "title_cn": "大鼠骨髓组织细胞浸润（另一视野）", "title_en": "Histiocytic infiltration in rat bone marrow, alternate field", "figure_label": "Figure 4", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "NTP-CASE-RAT-MAST-CELL-INFILTRATION", "featured": true, "featured_reason_cn": "大鼠骨髓肥大细胞增加：H&E与Giemsa对照", "module_id": "bone-marrow-cases", "source_id": "NTP-BONE-MARROW-INFILTRATIONCELLULARMASTCELL", "source_title": "Bone marrow - Mast Cell Infiltration - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "Figures 1-4", "species": "Rat", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "慢性研究F344/N大鼠骨髓肥大细胞增加图组，对照展示H&E形态和Giemsa紫色胞质颗粒。", "display_title_cn": "大鼠骨髓肥大细胞增加：H&E与Giemsa对照", "title_en": "Increased marrow mast cells in F344/N rats, comparing H&E morphology with purple cytoplasmic granules on Giemsa stain.", "factor": "NR", "dose": "NR", "timecourse": "Chronic studies", "evidence_role": "Teaching_pattern", "causality_level": "Uncertain", "observation_summary_cn": "慢性研究F344/N大鼠骨髓肥大细胞增加图组，对照展示H&E形态和Giemsa紫色胞质颗粒。", "author_conclusion_summary_cn": "推荐记录相对同期对照的反应性、疏松散在肥大细胞增加；不应自动使用mastocytosis。Giemsa可辅助细胞身份确认。", "author_conclusion_summary_en": "The preferred observation is a reactive, loosely scattered increase relative to concurrent controls; mastocytosis should not be assigned automatically. Giemsa can assist cell identification.", "pairing_note_cn": "Figures 1-2为雌性大鼠H&E视野；Figures 3-4为雄性大鼠Giemsa低/高倍视图。它们是染色与形态教学对照，不是同一动物配对。", "pairing_note_en": "Figures 1-2 are H&E fields from female rats; Figures 3-4 are low/high-power Giemsa views from a male rat. They are staining and morphology teaching comparisons, not same-animal pairs.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-MASTCELL-F01", "BM-NTP-MASTCELL-F02", "BM-NTP-MASTCELL-F03", "BM-NTP-MASTCELL-F04" ], "pathology_evidence_count": 4, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-MASTCELL-F01", "title_cn": "大鼠骨髓肥大细胞增加（H&E，箭头）", "title_en": "Increased marrow mast cells in rat, H&E arrowed example", "figure_label": "Figure 1", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-MASTCELL-F02", "title_cn": "大鼠骨髓肥大细胞增加（H&E，另一视野）", "title_en": "Increased marrow mast cells in rat, alternate H&E field", "figure_label": "Figure 2", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-MASTCELL-F03", "title_cn": "大鼠骨髓肥大细胞增加（Giemsa）", "title_en": "Increased marrow mast cells in rat, Giemsa stain", "figure_label": "Figure 3", "specimen_type": "Special_stain", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-MASTCELL-F04", "title_cn": "大鼠骨髓肥大细胞增加（Giemsa，高倍）", "title_en": "Increased marrow mast cells in rat, higher-power Giemsa view", "figure_label": "Figure 4", "specimen_type": "Special_stain", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-RAT-INFLAMMATION", "featured": true, "featured_reason_cn": "NTP大鼠骨髓炎症的组织学鉴别", "module_id": "neutrophilia", "source_id": "NTP-BONE-MARROW-INFLAMMATION", "source_title": "Bone marrow - Inflammation - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "NR", "species": "Rat", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "大鼠骨髓炎症组织学鉴别", "display_title_cn": "NTP大鼠骨髓炎症的组织学鉴别", "title_en": "Rat marrow inflammation histology differential", "factor": "Acute_inflammation_emergency_granulopoiesis", "dose": "NR", "timecourse": "NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "大鼠骨髓炎症组织学鉴别", "author_conclusion_summary_cn": "教学性模式对应，不声称来自同一动物或同一研究中的CBC—骨髓配对。", "author_conclusion_summary_en": "Teaching correspondence only; not presented as a paired CBC-marrow observation from the same animal or study group.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-INFLAM-F01", "BM-NTP-INFLAM-F02" ], "pathology_evidence_count": 2, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-INFLAM-F01", "title_cn": "大鼠骨髓肉芽肿性炎症（低倍）", "title_en": "Granulomatous inflammation in rat bone marrow, low power", "figure_label": "Figure 1", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "expert_review_status": "Pending" }, { "image_id": "BM-NTP-INFLAM-F02", "title_cn": "大鼠骨髓肉芽肿性炎症（高倍）", "title_en": "Granulomatous inflammation in rat bone marrow, higher magnification", "figure_label": "Figure 2", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-CASE-PMC5544077", "featured": true, "featured_reason_cn": "恒河猴疾病鉴别：红系扩增、疟色素和巨核异常", "module_id": "toxicity_atlas", "source_id": "PMC5544077-RHESUS-MALARIA-MARROW", "source_title": "Case Report: Severe and Complicated Cynomolgi Malaria in a Rhesus Macaque Resulted in Similar Histopathological Changes as Those Seen in Human Malaria", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5544077/", "doi": "10.4269/ajtmh.16-0742", "pmid": "28829738", "pmcid": "PMC5544077", "source_page": "Figure 2, panels A-D; Discussion: marrow morphology", "species": "Rhesus_monkey", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "恒河猴重症诺氏疟原虫感染鉴别：骨髓红/粒系扩增、疟色素巨噬细胞及巨核细胞核成熟异常。", "display_title_cn": "恒河猴疾病鉴别：红系扩增、疟色素和巨核异常", "title_en": "Severe cynomolgi malaria in a rhesus macaque showed erythroid/myeloid expansion, hemozoin-laden macrophages, and abnormal megakaryocytic maturation.", "factor": "Severe and complicated Plasmodium cynomolgi malaria", "dose": "Not applicable; naturally relevant infection model/case report", "timecourse": "Terminal marrow evaluation after severe anemia, thrombocytopenia, hyperparasitemia, and renal failure", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "恒河猴重症诺氏疟原虫感染鉴别：骨髓红/粒系扩增、疟色素巨噬细胞及巨核细胞核成熟异常。", "author_conclusion_summary_cn": "这是单只恒河猴的重症感染病例，不是药物毒性研究。原作者报告骨髓高细胞性、红系和粒系显著增加，含疟色素巨噬细胞邻近红系细胞，并将巨核细胞形态描述为异常/发育异常。Figure 2D电镜显示来自Panel C的巨核细胞具有未成熟凹陷核和降低的核浆比。该病例提示感染、严重贫血和全身疾病可模拟处理相关反应性或发育异常性骨髓改变；网站保留作者术语，但不把单病例自动转化为药物相关dysplasia、发生率或因果机制。", "author_conclusion_summary_en": "This is a single severe-infection case, not a drug-toxicity study. The authors reported hypercellular marrow, marked erythroid and myeloid expansion, hemozoin-laden macrophages, and abnormal/dysplastic megakaryocytes. It is a disease differential and does not establish treatment-related dysplasia or frequency.", "pairing_note_cn": "Figure 2A-C为同一重症疟疾恒河猴的骨髓H&E切片，D为Panel C中巨核细胞的透射电镜图；属于同病例、多方法支持。贫血、血小板减少和高寄生虫血症也来自同一病例，但文章未提供可从图像重算的固定分母骨髓分类计数，因此不能由代表视野量化各谱系比例或异常发生率。", "pairing_note_en": "Figure 2A-C are H&E marrow sections from the same severe-malaria rhesus case; panel D is TEM of a megakaryocyte from panel C. Anemia, thrombocytopenia, and hyperparasitemia are same-case support, but no denominator-based marrow differential can be recalculated from these representative fields.", "rights_note_cn": "文章页面标示© The American Society of Tropical Medicine and Hygiene，未见明确Creative Commons图片再利用许可；本站不复制Figure 2，仅提供原始来源链接和结构化鉴别案例。", "rights_note_en": "The article page identifies copyright by the American Society of Tropical Medicine and Hygiene and no explicit Creative Commons image-reuse license. Figure 2 is source-linked but not republished.", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC11697499-CASE-AML-BLOOD", "featured": true, "featured_reason_cn": "犬AML鉴别：外周血原始细胞与近全细胞性骨髓切片", "module_id": "bone-marrow-cases", "source_id": "SUP-PMC11697499", "source_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_page": "Figure 3, panels a-b", "species": "Dog", "toxicity_type": "T12", "toxicity_title_cn": "MDS、AML及增殖性病变鉴别对照", "toxicity_title_en": "MDS, AML and proliferative disease differentials", "title_cn": "犬AML同病例鉴别：外周血原始细胞和髓单核样细胞，以及近全细胞性骨髓切片。", "display_title_cn": "犬AML鉴别：外周血原始细胞与近全细胞性骨髓切片", "title_en": "Same-case canine AML differential with blood blasts and myelomonocytic cells plus a near-totally cellular marrow section.", "factor": "Spontaneous/clinical canine acute myeloid leukemia", "dose": "Not applicable", "timecourse": "Diagnostic evaluation; Case 6", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬AML同病例鉴别：外周血原始细胞和髓单核样细胞，以及近全细胞性骨髓切片。", "author_conclusion_summary_cn": "外周血显示偶见原始细胞、多量大型髓单核样细胞和发育异常中性粒细胞；死后骨髓切片接近100%细胞性，并见核形不规则、核仁明显的细胞。谱系和疾病定类仍需骨髓分类、免疫表型及其他证据。", "author_conclusion_summary_en": "The blood shows occasional blasts, numerous large myelomonocytic cells, and dysplastic neutrophils; the postmortem marrow is nearly 100% cellular with cells having irregular nuclei and prominent nucleoli. Lineage and disease classification still require marrow differential, immunophenotypic, and other evidence.", "pairing_note_cn": "Figure 3a-b均明确属于Case 6，是同病例的外周血—死后骨髓支持性对照；图注未声明两种标本的精确时间差。", "pairing_note_en": "Figure 3a-b explicitly belongs to Case 6 and provides a same-case blood-postmortem-marrow supportive comparison; the legend does not state the exact interval between specimens.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-AML-F03-A" ], "public_image_paths": [ "../images/BM-CC-DOG-AML-F03-A.jpg" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-AML-F03-A.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-AML-F03-A", "title_cn": "犬AML外周血：原始细胞、大型髓单核样细胞与发育异常中性粒细胞", "title_en": "Canine AML blood film: blasts, large myelomonocytic cells, and dysplastic neutrophils", "figure_label": "Figure 3", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-AML-F03-A.jpg", "preview_path": "../previews/BM-CC-DOG-AML-F03-A.jpg", "caption_original_en": "Acute myeloid leukemia, dog. Case 6. (a) The blood film contains occasional blasts (arrowhead), numerous large myelomonocytes with irregular nuclear shapes, and occasional cytoplasmic vacuoles. Neutrophils are dysplastic with irregular nuclear lobes and incomplete segmentation (*). The dog had a leukocytosis of 157 × 10^9/L (reference interval = 4.9-15.4 × 10^9/L), thrombocytopenia, and anemia. Wright stain. (b) The postmortem marrow section is nearly 100% cellular and includes many cells with irregular nuclear shapes and large, sometimes amphophilic, nucleoli (arrowheads). Hematoxylin and eosin.", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [ "BM-CC-DOG-AML-F03-B" ], "pathology_evidence_count": 1, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-CC-DOG-AML-F03-B", "title_cn": "犬AML骨髓切片：近全细胞性并见核形不规则、核仁明显的细胞群", "title_en": "Canine AML marrow histology: near-total cellularity with irregular nuclei and prominent nucleoli", "figure_label": "Figure 3", "specimen_type": "Histology_HE", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC11697499-CASE-AML-BLOOD-MARROW-PAIR", "featured": true, "featured_reason_cn": "犬AML鉴别：同病例外周血—骨髓原始细胞对照", "module_id": "bone-marrow-cases", "source_id": "SUP-PMC11697499", "source_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_page": "Figure 4, panels a-b", "species": "Dog", "toxicity_type": "T12", "toxicity_title_cn": "MDS、AML及增殖性病变鉴别对照", "toxicity_title_en": "MDS, AML and proliferative disease differentials", "title_cn": "犬AML同病例对照：外周血约40%白细胞为大型原始细胞，骨髓吸取物约45%为原始细胞。", "display_title_cn": "犬AML鉴别：同病例外周血—骨髓原始细胞对照", "title_en": "Same-case canine AML comparison: approximately 40% large blasts among blood leukocytes and approximately 45% blasts in the marrow aspirate.", "factor": "Spontaneous/clinical canine acute myeloid leukemia", "dose": "Not applicable", "timecourse": "Diagnostic evaluation; Case 7", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬AML同病例对照：外周血约40%白细胞为大型原始细胞，骨髓吸取物约45%为原始细胞。", "author_conclusion_summary_cn": "该组图展示同一AML病例的外周血和骨髓原始细胞负荷均明显升高，并伴中性粒细胞减少、贫血和血小板减少。百分比为原作者计数，不由网站从代表视野重新估算。", "author_conclusion_summary_en": "The same AML case shows a high blast burden in both blood and marrow, with neutropenia, anemia, and thrombocytopenia. Percentages are author-reported and are not re-estimated by the website from representative fields.", "pairing_note_cn": "Panels a和b均明确属于Case 7，是同病例支持性血液—骨髓对照；图注未单独声明两种标本的精确采集时间差。", "pairing_note_en": "Panels a and b are explicitly from Case 7 and form a same-case supportive blood-marrow comparison; the legend does not state the exact interval between specimen collections.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-AML-F04-A", "BM-CC-DOG-AML-F04-B" ], "public_image_paths": [ "../images/BM-CC-DOG-AML-F04-A.jpg", "../images/BM-CC-DOG-AML-F04-B.jpg" ], "public_image_preview_paths": [ "../previews/BM-CC-DOG-AML-F04-A.jpg", "../previews/BM-CC-DOG-AML-F04-B.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-AML-F04-A", "title_cn": "犬AML外周血：约40%白细胞为大型原始细胞", "title_en": "Canine AML blood film: approximately 40% of leukocytes are large blasts", "figure_label": "Figure 4", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-AML-F04-A.jpg", "preview_path": "../previews/BM-CC-DOG-AML-F04-A.jpg", "caption_original_en": "Acute myeloid leukemia, dog. Case 7. Wright stain. (a) The dog had neutropenia, anemia, and thrombocytopenia. Approximately 40% of leukocytes are large blasts. (b) The marrow aspirate is highly cellular and contains approximately 45% blasts (*).", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" }, { "image_id": "BM-CC-DOG-AML-F04-B", "title_cn": "犬AML骨髓吸取物：高细胞性并含约45%原始细胞", "title_en": "Canine AML marrow aspirate: high cellularity with approximately 45% blasts", "figure_label": "Figure 4", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-AML-F04-B.jpg", "preview_path": "../previews/BM-CC-DOG-AML-F04-B.jpg", "caption_original_en": "Acute myeloid leukemia, dog. Case 7. Wright stain. (a) The dog had neutropenia, anemia, and thrombocytopenia. Approximately 40% of leukocytes are large blasts. (b) The marrow aspirate is highly cellular and contains approximately 45% blasts (*).", "reuse_status": "cc_reuse_allowed", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-DOG-MDSMPN", "featured": true, "featured_reason_cn": "犬MDS/MPN鉴别：中性粒细胞增多、粒系增生与发育异常", "module_id": "neutrophilia", "source_id": "PMC12710095-CANINE-MDS-MPN", "source_title": "Myelodysplastic/Myeloproliferative Neoplasm in a Dog: A Case Report", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12710095/", "doi": "NR", "pmid": "NR", "pmcid": "PMC12710095", "source_page": "Figures 1 and 3", "species": "Dog", "toxicity_type": "T12", "toxicity_title_cn": "MDS、AML及增殖性病变鉴别对照", "toxicity_title_en": "MDS, AML and proliferative disease differentials", "title_cn": "犬MDS/MPN：中性粒细胞增多伴骨髓粒系增生和发育异常", "display_title_cn": "犬MDS/MPN鉴别：中性粒细胞增多、粒系增生与发育异常", "title_en": "Canine MDS/MPN with neutrophilia, marrow myeloid hyperplasia, and dysplasia", "factor": "Spontaneous/clinical canine MDS/MPN", "dose": "Not applicable", "timecourse": "Diagnostic evaluation; exact blood-marrow sampling interval not stated in the figure legends", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬MDS/MPN：中性粒细胞增多伴骨髓粒系增生和发育异常", "author_conclusion_summary_cn": "同一犬MDS/MPN病例报告中，外周血显示过分叶中性粒细胞及核分节单核细胞，骨髓吸取物显示粒系增生、M:E约10:1、原始细胞约16%以及红系和巨核系低增生。该组图用于疾病性发育异常鉴别，不代表药物相关骨髓毒性。", "author_conclusion_summary_en": "See the cited source for the complete author interpretation.", "pairing_note_cn": "Figure 1和Figure 3来自同一犬病例报告，可作为同病例支持性血液—骨髓对照；图注未明确两种标本是否同一采样时刻，因此不标记为严格同动物同时间点配对。", "pairing_note_en": "Figures 1 and 3 are from the same canine case report and provide a supportive blood-marrow comparison. The legends do not establish that both specimens were collected at the same time, so the pair is not labeled as strict same-animal/same-time-point evidence.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Public_image_linked", "public_image_ids": [ "BM-CC-DOG-MDSMPN-F01", "BM-CC-DOG-MDSMPN-F03" ], "public_image_paths": [ "../images/BM-CC-DOG-MDSMPN-F01.jpg", "../images/BM-CC-DOG-MDSMPN-F03.jpg" ], "public_image_preview_paths": [ "../images/BM-CC-DOG-MDSMPN-F01.jpg", "../images/BM-CC-DOG-MDSMPN-F03.jpg" ], "public_images": [ { "image_id": "BM-CC-DOG-MDSMPN-F01", "title_cn": "犬MDS/MPN外周血鉴别：过分叶中性粒细胞与核分节单核细胞", "title_en": "Canine MDS/MPN blood differential: hypersegmented neutrophils and monocytes with segmented nuclei", "figure_label": "Figure 1", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-MDSMPN-F01.jpg", "preview_path": "../images/BM-CC-DOG-MDSMPN-F01.jpg", "caption_original_en": "Peripheral blood smear examination (Diff‐Quik stain). Peripheral blood smear demonstrating numerous dysplastic cells, including hypersegmented neutrophils and monocytes with segmented nuclei. (A) 400× magnification and (B) 1000× magnification.", "reuse_status": "cc_noncommercial_only", "expert_review_status": "Pending" }, { "image_id": "BM-CC-DOG-MDSMPN-F03", "title_cn": "犬MDS/MPN骨髓吸取物：粒系增生、原始细胞增加与红系/巨核系低增生", "title_en": "Canine MDS/MPN marrow aspirate: myeloid hyperplasia, increased blasts, and erythroid/megakaryocytic hypoplasia", "figure_label": "Figure 3", "species": "Dog", "evidence_role": "Disease_differential", "asset_path": "../images/BM-CC-DOG-MDSMPN-F03.jpg", "preview_path": "../images/BM-CC-DOG-MDSMPN-F03.jpg", "caption_original_en": "Bone marrow aspiration cytology (Diff‐Quik stain). Bone marrow sample showing hypercellularity, myeloid hyperplasia with a markedly increased myeloid‐to‐erythroid (M:E) ratio of 10:1, and dysplastic changes consistent with peripheral blood findings. Additionally, the sample exhibits an increased myeloblast count (16%), with marked megakaryocytic and erythroid hypoplasia. (A) 200× magnification; (B) 400× magnification; and (C) 1000× magnification.", "reuse_status": "cc_noncommercial_only", "expert_review_status": "Pending" } ], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "PMC4219468-CASE-TELSYK-APMF", "featured": true, "featured_reason_cn": "小鼠TEL-SYK模型：APMF样AML、多系发育异常与骨髓纤维化", "module_id": "bone-marrow-cases", "source_id": "PMC4219468", "source_title": "Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4219468/", "doi": "10.1038/bcj.2014.53", "pmid": "25148222", "pmcid": "PMC4219468", "source_page": "Figure 3, panels a-c", "species": "Mouse", "toxicity_type": "T12", "toxicity_title_cn": "MDS、AML及增殖性病变鉴别对照", "toxicity_title_en": "MDS, AML and proliferative disease differentials", "title_cn": "TEL-SYK小鼠模型完整Figure展示APMF样AML、多系发育异常、未成熟巨核系细胞浸润和II-III级纤维化。", "display_title_cn": "小鼠TEL-SYK模型：APMF样AML、多系发育异常与骨髓纤维化", "title_en": "The complete TEL-SYK mouse figure demonstrates APMF-like AML, multilineage dysplasia, immature megakaryocytic infiltration, and grade II-III fibrosis.", "factor": "TEL-SYK bone marrow transplantation disease model", "dose": "Not applicable", "timecourse": "Terminal disease, approximately 21-28 days after transplantation", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "TEL-SYK小鼠模型完整Figure展示APMF样AML、多系发育异常、未成熟巨核系细胞浸润和II-III级纤维化。", "author_conclusion_summary_cn": "原作者依据骨髓、脾和肝形态及相关实验将多数TEL-SYK小鼠归为具有APMF特征的AML。网站将其保留为增殖性病变和MDS/AML鉴别模型，不作为一般药物性骨髓毒性。", "author_conclusion_summary_en": "The authors classified most TEL-SYK mice as AML with features of acute panmyelosis with myelofibrosis using marrow, spleen, liver, and supporting data. The website retains it as a proliferative/MDS-AML differential model, not general drug-induced marrow toxicity.", "pairing_note_cn": "完整Figure 3含骨髓、脾和肝H&E，以及骨髓/脾PAS和网状纤维染色；不同组织和组别是复合比较，不是同一视野的多重染色。", "pairing_note_en": "Complete Figure 3 combines H&E from marrow, spleen, and liver with PAS and reticulin stains from marrow and spleen. The tissues and groups form a composite comparison, not multiple stains of one identical field.", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-CC-MOUSE-TELSYK-F03" ], "pathology_evidence_count": 1, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-CC-MOUSE-TELSYK-F03", "title_cn": "小鼠TEL-SYK模型：APMF样AML、多系发育异常与骨髓纤维化", "title_en": "Mouse TEL-SYK model: APMF-like AML with multilineage dysplasia and myelofibrosis", "figure_label": "Figure 3", "specimen_type": "Mixed_bone_marrow_spleen_liver_histology", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4219468/", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Featured_case", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-008", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-008", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "33", "species": "Cynomolgus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 33；研究类型：unclear；动物：monkey；骨髓评价类型：both；骨髓细胞量/造血细胞：no change；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "display_title_cn": "食蟹猴：骨髓证据案例（Sirturo）", "title_en": "Cynomolgus_monkey: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "0.5 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 33；研究类型：unclear；动物：monkey；骨髓评价类型：both；骨髓细胞量/造血细胞：no change；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "author_conclusion_summary_cn": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-027", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-027", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "216", "species": "Cynomolgus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 216；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "食蟹猴：骨髓证据案例（Sirturo）", "title_en": "Cynomolgus_monkey: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "200 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 216；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-029", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-029", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "219", "species": "Cynomolgus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 219；研究类型：unclear；动物：monkey；骨髓评价类型：smear/cytology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased；M:E：decreased。", "display_title_cn": "食蟹猴：骨髓证据案例（Sirturo）", "title_en": "Cynomolgus_monkey: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "100 mg/kg/day; 33.33 mg/kg; 50 and 100 mg/kg/day; 50 mg/kg/day; 10 and 50 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 219；研究类型：unclear；动物：monkey；骨髓评价类型：smear/cytology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased；M:E：decreased。", "author_conclusion_summary_cn": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-034", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-034", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "235", "species": "Cynomolgus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 235；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：no change。", "display_title_cn": "食蟹猴：骨髓证据案例（Sirturo）", "title_en": "Cynomolgus_monkey: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "50 and 100 mg/kg/day; 50 mg/kg/day; 100 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 235；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：no change。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-035", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-035", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "253", "species": "Cynomolgus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 253；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "食蟹猴：骨髓证据案例（Sirturo）", "title_en": "Cynomolgus_monkey: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 253；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-036", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-036", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "254", "species": "Cynomolgus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 254；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "食蟹猴：骨髓证据案例（Sirturo）", "title_en": "Cynomolgus_monkey: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 254；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-054", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-054", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "477", "species": "Cynomolgus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 477；研究类型：unclear；动物：monkey；骨髓评价类型：both；骨髓细胞量/造血细胞：no change；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "display_title_cn": "食蟹猴：骨髓证据案例（Sirturo）", "title_en": "Cynomolgus_monkey: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "0.5 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 477；研究类型：unclear；动物：monkey；骨髓评价类型：both；骨髓细胞量/造血细胞：no change；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "author_conclusion_summary_cn": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-059", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-059", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "522", "species": "Cynomolgus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 522；研究类型：unclear；动物：monkey；骨髓评价类型：both；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "食蟹猴：骨髓证据案例（Sirturo）", "title_en": "Cynomolgus_monkey: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "10 mg/kg/day; 0.5 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 522；研究类型：unclear；动物：monkey；骨髓评价类型：both；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-CYN-BACKGROUND", "featured": false, "featured_reason_cn": "NR", "module_id": "neutrophilia", "source_id": "CARTER-2016-CYNO-BM", "source_title": "Cytological Bone Marrow Cell Differential Counts and Morphologic Findings in Healthy Cynomolgus Monkeys from Nonclinical Toxicology Studies", "source_type": "Traceable_official_or_publisher_source", "source_url": "https://doi.org/10.1177/0192623316677067", "doi": "10.1177/0192623316677067", "pmid": "NR", "pmcid": "NR", "source_page": "NR", "species": "Cynomolgus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "健康食蟹猴粒系背景形态变异", "display_title_cn": "健康食蟹猴粒系背景形态变异", "title_en": "Healthy cynomolgus granulocytic background variants", "factor": "Normal_or_background_comparator", "dose": "NR", "timecourse": "NR", "evidence_role": "Teaching_pattern", "causality_level": "NR", "observation_summary_cn": "健康食蟹猴粒系背景形态变异", "author_conclusion_summary_cn": "教学性模式对应，不声称来自同一动物或同一研究中的CBC—骨髓配对。", "author_conclusion_summary_en": "Teaching correspondence only; not presented as a paired CBC-marrow observation from the same animal or study group.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-CYN-TEST-ARTICLE", "featured": false, "featured_reason_cn": "NR", "module_id": "neutrophilia", "source_id": "PMC1797897-BM-HISTOLOGY-BESTPRACTICES", "source_title": "Best Practices for Evaluation of Bone Marrow in Nonclinical Toxicity Studies", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC1797897/", "doi": "10.1177/0192623310396907", "pmid": "NR", "pmcid": "PMC1797897", "source_page": "NR", "species": "Cynomolgus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "食蟹猴给药后轻度粒系生成增加", "display_title_cn": "食蟹猴给药后轻度粒系生成增加", "title_en": "Cynomolgus slight increased granulopoiesis after test-article dosing", "factor": "Sustained_inflammatory_response", "dose": "NR", "timecourse": "NR", "evidence_role": "Teaching_pattern", "causality_level": "NR", "observation_summary_cn": "食蟹猴给药后轻度粒系生成增加", "author_conclusion_summary_cn": "教学性模式对应，不声称来自同一动物或同一研究中的CBC—骨髓配对。", "author_conclusion_summary_en": "Teaching correspondence only; not presented as a paired CBC-marrow observation from the same animal or study group.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-001", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "CARTER-2016-CYNO-BM", "source_title": "Cytological Bone Marrow Cell Differential Counts and Morphologic Findings in Healthy Cynomolgus Monkeys from Nonclinical Toxicology Studies", "source_type": "Traceable_official_or_publisher_source", "source_url": "https://doi.org/10.1177/0192623316677067", "doi": "10.1177/0192623316677067", "pmid": "NR", "pmcid": "NR", "source_page": "NR", "species": "Cynomolgus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "健康对照食蟹猴骨髓涂片中观察到的低频形态发现；按原文不作为药物毒性结论。", "display_title_cn": "健康对照食蟹猴骨髓涂片中观察到的低频形态发现；按原文不作为药物毒性结论。", "title_en": "Cynomolgus_monkey: Bone marrow evidence case associated with Expected_background_variation_in_healthy_controls", "factor": "Expected_background_variation_in_healthy_controls", "dose": "NR", "timecourse": "NR", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "健康对照食蟹猴骨髓涂片中观察到的低频形态发现；按原文不作为药物毒性结论。", "author_conclusion_summary_cn": "健康对照食蟹猴骨髓涂片中观察到的低频形态发现；按原文不作为药物毒性结论。", "author_conclusion_summary_en": "Metarubricyte nuclear blebbing/lobulation and binucleation (thin arrows). These metarubricyte nuclear changes encompassed a wide variety of shapes, including small single blebs (A), nuclear fragmentation or binucleation (B), trilobulation (C), and irregular blebbing/lobulation (D). Wright-Giemsa stain.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-003", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "SUP-PMC4485636", "source_title": "Severe Acquired Idiopathic Thrombocytopenia in a Female Cynomolgus Macaque (Macaca fascicularis)", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4485636/", "doi": "NR", "pmid": "26141452", "pmcid": "PMC4485636", "source_page": "NR", "species": "Cynomolgus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "食蟹猴骨髓刷片：幼稚巨核细胞增多", "display_title_cn": "食蟹猴骨髓刷片：幼稚巨核细胞增多", "title_en": "Panel A shows increased immature megakaryocytes in femoral marrow brush smear.", "factor": "Reactive_change_thrombocytopenia_context", "dose": "NR", "timecourse": "NR", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "食蟹猴骨髓刷片：幼稚巨核细胞增多", "author_conclusion_summary_cn": "食蟹猴骨髓刷片：幼稚巨核细胞增多", "author_conclusion_summary_en": "Panel A shows increased immature megakaryocytes in femoral marrow brush smear.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-004", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "SUP-PMC4485636", "source_title": "Severe Acquired Idiopathic Thrombocytopenia in a Female Cynomolgus Macaque (Macaca fascicularis)", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4485636/", "doi": "NR", "pmid": "26141452", "pmcid": "PMC4485636", "source_page": "NR", "species": "Cynomolgus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "食蟹猴骨髓刷片：成熟巨核细胞，单个多分叶细胞核及丰富淡颗粒胞质", "display_title_cn": "食蟹猴骨髓刷片：成熟巨核细胞，单个多分叶细胞核及丰富淡颗粒胞质", "title_en": "Panel B shows mature megakaryocytes, the largest hematopoietic cells with multilobed nuclei and abundant pale granular cytoplasm.", "factor": "Reactive_change_thrombocytopenia_context", "dose": "NR", "timecourse": "NR", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "食蟹猴骨髓刷片：成熟巨核细胞，单个多分叶细胞核及丰富淡颗粒胞质", "author_conclusion_summary_cn": "食蟹猴骨髓刷片：成熟巨核细胞，单个多分叶细胞核及丰富淡颗粒胞质", "author_conclusion_summary_en": "Panel B shows mature megakaryocytes, the largest hematopoietic cells with multilobed nuclei and abundant pale granular cytoplasm.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-010", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "SUP-PMC4485636", "source_title": "Severe Acquired Idiopathic Thrombocytopenia in a Female Cynomolgus Macaque (Macaca fascicularis)", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4485636/", "doi": "NR", "pmid": "26141452", "pmcid": "PMC4485636", "source_page": "NR", "species": "Cynomolgus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "成年雌性食蟹猴股骨骨髓刷片：幼稚和成熟巨核细胞增多，部分破碎巨核细胞提示制备影响。", "display_title_cn": "成年雌性食蟹猴股骨骨髓刷片：幼稚和成熟巨核细胞增多，部分破碎巨核细胞提示制备影响。", "title_en": "Cynomolgus monkey femoral marrow brush smear with increased immature and mature megakaryocytes.", "factor": "Uncertain", "dose": "NR", "timecourse": "NR", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "成年雌性食蟹猴股骨骨髓刷片：幼稚和成熟巨核细胞增多，部分破碎巨核细胞提示制备影响。", "author_conclusion_summary_cn": "成年雌性食蟹猴股骨骨髓刷片：幼稚和成熟巨核细胞增多，部分破碎巨核细胞提示制备影响。", "author_conclusion_summary_en": "Cynomolgus monkey femoral marrow brush smear with increased immature and mature megakaryocytes.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_001-BM-019", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_001-BM-019", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "42", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Melflufen / Pepaxto；页码 42；研究类型：unclear；动物：dog；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：骨髓证据案例（Melflufen / Pepaxto）", "title_en": "Dog: Bone marrow evidence case associated with Melflufen / Pepaxto", "factor": "Melflufen / Pepaxto", "dose": "0.2 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Melflufen / Pepaxto；页码 42；研究类型：unclear；动物：dog；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_008-BM-010", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_008-BM-010", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "95", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Zepatier；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "犬：骨髓证据案例（Zepatier）", "title_en": "Dog: Bone marrow evidence case associated with Zepatier", "factor": "Zepatier", "dose": "15 mg/kg/day; 100 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Zepatier；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_009-BM-014", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_009-BM-014", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "95", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：increased。", "display_title_cn": "犬：骨髓证据案例（Lynparza）", "title_en": "Dog: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "2.5 mg/kg", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：increased。", "author_conclusion_summary_cn": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_009-BM-017", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_009-BM-017", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "99", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 99；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：骨髓证据案例（Lynparza）", "title_en": "Dog: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "1 and 3 mg/kg; 10 mg/kg; 3 mg/kg; 1 mg/kg/day; 3 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 99；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_009-BM-018", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_009-BM-018", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "103", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 103；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "display_title_cn": "犬：骨髓证据案例（Lynparza）", "title_en": "Dog: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "10 mg/kg", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 103；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "author_conclusion_summary_cn": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_010-BM-011", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_010-BM-011", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "71", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Inrebic；页码 71；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "犬：骨髓证据案例（Inrebic）", "title_en": "Dog: Bone marrow evidence case associated with Inrebic", "factor": "Inrebic", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Inrebic；页码 71；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_010-BM-012", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_010-BM-012", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "72", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Inrebic；页码 72；研究类型：unclear；动物：dog；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "犬：骨髓证据案例（Inrebic）", "title_en": "Dog: Bone marrow evidence case associated with Inrebic", "factor": "Inrebic", "dose": "20 mg/kg; 15 mg/kg; 15 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Inrebic；页码 72；研究类型：unclear；动物：dog；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_001-BM-019", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-214120", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "42", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Melflufen / Pepaxto；页码 42；研究类型：unclear；动物：dog；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：骨髓证据案例（Melflufen / Pepaxto）", "title_en": "Dog: Bone marrow evidence case associated with Melflufen / Pepaxto", "factor": "Melflufen / Pepaxto", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Melflufen / Pepaxto；页码 42；研究类型：unclear；动物：dog；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Melflufen / Pepaxto；页码 42；研究类型：unclear；动物：dog；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_001-BM-023", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-214120", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "47", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Melflufen / Pepaxto；页码 47；研究类型：unclear；动物：dog；骨髓评价类型：smear/cytology；M:E：decreased。", "display_title_cn": "犬：骨髓证据案例（Melflufen / Pepaxto）", "title_en": "Dog: Bone marrow evidence case associated with Melflufen / Pepaxto", "factor": "Melflufen / Pepaxto", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Melflufen / Pepaxto；页码 47；研究类型：unclear；动物：dog；骨髓评价类型：smear/cytology；M:E：decreased。", "author_conclusion_summary_cn": "Melflufen / Pepaxto；页码 47；研究类型：unclear；动物：dog；骨髓评价类型：smear/cytology；M:E：decreased。", "author_conclusion_summary_en": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_008-BM-010", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-208261", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "95", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Zepatier；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "犬：骨髓证据案例（Zepatier）", "title_en": "Dog: Bone marrow evidence case associated with Zepatier", "factor": "Zepatier", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Zepatier；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "Zepatier；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_009-BM-011", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "92", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 92；研究类型：repeat-dose toxicity；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "display_title_cn": "犬：骨髓证据案例（Lynparza）", "title_en": "Dog: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 92；研究类型：repeat-dose toxicity；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "author_conclusion_summary_cn": "Lynparza；页码 92；研究类型：repeat-dose toxicity；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "author_conclusion_summary_en": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_009-BM-014", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "95", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：increased。", "display_title_cn": "犬：骨髓证据案例（Lynparza）", "title_en": "Dog: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：increased。", "author_conclusion_summary_cn": "Lynparza；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：increased。", "author_conclusion_summary_en": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_009-BM-015", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "96", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 96；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "display_title_cn": "犬：骨髓证据案例（Lynparza）", "title_en": "Dog: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 96；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "author_conclusion_summary_cn": "Lynparza；页码 96；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "author_conclusion_summary_en": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_009-BM-016", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "98", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 98；研究类型：unclear；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "display_title_cn": "犬：骨髓证据案例（Lynparza）", "title_en": "Dog: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 98；研究类型：unclear；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "author_conclusion_summary_cn": "Lynparza；页码 98；研究类型：unclear；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "author_conclusion_summary_en": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_009-BM-017", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "99", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 99；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：骨髓证据案例（Lynparza）", "title_en": "Dog: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 99；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Lynparza；页码 99；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_009-BM-018", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "103", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 103；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "display_title_cn": "犬：骨髓证据案例（Lynparza）", "title_en": "Dog: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 103；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "author_conclusion_summary_cn": "Lynparza；页码 103；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "author_conclusion_summary_en": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_010-BM-011", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-212327", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "71", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Inrebic；页码 71；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "犬：骨髓证据案例（Inrebic）", "title_en": "Dog: Bone marrow evidence case associated with Inrebic", "factor": "Inrebic", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Inrebic；页码 71；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "Inrebic；页码 71；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_013-BM-017", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-214200", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214200Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "48", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Cosela；页码 48；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "display_title_cn": "犬：骨髓证据案例（Cosela）", "title_en": "Dog: Bone marrow evidence case associated with Cosela", "factor": "Cosela", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Cosela；页码 48；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "author_conclusion_summary_cn": "Cosela；页码 48；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_013-BM-018", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-214200", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214200Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "49", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Cosela；页码 49；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "display_title_cn": "犬：骨髓证据案例（Cosela）", "title_en": "Dog: Bone marrow evidence case associated with Cosela", "factor": "Cosela", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Cosela；页码 49；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "author_conclusion_summary_cn": "Cosela；页码 49；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_013-BM-022", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-214200", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214200Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "58", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Cosela；页码 58；研究类型：reproductive/developmental toxicity；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "display_title_cn": "犬：骨髓证据案例（Cosela）", "title_en": "Dog: Bone marrow evidence case associated with Cosela", "factor": "Cosela", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Cosela；页码 58；研究类型：reproductive/developmental toxicity；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "author_conclusion_summary_cn": "Cosela；页码 58；研究类型：reproductive/developmental toxicity；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_013-BM-023", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-214200", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214200Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "59", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Cosela；页码 59；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "犬：骨髓证据案例（Cosela）", "title_en": "Dog: Bone marrow evidence case associated with Cosela", "factor": "Cosela", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Cosela；页码 59；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "Cosela；页码 59；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_013-BM-024", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-214200", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214200Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "63", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Cosela；页码 63；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：骨髓证据案例（Cosela）", "title_en": "Dog: Bone marrow evidence case associated with Cosela", "factor": "Cosela", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Cosela；页码 63；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Cosela；页码 63；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_015-BM-007", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-203971", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "95", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Xofigo；页码 95；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "犬：骨髓证据案例（Xofigo）", "title_en": "Dog: Bone marrow evidence case associated with Xofigo", "factor": "Xofigo", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Xofigo；页码 95；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "Xofigo；页码 95；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_015-BM-008", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-203971", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "99", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Xofigo；页码 99；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：mixed/unclear；M:E：reported, direction unclear。", "display_title_cn": "犬：骨髓证据案例（Xofigo）", "title_en": "Dog: Bone marrow evidence case associated with Xofigo", "factor": "Xofigo", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Xofigo；页码 99；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：mixed/unclear；M:E：reported, direction unclear。", "author_conclusion_summary_cn": "Xofigo；页码 99；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：mixed/unclear；M:E：reported, direction unclear。", "author_conclusion_summary_en": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_015-BM-014", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-203971", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "133", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Xofigo；页码 133；研究类型：repeat-dose toxicity；动物：dog；骨髓评价类型：both；M:E：reported, direction unclear。", "display_title_cn": "犬：骨髓证据案例（Xofigo）", "title_en": "Dog: Bone marrow evidence case associated with Xofigo", "factor": "Xofigo", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Xofigo；页码 133；研究类型：repeat-dose toxicity；动物：dog；骨髓评价类型：both；M:E：reported, direction unclear。", "author_conclusion_summary_cn": "Xofigo；页码 133；研究类型：repeat-dose toxicity；动物：dog；骨髓评价类型：both；M:E：reported, direction unclear。", "author_conclusion_summary_en": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-PMDA_005-BM-002", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "PMDA-", "source_title": "Review Report", "source_type": "Traceable_official_or_publisher_source", "source_url": "https://www.pmda.go.jp/files/000233298.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "12", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Doptelet；页码 12；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "犬：骨髓证据案例（Doptelet）", "title_en": "Dog: Bone marrow evidence case associated with Doptelet", "factor": "Doptelet", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Doptelet；页码 12；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Doptelet；页码 12；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-PMDA_005-BM-005", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "PMDA-", "source_title": "Review Report", "source_type": "Traceable_official_or_publisher_source", "source_url": "https://www.pmda.go.jp/files/000233298.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "21", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Doptelet；页码 21；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；巨核细胞：mixed/unclear。", "display_title_cn": "犬：骨髓证据案例（Doptelet）", "title_en": "Dog: Bone marrow evidence case associated with Doptelet", "factor": "Doptelet", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Doptelet；页码 21；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；巨核细胞：mixed/unclear。", "author_conclusion_summary_cn": "Doptelet；页码 21；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；巨核细胞：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-DOG-BEAGLE-GRAN", "featured": false, "featured_reason_cn": "NR", "module_id": "neutrophilia", "source_id": "SUP-PMC1797897", "source_title": "Enhanced Histopathology of the Bone Marrow", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC1797897/", "doi": "10.1080/01926230600939971", "pmid": "17067952", "pmcid": "PMC1797897", "source_page": "NR", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Beagle重度粒系生成增加并伴红系减少", "display_title_cn": "Beagle重度粒系生成增加并伴红系减少", "title_en": "Beagle severe increased granulopoiesis with decreased erythropoiesis", "factor": "Sustained_inflammatory_response", "dose": "NR", "timecourse": "NR", "evidence_role": "Teaching_pattern", "causality_level": "NR", "observation_summary_cn": "Beagle重度粒系生成增加并伴红系减少", "author_conclusion_summary_cn": "教学性模式对应，不声称来自同一动物或同一研究中的CBC—骨髓配对。", "author_conclusion_summary_en": "Teaching correspondence only; not presented as a paired CBC-marrow observation from the same animal or study group.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2E-CASE-DOG-TOXIC-NEUT", "featured": false, "featured_reason_cn": "NR", "module_id": "neutrophilia", "source_id": "PMC7158316-VETERINARY-HEMATOLOGY", "source_title": "Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic System", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7158316/", "doi": "NR", "pmid": "NR", "pmcid": "PMC7158316", "source_page": "NR", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "犬外周血中性粒细胞毒性改变", "display_title_cn": "犬外周血中性粒细胞毒性改变", "title_en": "Canine peripheral neutrophil toxic change", "factor": "Acute_inflammation_emergency_granulopoiesis", "dose": "NR", "timecourse": "NR", "evidence_role": "Teaching_pattern", "causality_level": "NR", "observation_summary_cn": "犬外周血中性粒细胞毒性改变", "author_conclusion_summary_cn": "教学性模式对应，不声称来自同一动物或同一研究中的CBC—骨髓配对。", "author_conclusion_summary_en": "Teaching correspondence only; not presented as a paired CBC-marrow observation from the same animal or study group.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-006", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "PMC7158316-VETERINARY-HEMATOLOGY", "source_title": "Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic System", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7158316/", "doi": "NR", "pmid": "NR", "pmcid": "PMC7158316", "source_page": "NR", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "犬血涂片网织红细胞增多示例，可作为骨髓红系反应的外周血对照。", "display_title_cn": "犬血涂片网织红细胞增多示例，可作为骨髓红系反应的外周血对照。", "title_en": "Dog: Bone marrow evidence case", "factor": "NR", "dose": "NR", "timecourse": "NR", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "犬血涂片网织红细胞增多示例，可作为骨髓红系反应的外周血对照。", "author_conclusion_summary_cn": "兽医血液学章节中的教学/参考图，用作内部形态学习背景，待专家复核。", "author_conclusion_summary_en": "Teaching/reference image from a veterinary hematology chapter; use as internal morphology context pending expert review.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-007", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "PMC7158316-VETERINARY-HEMATOLOGY", "source_title": "Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic System", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7158316/", "doi": "NR", "pmid": "NR", "pmcid": "PMC7158316", "source_page": "NR", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "犬免疫介导性溶血性贫血血涂片形态，可作为红系反应/溶血背景案例。", "display_title_cn": "犬免疫介导性溶血性贫血血涂片形态，可作为红系反应/溶血背景案例。", "title_en": "Dog: Bone marrow evidence case", "factor": "NR", "dose": "NR", "timecourse": "NR", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "犬免疫介导性溶血性贫血血涂片形态，可作为红系反应/溶血背景案例。", "author_conclusion_summary_cn": "兽医血液学章节中的教学/参考图，用作内部形态学习背景，待专家复核。", "author_conclusion_summary_en": "Teaching/reference image from a veterinary hematology chapter; use as internal morphology context pending expert review.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-008", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "PMC7158316-VETERINARY-HEMATOLOGY", "source_title": "Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic System", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7158316/", "doi": "NR", "pmid": "NR", "pmcid": "PMC7158316", "source_page": "NR", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "犬红细胞常见形态异常复合图，作为红系异常学习对照。", "display_title_cn": "犬红细胞常见形态异常复合图，作为红系异常学习对照。", "title_en": "Dog: Bone marrow evidence case", "factor": "NR", "dose": "NR", "timecourse": "NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬红细胞常见形态异常复合图，作为红系异常学习对照。", "author_conclusion_summary_cn": "兽医血液学章节中的教学/参考图，用作内部形态学习背景，待专家复核。", "author_conclusion_summary_en": "Teaching/reference image from a veterinary hematology chapter; use as internal morphology context pending expert review.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-009", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "PMC7158316-VETERINARY-HEMATOLOGY", "source_title": "Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic System", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7158316/", "doi": "NR", "pmid": "NR", "pmcid": "PMC7158316", "source_page": "NR", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "犬巴贝斯虫病血涂片，可作为红系/溶血相关外周血对照。", "display_title_cn": "犬巴贝斯虫病血涂片，可作为红系/溶血相关外周血对照。", "title_en": "Dog: Bone marrow evidence case", "factor": "NR", "dose": "NR", "timecourse": "NR", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "犬巴贝斯虫病血涂片，可作为红系/溶血相关外周血对照。", "author_conclusion_summary_cn": "兽医血液学章节中的教学/参考图，用作内部形态学习背景，待专家复核。", "author_conclusion_summary_en": "Teaching/reference image from a veterinary hematology chapter; use as internal morphology context pending expert review.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-011", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "SUP-PMC11697499", "source_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_page": "NR", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "犬巨核细胞核分叶异常/低分叶", "display_title_cn": "犬巨核细胞核分叶异常/低分叶", "title_en": "Immature megakaryocyte with abnormal nuclear lobulation and small megakaryocyte with hypolobulated nucleus.", "factor": "NR", "dose": "NR", "timecourse": "NR", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "犬巨核细胞核分叶异常/低分叶", "author_conclusion_summary_cn": "犬巨核细胞核分叶异常/低分叶", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-012", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "SUP-PMC11697499", "source_title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "source_page": "NR", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "犬微巨核细胞，多枚分离核/核未融合", "display_title_cn": "犬微巨核细胞，多枚分离核/核未融合", "title_en": "Micromegakaryocyte approximately 24 µm with multiple widely separated nuclei.", "factor": "NR", "dose": "NR", "timecourse": "NR", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "犬微巨核细胞，多枚分离核/核未融合", "author_conclusion_summary_cn": "犬微巨核细胞，多枚分离核/核未融合", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-013", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "PMC7158316-VETERINARY-HEMATOLOGY", "source_title": "Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic System", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7158316/", "doi": "NR", "pmid": "NR", "pmcid": "PMC7158316", "source_page": "NR", "species": "Dog", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "犬骨髓吸取物巨核细胞：细胞体积大，核分叶，胞质颗粒丰富，Wright染色。", "display_title_cn": "犬骨髓吸取物巨核细胞：细胞体积大，核分叶，胞质颗粒丰富，Wright染色。", "title_en": "Dog: Bone marrow evidence case", "factor": "NR", "dose": "NR", "timecourse": "NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "犬骨髓吸取物巨核细胞：细胞体积大，核分叶，胞质颗粒丰富，Wright染色。", "author_conclusion_summary_cn": "兽医血液学章节中的教学/参考图，用作内部形态学习背景，待专家复核。", "author_conclusion_summary_en": "Teaching/reference image from a veterinary hematology chapter; use as internal morphology context pending expert review.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_001-BM-008", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_001-BM-008", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "22", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Melflufen / Pepaxto；页码 22；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "小鼠：骨髓证据案例（Melflufen / Pepaxto）", "title_en": "Mouse: Bone marrow evidence case associated with Melflufen / Pepaxto", "factor": "Melflufen / Pepaxto", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Melflufen / Pepaxto；页码 22；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_001-BM-018", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_001-BM-018", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "41", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Melflufen / Pepaxto；页码 41；研究类型：unclear；动物：dog; mouse; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "小鼠：骨髓证据案例（Melflufen / Pepaxto）", "title_en": "Mouse: Bone marrow evidence case associated with Melflufen / Pepaxto", "factor": "Melflufen / Pepaxto", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Melflufen / Pepaxto；页码 41；研究类型：unclear；动物：dog; mouse; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_001-BM-024", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_001-BM-024", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "55", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Melflufen / Pepaxto；页码 55；研究类型：unclear；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "小鼠：骨髓证据案例（Melflufen / Pepaxto）", "title_en": "Mouse: Bone marrow evidence case associated with Melflufen / Pepaxto", "factor": "Melflufen / Pepaxto", "dose": "0.63 and 1.26 mg/kg/day; 0.63 mg/kg/day; 1.26 mg/kg/day; 3 mg/kg/day; 0.045 mg/kg/day; 0.09 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Melflufen / Pepaxto；页码 55；研究类型：unclear；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_002-BM-002", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_002-BM-002", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/125268s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "46", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Nplate；页码 46；研究类型：repeat-dose toxicity；动物：monkey; mouse; rabbit; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；巨核细胞：increased。", "display_title_cn": "小鼠：骨髓证据案例（Nplate）", "title_en": "Mouse: Bone marrow evidence case associated with Nplate", "factor": "Nplate", "dose": "1000 mcg/kg; 10 mcg/kg", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Nplate；页码 46；研究类型：repeat-dose toxicity；动物：monkey; mouse; rabbit; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；巨核细胞：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-043", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-043", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "326", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 326；研究类型：carcinogenicity；动物：mouse; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：no change；红系：increased；粒系：increased。", "display_title_cn": "小鼠：骨髓证据案例（Sirturo）", "title_en": "Mouse: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "75 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 326；研究类型：carcinogenicity；动物：mouse; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：no change；红系：increased；粒系：increased。", "author_conclusion_summary_cn": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-049", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-049", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "364", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 364；研究类型：unclear；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；粒系：increased。", "display_title_cn": "小鼠：骨髓证据案例（Sirturo）", "title_en": "Mouse: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 364；研究类型：unclear；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；粒系：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-050", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-050", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "370", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 370；研究类型：unclear；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "小鼠：骨髓证据案例（Sirturo）", "title_en": "Mouse: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "200 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 370；研究类型：unclear；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-055", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-055", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "479", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 479；研究类型：reproductive/developmental toxicity；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "小鼠：骨髓证据案例（Sirturo）", "title_en": "Mouse: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 479；研究类型：reproductive/developmental toxicity；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_007-BM-003", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_007-BM-003", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022277s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "28", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Temodar；页码 28；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "小鼠：骨髓证据案例（Temodar）", "title_en": "Mouse: Bone marrow evidence case associated with Temodar", "factor": "Temodar", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Temodar；页码 28；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_008-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_008-BM-001", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "25", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Zepatier；页码 25；研究类型：unclear；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "小鼠：骨髓证据案例（Zepatier）", "title_en": "Mouse: Bone marrow evidence case associated with Zepatier", "factor": "Zepatier", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Zepatier；页码 25；研究类型：unclear；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_008-BM-013", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_008-BM-013", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "141", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Zepatier；页码 141；研究类型：unclear；动物：dog; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "小鼠：骨髓证据案例（Zepatier）", "title_en": "Mouse: Bone marrow evidence case associated with Zepatier", "factor": "Zepatier", "dose": "100 mg/kg/day; 200 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Zepatier；页码 141；研究类型：unclear；动物：dog; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_009-BM-002", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_009-BM-002", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "16", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 16；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "小鼠：骨髓证据案例（Lynparza）", "title_en": "Mouse: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 16；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_010-BM-003", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_010-BM-003", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "9", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Inrebic；页码 9；研究类型：reproductive/developmental toxicity；动物：mouse; rabbit; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "小鼠：骨髓证据案例（Inrebic）", "title_en": "Mouse: Bone marrow evidence case associated with Inrebic", "factor": "Inrebic", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Inrebic；页码 9；研究类型：reproductive/developmental toxicity；动物：mouse; rabbit; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_010-BM-008", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_010-BM-008", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "59", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Inrebic；页码 59；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "小鼠：骨髓证据案例（Inrebic）", "title_en": "Mouse: Bone marrow evidence case associated with Inrebic", "factor": "Inrebic", "dose": "30 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Inrebic；页码 59；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_010-BM-014", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_010-BM-014", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "77", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Inrebic；页码 77；研究类型：carcinogenicity；动物：mouse; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "小鼠：骨髓证据案例（Inrebic）", "title_en": "Mouse: Bone marrow evidence case associated with Inrebic", "factor": "Inrebic", "dose": "80 mg/kg; 30 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Inrebic；页码 77；研究类型：carcinogenicity；动物：mouse; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_011-BM-003", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_011-BM-003", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022465s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "6", "species": "Mouse", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Votrient；页码 6；研究类型：unclear；动物：mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "小鼠：骨髓证据案例（Votrient）", "title_en": "Mouse: Bone marrow evidence case associated with Votrient", "factor": "Votrient", "dose": "1000 mg/kg/day; 30 mg/kg/day; 100 mg/kg/day; 300 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Votrient；页码 6；研究类型：unclear；动物：mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-EMA_003-BM-007", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/vidaza-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "14", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Vidaza；页码 14；研究类型：unclear；动物：dog; mouse；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "多物种：骨髓证据案例（Vidaza）", "title_en": "Multiple_species: Bone marrow evidence case associated with Vidaza", "factor": "Vidaza", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Vidaza；页码 14；研究类型：unclear；动物：dog; mouse；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Vidaza；页码 14；研究类型：unclear；动物：dog; mouse；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-EMA_004-BM-010", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/dacogen-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "26", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Dacogen；页码 26；研究类型：unclear；动物：dog; monkey; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "多物种：骨髓证据案例（Dacogen）", "title_en": "Multiple_species: Bone marrow evidence case associated with Dacogen", "factor": "Dacogen", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Dacogen；页码 26；研究类型：unclear；动物：dog; monkey; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Dacogen；页码 26；研究类型：unclear；动物：dog; monkey; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-EMA_004-BM-012", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/dacogen-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "28", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Dacogen；页码 28；研究类型：unclear；动物：dog; rabbit; rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "多物种：骨髓证据案例（Dacogen）", "title_en": "Multiple_species: Bone marrow evidence case associated with Dacogen", "factor": "Dacogen", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Dacogen；页码 28；研究类型：unclear；动物：dog; rabbit; rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Dacogen；页码 28；研究类型：unclear；动物：dog; rabbit; rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-EMA_004-BM-015", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/dacogen-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "35", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Dacogen；页码 35；研究类型：repeat-dose toxicity；动物：dog; monkey; rabbit; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "多物种：骨髓证据案例（Dacogen）", "title_en": "Multiple_species: Bone marrow evidence case associated with Dacogen", "factor": "Dacogen", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Dacogen；页码 35；研究类型：repeat-dose toxicity；动物：dog; monkey; rabbit; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Dacogen；页码 35；研究类型：repeat-dose toxicity；动物：dog; monkey; rabbit; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-EMA_004-BM-018", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/dacogen-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "38", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Dacogen；页码 38；研究类型：unclear；动物：dog; monkey; mouse; rabbit; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "多物种：骨髓证据案例（Dacogen）", "title_en": "Multiple_species: Bone marrow evidence case associated with Dacogen", "factor": "Dacogen", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Dacogen；页码 38；研究类型：unclear；动物：dog; monkey; mouse; rabbit; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Dacogen；页码 38；研究类型：unclear；动物：dog; monkey; mouse; rabbit; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-EMA_006-BM-007", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/oxbryta-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "48", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Oxbryta；页码 48；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear；M:E：increased。", "display_title_cn": "多物种：骨髓证据案例（Oxbryta）", "title_en": "Multiple_species: Bone marrow evidence case associated with Oxbryta", "factor": "Oxbryta", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Oxbryta；页码 48；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear；M:E：increased。", "author_conclusion_summary_cn": "Oxbryta；页码 48；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear；M:E：increased。", "author_conclusion_summary_en": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-EMA_006-BM-008", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/oxbryta-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "50", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Oxbryta；页码 50；研究类型：repeat-dose toxicity；动物：dog; monkey; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "display_title_cn": "多物种：骨髓证据案例（Oxbryta）", "title_en": "Multiple_species: Bone marrow evidence case associated with Oxbryta", "factor": "Oxbryta", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Oxbryta；页码 50；研究类型：repeat-dose toxicity；动物：dog; monkey; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "author_conclusion_summary_cn": "Oxbryta；页码 50；研究类型：repeat-dose toxicity；动物：dog; monkey; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-EMA_009-BM-003", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/revolade-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "20", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Revolade；页码 20；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "多物种：骨髓证据案例（Revolade）", "title_en": "Multiple_species: Bone marrow evidence case associated with Revolade", "factor": "Revolade", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Revolade；页码 20；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "Revolade；页码 20；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-EMA_009-BM-009", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/revolade-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "76", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Revolade；页码 76；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "display_title_cn": "多物种：骨髓证据案例（Revolade）", "title_en": "Multiple_species: Bone marrow evidence case associated with Revolade", "factor": "Revolade", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Revolade；页码 76；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "author_conclusion_summary_cn": "Revolade；页码 76；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-EMA_010-BM-009", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/vanflyta-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "29", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Vanflyta；页码 29；研究类型：juvenile toxicity；动物：dog; monkey; mouse; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "多物种：骨髓证据案例（Vanflyta）", "title_en": "Multiple_species: Bone marrow evidence case associated with Vanflyta", "factor": "Vanflyta", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Vanflyta；页码 29；研究类型：juvenile toxicity；动物：dog; monkey; mouse; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Vanflyta；页码 29；研究类型：juvenile toxicity；动物：dog; monkey; mouse; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-EMA_010-BM-011", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/vanflyta-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "33", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Vanflyta；页码 33；研究类型：repeat-dose toxicity；动物：dog; monkey; rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "多物种：骨髓证据案例（Vanflyta）", "title_en": "Multiple_species: Bone marrow evidence case associated with Vanflyta", "factor": "Vanflyta", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Vanflyta；页码 33；研究类型：repeat-dose toxicity；动物：dog; monkey; rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Vanflyta；页码 33；研究类型：repeat-dose toxicity；动物：dog; monkey; rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_001-BM-008", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-214120", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "22", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Melflufen / Pepaxto；页码 22；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "多物种：骨髓证据案例（Melflufen / Pepaxto）", "title_en": "Multiple_species: Bone marrow evidence case associated with Melflufen / Pepaxto", "factor": "Melflufen / Pepaxto", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Melflufen / Pepaxto；页码 22；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Melflufen / Pepaxto；页码 22；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_007-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-22277", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022277s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "23", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Temodar；页码 23；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "多物种：骨髓证据案例（Temodar）", "title_en": "Multiple_species: Bone marrow evidence case associated with Temodar", "factor": "Temodar", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Temodar；页码 23；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Temodar；页码 23；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_007-BM-003", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-22277", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022277s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "28", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Temodar；页码 28；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "多物种：骨髓证据案例（Temodar）", "title_en": "Multiple_species: Bone marrow evidence case associated with Temodar", "factor": "Temodar", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Temodar；页码 28；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Temodar；页码 28；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_008-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-208261", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "25", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Zepatier；页码 25；研究类型：unclear；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "多物种：骨髓证据案例（Zepatier）", "title_en": "Multiple_species: Bone marrow evidence case associated with Zepatier", "factor": "Zepatier", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Zepatier；页码 25；研究类型：unclear；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "Zepatier；页码 25；研究类型：unclear；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_008-BM-005", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-208261", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "52", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Zepatier；页码 52；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "多物种：骨髓证据案例（Zepatier）", "title_en": "Multiple_species: Bone marrow evidence case associated with Zepatier", "factor": "Zepatier", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Zepatier；页码 52；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Zepatier；页码 52；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_008-BM-013", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-208261", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "141", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Zepatier；页码 141；研究类型：unclear；动物：dog; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "多物种：骨髓证据案例（Zepatier）", "title_en": "Multiple_species: Bone marrow evidence case associated with Zepatier", "factor": "Zepatier", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Zepatier；页码 141；研究类型：unclear；动物：dog; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "Zepatier；页码 141；研究类型：unclear；动物：dog; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_009-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "5", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 5；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "多物种：骨髓证据案例（Lynparza）", "title_en": "Multiple_species: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 5；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Lynparza；页码 5；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_009-BM-002", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "16", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 16；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "多物种：骨髓证据案例（Lynparza）", "title_en": "Multiple_species: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 16；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Lynparza；页码 16；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_009-BM-021", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "138", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 138；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "多物种：骨髓证据案例（Lynparza）", "title_en": "Multiple_species: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 138；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Lynparza；页码 138；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_010-BM-002", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-212327", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "8", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Inrebic；页码 8；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "多物种：骨髓证据案例（Inrebic）", "title_en": "Multiple_species: Bone marrow evidence case associated with Inrebic", "factor": "Inrebic", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Inrebic；页码 8；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "Inrebic；页码 8；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_010-BM-008", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-212327", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "59", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Inrebic；页码 59；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "多物种：骨髓证据案例（Inrebic）", "title_en": "Multiple_species: Bone marrow evidence case associated with Inrebic", "factor": "Inrebic", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Inrebic；页码 59；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "Inrebic；页码 59；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_012-BM-005", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-208065", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/208065Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "133", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Tagrisso；页码 133；研究类型：genotoxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "多物种：骨髓证据案例（Tagrisso）", "title_en": "Multiple_species: Bone marrow evidence case associated with Tagrisso", "factor": "Tagrisso", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Tagrisso；页码 133；研究类型：genotoxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "Tagrisso；页码 133；研究类型：genotoxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_015-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-203971", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "4", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Xofigo；页码 4；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear；粒系：mixed/unclear。", "display_title_cn": "多物种：骨髓证据案例（Xofigo）", "title_en": "Multiple_species: Bone marrow evidence case associated with Xofigo", "factor": "Xofigo", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Xofigo；页码 4；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear；粒系：mixed/unclear。", "author_conclusion_summary_cn": "Xofigo；页码 4；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear；粒系：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_015-BM-005", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-203971", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "92", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Xofigo；页码 92；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "多物种：骨髓证据案例（Xofigo）", "title_en": "Multiple_species: Bone marrow evidence case associated with Xofigo", "factor": "Xofigo", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Xofigo；页码 92；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Xofigo；页码 92；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_015-BM-017", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-203971", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "140", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Xofigo；页码 140；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased；M:E：decreased。", "display_title_cn": "多物种：骨髓证据案例（Xofigo）", "title_en": "Multiple_species: Bone marrow evidence case associated with Xofigo", "factor": "Xofigo", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Xofigo；页码 140；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased；M:E：decreased。", "author_conclusion_summary_cn": "Xofigo；页码 140；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased；M:E：decreased。", "author_conclusion_summary_en": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_015-BM-018", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-203971", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "141", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Xofigo；页码 141；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "多物种：骨髓证据案例（Xofigo）", "title_en": "Multiple_species: Bone marrow evidence case associated with Xofigo", "factor": "Xofigo", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Xofigo；页码 141；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Xofigo；页码 141；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_020-BM-010", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-214783", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2021/214783Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "56", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Rezurock；页码 56；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "多物种：骨髓证据案例（Rezurock）", "title_en": "Multiple_species: Bone marrow evidence case associated with Rezurock", "factor": "Rezurock", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Rezurock；页码 56；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Rezurock；页码 56；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-FDA_022-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "FDA-211810", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/211810Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "39", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Turalio；页码 39；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "多物种：骨髓证据案例（Turalio）", "title_en": "Multiple_species: Bone marrow evidence case associated with Turalio", "factor": "Turalio", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Turalio；页码 39；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Turalio；页码 39；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2A-CASE-NTP_002-BM-011", "featured": false, "featured_reason_cn": "NR", "module_id": "canine", "source_id": "NTP-", "source_title": "Toxicity Report", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox050.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "39", "species": "Multiple_species", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Cyclohexanone oxime；页码 39；研究类型：unclear；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased。", "display_title_cn": "多物种：骨髓证据案例（Cyclohexanone oxime）", "title_en": "Multiple_species: Bone marrow evidence case associated with Cyclohexanone oxime", "factor": "Cyclohexanone oxime", "dose": "NR", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Cyclohexanone oxime；页码 39；研究类型：unclear；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased。", "author_conclusion_summary_cn": "Cyclohexanone oxime；页码 39；研究类型：unclear；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_002-BM-003", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_002-BM-003", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/125268s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "50", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Nplate；页码 50；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased。", "display_title_cn": "大鼠：骨髓证据案例（Nplate）", "title_en": "Rat: Bone marrow evidence case associated with Nplate", "factor": "Nplate", "dose": "100 mcg/kg", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Nplate；页码 50；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-001", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "14", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 14；研究类型：single-dose/acute toxicity；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：increased。", "display_title_cn": "大鼠：骨髓证据案例（Sirturo）", "title_en": "Rat: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "100 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 14；研究类型：single-dose/acute toxicity；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-002", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-002", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "15", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 15；研究类型：repeat-dose toxicity；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "大鼠：骨髓证据案例（Sirturo）", "title_en": "Rat: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "0.5, 2 and 10 mg/kg/day; 5 mg/kg; 2 mg/kg/day; 1 mg/kg", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 15；研究类型：repeat-dose toxicity；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-011", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-011", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "140", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 140；研究类型：unclear；动物：rat；骨髓评价类型：smear/cytology；骨髓细胞量/造血细胞：decreased；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "display_title_cn": "大鼠：骨髓证据案例（Sirturo）", "title_en": "Rat: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "1000 mg/kg/day; 100 mg/kg/day; 10 mg/kg/day; 300 and 1000 mg/kg/day; 30 mg/kg", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 140；研究类型：unclear；动物：rat；骨髓评价类型：smear/cytology；骨髓细胞量/造血细胞：decreased；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "author_conclusion_summary_cn": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-012", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-012", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "142", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 142；研究类型：unclear；动物：rat；骨髓评价类型：unclear；红系：mixed/unclear。", "display_title_cn": "大鼠：骨髓证据案例（Sirturo）", "title_en": "Rat: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "1000 mg/kg/day; 10 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 142；研究类型：unclear；动物：rat；骨髓评价类型：unclear；红系：mixed/unclear。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-016", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-016", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "151", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 151；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "大鼠：骨髓证据案例（Sirturo）", "title_en": "Rat: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "100 mg/kg; 1 and 10 mg/kg/day; 100 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 151；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-021", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-021", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "181", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 181；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "大鼠：骨髓证据案例（Sirturo）", "title_en": "Rat: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "100 mg/kg/day; 10 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 181；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-042", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-042", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "304", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 304；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：increased。", "display_title_cn": "大鼠：骨髓证据案例（Sirturo）", "title_en": "Rat: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 304；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：increased。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-045", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-045", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "349", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 349；研究类型：unclear；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "大鼠：骨髓证据案例（Sirturo）", "title_en": "Rat: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 349；研究类型：unclear；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-053", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-053", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "471", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 471；研究类型：unclear；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "display_title_cn": "大鼠：骨髓证据案例（Sirturo）", "title_en": "Rat: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "100 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 471；研究类型：unclear；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-056", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-056", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "507", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 507；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "大鼠：骨髓证据案例（Sirturo）", "title_en": "Rat: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "10 mg/kg", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 507；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-057", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-057", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "520", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 520；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "display_title_cn": "大鼠：骨髓证据案例（Sirturo）", "title_en": "Rat: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "1 mg/kg; 10 mg/kg; 10 mg/kg/day; 1 mg/kg/day; 100 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 520；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-058", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-058", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "521", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 521；研究类型：unclear；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；粒系：decreased。", "display_title_cn": "大鼠：骨髓证据案例（Sirturo）", "title_en": "Rat: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "1 mg/kg/day; 100 mg/kg/day; 10 mg/kg/day; 50 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 521；研究类型：unclear；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；粒系：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_003-BM-060", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_003-BM-060", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "523", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Sirturo；页码 523；研究类型：repeat-dose toxicity；动物：monkey; rat；骨髓评价类型：smear/cytology；红系：no change。", "display_title_cn": "大鼠：骨髓证据案例（Sirturo）", "title_en": "Rat: Bone marrow evidence case associated with Sirturo", "factor": "Sirturo", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Sirturo；页码 523；研究类型：repeat-dose toxicity；动物：monkey; rat；骨髓评价类型：smear/cytology；红系：no change。", "author_conclusion_summary_cn": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_007-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_007-BM-001", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022277s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "23", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Temodar；页码 23；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "大鼠：骨髓证据案例（Temodar）", "title_en": "Rat: Bone marrow evidence case associated with Temodar", "factor": "Temodar", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Temodar；页码 23；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_007-BM-006", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_007-BM-006", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022277s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "41", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Temodar；页码 41；研究类型：unclear；动物：rat；骨髓评价类型：both；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "大鼠：骨髓证据案例（Temodar）", "title_en": "Rat: Bone marrow evidence case associated with Temodar", "factor": "Temodar", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Temodar；页码 41；研究类型：unclear；动物：rat；骨髓评价类型：both；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_008-BM-004", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_008-BM-004", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "40", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Zepatier；页码 40；研究类型：unclear；动物：rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "大鼠：骨髓证据案例（Zepatier）", "title_en": "Rat: Bone marrow evidence case associated with Zepatier", "factor": "Zepatier", "dose": "30 mg/kg", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Zepatier；页码 40；研究类型：unclear；动物：rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_008-BM-011", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_008-BM-011", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "100", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Zepatier；页码 100；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：no change。", "display_title_cn": "大鼠：骨髓证据案例（Zepatier）", "title_en": "Rat: Bone marrow evidence case associated with Zepatier", "factor": "Zepatier", "dose": "200 mg/kg; 0, 50 mg/kg/day; 0, 50, 200 mg/kg/day; 0.6 and 1.6 mg/kg", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Zepatier；页码 100；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：no change。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_009-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_009-BM-001", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "5", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 5；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "大鼠：骨髓证据案例（Lynparza）", "title_en": "Rat: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 5；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_009-BM-006", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_009-BM-006", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "77", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 77；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：no change。", "display_title_cn": "大鼠：骨髓证据案例（Lynparza）", "title_en": "Rat: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "15 mg/kg/day; 40 mg/kg/day; 40 mg/kg", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 77；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：no change。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_009-BM-007", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_009-BM-007", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "78", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 78；研究类型：unclear；动物：rat；骨髓评价类型：both；骨髓细胞量/造血细胞：increased；红系：mixed/unclear。", "display_title_cn": "大鼠：骨髓证据案例（Lynparza）", "title_en": "Rat: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "0 mg/kg; 5 mg/kg; 15 mg/kg; 40 mg/kg", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 78；研究类型：unclear；动物：rat；骨髓评价类型：both；骨髓细胞量/造血细胞：increased；红系：mixed/unclear。", "author_conclusion_summary_cn": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_009-BM-019", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_009-BM-019", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "115", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 115；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "大鼠：骨髓证据案例（Lynparza）", "title_en": "Rat: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 115；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_009-BM-021", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_009-BM-021", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "138", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Lynparza；页码 138；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "大鼠：骨髓证据案例（Lynparza）", "title_en": "Rat: Bone marrow evidence case associated with Lynparza", "factor": "Lynparza", "dose": "2.5 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Lynparza；页码 138；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_010-BM-002", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_010-BM-002", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "8", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Inrebic；页码 8；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "大鼠：骨髓证据案例（Inrebic）", "title_en": "Rat: Bone marrow evidence case associated with Inrebic", "factor": "Inrebic", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Inrebic；页码 8；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_010-BM-010", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_010-BM-010", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "68", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Inrebic；页码 68；研究类型：unclear；动物：rabbit; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "大鼠：骨髓证据案例（Inrebic）", "title_en": "Rat: Bone marrow evidence case associated with Inrebic", "factor": "Inrebic", "dose": "10 mg/kg; 30 mg/kg", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Inrebic；页码 68；研究类型：unclear；动物：rabbit; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_011-BM-004", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_011-BM-004", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022465s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "14", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Votrient；页码 14；研究类型：genotoxicity；动物：monkey; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "大鼠：骨髓证据案例（Votrient）", "title_en": "Rat: Bone marrow evidence case associated with Votrient", "factor": "Votrient", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Votrient；页码 14；研究类型：genotoxicity；动物：monkey; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_011-BM-017", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_011-BM-017", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022465s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "202", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Votrient；页码 202；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "大鼠：骨髓证据案例（Votrient）", "title_en": "Rat: Bone marrow evidence case associated with Votrient", "factor": "Votrient", "dose": "unclear", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Votrient；页码 202；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "HP-CASE-FDA_011-BM-018", "featured": false, "featured_reason_cn": "NR", "module_id": "high_power", "source_id": "FDA_011-BM-018", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022465s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "203", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Votrient；页码 203；研究类型：unclear；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "大鼠：骨髓证据案例（Votrient）", "title_en": "Rat: Bone marrow evidence case associated with Votrient", "factor": "Votrient", "dose": "2000 mg/kg/day", "timecourse": "NR", "evidence_role": "NR", "causality_level": "NR", "observation_summary_cn": "Votrient；页码 203；研究类型：unclear；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-013", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "NTP-BONE-MARROW-HYPERCELLULARITY", "source_title": "Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "NR", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "同期对照F344雌性大鼠骨髓切片，用于评价红系细胞密度与M:E背景。", "display_title_cn": "大鼠：骨髓证据案例（Reactive_or_proliferative_change）", "title_en": "Bone marrow in a control female F344 rat from a subchronic study.", "factor": "Reactive_or_proliferative_change", "dose": "NR", "timecourse": "NR", "evidence_role": "Normal_comparator", "causality_level": "Treatment_associated", "observation_summary_cn": "同期对照F344雌性大鼠骨髓切片，用于评价红系细胞密度与M:E背景。", "author_conclusion_summary_cn": "NTP hypercellularity lesion.", "author_conclusion_summary_en": "Bone marrow in a control female F344 rat from a subchronic study.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-HYPER-F01" ], "pathology_evidence_count": 1, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-HYPER-F01", "title_cn": "对照大鼠骨髓细胞量（低倍）", "title_en": "Control rat bone marrow cellularity, low power", "figure_label": "Figure 1", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-014", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "NTP-BONE-MARROW-HYPERCELLULARITY", "source_title": "Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "NR", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "处理组F344/N雌性大鼠骨髓；原图注明与同期对照相比，为处理相关贫血反应中的红系细胞增多。", "display_title_cn": "处理组F344/N雌性大鼠骨髓；原图注明与同期对照相比，为处理相关贫血反应中的红系细胞增多。", "title_en": "Bone marrow in a treated female F344/N rat from a subchronic study. Compared with the concurrent control (Figure 1), there is erythroid hypercellularity in response to a treatment-related anemia.", "factor": "Reactive_or_proliferative_change", "dose": "NR", "timecourse": "NR", "evidence_role": "Toxicity_image", "causality_level": "Treatment_associated", "observation_summary_cn": "处理组F344/N雌性大鼠骨髓；原图注明与同期对照相比，为处理相关贫血反应中的红系细胞增多。", "author_conclusion_summary_cn": "NTP hypercellularity lesion.", "author_conclusion_summary_en": "Bone marrow in a treated female F344/N rat from a subchronic study. Compared with the concurrent control (Figure 1), there is erythroid hypercellularity in response to a treatment-related anemia.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-HYPER-F02" ], "pathology_evidence_count": 1, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-HYPER-F02", "title_cn": "处理相关贫血后的红系高细胞性（大鼠，低倍）", "title_en": "Erythroid hypercellularity after treatment-related anemia in rat, low power", "figure_label": "Figure 2", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-015", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "NTP-BONE-MARROW-HYPERCELLULARITY", "source_title": "Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "NR", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Figure 1同期对照的高倍视野，用于与处理组红系增多进行成对比较。", "display_title_cn": "Figure 1同期对照的高倍视野，用于与处理组红系增多进行成对比较。", "title_en": "Bone marrow in a control female F344/N rat from a subchronic study (higher magnification of Figure 1).", "factor": "Reactive_or_proliferative_change", "dose": "NR", "timecourse": "NR", "evidence_role": "Normal_comparator", "causality_level": "Treatment_associated", "observation_summary_cn": "Figure 1同期对照的高倍视野，用于与处理组红系增多进行成对比较。", "author_conclusion_summary_cn": "NTP hypercellularity lesion.", "author_conclusion_summary_en": "Bone marrow in a control female F344/N rat from a subchronic study (higher magnification of Figure 1).", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-HYPER-F03" ], "pathology_evidence_count": 1, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-HYPER-F03", "title_cn": "对照大鼠骨髓细胞量（高倍）", "title_en": "Control rat bone marrow cellularity, higher magnification", "figure_label": "Figure 3", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-016", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "NTP-BONE-MARROW-HYPERCELLULARITY", "source_title": "Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "NR", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "Figure 2处理组的高倍视野；原图注明与Figure 3相比可见红系细胞增多。", "display_title_cn": "Figure 2处理组的高倍视野；原图注明与Figure 3相比可见红系细胞增多。", "title_en": "Rat: Bone marrow evidence case associated with Reactive_or_proliferative_change", "factor": "Reactive_or_proliferative_change", "dose": "NR", "timecourse": "NR", "evidence_role": "Toxicity_image", "causality_level": "Treatment_associated", "observation_summary_cn": "Figure 2处理组的高倍视野；原图注明与Figure 3相比可见红系细胞增多。", "author_conclusion_summary_cn": "NTP hypercellularity lesion.", "author_conclusion_summary_en": "Bone marrow in a treated female F344/N rat from a subchronic study (higher magnification of Figure 2). Compared with the concurrent control (Figure 3), there is erythroid hypercellularity in response to a treatment-related anemia.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Pathology_evidence_routed", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [ "BM-NTP-HYPER-F04" ], "pathology_evidence_count": 1, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [ { "image_id": "BM-NTP-HYPER-F04", "title_cn": "处理相关贫血后的红系高细胞性（大鼠，高倍）", "title_en": "Erythroid hypercellularity after treatment-related anemia in rat, higher magnification", "figure_label": "Figure 4", "specimen_type": "Histology_HE", "source_url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "expert_review_status": "Pending" } ], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-005", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "LEGACY-RPBM-001", "source_title": "Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9181531/", "doi": "10.3390/ijms23116290", "pmid": "35682967", "pmcid": "PMC9181531", "source_page": "NR", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "大鼠骨髓洗脱物：卡铂处理后巨核细胞减少的形态对照", "display_title_cn": "大鼠骨髓洗脱物：卡铂处理后巨核细胞减少的形态对照", "title_en": "Bone marrow washout from control and carboplatin-treated rats after fixation and Liu staining.", "factor": "Toxicity_context_author_reported", "dose": "NR", "timecourse": "NR", "evidence_role": "Toxicity_image", "causality_level": "Treatment_associated", "observation_summary_cn": "大鼠骨髓洗脱物：卡铂处理后巨核细胞减少的形态对照", "author_conclusion_summary_cn": "大鼠骨髓洗脱物：卡铂处理后巨核细胞减少的形态对照", "author_conclusion_summary_en": "Bone marrow washout from control and carboplatin-treated rats after fixation and Liu staining.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-006", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "LEGACY-RPBM-001", "source_title": "Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9181531/", "doi": "10.3390/ijms23116290", "pmid": "35682967", "pmcid": "PMC9181531", "source_page": "NR", "species": "Rat", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "大鼠骨髓巨核细胞JAK2信号下降示例", "display_title_cn": "大鼠骨髓巨核细胞JAK2信号下降示例", "title_en": "JAK2 expression in bone marrow sections from control and carboplatin-treated rats.", "factor": "Toxicity_context_author_reported", "dose": "NR", "timecourse": "NR", "evidence_role": "Toxicity_image", "causality_level": "Treatment_associated", "observation_summary_cn": "大鼠骨髓巨核细胞JAK2信号下降示例", "author_conclusion_summary_cn": "大鼠骨髓巨核细胞JAK2信号下降示例", "author_conclusion_summary_en": "JAK2 expression in bone marrow sections from control and carboplatin-treated rats.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-010", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "PMC10699128-RHESUS-EBOV-ERYTHROID", "source_title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "source_page": "NR", "species": "Rhesus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "埃博拉病毒病过程中CD71阳性红系细胞减少；panel A。", "display_title_cn": "埃博拉病毒病过程中CD71阳性红系细胞减少；panel A。", "title_en": "Rhesus_monkey: Bone marrow evidence case associated with Ebolavirus infection", "factor": "Ebolavirus infection", "dose": "NR", "timecourse": "Caption-defined", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "埃博拉病毒病过程中CD71阳性红系细胞减少；panel A。", "author_conclusion_summary_cn": "埃博拉病毒病过程中CD71阳性红系细胞减少；panel A。", "author_conclusion_summary_en": "Loss of CD71-positive erythroid cells during Ebolavirus disease; panel A.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-011", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "PMC10699128-RHESUS-EBOV-ERYTHROID", "source_title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "source_page": "NR", "species": "Rhesus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "埃博拉病毒病过程中CD71阳性红系细胞减少；panel B。", "display_title_cn": "埃博拉病毒病过程中CD71阳性红系细胞减少；panel B。", "title_en": "Rhesus_monkey: Bone marrow evidence case associated with Ebolavirus infection", "factor": "Ebolavirus infection", "dose": "NR", "timecourse": "Caption-defined", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "埃博拉病毒病过程中CD71阳性红系细胞减少；panel B。", "author_conclusion_summary_cn": "埃博拉病毒病过程中CD71阳性红系细胞减少；panel B。", "author_conclusion_summary_en": "Loss of CD71-positive erythroid cells during Ebolavirus disease; panel B.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ER-CASE-012", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "PMC10699128-RHESUS-EBOV-ERYTHROID", "source_title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "source_page": "NR", "species": "Rhesus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "埃博拉病毒病过程中CD71阳性红系细胞减少；panel C。", "display_title_cn": "埃博拉病毒病过程中CD71阳性红系细胞减少；panel C。", "title_en": "Rhesus_monkey: Bone marrow evidence case associated with Ebolavirus infection", "factor": "Ebolavirus infection", "dose": "NR", "timecourse": "Caption-defined", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "埃博拉病毒病过程中CD71阳性红系细胞减少；panel C。", "author_conclusion_summary_cn": "埃博拉病毒病过程中CD71阳性红系细胞减少；panel C。", "author_conclusion_summary_en": "Loss of CD71-positive erythroid cells during Ebolavirus disease; panel C.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-014", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "PMC10699128-RHESUS-EBOV-MEGAKARYOCYTES", "source_title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "source_page": "NR", "species": "Rhesus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel A。", "display_title_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel A。", "title_en": "Rhesus_monkey: Bone marrow evidence case associated with Ebolavirus infection", "factor": "Ebolavirus infection", "dose": "NR", "timecourse": "Caption-defined", "evidence_role": "Background_comparator", "causality_level": "Differential_only", "observation_summary_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel A。", "author_conclusion_summary_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel A。", "author_conclusion_summary_en": "EBOV-associated megakaryocyte infection and injury; panel A.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-015", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "PMC10699128-RHESUS-EBOV-MEGAKARYOCYTES", "source_title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "source_page": "NR", "species": "Rhesus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel B。", "display_title_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel B。", "title_en": "Rhesus_monkey: Bone marrow evidence case associated with Ebolavirus infection", "factor": "Ebolavirus infection", "dose": "NR", "timecourse": "Caption-defined", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel B。", "author_conclusion_summary_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel B。", "author_conclusion_summary_en": "EBOV-associated megakaryocyte infection and injury; panel B.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-016", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "PMC10699128-RHESUS-EBOV-MEGAKARYOCYTES", "source_title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "source_page": "NR", "species": "Rhesus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel C。", "display_title_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel C。", "title_en": "Rhesus_monkey: Bone marrow evidence case associated with Ebolavirus infection", "factor": "Ebolavirus infection", "dose": "NR", "timecourse": "Caption-defined", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel C。", "author_conclusion_summary_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel C。", "author_conclusion_summary_en": "EBOV-associated megakaryocyte infection and injury; panel C.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-017", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "PMC10699128-RHESUS-EBOV-MEGAKARYOCYTES", "source_title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "source_page": "NR", "species": "Rhesus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel D。", "display_title_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel D。", "title_en": "Rhesus_monkey: Bone marrow evidence case associated with Ebolavirus infection", "factor": "Ebolavirus infection", "dose": "NR", "timecourse": "Caption-defined", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel D。", "author_conclusion_summary_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel D。", "author_conclusion_summary_en": "EBOV-associated megakaryocyte infection and injury; panel D.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-018", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "PMC10699128-RHESUS-EBOV-MEGAKARYOCYTES", "source_title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "source_page": "NR", "species": "Rhesus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel E。", "display_title_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel E。", "title_en": "Rhesus_monkey: Bone marrow evidence case associated with Ebolavirus infection", "factor": "Ebolavirus infection", "dose": "NR", "timecourse": "Caption-defined", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel E。", "author_conclusion_summary_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel E。", "author_conclusion_summary_en": "EBOV-associated megakaryocyte infection and injury; panel E.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2F-ME-CASE-019", "featured": false, "featured_reason_cn": "NR", "module_id": "lineage", "source_id": "PMC10699128-RHESUS-EBOV-MEGAKARYOCYTES", "source_title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "source_page": "NR", "species": "Rhesus_monkey", "toxicity_type": "NR", "toxicity_title_cn": "NR", "toxicity_title_en": "NR", "title_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel F。", "display_title_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel F。", "title_en": "Rhesus_monkey: Bone marrow evidence case associated with Ebolavirus infection", "factor": "Ebolavirus infection", "dose": "NR", "timecourse": "Caption-defined", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel F。", "author_conclusion_summary_cn": "埃博拉病毒病相关巨核细胞感染与损伤；panel F。", "author_conclusion_summary_en": "EBOV-associated megakaryocyte infection and injury; panel F.", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Source_reports_image_not_republished", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_008-BM-005", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-208261", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "52", "species": "Dog", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "Zepatier；页码 52；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "犬：骨髓低细胞性、全系减少和再生障碍（Zepatier）", "title_en": "Dog: Hypocellularity, pancytopenia and aplasia associated with Zepatier", "factor": "Zepatier", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Zepatier；页码 52；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Zepatier；页码 52；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_009-BM-016", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "98", "species": "Dog", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "Lynparza；页码 98；研究类型：unclear；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "display_title_cn": "犬：骨髓低细胞性、全系减少和再生障碍（Lynparza）", "title_en": "Dog: Hypocellularity, pancytopenia and aplasia associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 98；研究类型：unclear；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "author_conclusion_summary_cn": "Lynparza；页码 98；研究类型：unclear；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "author_conclusion_summary_en": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_010-BM-002", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-212327", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "8", "species": "Dog", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "Inrebic；页码 8；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "犬：骨髓低细胞性、全系减少和再生障碍（Inrebic）", "title_en": "Dog: Hypocellularity, pancytopenia and aplasia associated with Inrebic", "factor": "Inrebic", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Inrebic；页码 8；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "Inrebic；页码 8；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_013-BM-023", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-214200", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214200Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "59", "species": "Dog", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "Cosela；页码 59；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "犬：骨髓低细胞性、全系减少和再生障碍（Cosela）", "title_en": "Dog: Hypocellularity, pancytopenia and aplasia associated with Cosela", "factor": "Cosela", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Cosela；页码 59；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "Cosela；页码 59；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_015-BM-018", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-203971", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "141", "species": "Dog", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "Xofigo；页码 141；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "犬：骨髓低细胞性、全系减少和再生障碍（Xofigo）", "title_en": "Dog: Hypocellularity, pancytopenia and aplasia associated with Xofigo", "factor": "Xofigo", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Xofigo；页码 141；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Xofigo；页码 141；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_022-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-211810", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/211810Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "39", "species": "Dog", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "Turalio；页码 39；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "犬：骨髓低细胞性、全系减少和再生障碍（Turalio）", "title_en": "Dog: Hypocellularity, pancytopenia and aplasia associated with Turalio", "factor": "Turalio", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Turalio；页码 39；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Turalio；页码 39；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "AUTH-CASE-PMC8005067", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_library", "source_id": "AUTH-PMC8005067", "source_title": "Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8005067/", "doi": "10.3390/ijms22063286", "pmid": "33807089", "pmcid": "PMC8005067", "source_page": "NR", "species": "Minipig", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "权威候选来源记录：Marrow hypocellularity described in histopathology。具体图像与处理相关性仍需逐图专家复核。", "display_title_cn": "权威候选来源记录：Marrow hypocellularity described in histopathology。具体图像与处理相关性仍需逐图专家复核。", "title_en": "Marrow hypocellularity described in histopathology", "factor": "Case evidence pending morphology image", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "权威候选来源记录：Marrow hypocellularity described in histopathology。具体图像与处理相关性仍需逐图专家复核。", "author_conclusion_summary_cn": "NR", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "AUTH-CASE-PMC8844892", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_library", "source_id": "AUTH-PMC8844892", "source_title": "Gene Expression Profiles from Heart, Lung and Liver Samples of Total-Body-Irradiated Minipigs: Implications for Predicting Radiation-Induced Tissue Toxicity", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8844892/", "doi": "10.1667/RADE-20-00123.1", "pmid": "32936898", "pmcid": "PMC8844892", "source_page": "NR", "species": "Minipig", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "权威候选来源记录：Diffuse hypocellular marrow described in text。具体图像与处理相关性仍需逐图专家复核。", "display_title_cn": "权威候选来源记录：Diffuse hypocellular marrow described in text。具体图像与处理相关性仍需逐图专家复核。", "title_en": "Diffuse hypocellular marrow described in text", "factor": "Case evidence only", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "权威候选来源记录：Diffuse hypocellular marrow described in text。具体图像与处理相关性仍需逐图专家复核。", "author_conclusion_summary_cn": "NR", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_001-BM-018", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_001-BM-018", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "41", "species": "Mouse", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "Melflufen / Pepaxto；页码 41；研究类型：unclear；动物：dog; mouse; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "小鼠：骨髓低细胞性、全系减少和再生障碍（Melflufen / Pepaxto）", "title_en": "Mouse: Hypocellularity, pancytopenia and aplasia associated with Melflufen / Pepaxto", "factor": "Melflufen / Pepaxto", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Melflufen / Pepaxto；页码 41；研究类型：unclear；动物：dog; mouse; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-055", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-055", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "479", "species": "Mouse", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "Sirturo；页码 479；研究类型：reproductive/developmental toxicity；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "小鼠：骨髓低细胞性、全系减少和再生障碍（Sirturo）", "title_en": "Mouse: Hypocellularity, pancytopenia and aplasia associated with Sirturo", "factor": "Sirturo", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 479；研究类型：reproductive/developmental toxicity；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-042", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-042", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "304", "species": "Rat", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "Sirturo；页码 304；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：increased。", "display_title_cn": "大鼠：骨髓低细胞性、全系减少和再生障碍（Sirturo）", "title_en": "Rat: Hypocellularity, pancytopenia and aplasia associated with Sirturo", "factor": "Sirturo", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 304；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：increased。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_008-BM-011", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_008-BM-011", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "100", "species": "Rat", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "Zepatier；页码 100；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：no change。", "display_title_cn": "大鼠：骨髓低细胞性、全系减少和再生障碍（Zepatier）", "title_en": "Rat: Hypocellularity, pancytopenia and aplasia associated with Zepatier", "factor": "Zepatier", "dose": "200 mg/kg; 0, 50 mg/kg/day; 0, 50, 200 mg/kg/day; 0.6 and 1.6 mg/kg", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Zepatier；页码 100；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：no change。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_009-BM-019", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_009-BM-019", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "115", "species": "Rat", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "Lynparza；页码 115；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "大鼠：骨髓低细胞性、全系减少和再生障碍（Lynparza）", "title_en": "Rat: Hypocellularity, pancytopenia and aplasia associated with Lynparza", "factor": "Lynparza", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 115；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_010-BM-002", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_010-BM-002", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "8", "species": "Rat", "toxicity_type": "T01", "toxicity_title_cn": "骨髓低细胞性、全系减少和再生障碍", "toxicity_title_en": "Hypocellularity, pancytopenia and aplasia", "title_cn": "Inrebic；页码 8；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "大鼠：骨髓低细胞性、全系减少和再生障碍（Inrebic）", "title_en": "Rat: Hypocellularity, pancytopenia and aplasia associated with Inrebic", "factor": "Inrebic", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Inrebic；页码 8；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-035", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-035", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "253", "species": "Cynomolgus_monkey", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Sirturo；页码 253；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "食蟹猴：红系、粒系或巨核系选择性减少（Sirturo）", "title_en": "Cynomolgus_monkey: Selective erythroid, myeloid or megakaryocytic decrease associated with Sirturo", "factor": "Sirturo", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 253；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-059", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-059", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "522", "species": "Cynomolgus_monkey", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Sirturo；页码 522；研究类型：unclear；动物：monkey；骨髓评价类型：both；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "食蟹猴：红系、粒系或巨核系选择性减少（Sirturo）", "title_en": "Cynomolgus_monkey: Selective erythroid, myeloid or megakaryocytic decrease associated with Sirturo", "factor": "Sirturo", "dose": "10 mg/kg/day; 0.5 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 522；研究类型：unclear；动物：monkey；骨髓评价类型：both；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_001-BM-019", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_001-BM-019", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "42", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Melflufen / Pepaxto；页码 42；研究类型：unclear；动物：dog；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Melflufen / Pepaxto）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Melflufen / Pepaxto", "factor": "Melflufen / Pepaxto", "dose": "0.2 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Melflufen / Pepaxto；页码 42；研究类型：unclear；动物：dog；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-EMA_003-BM-007", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/vidaza-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "14", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Vidaza；页码 14；研究类型：unclear；动物：dog; mouse；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Vidaza）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Vidaza", "factor": "Vidaza", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Vidaza；页码 14；研究类型：unclear；动物：dog; mouse；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Vidaza；页码 14；研究类型：unclear；动物：dog; mouse；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-EMA_006-BM-008", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/oxbryta-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "50", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Oxbryta；页码 50；研究类型：repeat-dose toxicity；动物：dog; monkey; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Oxbryta）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Oxbryta", "factor": "Oxbryta", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Oxbryta；页码 50；研究类型：repeat-dose toxicity；动物：dog; monkey; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "author_conclusion_summary_cn": "Oxbryta；页码 50；研究类型：repeat-dose toxicity；动物：dog; monkey; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-EMA_009-BM-003", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/revolade-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "20", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Revolade；页码 20；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Revolade）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Revolade", "factor": "Revolade", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Revolade；页码 20；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "Revolade；页码 20；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-EMA_010-BM-009", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/vanflyta-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "29", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Vanflyta；页码 29；研究类型：juvenile toxicity；动物：dog; monkey; mouse; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Vanflyta）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Vanflyta", "factor": "Vanflyta", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Vanflyta；页码 29；研究类型：juvenile toxicity；动物：dog; monkey; mouse; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Vanflyta；页码 29；研究类型：juvenile toxicity；动物：dog; monkey; mouse; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-EMA_010-BM-011", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/vanflyta-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "33", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Vanflyta；页码 33；研究类型：repeat-dose toxicity；动物：dog; monkey; rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Vanflyta）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Vanflyta", "factor": "Vanflyta", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Vanflyta；页码 33；研究类型：repeat-dose toxicity；动物：dog; monkey; rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Vanflyta；页码 33；研究类型：repeat-dose toxicity；动物：dog; monkey; rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_001-BM-019", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-214120", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "42", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Melflufen / Pepaxto；页码 42；研究类型：unclear；动物：dog；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Melflufen / Pepaxto）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Melflufen / Pepaxto", "factor": "Melflufen / Pepaxto", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Melflufen / Pepaxto；页码 42；研究类型：unclear；动物：dog；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Melflufen / Pepaxto；页码 42；研究类型：unclear；动物：dog；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_001-BM-023", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-214120", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "47", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Melflufen / Pepaxto；页码 47；研究类型：unclear；动物：dog；骨髓评价类型：smear/cytology；M:E：decreased。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Melflufen / Pepaxto）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Melflufen / Pepaxto", "factor": "Melflufen / Pepaxto", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Melflufen / Pepaxto；页码 47；研究类型：unclear；动物：dog；骨髓评价类型：smear/cytology；M:E：decreased。", "author_conclusion_summary_cn": "Melflufen / Pepaxto；页码 47；研究类型：unclear；动物：dog；骨髓评价类型：smear/cytology；M:E：decreased。", "author_conclusion_summary_en": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_007-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-22277", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022277s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "23", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Temodar；页码 23；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Temodar）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Temodar", "factor": "Temodar", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Temodar；页码 23；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Temodar；页码 23；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_007-BM-003", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-22277", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022277s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "28", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Temodar；页码 28；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Temodar）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Temodar", "factor": "Temodar", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Temodar；页码 28；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Temodar；页码 28；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_009-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "5", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Lynparza；页码 5；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Lynparza）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 5；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Lynparza；页码 5；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_009-BM-011", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "92", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Lynparza；页码 92；研究类型：repeat-dose toxicity；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Lynparza）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 92；研究类型：repeat-dose toxicity；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "author_conclusion_summary_cn": "Lynparza；页码 92；研究类型：repeat-dose toxicity；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "author_conclusion_summary_en": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_009-BM-015", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "96", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Lynparza；页码 96；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Lynparza）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 96；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "author_conclusion_summary_cn": "Lynparza；页码 96；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；M:E：reported, direction unclear。", "author_conclusion_summary_en": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_009-BM-021", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "138", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Lynparza；页码 138；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Lynparza）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 138；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Lynparza；页码 138；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_013-BM-017", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-214200", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214200Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "48", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Cosela；页码 48；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Cosela）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Cosela", "factor": "Cosela", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Cosela；页码 48；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "author_conclusion_summary_cn": "Cosela；页码 48；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_013-BM-024", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-214200", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214200Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "63", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Cosela；页码 63；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Cosela）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Cosela", "factor": "Cosela", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Cosela；页码 63；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Cosela；页码 63；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_015-BM-005", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-203971", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "92", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Xofigo；页码 92；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Xofigo）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Xofigo", "factor": "Xofigo", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Xofigo；页码 92；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Xofigo；页码 92；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_015-BM-017", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-203971", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "140", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Xofigo；页码 140；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased；M:E：decreased。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Xofigo）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Xofigo", "factor": "Xofigo", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Xofigo；页码 140；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased；M:E：decreased。", "author_conclusion_summary_cn": "Xofigo；页码 140；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased；M:E：decreased。", "author_conclusion_summary_en": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-PMDA_005-BM-002", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "PMDA-", "source_title": "Review Report", "source_type": "Traceable_official_or_publisher_source", "source_url": "https://www.pmda.go.jp/files/000233298.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "12", "species": "Dog", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Doptelet；页码 12；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "犬：红系、粒系或巨核系选择性减少（Doptelet）", "title_en": "Dog: Selective erythroid, myeloid or megakaryocytic decrease associated with Doptelet", "factor": "Doptelet", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Doptelet；页码 12；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Doptelet；页码 12；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-043", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-043", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "326", "species": "Mouse", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Sirturo；页码 326；研究类型：carcinogenicity；动物：mouse; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：no change；红系：increased；粒系：increased。", "display_title_cn": "小鼠：红系、粒系或巨核系选择性减少（Sirturo）", "title_en": "Mouse: Selective erythroid, myeloid or megakaryocytic decrease associated with Sirturo", "factor": "Sirturo", "dose": "75 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 326；研究类型：carcinogenicity；动物：mouse; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：no change；红系：increased；粒系：increased。", "author_conclusion_summary_cn": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-049", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-049", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "364", "species": "Mouse", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Sirturo；页码 364；研究类型：unclear；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；粒系：increased。", "display_title_cn": "小鼠：红系、粒系或巨核系选择性减少（Sirturo）", "title_en": "Mouse: Selective erythroid, myeloid or megakaryocytic decrease associated with Sirturo", "factor": "Sirturo", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 364；研究类型：unclear；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；粒系：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_010-BM-003", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_010-BM-003", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "9", "species": "Mouse", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Inrebic；页码 9；研究类型：reproductive/developmental toxicity；动物：mouse; rabbit; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "小鼠：红系、粒系或巨核系选择性减少（Inrebic）", "title_en": "Mouse: Selective erythroid, myeloid or megakaryocytic decrease associated with Inrebic", "factor": "Inrebic", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Inrebic；页码 9；研究类型：reproductive/developmental toxicity；动物：mouse; rabbit; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_010-BM-014", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_010-BM-014", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "77", "species": "Mouse", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Inrebic；页码 77；研究类型：carcinogenicity；动物：mouse; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "小鼠：红系、粒系或巨核系选择性减少（Inrebic）", "title_en": "Mouse: Selective erythroid, myeloid or megakaryocytic decrease associated with Inrebic", "factor": "Inrebic", "dose": "80 mg/kg; 30 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Inrebic；页码 77；研究类型：carcinogenicity；动物：mouse; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-012", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-012", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "142", "species": "Rat", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Sirturo；页码 142；研究类型：unclear；动物：rat；骨髓评价类型：unclear；红系：mixed/unclear。", "display_title_cn": "大鼠：红系、粒系或巨核系选择性减少（Sirturo）", "title_en": "Rat: Selective erythroid, myeloid or megakaryocytic decrease associated with Sirturo", "factor": "Sirturo", "dose": "1000 mg/kg/day; 10 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 142；研究类型：unclear；动物：rat；骨髓评价类型：unclear；红系：mixed/unclear。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-016", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-016", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "151", "species": "Rat", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Sirturo；页码 151；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "大鼠：红系、粒系或巨核系选择性减少（Sirturo）", "title_en": "Rat: Selective erythroid, myeloid or megakaryocytic decrease associated with Sirturo", "factor": "Sirturo", "dose": "100 mg/kg; 1 and 10 mg/kg/day; 100 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 151；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-053", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-053", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "471", "species": "Rat", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Sirturo；页码 471；研究类型：unclear；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "display_title_cn": "大鼠：红系、粒系或巨核系选择性减少（Sirturo）", "title_en": "Rat: Selective erythroid, myeloid or megakaryocytic decrease associated with Sirturo", "factor": "Sirturo", "dose": "100 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 471；研究类型：unclear；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-057", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-057", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "520", "species": "Rat", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Sirturo；页码 520；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "display_title_cn": "大鼠：红系、粒系或巨核系选择性减少（Sirturo）", "title_en": "Rat: Selective erythroid, myeloid or megakaryocytic decrease associated with Sirturo", "factor": "Sirturo", "dose": "1 mg/kg; 10 mg/kg; 10 mg/kg/day; 1 mg/kg/day; 100 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 520；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_009-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_009-BM-001", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "5", "species": "Rat", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Lynparza；页码 5；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "大鼠：红系、粒系或巨核系选择性减少（Lynparza）", "title_en": "Rat: Selective erythroid, myeloid or megakaryocytic decrease associated with Lynparza", "factor": "Lynparza", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 5；研究类型：reproductive/developmental toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_011-BM-004", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_011-BM-004", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022465s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "14", "species": "Rat", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Votrient；页码 14；研究类型：genotoxicity；动物：monkey; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "大鼠：红系、粒系或巨核系选择性减少（Votrient）", "title_en": "Rat: Selective erythroid, myeloid or megakaryocytic decrease associated with Votrient", "factor": "Votrient", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Votrient；页码 14；研究类型：genotoxicity；动物：monkey; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_011-BM-017", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_011-BM-017", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022465s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "202", "species": "Rat", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Votrient；页码 202；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "大鼠：红系、粒系或巨核系选择性减少（Votrient）", "title_en": "Rat: Selective erythroid, myeloid or megakaryocytic decrease associated with Votrient", "factor": "Votrient", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Votrient；页码 202；研究类型：genotoxicity；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_011-BM-018", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_011-BM-018", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022465s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "203", "species": "Rat", "toxicity_type": "T02", "toxicity_title_cn": "红系、粒系或巨核系选择性减少", "toxicity_title_en": "Selective erythroid, myeloid or megakaryocytic decrease", "title_cn": "Votrient；页码 203；研究类型：unclear；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "大鼠：红系、粒系或巨核系选择性减少（Votrient）", "title_en": "Rat: Selective erythroid, myeloid or megakaryocytic decrease associated with Votrient", "factor": "Votrient", "dose": "2000 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Votrient；页码 203；研究类型：unclear；动物：rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-027", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-027", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "216", "species": "Cynomolgus_monkey", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Sirturo；页码 216；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "食蟹猴：细胞凋亡、变性和骨髓坏死（Sirturo）", "title_en": "Cynomolgus_monkey: Apoptosis, degeneration and marrow necrosis associated with Sirturo", "factor": "Sirturo", "dose": "200 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 216；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-034", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-034", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "235", "species": "Cynomolgus_monkey", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Sirturo；页码 235；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：no change。", "display_title_cn": "食蟹猴：细胞凋亡、变性和骨髓坏死（Sirturo）", "title_en": "Cynomolgus_monkey: Apoptosis, degeneration and marrow necrosis associated with Sirturo", "factor": "Sirturo", "dose": "50 and 100 mg/kg/day; 50 mg/kg/day; 100 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 235；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：no change。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_008-BM-010", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_008-BM-010", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "95", "species": "Dog", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Zepatier；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "犬：细胞凋亡、变性和骨髓坏死（Zepatier）", "title_en": "Dog: Apoptosis, degeneration and marrow necrosis associated with Zepatier", "factor": "Zepatier", "dose": "15 mg/kg/day; 100 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Zepatier；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_010-BM-011", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_010-BM-011", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "71", "species": "Dog", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Inrebic；页码 71；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "犬：细胞凋亡、变性和骨髓坏死（Inrebic）", "title_en": "Dog: Apoptosis, degeneration and marrow necrosis associated with Inrebic", "factor": "Inrebic", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Inrebic；页码 71；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-EMA_004-BM-010", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/dacogen-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "26", "species": "Dog", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Dacogen；页码 26；研究类型：unclear；动物：dog; monkey; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：细胞凋亡、变性和骨髓坏死（Dacogen）", "title_en": "Dog: Apoptosis, degeneration and marrow necrosis associated with Dacogen", "factor": "Dacogen", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Dacogen；页码 26；研究类型：unclear；动物：dog; monkey; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Dacogen；页码 26；研究类型：unclear；动物：dog; monkey; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-EMA_004-BM-015", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/dacogen-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "35", "species": "Dog", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Dacogen；页码 35；研究类型：repeat-dose toxicity；动物：dog; monkey; rabbit; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：细胞凋亡、变性和骨髓坏死（Dacogen）", "title_en": "Dog: Apoptosis, degeneration and marrow necrosis associated with Dacogen", "factor": "Dacogen", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Dacogen；页码 35；研究类型：repeat-dose toxicity；动物：dog; monkey; rabbit; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Dacogen；页码 35；研究类型：repeat-dose toxicity；动物：dog; monkey; rabbit; rat；骨髓评价类型：unclear；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-EMA_009-BM-009", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/revolade-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "76", "species": "Dog", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Revolade；页码 76；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "display_title_cn": "犬：细胞凋亡、变性和骨髓坏死（Revolade）", "title_en": "Dog: Apoptosis, degeneration and marrow necrosis associated with Revolade", "factor": "Revolade", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Revolade；页码 76；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "author_conclusion_summary_cn": "Revolade；页码 76；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_008-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-208261", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "25", "species": "Dog", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Zepatier；页码 25；研究类型：unclear；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "犬：细胞凋亡、变性和骨髓坏死（Zepatier）", "title_en": "Dog: Apoptosis, degeneration and marrow necrosis associated with Zepatier", "factor": "Zepatier", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Zepatier；页码 25；研究类型：unclear；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "Zepatier；页码 25；研究类型：unclear；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_008-BM-010", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-208261", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "95", "species": "Dog", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Zepatier；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "犬：细胞凋亡、变性和骨髓坏死（Zepatier）", "title_en": "Dog: Apoptosis, degeneration and marrow necrosis associated with Zepatier", "factor": "Zepatier", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Zepatier；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "Zepatier；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-PMDA_005-BM-005", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "PMDA-", "source_title": "Review Report", "source_type": "Traceable_official_or_publisher_source", "source_url": "https://www.pmda.go.jp/files/000233298.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "21", "species": "Dog", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Doptelet；页码 21；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；巨核细胞：mixed/unclear。", "display_title_cn": "犬：细胞凋亡、变性和骨髓坏死（Doptelet）", "title_en": "Dog: Apoptosis, degeneration and marrow necrosis associated with Doptelet", "factor": "Doptelet", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Doptelet；页码 21；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；巨核细胞：mixed/unclear。", "author_conclusion_summary_cn": "Doptelet；页码 21；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；巨核细胞：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_007-BM-003", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_007-BM-003", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022277s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "28", "species": "Mouse", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Temodar；页码 28；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "小鼠：细胞凋亡、变性和骨髓坏死（Temodar）", "title_en": "Mouse: Apoptosis, degeneration and marrow necrosis associated with Temodar", "factor": "Temodar", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Temodar；页码 28；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_008-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_008-BM-001", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "25", "species": "Mouse", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Zepatier；页码 25；研究类型：unclear；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "小鼠：细胞凋亡、变性和骨髓坏死（Zepatier）", "title_en": "Mouse: Apoptosis, degeneration and marrow necrosis associated with Zepatier", "factor": "Zepatier", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Zepatier；页码 25；研究类型：unclear；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_011-BM-003", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_011-BM-003", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022465s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "6", "species": "Mouse", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Votrient；页码 6；研究类型：unclear；动物：mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "小鼠：细胞凋亡、变性和骨髓坏死（Votrient）", "title_en": "Mouse: Apoptosis, degeneration and marrow necrosis associated with Votrient", "factor": "Votrient", "dose": "1000 mg/kg/day; 30 mg/kg/day; 100 mg/kg/day; 300 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Votrient；页码 6；研究类型：unclear；动物：mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-011", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-011", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "140", "species": "Rat", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Sirturo；页码 140；研究类型：unclear；动物：rat；骨髓评价类型：smear/cytology；骨髓细胞量/造血细胞：decreased；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "display_title_cn": "大鼠：细胞凋亡、变性和骨髓坏死（Sirturo）", "title_en": "Rat: Apoptosis, degeneration and marrow necrosis associated with Sirturo", "factor": "Sirturo", "dose": "1000 mg/kg/day; 100 mg/kg/day; 10 mg/kg/day; 300 and 1000 mg/kg/day; 30 mg/kg", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 140；研究类型：unclear；动物：rat；骨髓评价类型：smear/cytology；骨髓细胞量/造血细胞：decreased；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "author_conclusion_summary_cn": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_007-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_007-BM-001", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022277s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "23", "species": "Rat", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Temodar；页码 23；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "大鼠：细胞凋亡、变性和骨髓坏死（Temodar）", "title_en": "Rat: Apoptosis, degeneration and marrow necrosis associated with Temodar", "factor": "Temodar", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Temodar；页码 23；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_007-BM-006", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_007-BM-006", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022277s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "41", "species": "Rat", "toxicity_type": "T04", "toxicity_title_cn": "细胞凋亡、变性和骨髓坏死", "toxicity_title_en": "Apoptosis, degeneration and marrow necrosis", "title_cn": "Temodar；页码 41；研究类型：unclear；动物：rat；骨髓评价类型：both；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "大鼠：细胞凋亡、变性和骨髓坏死（Temodar）", "title_en": "Rat: Apoptosis, degeneration and marrow necrosis associated with Temodar", "factor": "Temodar", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Temodar；页码 41；研究类型：unclear；动物：rat；骨髓评价类型：both；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_002-BM-002", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_002-BM-002", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/125268s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "46", "species": "Mouse", "toxicity_type": "T05", "toxicity_title_cn": "骨髓纤维化和基质改变", "toxicity_title_en": "Fibrosis and stromal or microenvironment change", "title_cn": "Nplate；页码 46；研究类型：repeat-dose toxicity；动物：monkey; mouse; rabbit; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；巨核细胞：increased。", "display_title_cn": "小鼠：骨髓纤维化和基质改变（Nplate）", "title_en": "Mouse: Fibrosis and stromal or microenvironment change associated with Nplate", "factor": "Nplate", "dose": "1000 mcg/kg; 10 mcg/kg", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Nplate；页码 46；研究类型：repeat-dose toxicity；动物：monkey; mouse; rabbit; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；巨核细胞：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-045", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-045", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "349", "species": "Rat", "toxicity_type": "T05", "toxicity_title_cn": "骨髓纤维化和基质改变", "toxicity_title_en": "Fibrosis and stromal or microenvironment change", "title_cn": "Sirturo；页码 349；研究类型：unclear；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "大鼠：骨髓纤维化和基质改变（Sirturo）", "title_en": "Rat: Fibrosis and stromal or microenvironment change associated with Sirturo", "factor": "Sirturo", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 349；研究类型：unclear；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-NTP_002-BM-011", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "NTP-", "source_title": "Toxicity Report", "source_type": "NTP_official_atlas", "source_url": "https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox050.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "39", "species": "Dog", "toxicity_type": "T06", "toxicity_title_cn": "反应性增生、恢复期反跳和高细胞性", "toxicity_title_en": "Reactive hyperplasia, rebound and hypercellularity", "title_cn": "Cyclohexanone oxime；页码 39；研究类型：unclear；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased。", "display_title_cn": "犬：反应性增生、恢复期反跳和高细胞性（Cyclohexanone oxime）", "title_en": "Dog: Reactive hyperplasia, rebound and hypercellularity associated with Cyclohexanone oxime", "factor": "Cyclohexanone oxime", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Cyclohexanone oxime；页码 39；研究类型：unclear；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased。", "author_conclusion_summary_cn": "Cyclohexanone oxime；页码 39；研究类型：unclear；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_009-BM-017", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_009-BM-017", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "99", "species": "Dog", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "Lynparza；页码 99；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：巨核细胞损伤、减少及血小板毒性（Lynparza）", "title_en": "Dog: Megakaryocyte injury, decrease and platelet toxicity associated with Lynparza", "factor": "Lynparza", "dose": "1 and 3 mg/kg; 10 mg/kg; 3 mg/kg; 1 mg/kg/day; 3 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 99；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-EMA_004-BM-012", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/dacogen-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "28", "species": "Dog", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "Dacogen；页码 28；研究类型：unclear；动物：dog; rabbit; rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "犬：巨核细胞损伤、减少及血小板毒性（Dacogen）", "title_en": "Dog: Megakaryocyte injury, decrease and platelet toxicity associated with Dacogen", "factor": "Dacogen", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Dacogen；页码 28；研究类型：unclear；动物：dog; rabbit; rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Dacogen；页码 28；研究类型：unclear；动物：dog; rabbit; rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-EMA_006-BM-007", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/oxbryta-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "48", "species": "Dog", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "Oxbryta；页码 48；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear；M:E：increased。", "display_title_cn": "犬：巨核细胞损伤、减少及血小板毒性（Oxbryta）", "title_en": "Dog: Megakaryocyte injury, decrease and platelet toxicity associated with Oxbryta", "factor": "Oxbryta", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Oxbryta；页码 48；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear；M:E：increased。", "author_conclusion_summary_cn": "Oxbryta；页码 48；研究类型：unclear；动物：dog; rat；骨髓评价类型：both；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear；M:E：increased。", "author_conclusion_summary_en": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_009-BM-002", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "16", "species": "Dog", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "Lynparza；页码 16；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "犬：巨核细胞损伤、减少及血小板毒性（Lynparza）", "title_en": "Dog: Megakaryocyte injury, decrease and platelet toxicity associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 16；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Lynparza；页码 16；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_009-BM-017", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "99", "species": "Dog", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "Lynparza；页码 99；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：巨核细胞损伤、减少及血小板毒性（Lynparza）", "title_en": "Dog: Megakaryocyte injury, decrease and platelet toxicity associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 99；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Lynparza；页码 99；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_010-BM-008", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-212327", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "59", "species": "Dog", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "Inrebic；页码 59；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "犬：巨核细胞损伤、减少及血小板毒性（Inrebic）", "title_en": "Dog: Megakaryocyte injury, decrease and platelet toxicity associated with Inrebic", "factor": "Inrebic", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Inrebic；页码 59；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "Inrebic；页码 59；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_015-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-203971", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "4", "species": "Dog", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "Xofigo；页码 4；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear；粒系：mixed/unclear。", "display_title_cn": "犬：巨核细胞损伤、减少及血小板毒性（Xofigo）", "title_en": "Dog: Megakaryocyte injury, decrease and platelet toxicity associated with Xofigo", "factor": "Xofigo", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Xofigo；页码 4；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear；粒系：mixed/unclear。", "author_conclusion_summary_cn": "Xofigo；页码 4；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear；粒系：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_015-BM-014", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-203971", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "133", "species": "Dog", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "Xofigo；页码 133；研究类型：repeat-dose toxicity；动物：dog；骨髓评价类型：both；M:E：reported, direction unclear。", "display_title_cn": "犬：巨核细胞损伤、减少及血小板毒性（Xofigo）", "title_en": "Dog: Megakaryocyte injury, decrease and platelet toxicity associated with Xofigo", "factor": "Xofigo", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Xofigo；页码 133；研究类型：repeat-dose toxicity；动物：dog；骨髓评价类型：both；M:E：reported, direction unclear。", "author_conclusion_summary_cn": "Xofigo；页码 133；研究类型：repeat-dose toxicity；动物：dog；骨髓评价类型：both；M:E：reported, direction unclear。", "author_conclusion_summary_en": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_001-BM-024", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_001-BM-024", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "55", "species": "Mouse", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "Melflufen / Pepaxto；页码 55；研究类型：unclear；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "小鼠：巨核细胞损伤、减少及血小板毒性（Melflufen / Pepaxto）", "title_en": "Mouse: Megakaryocyte injury, decrease and platelet toxicity associated with Melflufen / Pepaxto", "factor": "Melflufen / Pepaxto", "dose": "0.63 and 1.26 mg/kg/day; 0.63 mg/kg/day; 1.26 mg/kg/day; 3 mg/kg/day; 0.045 mg/kg/day; 0.09 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Melflufen / Pepaxto；页码 55；研究类型：unclear；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_009-BM-002", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_009-BM-002", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "16", "species": "Mouse", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "Lynparza；页码 16；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "小鼠：巨核细胞损伤、减少及血小板毒性（Lynparza）", "title_en": "Mouse: Megakaryocyte injury, decrease and platelet toxicity associated with Lynparza", "factor": "Lynparza", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 16；研究类型：repeat-dose toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_010-BM-008", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_010-BM-008", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "59", "species": "Mouse", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "Inrebic；页码 59；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "小鼠：巨核细胞损伤、减少及血小板毒性（Inrebic）", "title_en": "Mouse: Megakaryocyte injury, decrease and platelet toxicity associated with Inrebic", "factor": "Inrebic", "dose": "30 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Inrebic；页码 59；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_002-BM-003", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_002-BM-003", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/125268s000_PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "50", "species": "Rat", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "Nplate；页码 50；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased。", "display_title_cn": "大鼠：巨核细胞损伤、减少及血小板毒性（Nplate）", "title_en": "Rat: Megakaryocyte injury, decrease and platelet toxicity associated with Nplate", "factor": "Nplate", "dose": "100 mcg/kg", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Nplate；页码 50；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_009-BM-006", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_009-BM-006", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "77", "species": "Rat", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "Lynparza；页码 77；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：no change。", "display_title_cn": "大鼠：巨核细胞损伤、减少及血小板毒性（Lynparza）", "title_en": "Rat: Megakaryocyte injury, decrease and platelet toxicity associated with Lynparza", "factor": "Lynparza", "dose": "15 mg/kg/day; 40 mg/kg/day; 40 mg/kg", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 77；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：no change。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_010-BM-010", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_010-BM-010", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "68", "species": "Rat", "toxicity_type": "T07", "toxicity_title_cn": "巨核细胞损伤、减少及血小板毒性", "toxicity_title_en": "Megakaryocyte injury, decrease and platelet toxicity", "title_cn": "Inrebic；页码 68；研究类型：unclear；动物：rabbit; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "大鼠：巨核细胞损伤、减少及血小板毒性（Inrebic）", "title_en": "Rat: Megakaryocyte injury, decrease and platelet toxicity associated with Inrebic", "factor": "Inrebic", "dose": "10 mg/kg; 30 mg/kg", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Inrebic；页码 68；研究类型：unclear；动物：rabbit; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_013-BM-018", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-214200", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214200Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "49", "species": "Dog", "toxicity_type": "T08", "toxicity_title_cn": "嗜血、红细胞吞噬和巨噬细胞改变", "toxicity_title_en": "Hemophagocytosis, erythrophagocytosis and macrophage change", "title_cn": "Cosela；页码 49；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "display_title_cn": "犬：嗜血、红细胞吞噬和巨噬细胞改变（Cosela）", "title_en": "Dog: Hemophagocytosis, erythrophagocytosis and macrophage change associated with Cosela", "factor": "Cosela", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Cosela；页码 49；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "author_conclusion_summary_cn": "Cosela；页码 49；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-021", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-021", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "181", "species": "Rat", "toxicity_type": "T08", "toxicity_title_cn": "嗜血、红细胞吞噬和巨噬细胞改变", "toxicity_title_en": "Hemophagocytosis, erythrophagocytosis and macrophage change", "title_cn": "Sirturo；页码 181；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "大鼠：嗜血、红细胞吞噬和巨噬细胞改变（Sirturo）", "title_en": "Rat: Hemophagocytosis, erythrophagocytosis and macrophage change associated with Sirturo", "factor": "Sirturo", "dose": "100 mg/kg/day; 10 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 181；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "AUTH-CASE-PMC4766527", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_library", "source_id": "AUTH-PMC4766527", "source_title": "Malaria in cynomolgus monkeys used in toxicity studies in Japan", "source_type": "Peer_reviewed_full_text", "source_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4766527/", "doi": "10.1293/tox.2015-0051", "pmid": "26989299", "pmcid": "PMC4766527", "source_page": "NR", "species": "Cynomolgus_monkey", "toxicity_type": "T09", "toxicity_title_cn": "色素、含铁血黄素及异物蓄积", "toxicity_title_en": "Pigment, hemosiderin and foreign material accumulation", "title_cn": "权威候选来源记录：Hemozoin-laden macrophages and infection-associated marrow changes。具体图像与处理相关性仍需逐图专家复核。", "display_title_cn": "食蟹猴：色素、含铁血黄素及异物蓄积（Disease/background differential for toxicity studies）", "title_en": "Hemozoin-laden macrophages and infection-associated marrow changes", "factor": "Disease/background differential for toxicity studies", "dose": "NR", "timecourse": "NR", "evidence_role": "Disease_differential", "causality_level": "Differential_only", "observation_summary_cn": "权威候选来源记录：Hemozoin-laden macrophages and infection-associated marrow changes。具体图像与处理相关性仍需逐图专家复核。", "author_conclusion_summary_cn": "NR", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_009-BM-014", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_009-BM-014", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "95", "species": "Dog", "toxicity_type": "T09", "toxicity_title_cn": "色素、含铁血黄素及异物蓄积", "toxicity_title_en": "Pigment, hemosiderin and foreign material accumulation", "title_cn": "Lynparza；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：increased。", "display_title_cn": "犬：色素、含铁血黄素及异物蓄积（Lynparza）", "title_en": "Dog: Pigment, hemosiderin and foreign material accumulation associated with Lynparza", "factor": "Lynparza", "dose": "2.5 mg/kg", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：increased。", "author_conclusion_summary_cn": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_008-BM-013", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-208261", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "141", "species": "Dog", "toxicity_type": "T09", "toxicity_title_cn": "色素、含铁血黄素及异物蓄积", "toxicity_title_en": "Pigment, hemosiderin and foreign material accumulation", "title_cn": "Zepatier；页码 141；研究类型：unclear；动物：dog; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "犬：色素、含铁血黄素及异物蓄积（Zepatier）", "title_en": "Dog: Pigment, hemosiderin and foreign material accumulation associated with Zepatier", "factor": "Zepatier", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Zepatier；页码 141；研究类型：unclear；动物：dog; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "Zepatier；页码 141；研究类型：unclear；动物：dog; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_009-BM-014", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "95", "species": "Dog", "toxicity_type": "T09", "toxicity_title_cn": "色素、含铁血黄素及异物蓄积", "toxicity_title_en": "Pigment, hemosiderin and foreign material accumulation", "title_cn": "Lynparza；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：increased。", "display_title_cn": "犬：色素、含铁血黄素及异物蓄积（Lynparza）", "title_en": "Dog: Pigment, hemosiderin and foreign material accumulation associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：increased。", "author_conclusion_summary_cn": "Lynparza；页码 95；研究类型：unclear；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：decreased；红系：increased。", "author_conclusion_summary_en": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_015-BM-007", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-203971", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "95", "species": "Dog", "toxicity_type": "T09", "toxicity_title_cn": "色素、含铁血黄素及异物蓄积", "toxicity_title_en": "Pigment, hemosiderin and foreign material accumulation", "title_cn": "Xofigo；页码 95；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "犬：色素、含铁血黄素及异物蓄积（Xofigo）", "title_en": "Dog: Pigment, hemosiderin and foreign material accumulation associated with Xofigo", "factor": "Xofigo", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Xofigo；页码 95；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "Xofigo；页码 95；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_015-BM-008", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-203971", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "99", "species": "Dog", "toxicity_type": "T09", "toxicity_title_cn": "色素、含铁血黄素及异物蓄积", "toxicity_title_en": "Pigment, hemosiderin and foreign material accumulation", "title_cn": "Xofigo；页码 99；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：mixed/unclear；M:E：reported, direction unclear。", "display_title_cn": "犬：色素、含铁血黄素及异物蓄积（Xofigo）", "title_en": "Dog: Pigment, hemosiderin and foreign material accumulation associated with Xofigo", "factor": "Xofigo", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Xofigo；页码 99；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：mixed/unclear；M:E：reported, direction unclear。", "author_conclusion_summary_cn": "Xofigo；页码 99；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：both；骨髓细胞量/造血细胞：mixed/unclear；M:E：reported, direction unclear。", "author_conclusion_summary_en": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_020-BM-010", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-214783", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2021/214783Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "56", "species": "Dog", "toxicity_type": "T09", "toxicity_title_cn": "色素、含铁血黄素及异物蓄积", "toxicity_title_en": "Pigment, hemosiderin and foreign material accumulation", "title_cn": "Rezurock；页码 56；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：色素、含铁血黄素及异物蓄积（Rezurock）", "title_en": "Dog: Pigment, hemosiderin and foreign material accumulation associated with Rezurock", "factor": "Rezurock", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Rezurock；页码 56；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Rezurock；页码 56；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_008-BM-013", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_008-BM-013", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "141", "species": "Mouse", "toxicity_type": "T09", "toxicity_title_cn": "色素、含铁血黄素及异物蓄积", "toxicity_title_en": "Pigment, hemosiderin and foreign material accumulation", "title_cn": "Zepatier；页码 141；研究类型：unclear；动物：dog; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "小鼠：色素、含铁血黄素及异物蓄积（Zepatier）", "title_en": "Mouse: Pigment, hemosiderin and foreign material accumulation associated with Zepatier", "factor": "Zepatier", "dose": "100 mg/kg/day; 200 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Zepatier；页码 141；研究类型：unclear；动物：dog; mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_008-BM-004", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_008-BM-004", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "40", "species": "Rat", "toxicity_type": "T09", "toxicity_title_cn": "色素、含铁血黄素及异物蓄积", "toxicity_title_en": "Pigment, hemosiderin and foreign material accumulation", "title_cn": "Zepatier；页码 40；研究类型：unclear；动物：rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "大鼠：色素、含铁血黄素及异物蓄积（Zepatier）", "title_en": "Rat: Pigment, hemosiderin and foreign material accumulation associated with Zepatier", "factor": "Zepatier", "dose": "30 mg/kg", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Zepatier；页码 40；研究类型：unclear；动物：rat；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_009-BM-007", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_009-BM-007", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "78", "species": "Rat", "toxicity_type": "T09", "toxicity_title_cn": "色素、含铁血黄素及异物蓄积", "toxicity_title_en": "Pigment, hemosiderin and foreign material accumulation", "title_cn": "Lynparza；页码 78；研究类型：unclear；动物：rat；骨髓评价类型：both；骨髓细胞量/造血细胞：increased；红系：mixed/unclear。", "display_title_cn": "大鼠：色素、含铁血黄素及异物蓄积（Lynparza）", "title_en": "Rat: Pigment, hemosiderin and foreign material accumulation associated with Lynparza", "factor": "Lynparza", "dose": "0 mg/kg; 5 mg/kg; 15 mg/kg; 40 mg/kg", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 78；研究类型：unclear；动物：rat；骨髓评价类型：both；骨髓细胞量/造血细胞：increased；红系：mixed/unclear。", "author_conclusion_summary_cn": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-008", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-008", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "33", "species": "Cynomolgus_monkey", "toxicity_type": "T10", "toxicity_title_cn": "血管扩张、缺血和骨髓微环境损伤", "toxicity_title_en": "Angiectasis, ischemia and marrow vascular injury", "title_cn": "Sirturo；页码 33；研究类型：unclear；动物：monkey；骨髓评价类型：both；骨髓细胞量/造血细胞：no change；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "display_title_cn": "食蟹猴：血管扩张、缺血和骨髓微环境损伤（Sirturo）", "title_en": "Cynomolgus_monkey: Angiectasis, ischemia and marrow vascular injury associated with Sirturo", "factor": "Sirturo", "dose": "0.5 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 33；研究类型：unclear；动物：monkey；骨髓评价类型：both；骨髓细胞量/造血细胞：no change；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "author_conclusion_summary_cn": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-054", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-054", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "477", "species": "Cynomolgus_monkey", "toxicity_type": "T10", "toxicity_title_cn": "血管扩张、缺血和骨髓微环境损伤", "toxicity_title_en": "Angiectasis, ischemia and marrow vascular injury", "title_cn": "Sirturo；页码 477；研究类型：unclear；动物：monkey；骨髓评价类型：both；骨髓细胞量/造血细胞：no change；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "display_title_cn": "食蟹猴：血管扩张、缺血和骨髓微环境损伤（Sirturo）", "title_en": "Cynomolgus_monkey: Angiectasis, ischemia and marrow vascular injury associated with Sirturo", "factor": "Sirturo", "dose": "0.5 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 477；研究类型：unclear；动物：monkey；骨髓评价类型：both；骨髓细胞量/造血细胞：no change；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "author_conclusion_summary_cn": "同时涉及涂片/细胞学和组织病理，可用于学习如何整合两个评价层面的差异或一致性。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-EMA_004-BM-018", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "EMA-", "source_title": "EPAR Assessment Report", "source_type": "EMA_regulatory_review", "source_url": "https://www.ema.europa.eu/en/documents/assessment-report/dacogen-epar-public-assessment-report_en.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "38", "species": "Dog", "toxicity_type": "T10", "toxicity_title_cn": "血管扩张、缺血和骨髓微环境损伤", "toxicity_title_en": "Angiectasis, ischemia and marrow vascular injury", "title_cn": "Dacogen；页码 38；研究类型：unclear；动物：dog; monkey; mouse; rabbit; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "display_title_cn": "犬：血管扩张、缺血和骨髓微环境损伤（Dacogen）", "title_en": "Dog: Angiectasis, ischemia and marrow vascular injury associated with Dacogen", "factor": "Dacogen", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Dacogen；页码 38；研究类型：unclear；动物：dog; monkey; mouse; rabbit; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_cn": "Dacogen；页码 38；研究类型：unclear；动物：dog; monkey; mouse; rabbit; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_013-BM-022", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-214200", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214200Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "58", "species": "Dog", "toxicity_type": "T10", "toxicity_title_cn": "血管扩张、缺血和骨髓微环境损伤", "toxicity_title_en": "Angiectasis, ischemia and marrow vascular injury", "title_cn": "Cosela；页码 58；研究类型：reproductive/developmental toxicity；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "display_title_cn": "犬：血管扩张、缺血和骨髓微环境损伤（Cosela）", "title_en": "Dog: Angiectasis, ischemia and marrow vascular injury associated with Cosela", "factor": "Cosela", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Cosela；页码 58；研究类型：reproductive/developmental toxicity；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "author_conclusion_summary_cn": "Cosela；页码 58；研究类型：reproductive/developmental toxicity；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-050", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-050", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "370", "species": "Mouse", "toxicity_type": "T10", "toxicity_title_cn": "血管扩张、缺血和骨髓微环境损伤", "toxicity_title_en": "Angiectasis, ischemia and marrow vascular injury", "title_cn": "Sirturo；页码 370；研究类型：unclear；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "小鼠：血管扩张、缺血和骨髓微环境损伤（Sirturo）", "title_en": "Mouse: Angiectasis, ischemia and marrow vascular injury associated with Sirturo", "factor": "Sirturo", "dose": "200 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 370；研究类型：unclear；动物：mouse；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-002", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-002", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "15", "species": "Rat", "toxicity_type": "T10", "toxicity_title_cn": "血管扩张、缺血和骨髓微环境损伤", "toxicity_title_en": "Angiectasis, ischemia and marrow vascular injury", "title_cn": "Sirturo；页码 15；研究类型：repeat-dose toxicity；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "大鼠：血管扩张、缺血和骨髓微环境损伤（Sirturo）", "title_en": "Rat: Angiectasis, ischemia and marrow vascular injury associated with Sirturo", "factor": "Sirturo", "dose": "0.5, 2 and 10 mg/kg/day; 5 mg/kg; 2 mg/kg/day; 1 mg/kg", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 15；研究类型：repeat-dose toxicity；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-029", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-029", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "219", "species": "Cynomolgus_monkey", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "Sirturo；页码 219；研究类型：unclear；动物：monkey；骨髓评价类型：smear/cytology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased；M:E：decreased。", "display_title_cn": "食蟹猴：炎症、感染性改变和异常细胞浸润（Sirturo）", "title_en": "Cynomolgus_monkey: Inflammation, infection and abnormal cellular infiltration associated with Sirturo", "factor": "Sirturo", "dose": "100 mg/kg/day; 33.33 mg/kg; 50 and 100 mg/kg/day; 50 mg/kg/day; 10 and 50 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 219；研究类型：unclear；动物：monkey；骨髓评价类型：smear/cytology；骨髓细胞量/造血细胞：decreased；红系：decreased；粒系：decreased；M:E：decreased。", "author_conclusion_summary_cn": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-036", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-036", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "254", "species": "Cynomolgus_monkey", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "Sirturo；页码 254；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "display_title_cn": "食蟹猴：炎症、感染性改变和异常细胞浸润（Sirturo）", "title_en": "Cynomolgus_monkey: Inflammation, infection and abnormal cellular infiltration associated with Sirturo", "factor": "Sirturo", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 254；研究类型：unclear；动物：monkey；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：increased；红系：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_009-BM-018", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_009-BM-018", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "103", "species": "Dog", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "Lynparza；页码 103；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "display_title_cn": "犬：炎症、感染性改变和异常细胞浸润（Lynparza）", "title_en": "Dog: Inflammation, infection and abnormal cellular infiltration associated with Lynparza", "factor": "Lynparza", "dose": "10 mg/kg", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 103；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "author_conclusion_summary_cn": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_010-BM-012", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_010-BM-012", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "72", "species": "Dog", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "Inrebic；页码 72；研究类型：unclear；动物：dog；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "犬：炎症、感染性改变和异常细胞浸润（Inrebic）", "title_en": "Dog: Inflammation, infection and abnormal cellular infiltration associated with Inrebic", "factor": "Inrebic", "dose": "20 mg/kg; 15 mg/kg; 15 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Inrebic；页码 72；研究类型：unclear；动物：dog；骨髓评价类型：unclear；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "骨髓相关性需结合全文和表格进一步判断，宜作为候选案例复核。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_001-BM-008", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-214120", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "22", "species": "Dog", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "Melflufen / Pepaxto；页码 22；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "犬：炎症、感染性改变和异常细胞浸润（Melflufen / Pepaxto）", "title_en": "Dog: Inflammation, infection and abnormal cellular infiltration associated with Melflufen / Pepaxto", "factor": "Melflufen / Pepaxto", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Melflufen / Pepaxto；页码 22；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "Melflufen / Pepaxto；页码 22；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_009-BM-018", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-206162", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "103", "species": "Dog", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "Lynparza；页码 103；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "display_title_cn": "犬：炎症、感染性改变和异常细胞浸润（Lynparza）", "title_en": "Dog: Inflammation, infection and abnormal cellular infiltration associated with Lynparza", "factor": "Lynparza", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 103；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "author_conclusion_summary_cn": "Lynparza；页码 103；研究类型：single-dose/acute toxicity；动物：dog；骨髓评价类型：smear/cytology；红系：mixed/unclear；粒系：mixed/unclear；M:E：increased。", "author_conclusion_summary_en": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_010-BM-011", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-212327", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "71", "species": "Dog", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "Inrebic；页码 71；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "犬：炎症、感染性改变和异常细胞浸润（Inrebic）", "title_en": "Dog: Inflammation, infection and abnormal cellular infiltration associated with Inrebic", "factor": "Inrebic", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Inrebic；页码 71；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "Inrebic；页码 71；研究类型：unclear；动物：dog；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-S2A-CASE-FDA_012-BM-005", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA-208065", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/208065Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "133", "species": "Dog", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "Tagrisso；页码 133；研究类型：genotoxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "display_title_cn": "犬：炎症、感染性改变和异常细胞浸润（Tagrisso）", "title_en": "Dog: Inflammation, infection and abnormal cellular infiltration associated with Tagrisso", "factor": "Tagrisso", "dose": "NR", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Tagrisso；页码 133；研究类型：genotoxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_cn": "Tagrisso；页码 133；研究类型：genotoxicity；动物：dog; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear。", "author_conclusion_summary_en": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_001-BM-008", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_001-BM-008", "source_title": "Multi-discipline Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "22", "species": "Mouse", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "Melflufen / Pepaxto；页码 22；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "小鼠：炎症、感染性改变和异常细胞浸润（Melflufen / Pepaxto）", "title_en": "Mouse: Inflammation, infection and abnormal cellular infiltration associated with Melflufen / Pepaxto", "factor": "Melflufen / Pepaxto", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Melflufen / Pepaxto；页码 22；研究类型：reproductive/developmental toxicity；动物：dog; mouse; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-001", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-001", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "14", "species": "Rat", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "Sirturo；页码 14；研究类型：single-dose/acute toxicity；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：increased。", "display_title_cn": "大鼠：炎症、感染性改变和异常细胞浸润（Sirturo）", "title_en": "Rat: Inflammation, infection and abnormal cellular infiltration associated with Sirturo", "factor": "Sirturo", "dose": "100 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 14；研究类型：single-dose/acute toxicity；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：mixed/unclear；红系：increased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-056", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-056", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "507", "species": "Rat", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "Sirturo；页码 507；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "大鼠：炎症、感染性改变和异常细胞浸润（Sirturo）", "title_en": "Rat: Inflammation, infection and abnormal cellular infiltration associated with Sirturo", "factor": "Sirturo", "dose": "10 mg/kg", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 507；研究类型：unclear；动物：rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-058", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-058", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "521", "species": "Rat", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "Sirturo；页码 521；研究类型：unclear；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；粒系：decreased。", "display_title_cn": "大鼠：炎症、感染性改变和异常细胞浸润（Sirturo）", "title_en": "Rat: Inflammation, infection and abnormal cellular infiltration associated with Sirturo", "factor": "Sirturo", "dose": "1 mg/kg/day; 100 mg/kg/day; 10 mg/kg/day; 50 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 521；研究类型：unclear；动物：monkey; rat；骨髓评价类型：histopathology；骨髓细胞量/造血细胞：decreased；粒系：decreased。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_003-BM-060", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_003-BM-060", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "523", "species": "Rat", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "Sirturo；页码 523；研究类型：repeat-dose toxicity；动物：monkey; rat；骨髓评价类型：smear/cytology；红系：no change。", "display_title_cn": "大鼠：炎症、感染性改变和异常细胞浸润（Sirturo）", "title_en": "Rat: Inflammation, infection and abnormal cellular infiltration associated with Sirturo", "factor": "Sirturo", "dose": "unclear", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Sirturo；页码 523；研究类型：repeat-dose toxicity；动物：monkey; rat；骨髓评价类型：smear/cytology；红系：no change。", "author_conclusion_summary_cn": "适合学习骨髓涂片/细胞学写法，尤其是 M:E 比值、红系/粒系比例和外周血结果的对应。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." }, { "case_id": "S2D-HP-CASE-FDA_009-BM-021", "featured": false, "featured_reason_cn": "NR", "module_id": "toxicity_atlas", "source_id": "FDA_009-BM-021", "source_title": "Pharmacology Review", "source_type": "FDA_regulatory_review", "source_url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "doi": "NR", "pmid": "NR", "pmcid": "NR", "source_page": "138", "species": "Rat", "toxicity_type": "T11", "toxicity_title_cn": "炎症、感染性改变和异常细胞浸润", "toxicity_title_en": "Inflammation, infection and abnormal cellular infiltration", "title_cn": "Lynparza；页码 138；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "display_title_cn": "大鼠：炎症、感染性改变和异常细胞浸润（Lynparza）", "title_en": "Rat: Inflammation, infection and abnormal cellular infiltration associated with Lynparza", "factor": "Lynparza", "dose": "2.5 mg/kg/day", "timecourse": "NR", "evidence_role": "Case_only", "causality_level": "Uncertain", "observation_summary_cn": "Lynparza；页码 138；研究类型：repeat-dose toxicity；动物：dog; rat；骨髓评价类型：histopathology；原文提到骨髓/造血相关术语，但具体方向需复核。", "author_conclusion_summary_cn": "适合学习组织病理层面描述骨髓细胞量、造血细胞减少/增多或巨核系统改变。 原文含有相关性或一致性表述，可模仿其把外周血和骨髓结果联系起来的方式。", "author_conclusion_summary_en": "NR", "pairing_note_cn": "NR", "pairing_note_en": "NR", "rights_note_cn": "NR", "rights_note_en": "NR", "image_status": "Metadata_only", "public_image_ids": [], "public_image_paths": [], "public_image_preview_paths": [], "public_images": [], "pathology_evidence_ids": [], "pathology_evidence_count": 0, "pathology_atlas_url": "../public-atlas/?system=bone_marrow", "pathology_evidence": [], "expert_review_status": "Pending", "publication_level": "Traceable_case_index", "curatorial_note_cn": "观察结果、作者解释和网站标签分开保存；请回到原始来源核对完整上下文。", "text_use_note": "Paraphrased metadata summary with source attribution; no full-text passage is republished." } ], "sources": [ { "source_id": "AUTH-PMC2517354", "title": "Characterization of the myelotoxicity of chloramphenicol succinate in the B6C3F1 mouse", "species": "Mouse", "doi": "10.1111/j.0959-9673.2006.00460.x", "pmid": "16623754", "pmcid": "PMC2517354", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2517354/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "AUTH-PMC2974595", "title": "Hematopoiesis in 3 dimensions: human and murine bone marrow architecture visualized by confocal microscopy", "species": "Mouse", "doi": "10.1182/blood-2010-02-268466", "pmid": "20647571", "pmcid": "PMC2974595", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2974595/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "AUTH-PMC3252037", "title": "Importance of Starting Age for Myelotoxicity Study in Dietary Restricted Rats", "species": "Rat", "doi": "10.1293/tox.22.153", "pmid": "22271989", "pmcid": "PMC3252037", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3252037/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "AUTH-PMC3320159", "title": "Histopathology of Incidental Findings in Cynomolgus Monkeys (Macaca Fascicularis) Used in Toxicity Studies", "species": "Cynomolgus_monkey", "doi": "10.1293/tox.25.63", "pmid": "22481861", "pmcid": "PMC3320159", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3320159/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "AUTH-PMC4408895", "title": "Practical Murine Hematopathology: A Comparative Review and Implications for Research", "species": "Mouse", "doi": "NR", "pmid": "25926395", "pmcid": "PMC4408895", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4408895/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "AUTH-PMC4766527", "title": "Malaria in cynomolgus monkeys used in toxicity studies in Japan", "species": "Cynomolgus_monkey", "doi": "10.1293/tox.2015-0051", "pmid": "26989299", "pmcid": "PMC4766527", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4766527/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "AUTH-PMC6398341", "title": "Neutrophil Progenitor Populations of Rhesus Macaques", "species": "Rhesus_monkey", "doi": "10.1002/JLB.1TA1117-431RR", "pmid": "30395351", "pmcid": "PMC6398341", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6398341/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "AUTH-PMC7040758", "title": "Effect of cyclophosphamide on hematopoietic stem cells in mice with iron overload", "species": "Mouse", "doi": "10.12122/j.issn.1673-4254.2020.01.18", "pmid": "32376555", "pmcid": "PMC7040758", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7040758/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "AUTH-PMC8005067", "title": "Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling", "species": "Minipig", "doi": "10.3390/ijms22063286", "pmid": "33807089", "pmcid": "PMC8005067", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8005067/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "AUTH-PMC8544165", "title": "International Harmonization of Nomenclature and Diagnostic Criteria (INHAND): Non-proliferative and Proliferative Lesions of the Non-human Primate (M. fascicularis)", "species": "Cynomolgus_monkey", "doi": "10.1293/tox.34.1S", "pmid": "34712008", "pmcid": "PMC8544165", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8544165/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "AUTH-PMC8844892", "title": "Gene Expression Profiles from Heart, Lung and Liver Samples of Total-Body-Irradiated Minipigs: Implications for Predicting Radiation-Induced Tissue Toxicity", "species": "Minipig", "doi": "10.1667/RADE-20-00123.1", "pmid": "32936898", "pmcid": "PMC8844892", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8844892/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "CARTER-2016-CYNO-BM", "title": "Cytological Bone Marrow Cell Differential Counts and Morphologic Findings in Healthy Cynomolgus Monkeys from Nonclinical Toxicology Studies", "species": "Cynomolgus_monkey", "doi": "10.1177/0192623316677067", "pmid": "NR", "pmcid": "NR", "url": "https://doi.org/10.1177/0192623316677067", "source_type": "Traceable_official_or_publisher_source", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "EMA-", "title": "EPAR Assessment Report", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.ema.europa.eu/en/documents/assessment-report/vidaza-epar-public-assessment-report_en.pdf", "source_type": "EMA_regulatory_review", "case_count": 22, "expert_review_status": "Pending" }, { "source_id": "FDA-203971", "title": "Pharmacology Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2013/203971Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 14, "expert_review_status": "Pending" }, { "source_id": "FDA-206162", "title": "Pharmacology Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 18, "expert_review_status": "Pending" }, { "source_id": "FDA-208065", "title": "Pharmacology Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2015/208065Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA-208261", "title": "Pharmacology Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 8, "expert_review_status": "Pending" }, { "source_id": "FDA-211810", "title": "Multi-discipline Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/211810Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA-212327", "title": "Multi-discipline Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 6, "expert_review_status": "Pending" }, { "source_id": "FDA-214120", "title": "Multi-discipline Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 6, "expert_review_status": "Pending" }, { "source_id": "FDA-214200", "title": "Pharmacology Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214200Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 10, "expert_review_status": "Pending" }, { "source_id": "FDA-214783", "title": "Multi-discipline Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2021/214783Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA-22277", "title": "Pharmacology Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022277s000_PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 4, "expert_review_status": "Pending" }, { "source_id": "FDA_001-BM-008", "title": "Multi-discipline Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_001-BM-018", "title": "Multi-discipline Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_001-BM-019", "title": "Multi-discipline Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_001-BM-024", "title": "Multi-discipline Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/214120Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_002-BM-002", "title": "Pharmacology Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/125268s000_PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_002-BM-003", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2008/125268s000_PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-001", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-002", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-008", "title": "Pharmacology Review", "species": "Cynomolgus_monkey", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-011", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-012", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-016", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-021", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-027", "title": "Pharmacology Review", "species": "Cynomolgus_monkey", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-029", "title": "Pharmacology Review", "species": "Cynomolgus_monkey", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-034", "title": "Pharmacology Review", "species": "Cynomolgus_monkey", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-035", "title": "Pharmacology Review", "species": "Cynomolgus_monkey", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-036", "title": "Pharmacology Review", "species": "Cynomolgus_monkey", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-042", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-043", "title": "Pharmacology Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-045", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-049", "title": "Pharmacology Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-050", "title": "Pharmacology Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-053", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-054", "title": "Pharmacology Review", "species": "Cynomolgus_monkey", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-055", "title": "Pharmacology Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-056", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-057", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-058", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-059", "title": "Pharmacology Review", "species": "Cynomolgus_monkey", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_003-BM-060", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2012/203214Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_007-BM-001", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022277s000_PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_007-BM-003", "title": "Pharmacology Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022277s000_PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_007-BM-006", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022277s000_PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_008-BM-001", "title": "Pharmacology Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_008-BM-004", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_008-BM-010", "title": "Pharmacology Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_008-BM-011", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_008-BM-013", "title": "Pharmacology Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2016/208261Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_009-BM-001", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_009-BM-002", "title": "Pharmacology Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_009-BM-006", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_009-BM-007", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_009-BM-014", "title": "Pharmacology Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_009-BM-017", "title": "Pharmacology Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_009-BM-018", "title": "Pharmacology Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_009-BM-019", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_009-BM-021", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/206162Orig1s000PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_010-BM-002", "title": "Multi-discipline Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_010-BM-003", "title": "Multi-discipline Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_010-BM-008", "title": "Multi-discipline Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_010-BM-010", "title": "Multi-discipline Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_010-BM-011", "title": "Multi-discipline Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_010-BM-012", "title": "Multi-discipline Review", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_010-BM-014", "title": "Multi-discipline Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/212327Orig1s000MultidisciplineR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_011-BM-003", "title": "Pharmacology Review", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022465s000_PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_011-BM-004", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022465s000_PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_011-BM-017", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022465s000_PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "FDA_011-BM-018", "title": "Pharmacology Review", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.accessdata.fda.gov/drugsatfda_docs/nda/2009/022465s000_PharmR.pdf", "source_type": "FDA_regulatory_review", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "LEGACY-RPBM-001", "title": "Carboplatin-Induced Thrombocytopenia through JAK2 Downregulation, S-Phase Cell Cycle Arrest and Apoptosis in Megakaryocytes", "species": "Rat", "doi": "10.3390/ijms23116290", "pmid": "35682967", "pmcid": "PMC9181531", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9181531/", "source_type": "Peer_reviewed_full_text", "case_count": 5, "expert_review_status": "Pending" }, { "source_id": "LEGACY-RPBM-002", "title": "Protective Effect of Royal Jelly against Cyclophosphamide-Induced Thrombocytopenia and Spleen and Bone Marrow Damages in Rats", "species": "Rat", "doi": "10.22074/cellj.2020.6703", "pmid": "31863655", "pmcid": "PMC6947013", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6947013/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "NTP-", "title": "Toxicity Report", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://ntp.niehs.nih.gov/sites/default/files/ntp/htdocs/st_rpts/tox050.pdf", "source_type": "NTP_official_atlas", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "NTP-BONE-MARROW-ANGIECTASIS", "title": "Bone marrow - Angiectasis - Nonneoplastic Lesion Atlas", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Angiectasis", "source_type": "NTP_official_atlas", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "NTP-BONE-MARROW-FIBROSIS", "title": "Bone marrow - Fibrosis - Nonneoplastic Lesion Atlas", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Fibrosis", "source_type": "NTP_official_atlas", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "NTP-BONE-MARROW-GELATINOUSTRANSFORMATION", "title": "Bone marrow - Gelatinous Transformation - Nonneoplastic Lesion Atlas", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/GelatinousTransformation", "source_type": "NTP_official_atlas", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "NTP-BONE-MARROW-HYPERCELLULARITY", "title": "Bone marrow - Hypercellularity - Nonneoplastic Lesion Atlas", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypercellularity", "source_type": "NTP_official_atlas", "case_count": 6, "expert_review_status": "Pending" }, { "source_id": "NTP-BONE-MARROW-HYPOCELLULARITY", "title": "Bone marrow - Hypocellularity - Nonneoplastic Lesion Atlas", "species": "Multiple_species", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Hypocellularity", "source_type": "NTP_official_atlas", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "NTP-BONE-MARROW-INFILTRATIONCELLULARHISTIOCYTE", "title": "Bone marrow - Histiocytic Infiltration - Nonneoplastic Lesion Atlas", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularHistiocyte", "source_type": "NTP_official_atlas", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "NTP-BONE-MARROW-INFILTRATIONCELLULARMASTCELL", "title": "Bone marrow - Mast Cell Infiltration - Nonneoplastic Lesion Atlas", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/InfiltrationCellularMastCell", "source_type": "NTP_official_atlas", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "NTP-BONE-MARROW-INFLAMMATION", "title": "Bone marrow - Inflammation - Nonneoplastic Lesion Atlas", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Inflammation", "source_type": "NTP_official_atlas", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "NTP-BONE-MARROW-NECROSIS", "title": "Bone marrow - Necrosis - Nonneoplastic Lesion Atlas", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Necrosis", "source_type": "NTP_official_atlas", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "NTP-BONE-MARROW-PIGMENT", "title": "Bone marrow - Pigment - Nonneoplastic Lesion Atlas", "species": "Mouse", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://ntp.niehs.nih.gov/atlas/nnl/hematopoietic-system/bone-marrow/Pigment", "source_type": "NTP_official_atlas", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC10699128-RHESUS-EBOV-CELLULARITY", "title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "species": "Rhesus_monkey", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC10699128-RHESUS-EBOV-ERYTHROID", "title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "species": "Rhesus_monkey", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "source_type": "Peer_reviewed_full_text", "case_count": 3, "expert_review_status": "Pending" }, { "source_id": "PMC10699128-RHESUS-EBOV-MEGAKARYOCYTES", "title": "Depletion of Bone Marrow Hematopoietic Cells in Ebolavirus-Infected Rhesus Macaques: A Possible Cause of Hematologic Abnormalities in Ebolavirus Disease", "species": "Rhesus_monkey", "doi": "10.1016/j.ajpath.2023.08.010", "pmid": "37689386", "pmcid": "PMC10699128", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10699128/", "source_type": "Peer_reviewed_full_text", "case_count": 6, "expert_review_status": "Pending" }, { "source_id": "PMC10752361-RABBIT-EPO-MARROW", "title": "Effects of Exogenous Erythropoietin on Rabbit (Oryctolagus cuniculus) Hematological and Biochemical Parameters", "species": "Rabbit", "doi": "10.30802/AALAS-CM-22-000107", "pmid": "37967856", "pmcid": "PMC10752361", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10752361/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC10754359-RHESUS-RADIATION-IRON", "title": "Iron Deposition in the Bone Marrow and Spleen of Nonhuman Primates with Acute Radiation Syndrome", "species": "Rhesus_monkey", "doi": "10.1667/RADE-23-00107.1", "pmid": "37967581", "pmcid": "PMC10754359", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10754359/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC10923821-RHESUS-RADIATION-HISTOPATH", "title": "Histopathological studies of nonhuman primates exposed to supralethal doses of total- or partial-body radiation: influence of a medical countermeasure, gamma-tocotrienol", "species": "Rhesus_monkey", "doi": "10.1038/s41598-024-56135-w", "pmid": "38459144", "pmcid": "PMC10923821", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC10923821/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC12710095-CANINE-MDS-MPN", "title": "Myelodysplastic/Myeloproliferative Neoplasm in a Dog: A Case Report", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "PMC12710095", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12710095/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC13135069-RHESUS-RADIATION-DEPLETION", "title": "Comparative study of pathology of various organs of rhesus macaques exposed to two different doses of acute total-body radiation", "species": "Rhesus_monkey", "doi": "10.1038/s41598-026-49844-x", "pmid": "42034724", "pmcid": "PMC13135069", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13135069/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC1797897-BM-HISTOLOGY-BESTPRACTICES", "title": "Best Practices for Evaluation of Bone Marrow in Nonclinical Toxicity Studies", "species": "Rat", "doi": "10.1177/0192623310396907", "pmid": "NR", "pmcid": "PMC1797897", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC1797897/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC1880821-RAT-GCSF-KINETICS", "title": "Rat G-CSF early mobilization-to-proliferation sequence", "species": "Rat", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC1880821/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC2748286-DOG-ESTROGEN-MYELOTOXICITY", "title": "Canine estrogen myelotoxicity stage 2: neutrophilia with granulocytic hyperplasia", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2748286/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC3972870", "title": "Morphological Changes in the Bone Marrow of the Dogs with Visceral Leishmaniasis", "species": "Dog", "doi": "10.1155/2014/150582", "pmid": "24744957", "pmcid": "PMC3972870", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3972870/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC3996654-MOUSE-5FU-ENTOLIMOD", "title": "Toll-like receptor-5 agonist Entolimod broadens the therapeutic window of 5-fluorouracil by reducing its toxicity to normal tissues in mice", "species": "Mouse", "doi": "10.18632/oncotarget.1773", "pmid": "24583651", "pmcid": "PMC3996654", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC3996654/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC4219468", "title": "Depletion of STAT5 blocks TEL-SYK-induced APMF-type leukemia with myelofibrosis and myelodysplasia in mice", "species": "Mouse", "doi": "10.1038/bcj.2014.53", "pmid": "25148222", "pmcid": "PMC4219468", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4219468/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC4427713-RAT-CYPERMETHRIN", "title": "Peripheral blood and bone marrow responses under stress of cypermethrin in albino rats", "species": "Rat", "doi": "10.2478/intox-2014-0006", "pmid": "26038674", "pmcid": "PMC4427713", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4427713/", "source_type": "Peer_reviewed_full_text", "case_count": 5, "expert_review_status": "Pending" }, { "source_id": "PMC4566160-CYNO-RADIATION-MARROW", "title": "Molecular and cellular profiling of acute responses to total body radiation exposure in ovariectomized female cynomolgus macaques", "species": "Cynomolgus_monkey", "doi": "10.3109/09553002.2015.1028597", "pmid": "25786585", "pmcid": "PMC4566160", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4566160/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC4837595-MOUSE-5FU-TIMECOURSE", "title": "Delineating the effects of 5-fluorouracil and follicle-stimulating hormone on mouse bone marrow stem/progenitor cells", "species": "Mouse", "doi": "10.1186/s13287-016-0311-6", "pmid": "27095238", "pmcid": "PMC4837595", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4837595/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC4948781", "title": "Alkylator-Induced and Patient-Derived Xenograft Mouse Models of Therapy-Related Myeloid Neoplasms Model Clinical Disease and Suggest the Presence of Multiple Cell Subpopulations with Leukemia Stem Cell Activity", "species": "Mouse", "doi": "10.1371/journal.pone.0159189", "pmid": "27428079", "pmcid": "PMC4948781", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4948781/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC5544077-RHESUS-MALARIA-MARROW", "title": "Case Report: Severe and Complicated Cynomolgi Malaria in a Rhesus Macaque Resulted in Similar Histopathological Changes as Those Seen in Human Malaria", "species": "Rhesus_monkey", "doi": "10.4269/ajtmh.16-0742", "pmid": "28829738", "pmcid": "PMC5544077", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC5544077/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC6233195-JAPANESE-MACAQUE-MARROW", "title": "Haematological analysis of Japanese macaques (Macaca fuscata) in the area affected by the Fukushima Daiichi Nuclear Power Plant accident", "species": "Japanese_macaque", "doi": "10.1038/s41598-018-35104-0", "pmid": "30425289", "pmcid": "PMC6233195", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6233195/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC6298844-MINIPIG-SEROUS-ATROPHY", "title": "Proceedings of the 2018 National Toxicology Program Satellite Symposium", "species": "Minipig", "doi": "10.1177/0192623318800734", "pmid": "30282530", "pmcid": "PMC6298844", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC6298844/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC7158316-VETERINARY-HEMATOLOGY", "title": "Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic System", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "PMC7158316", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7158316/", "source_type": "Peer_reviewed_full_text", "case_count": 6, "expert_review_status": "Pending" }, { "source_id": "PMC7324823", "title": "Clinical and clinicopathological features and outcomes of Miniature Dachshunds with bone marrow disorders", "species": "Dog", "doi": "10.1292/jvms.19-0439", "pmid": "32307340", "pmcid": "PMC7324823", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7324823/", "source_type": "Peer_reviewed_full_text", "case_count": 2, "expert_review_status": "Pending" }, { "source_id": "PMC7723243-MOUSE-GCSF-GRANULOPOIESIS", "title": "G-CSF shifts erythropoiesis from bone marrow into spleen in the setting of systemic inflammation", "species": "Mouse", "doi": "10.26508/lsa.202000737", "pmid": "33234677", "pmcid": "PMC7723243", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC7723243/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC8478025", "title": "Congenital dyserythropoiesis and polymyopathy without cardiac disease in male Labrador retriever littermates", "species": "Dog", "doi": "10.1111/jvim.16214", "pmid": "34227150", "pmcid": "PMC8478025", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8478025/", "source_type": "Peer_reviewed_full_text", "case_count": 6, "expert_review_status": "Pending" }, { "source_id": "PMC8546475-RABBIT-GELATINOUS-MARROW", "title": "Gelatinous transformation of bone marrow in a rabbit", "species": "Rabbit", "doi": "10.1177/10406387211029916", "pmid": "34250866", "pmcid": "PMC8546475", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC8546475/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "PMC9407898", "title": "An EHPB1L1 Nonsense Mutation Associated with Congenital Dyserythropoietic Anemia and Polymyopathy in Labrador Retriever Littermates", "species": "Dog", "doi": "10.3390/genes13081427", "pmid": "36011338", "pmcid": "PMC9407898", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC9407898/", "source_type": "Peer_reviewed_full_text", "case_count": 4, "expert_review_status": "Pending" }, { "source_id": "PMDA-", "title": "Review Report", "species": "Dog", "doi": "NR", "pmid": "NR", "pmcid": "NR", "url": "https://www.pmda.go.jp/files/000233298.pdf", "source_type": "Traceable_official_or_publisher_source", "case_count": 4, "expert_review_status": "Pending" }, { "source_id": "S2M-PMC12910396", "title": "First Case Report of Precursor‐Targeted Immune‐Mediated Anaemia in a Dog From Italy Lacking Rubriphagocytosis and With Severe Hyperferraemia: Diagnosis, Treatment, and Clinical Outcome", "species": "Dog", "doi": "10.1002/vms3.70852", "pmid": "41700447", "pmcid": "PMC12910396", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC12910396/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "S2M-PMC2807276", "title": "Pathological features of bone marrow transplantation-related toxicity in a mouse", "species": "Mouse", "doi": "10.4142/jvs.2009.10.4.361", "pmid": "19934605", "pmcid": "PMC2807276", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC2807276/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "S2M-PMC4261574", "title": "Evaluation of blood and bone marrow in selected canine vector-borne diseases", "species": "Dog", "doi": "10.1186/s13071-014-0534-2", "pmid": "25441458", "pmcid": "PMC4261574", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4261574/", "source_type": "Peer_reviewed_full_text", "case_count": 5, "expert_review_status": "Pending" }, { "source_id": "S2M-PMC4569586", "title": "The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates", "species": "Rhesus_monkey", "doi": "10.1371/journal.pone.0135388", "pmid": "26367124", "pmcid": "PMC4569586", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4569586/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "SUP-PMC11697499", "title": "Standardized bone marrow assessment, risk variables, and survival in dogs with myelodysplastic syndrome and acute myeloid leukemia", "species": "Dog", "doi": "10.1177/03009858241277982", "pmid": "39291964", "pmcid": "PMC11697499", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC11697499/", "source_type": "Peer_reviewed_full_text", "case_count": 8, "expert_review_status": "Pending" }, { "source_id": "SUP-PMC1797897", "title": "Enhanced Histopathology of the Bone Marrow", "species": "Cynomolgus_monkey", "doi": "10.1080/01926230600939971", "pmid": "17067952", "pmcid": "PMC1797897", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC1797897/", "source_type": "Peer_reviewed_full_text", "case_count": 1, "expert_review_status": "Pending" }, { "source_id": "SUP-PMC4485636", "title": "Severe Acquired Idiopathic Thrombocytopenia in a Female Cynomolgus Macaque (Macaca fascicularis)", "species": "Cynomolgus_monkey", "doi": "NR", "pmid": "26141452", "pmcid": "PMC4485636", "url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC4485636/", "source_type": "Peer_reviewed_full_text", "case_count": 3, "expert_review_status": "Pending" } ], "migration_policy": { "public_text_layer": "Traceable paraphrased case summaries with source links.", "public_image_layer": "Only bone marrow smear/aspirate cytology and explicitly labeled peripheral-blood comparators are embedded in case cards.", "pathology_evidence_layer": "Bone marrow tissue sections remain traceable but are routed to the pathology atlas instead of being embedded in the smear atlas.", "local_only_layer": "All other image binaries remain local pending per-image rights and expert review." } }